Who we are What we do Where we are going How you can help

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Who we areWhat we doWhere we are going How you can help

This presentation is designed to introduce you to a young interdisciplinary group, The Organ Donor Research Consortium., who we are, what we do, where we are going and how you can help us get there 1our primary mission is to advance organ donation through scientific research in order to improve outcomes for donors, their families, recipients and society as a whole

501c corporation formed January, 2011

Our mission is to advance organ donation through scientific research in order to improve outcomes for donors, their families, recipients and society as a whole. We are a 501c corporation formed in January 20112Current membership represents involvement of all 11 UNOS regions, 25 OPOs

12 transplant centers

Who we areCurrently we have 50 active members representing all 11 UNOS regions, 25 OPOs, HRSA, AOPO and 12 transplant centers across the United States3ATC poster presentation 2012 Charles Wright, MD, Lifelink of FL8.6% of 2127 referrals to 5 OPOs treated with hypothermia suggested increase in OTPD in patients treated with hypothermia versus those not treated with hypothermia

What we do One of the first projects supported by the ODRC was a prospective evaluation of all referrals to five organ procurement organizations. Presented as a poster at the 2012 American Transplant Congress by Charley Wright, founding chair of the Executive Committee, this study demonstrated that 8.6% of 2127 referrals were treated with hypothermia prior to suffering brain death. The study also suggested that organs transplanted per donor (AKA OTPD) in patients treated with hypothermia was increased versus those donors not treated with hypothermia.4Prospective study of OTPD from anoxic donors treated with and without hypothermia20 OPOs 1296 donors enrolled data analysis under way

What we do Subsequently the ODRC funded a prospective study evaluating the number of organs transplanted per donor from anoxic donors treated with and without hypothermia. Twenty organ procurement organizations enrolled 1296 donors in the study. This is also the first study to employ a study coordinator to serve as a hub hosting conference calls, emailing documents, funneling questions and assessing data quality.51st RFP granted 2014 $20,000 Amy Friedman, MD Kristin Delli Carpini LiveOnNY How many biopsies does a kidney require $10,000 Bryan Tillman, MD University of Pittsburgh A vascular isolation catheter to mitigate warm ischemia of donor organs among donation after cardiac death donors

What we do Funded by membership dues, the ODRC has awarded $20,000 in seed grant money in 2013. In 2014, the ODRC funded its first grants as a result of an RFP to Amy Friedman, MD and Bryan Tillman6Not all requests for support are financial Pediatric intensivist evaluated donor management protocols, guidelines and goals employing an on-line survey tool and follow-up focused interview

100% participation rate of 58 OPOs

Submitted to Pediatric Critical Care, July 2015

What we do Not all requests for support are financial. One investigator interested in pediatric donor management protocols, guidelines and donor management goals, requested support of the ODRC in achieving a 100% participation rate of 58 OPOs in an on-line survey and follow-up focused interview. Both tools were developed with input from the ODRC, and trialing at 4 OPOs.7Not all requests for support are financial Wrote letter of support for Kiran Khush, MD, Stanford for NIH grantEvidence-Based Evaluation and Acceptance of Donor Hearts for Transplantation

Facilitated participation in the study

What we do Not all requests for support are financial. In June, 2013 Kiran Khush, a Stanford cardiologist presented a NIH proposal to formally integrate donor characteristics and recipient outcomes in order to facilitate process improvements in allocation, allow examination of important questions such as the impact of the expertise level of the cardiologist interpreting echocardiograms on recovery of donor hearts and potentiate interventions aimed at increasing the number of cardiac transplants and improving recipient outcomes. She received funding and is currently recruiting participants 8Intervention trial examining effect of pre-conditioning agent on mitochondrial function and whether alterations in mitochondrial function can be employed to assess suitability of organs for transplant

Where we are going Other funded activities include our first intervention trial examining the effect of a preconditioning agent on mitochondrial function as well as whether alterations in mitochondrial function can be employed to rapidly assess the suitability of organs for transplant . 9Collaborative review and scoring of grant applications addressing core mission

Independent ethical oversight of projects from submission to completion

Where we are going The ODRC employs a collaborative review and scoring of grant applications addressing our core mission. Additionally we have developed a process of independent ethical oversight of projects beginning with submission to completion10Foster investigator-initiated collaborative multidisciplinary clinical researchPromote a culture of scientific inquiry in the area of organ donationAdvance organ donor research methodologyMentor scientific investigators in this areaAchieve external funding to support the mission

Where we are going Our vision includes fostering investigator-initiated collaborative multidisciplinary clinical research, promoting a culture of scientific inquiry in the area of organ donation, advancing organ donor research methodology, mentoring scientific investigators in this area and achieving external funding to support our mission. 11Join us OHare Hilton Fly-in /Fly-out September 30, 2015

Membership info theodrc.org

How you can help If our mission and vision strike a chord within you, join us. Information is available on our our website https://theodrc.org. We support an all teach, all learn environment. 12Submit a proposal

How you can help . We are interested in all areas of organ donation including hospital development, family services, donor management, organ assessment, organ allocation, organ procurement and organ preservation. 13Participate in our studies OPO process and the efficiency of kidneys shared for cPRA 99-100% in the new KAS system Hepatitis C and organ utilization

How you can help When requested, participate in our studies and I am asking!14 Fund us

How you can help . Finally fund us. We are a 501c corporation, with all donations being tax-deductible. Employing only membership dues, we funded $40,000 in grants in 2013-2014. In 2013, funding requests evaluated by the ODRC and voted by the membership to be worthy of funding exceeded available funds by $7500.15