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TCM Wisdom TubeTM

Treating Infertility in Advance Aged Women Using the 8 Extra Meridians

by Brandon Horn

PhD, JD, LAc, FABORM

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Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 1

Treating Infertility in Advance Aged Women Using the

8 Extra Meridians

Brandon HornPhD, JD, LAc, FABORM

© Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine

Tel: (626) 780-7182 Fax: (626) 609-2929Web: www.elotus.org Email: [email protected]

Sources of Information

Main Teachers– Jeffrey C Yuen– Chang Qing– Fred Wu– Paul Yan

Research/PhD Dissertation at the American University of Complementary Medicine (AUCM.org)

What is Aging?

– Aging is the unfolding of Jing– Jing unfolds through movement (Yang)– Aging is Yang consuming Yin

Yang elements can be:– Physiological (e.g. Yang Qi) or– Pathological (e.g., fire toxins)

– The primary (not only) 8EVs involved in the process of aging are the Wei Channels

Aging Ovaries Illustrated (actual picture of human ovaries)

(c) 2007 Slide reproduced with permission from Seminar “Optimizing Ovarian Reserve”Lotuscenter.com/publications

Characteristics of Aging Ovaries(slide taken from ovarian reserve seminar)

Lusterless and wrinkledDecreased in volumeIncreasing fibrosis with accumulation of scar and connective tissueReduced vascular network, sclerosis of vessel wallsIncreased apoptotic and necrotic cells


The Aging Ovary

Older ovaries show evidence of greater oxidative damage than those in younger womenFollicular depletion accelerates during the last decade of reproductive life





• Mitochondrial Dysfunction (could be physiological or pathological)– Decreased number of mitochondria– Increased mitochondrial density– Increased incidence of mitochondrial membrane rupture in granulosa cells

• Smooth endoplasmic reticulum (SER) dysfunction– Increased frequency of dilated SER in granulosa cells (oxidative damage)– SER synthesizes lipids, metabolizes CHO, detoxifies drugs, attaches

receptors to cell membrane proteins• Golgi complex dysfunction

– Increase in dilation of golgi complex (oxidative damage)– Golgi processes proteins for secretion by the cell

• Increase in vacuole fraction– Vacuole functions include containing waste

• Overall follicle quality scores were NOT associated with age-related ovarian decline

Morphology of Aging vs. Young OvariesBiol Reprod. 2004 Feb;70(2):419-24. Epub 2003 Oct 15


Other Abnormalities Associated with Aging Ovaries

Increased meiotic non-disjunction in oocyte– Age-related damage due to oxidative stress– Reduced microcirculation around follicles– Hypooxygenation of preovulatory follicle

Deletions in mtDNAAcupuncture, herbs and nutrition can reduce oxidative damage, increase microcirculation to the ovaries, protect mtDNA and improve follicular oxygenation.


General Causes of Oocyte Aging: Deficiency and Excess

Deficiency– “Weakness” or “Deficiency” of DNA or cellular

structures (8EV)– Deficiency of Protective factors

Excess– “Excess” of insulting factors (e.g., oxidative stress)

(8EV+)Insulting factors can be:

– Endogenous (e.g., byproducts of energy production, etc.)– Exogenous (e.g., environmental toxins, microbes, etc.)


8EV and Ovarian Aging

8EV can – Strengthen the Jing (including DNA and cellular

structures)– Release deeply held PFs (including environmental

toxins, microorganisms, etc.)


What are/are not the 8EV

8EV are the “vessels” or conduits of Jing– Jing is the fundamental material component of life

“Qi” Jing Ba Mai: – Why are they strange?

8EV “Meridians” are conceptual inventions

Chapter 27 of the Nan Jing:– “8EV are beyond the reach of the primary channels”.

Note: all of the 8EV share common points and/or trajectories with the PM

Are the 8EV present in an embryo?– Embryogenesis is the unfolding of Jing

Conduits of Jing must be present in an embryoWhere is Chong mai, etc. in an embryo?

“Strange” Channels– “Strange” because they have trajectories or aspects

(like other meridians), but no defined path (unlike other meridians)




8EV “Meridians” are only one strategy for accessing the true 8EV

Slowing Aging: an 8EV Perspective

Energetics of structural integrity comes primarily from the Wei vesselsWei vessels: – Maintain structural integrity (morphology)– Assist in the removal of PFs located at the Jing

level– Help remove scar tissue and other morphological

factors stagnating the Jing– Increase the longevity of cells

Yinwei Mai

Governs susceptibility to agingStrengthens integrity of Jing to protects from both exogenous and endogenous insultsGoverns time and the keepers of time (e.g., telomeres)

Prolongs life of ovaries.

Yinwei Treatment “Protocol” for Ovarian Aging

Consolidate and strengthens oocytesPair with Dai Mai (Tonification) for added effect on protecting DNA

Sample Point Prescription: Sp13(+), Kd9(+), Pc6, Pc7, GB1, KD7(+), Sp10(-), Sp6(+)

Note: Don’t need to use all of these points

Caution: Overtreatment may increase risk of non-disjunction

If pulses begin to deviate medially or new signs of stagnation develop you may have over-treated.

If so, treat Yangwei mai and pulses should balance.

Yangwei “Linking” Mai

Important for proper DNA replicationControls disjunction

Helps prevent aneuploidy (e.g., Down Syndrome)

Assists with removal of toxins and other PFs from the Jing level

Yangwei treatment protocol for Ovarian Aging

Sample point prescription for optimal disjunction: UB63(-), GB35(-), GB29(-), GB15(-), TH4, TH5(-), Sp 6(+)Caution: Overtreatment can deplete yin and destabilize Jing

Always assess the state of yin and blood during treatments. If deficiency begins to arise, stop treatment until yin stabilizes then continue.




Diagnostic suggestions for using Wei Mai

Pulses Simplified:Normal pulses should have a straight trajectoryDeviations are assessed from proximal to distal

Inward deviations: yinwei excess/ yangwei deficiencyOutward deviations: yangwei excess/yinwei deficiencyBoth Inward and Outward: treat both channels and treat the liver PMNeither Inward or Outward (i.e., no deviations): treat yinwei(+)

Case Study

Female42 y/oG3P0A35 rounds of IVF: 2 chem +, 1 fhb aborted due to trisomy 21

Hx: Smoker for 10 years (tobacco + cannabis), one glass of wine with dinner, stressful jobWDx: Advanced maternal age. Recommendation egg donor

Case Study

Pulses: rapid, flooding and deviated medially in the Lr position. Lu x diff, sl. Rapid. Kd choppy and rapid, Pc sl. Flooding and tightTongue: Red tip, swollen on the right side, yellow coating in the back with red papules visible.Inspection: nails had several dark vertical stripes. Luo vessels apparent at Sp 21 and Lr14.

Case Study

Dx: Lr fire. Yinwei excess (Yinwei trying to contain the heat)Tx: UB63, GB35, GB27 – St 28 (30hz for 10 min), TH3, TH5, Kd 10, Lu6– Drain Lr fireResult: After 6 treatments the choppiness and heat in the pulses began to subside but was replaced by an emptiness in the liver position. Pulse less deviated. Tx: kd7, kd9 – sp15 (2 hz for 5 minutes), kd10, pc7, Lu5Add herbal medicine: Han Lian Cao 9g, Nu Zhen Zi 9g, Fu Pen Zi 6g, Wu Wei Zi 6g, Zhi Ke 3g, Zhi Zi 4.5g, no alcohol for 3 weeksResult: After 3 treatments (3 weeks) the pulses filled out. Lu began diffusing, TH reduced, Lr not rapid.

Case Study

Tongue remained swollen on right side. Papules @ root became a dull red.Pulses: intermittently choppy at blood level in guan positionTx: Lr5 (bled), Lr 8, Sp9, CV9, CV4

Case Study

Result: After 8 treatments pulses completely balanced except liver pulse slippery and sl. Rapid. Tongue still swollen on the right side. Requested patient stop alcohol completely. After 4 more treatments pulses normalized with only a slight deviation in guan remaining.




Case Study

REI allowed for another IVF following acu and resulted in a healthy pregnancy. No change in quantity of follicles, but quality of embryos improved dramatically.During pregnancy Tx: kd 9 moxa (ibuki 1 cone), Lu5, Lr8 for 1st trimester. Amnio was normal.

Contact Info

Brandon Horn, PhD, JD, LAcwww.lotuscenter.com

[email protected]: lotuscenter.com/facebooktwitter: twitter.com/lotusctroffice: (323) 551-5962

More information on the classic single herbs mentioned in this seminar/webinar can be found in the Chinese Medical Herbology and Pharmacology

More information on the classic formulas can be found in the Chinese Herbal Formulas and Applications

Collection formulas can be found in the eLotus Clinical Manual of Oriental Medicine

All the above texts are available through www.elotus.org

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