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26 November 2015

Dispensing New Experiences for the Consumer

Novel packaging and delivery solutions

Yan Lin Lye, Amanda Talhat & Peter Luebcke

26 November 2015 2Commercially Confidential

Our locations

Cambridge UK

Boston USA

Asia

500 engineers, scientists, and designers working from our offices in UK, USA and Asia

We have around 40 consultants across the business

For clients worldwide, we- develop breakthrough products and systems- create and license intellectual property- provide business consulting in technology critical issues

70% of our work is repeat business – we become trusted partners for our clients


Our clients range from established blue-chips to dynamic startups across sectors include Consumer, Medical and Industrial

http://www.pg.com/en_US/index.shtml

http://www.britvic.com/


Interfacial Phenomena - enhancing your formulations

We understand how formulations interact with devices and systems We develop systems that dispense the right dose with the right texture to the right place

• Film and bubble formation

• Droplet formation in sprays and emulsions.

• Crystallisation

• Gelation

• Electro & Thermo-chemistry

• Foam formation

• Mixing and dissolution

• Wetting


Personal Care Industry?


Understanding interfacial phenomena enables innovation in two major trends

Organic & Natural Personalisation

Minimising VOCs, excipients, e.g. preservatives

No need to derivatize natural actives

Dial-up/dial-down dosing

Fragrance/texture choice

Innovative packaging and

dispensing systems

Diagnostics informs user


Emulsions ‘on-demand’

We understand the emulsification process and the demanding needs of personal care formulation manufacture

By controlling the flow of multiple liquid phases different droplet sizes can be created

Ratios of lipid and aqueous phases can be varied to give various textures and sensorial characteristics Customised Emulsion

Surfactants excipients

Aqueous phase

Lipid phase


Benefits of in-situ emulsification

Less heating Shorter mixing time Control of droplet size Selection of viscosity and texture Creating only quantities needed

– Less/no preservative needed

– Less/milder surfactants


Novel Foaming System

• Topical foams have grown in popularity

• Over 100 patents filed in last 10 years

• We have developed a novel low-cost foaming system

• Benefits include:

• High quality (<50m bubbles, 95% gas phase)

• Lower pressures (<2 bar) allow use of PET packaging

• Air or nitrogen as a propellant (no VOCs)

Foamed emulsions


Benefits & applications of foaming

• Topical foams can be spread more easily

• Single phase solutions or emulsions can be foamed

• E.g. shaving foams, topical skincare, suncare

• High solids loading (e.g. 10% w/w TiO2)

• Oil-in-water & water-in-oil emulsions

• Less surfactant needed

• Suitable for appliances & hand pumps

Foamed emulsions


PROJECT EXAMPLE – Structured Idea Management

We developed Vortik in house, using our experience in drug delivery mechanisms

This spray head allows the customer to vary they spray properties in ways that are not possible in conventional aerosols

The liquids and gas are mixed in a specially designed, cyclonic chamber

Vortik does not require damaging VOCs to work. It uses air

…this delivers a tighter particle distribution than conventional sprays

…..and the spray characteristics can be varied by adjusting the relative pressures

Multiple liquids can be combined at the point of delivery. Swirling and shear perform the mixing

On demand spray


Benefits of in-situ combine and spray

Multiple inlets allow for mixing at point of spray

A 3mm cyclone typically delivers 0.1cc / second

A 20mm cyclone typically delivers 1 litre / minute

• Incompatible formulations and actives can be kept separate until the last second

• Ratios of different liquids can be varied in real time

• Particle size distribution can be controlled, e.g. minimising respirable droplets


TRENDS

Diagnostics leads to personalisation

Go beyond a gimmick and back this up with real science!

In-store DNA testing can recommend particular skincare products for that individual, increasing customised solutions

and brand loyalty

Consumers want personalisation in skin care, haircare and oral care products – one size does NOT fit all


In July 2015 we announced our XylemDx low-cost printable diagnostic


The test ‘cartridge’ consists of a printed electronics & fluidics with an adhesive area to collect a skin sample

Fluidics

Electronics

3M double sided adhesive (with backing)

View of unassembled test cartridge


The sample collection & analysis process is straightforward

1. Partially assembled test cartridge is supplied

2. Adhesive cover removed 3. Test cartridge applied to skin

4. Cartridge folded and wet reagents applied if required

5. Cartridge assembled into reader device

6. Reader device plugged into smartphone for data capture


Please contact us for further information

Yan Lin Lye

[email protected]

01223 420024

mailto:[email protected]

26 November 2015

Cambridge UK

Registered No. 1036296 England

Cambridge Consultants is part of the Altran group, a global leader in Innovation. www.Altran.com

www.CambridgeConsultants.comThe contents of this presentation are commercially confidential and the proprietary information of Cambridge Consultants © 2015 Cambridge Consultants Ltd. All rights reserved.

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