GEAR GRANTS & RELATIONSHIP TO CURRENT NSF RII GRANT
GEAR GRANTS
• Due March 29 2010
• Pilot projects targeted to submitting an extramural grant within 12 months
• Amount of awards (50-100K)
• Peer Reviewed
• 10 pages max (interdisciplinary)
• ALIGN with NSF RII Track 1 Award
GEAR GRANTS
• Instructions (SC EPSCOR OFFICE)
• Scott Little ([email protected])
• Isabel Sanchez ([email protected])
• Key: alignment with the NSF RII grant “The South Carolina Project”
NSF-RII Grant
Title “South Carolina Project”
Theme Tissue Based Engineering
Goal To Engineer a Vascular Tree by
Bioprinting
What is Bioprinting?
Bioprinting/Biofabrication is a computer-aided, robotic Bioprinting/Biofabrication is a computer-aided, robotic layer by layer addition of living building blocks to form 3D layer by layer addition of living building blocks to form 3D functional human tissue constructsfunctional human tissue constructs
BIOPRINTING
the ability to arrange bio-materials in a controlled but “additive” fashion in
three-dimensional (3D) space.
BioPrinting Using “BioInk”
BioInk = aggregates of stem cells + hydrogel (morphogens)
A B C
D E F
G
From Mironov, Markwald et al 2009 in Expert Opinion in Biological Therapy (in press)
BioInk BioInk
Stem cells + hydrogel
SOUTH CAROLINA PROJECT
Digital Anatomy
Blueprint
CAD
Bioink
Bioprinter
Biopaper
MATUROGENS
Tissue Constructs
Biomonitoring
I. Pre-processing
II. Processing
III. Post-processing
Components ofOrgan PrintingTechnology
Bioreactors
Enabling Technologies Required for Engineering a Vascular Tree
Vascular Tree
Bio Ink
BioPaper
BioReactor
BioMonitor
Bio informatics
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