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Where Life and Science Mean Business

Israel – Hungary Innovation Day

Israel Medical Technology3 October 2013

Jeff Dykan

SCP Vitalife Managing Director


Life Science Industry 2 Main Categories

Biotechnology Medical Devices


Life Science Industry 2 Main Categories

Biotechnology Medical Devices

Where Life and Science Mean Business$100M to $150 invested by Venture Capital

annually in Life Sciences

approximately 80% to Medical Devices

ILSI Database 2013 PWC Kesselman & Kesselman


Focus on MedTech Israel’s Life Sciences Industry - Sectors

Source: ILSI Database – 2013

Where Life and Science Mean BusinessFocus on Largest Markets

Medical Devices - Main Medical Fields



Focus on Disposables, Implantables, Diagnostics and Imaging

Israel’s Medical Device Companies - Subsectors


Where Life and Science Mean BusinessYoung Industry

65% of active companies founded in last decadeThe Israeli Life Science Industry

Number of Companies Founded

2010 –Incomplete dataILSI Database 2013


While the industry is young, 45% have revenues

Companies Developmental Stage



Trivia

Which country has the largest number of medical device patents in the world per

capita ?


Trivia

Which country has the largest number of medical device patents in the world per capita ?

ISRAEL


Israel is #1Medical Devices Patents per Million Capita

Source: www.uspto.gov, Analysis: ILSI ©


Medtech StartupsCriteria for Success

• Large market• Strong IP• Clinical evidence > superiority and value• Platform technology

• Path to Widespread Commercial Use

Where Life and Science Mean BusinessHistory of Israeli Medical Device Exits

ILSI database 2013


Overview of SCP Vitalife

SCP Vitalife II, L.P. 1

SCP Vitalife

• Medical Technology VC

• Total $ Under Management: $230M- Vitalife I & SCP Vitalife II

• Offices: Tel Aviv and Philadelphia

• Primary focus on investments sourced in Israel (65%) and U.S. (35%)

• Partners: Dr. Avi Ludomirski, Jeff Dykan, Wayne Weisman, Win Churchill

Fund’s Investment Focus & Portfolio

• Medical Devices for Therapeutic Uses Avedro, NovoGI,, Endospan, Sightline,

BetaO2, Fluidnet, Spine21

• Novel Diagnostic Methods, especially Imaging

Sensible, Deep Breeze, Denx, Trig, D.I.R., Pocared, MediGuide

• Biomaterials and Cell Therapies Regentis, GeneGrafts, Garnet, ColBar

• Specialty Pharmaceuticals and Drug Delivery Recro, TransPharma, CanFite

• Other Argo, Procognia

Major Exits

• ColBar: Acquired by a division of J&J

• Sightline: Acquired by Stryker

• MediGuide: Acquired by St. Jude

•CanFite: IPO on TASE


Active Portfolio Companies

Where Life and Science Mean BusinessDIR Technologies

Description• DIR Technologies was formed by SCP

Vitalife II via a spin-out from SCD, a leading Israeli developer and manufacturer of infrared detectors and laser diodes for defense and military purposes

• DIR applies infrared technology in a variety of non-contact pharmacological tests, such as identification of counterfeit drugs through the original package, and rigorous in-line quality assurance for the manufacture and packaging of drugs by the leading pharma companies

• Company is working with leading global pharma companies on both QA and anti-counterfeiting application


Beta-O2 Technologies

• Beta-O2 has developed a bio-artificialsubstitute pancreas for diabetic patients

• The ß-Air is an implantable device thatcontains islets of Langerhans (insulin andglucagon producing cells). The cells areprotected from the host’s immune systemand supplied with oxygen

• Following extensive pre-clinical testing, Beta-O2 performed its first-in-human implantation in a leading diabetes center in Germany during 2012

• Following seven months of implantation: “For the first time it has been shown that allogeneic islets integrated into an oxygenated macrochamber can survive and function after transplantation in man without any immunosuppressive therapy ….... This finding is outstanding and a case sui generis.”

Report by the German physicians

-400 -300 -200 -100 05

6

7

8

9

10

0 30 60 90

Normal Range

Days relative to Tx

Hb

A1c

(%

)

Initial Results of First-in-Human Implantation

Hemoglobin A1c After the First 90 Days


Sensible Medical Innovations

Description• Founded in May 2007, Sensible is developing the

SafePatchCHF, a non-invasive system for continuous monitoring of Congestive Heart Failure patients

• SafePatch is based on Remote Dielectric Sensing (ReDS) technology, which employs electromagnetic reflectometry using ultra-wide-band frequencies transmitted at very low intensities

• Technology was adapted from military application utilized by Sensible’s founders during their service in special technology units of the Israeli Defense Forces

• The SafePatch measures lung fluid content, respiratory rate and heart rate which, combined, provide an early indicator of heart failure de-compensation

• The market potential for CHF monitoring is estimated at hundreds of millions of dollars per year

Where Life and Science Mean BusinessPocared Diagnostics

Description

• Pocared Diagnostics has developed an innovative diagnostic system that provides physicians with real-time detection and identification of pathogens

• The standard (culture-based) testing process typically requires 30 hours to identify the infectious agent; Pocared’s solution will be able to provide bacterial identification within 1-2 hours

• Pathogen identification is made possible using the proprietary Pocared Optical Signature™ and Pocared Optical Fingerprint™

• The high-throughput system is compact, user-friendly and does not require the use of reagents

• Has become well-known to potential acquirers, who are awaiting results of clinical trials in first half of 2013


Argo Medical

• Argo Medical aims to fundamentally change the health and life experiences of individuals with spinal cord injury.

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