1Psihijatrija u svetlu neuronaukePB Psychiatry in the spotlight of neuroscience 1

NA­UČ­NI­­I­OR­GA­NI­ZA­CI­O­NI­OD­BORProf. dr Alek san dar Jo va no vić, di rek tor

Prof. dr Nad ja Ma rić Bo jo vić, pred sed nik

Doc. dr Mi lan La tas

Doc. dr Ma ja Iv ko vić

Prof. dr Sr djan Mi lo va no vić

Dr Mi li ca Ne šić, dr sci.

As. dr sci. Ma ri na Mi ha lje vić (kurs)

Dr Sre ten Vi ćen tić, dr sci. (akre di ta ci ja)

Zva nič ni je zi ci Sim po zi ju ma su srp ski i en gle ski.

 AKRE­DI­TA­CI­JAA-1-1866/17 - Nacionalni simpozijum sa međunarodnim učešćem Lekari, Farmaceuti,

Biohemičari, Zdravstveni tehničari, Psiholozi, Socijalni radnici

Pre da va či 9 po e na, Pa siv no učeš će 5 po e na

2 Psihijatrija u svetlu neuronauke2

SIM­PO­ZI­JUM­JE­OR­GA­NI­ZO­VAN­UZ­PO­DRŠ­KU

SCIENTIFIC­AND­ORGANIZING­COMMITTEES­Prof. dr Aleksandar Jovanović, director

Prof. dr Nadja Marić Bojović, president

Doc. dr Milan Latas

Doc. dr Maja Ivković

Prof. dr Srdjan Milovanović

Dr Milica Nešić, dr sci.

As. dr sci Marina Mihaljević (the Course)

Dr Sreten Vićentić, dr sci. (accreditation)

The official languages of the Symposium are Serbian and English.

 ACCREDITATION А-1-1866/17 – National Symposium with International Participantion

Physicians, Pharmacists, Biochemists, Medical technicians, Psychologists, Social workers

Pre da va či 9 po e na, Pa siv no učeš će 5 po e na

THE­SYMPOSIUM­IS­SUPPORTED­BY

3Psychiatry in the spotlight of neuroscience 3

4 Psihijatrija u svetlu neuronauke4 Psychiatry in the spotlight of neuroscience 5

DRA GE KO LE GE, DRA GI PRI JA TE LJI,

Ove go di ne po 44. put odr ža će se Sim po zi jum Kli ni ke za psi hi ja tri ju KCS. Tra di ci ja odr ža va nja na ših sim po zi ju ma da ti ra od 1976. go di ne i ob u hva ta raz li či te te me od zna ča ja za sve ko ji se ba ve zaš ti tom men tal nog zdra vlja, di jag no sti kom, pre ven ci jom i le če njem du šev nih po re me ća ja.

Glav ni pro gram Sim po zi ju ma odr ža će se 1-2. no vem bra 2017. go di ne u Ju go slo ven-skom dram skom po zo riš tu u Be o gra du.

Te ma ovo go diš njeg Sim po zi ju ma je „Psi hi ja tri ja u sve tlu ne u ro na u ke“. Ka da smo bi ra li te mu ovo go diš nje edu ka ci je, kao da smo na slu ti li šta će par me se ci ka sni je po sta ti glav na te ma ugled nog ča so pi sa JA MA Psychi a try. Na i me, u iz da nju ovog ča so pi sa od 8. mar ta 2017. na gla ša va da su se to kom po sled njih 20 go di na raz vi le re vo lu-ci o nar ne alat ke i pri stu pi u ne u ro na u ci ko ji su bez pre se da na u isto ri ji psi hi ja tri je (Hec kers, 2017), i da raz vo jem ne u ro na u ke, iz da na u dan mi do bi ja mo sve bo lju šan su da raz u me mo bi o loš ke osno ve psi hi ja trij skih bo le sti. Me đu tim, po sta vlja se pi ta nje ko li ko smo u sta nju da pra ti mo na pre dak ove obla sti? Da li po se du je mo do volj no „pi sme no sti“ da bi smo raz u me li sve što se de ša va to kom mo le ku lar nog de ši fro va nja mo zga i kom plek snih in ter ak ci ja u osno vi du šev nog ži vo ta čo ve ka?

Go to vo smo si gur ni da su udru ži va nje drev ne em pi ri je i ak tu el nih ino va ci ja, uz kri tič ku di sku si ju i pa žlji ve za ključ ke, naj si gur ni ji put da do bro raz u me mo i kva li tet no le či mo oso be ko je nam se obra ća ju za po moć. Zbog to ga, na Sim po zi ju mu će uz pre da va če sa Kli ni ke za psi hi ja tri ju, na ši go sti bi ti ugled ni struč nja ci i is tra ži va či iz Evro pe i Sr bi je, kao i mla di či jim je is tra ži va nji ma una pr eđe na ne u ro na u ka u Sr bi ji i u sve tu.

Na kon Sim po zi ju ma, 3. no vem bra 2017. odr ža će mo jed no dnev ni kurs iz obla sti ne u ro na u ke i psi hi ja tri je.

Kao i do sa da, ap strak ti sa Sim po zi ju ma će bi ti štam pa ni u su ple men tu ča so pi sa „En gra mi“. Oče ku je mo da nam se pri dru ži te!

S poš to va njem,

Prof. Aleksandar Jovanović, direktor Klinike

Prof. Na đa Ma rić Bo jo vić, na čel nik ode lje nja za na uč no-is tra ži vač ki rad

i ra ne in ter ven ci je u psi hi ja tri ji

5Psihijatrija u svetlu neuronauke4 Psychiatry in the spotlight of neuroscience 5

DEAR COLLEAGUES, DEAR FRIENDS,

This year we are organizing the 44th Symposium of the Clinic for Psychiatry, Clinical Centre of Serbia. Our main programme will be held from 1st to 2nd November 2017, in the Yugoslav Drama Theatre in Belgrade.

The tradition of our symposia dates back to 1976 and includes a broad range of topics of high significance to everyone involved in mental health prevention and mental disorder diagnostics and therapy.

The topic of this year’s Symposium is “Psychiatry in the Spotlight of Neuroscience.” It seems that when we chose the topic of this year’s education, we anticipated what would become the main subject of the distinguished journal JAMA Psychiatry a few months later. Namely, in the issue published on 8th March 2017, it is stated that in the last 20 years we have seen the development of revolutionary tools and approaches in Neuroscience that are unprecedented in the history of Psychiatry (Heckers, 2017), and that the development of Neuroscience gives us the opportunity to finally understand the biological underpinnings of psychiatric disorders. However, the question is − how competent are we to comprehend the advancement of this field? Do we possess enough “literacy” to understand the processes that occur during the molecular decoding of the brain, within the complex interactions which underlie mental disorders?

We are almost certain that the safest way to better understand and treat individuals who seek our help is to bridge together the cumulative empirical knowledge and current innovations, alongside critical discussions and prudent deductions. Therefore, together with lecturers from the Clinic for Psychiatry, the Symposium will host notable experts and researchers from Europe and Serbia, as well as young professionals who present continual to the advancement of Neuroscience in Serbia and across the world.

In addition to the Symposium’s main program, the one-day course on Neuroscience and Psychiatry will be held on 3rd November 2017.

As on previous occasions, the abstracts from the Symposium will be published in the supplement of the journal Engrami. We hope you will join us!

Sincerely,

Prof. Aleksandar Jovanovic, Director

Prof. Nadja Maric Bojovic, Head of the Department for research and

early interventions in psychiatry

6 Psihijatrija u svetlu neuronauke6 Psychiatry in the spotlight of neuroscience 7

1. Osnov ni prav ci kli nič ke psi hi ja tri je, 1976.2. Ak tu el no sti u psi ho far ma ko te ra pi ji, 1978.3. Bi hej vi or psi ho te ra pi ja, 1978.4. Fo ren zič ka psi hi ja tri ja, 1979.5. Nor mal nost i psi hi ja tri ja, 1979.6. Psi hi ja tri ja i an tip si hi ja tri ja, 1980.7. No vi grup ni prav ci, 1980.8. O shi zo fre ni ji, 1981.9. Psi ho pa to lo gi ja ne u ro za da nas, 1981.10. De pre si ja, 1982.11. Psi ho lo gi ja, psi hi ja tri ja i in ter per so nal­ni od no si, 1982.12. Psi ho or gan ski sin dro mi, 1983.13. Te ra pi ja psi hi ja trij skog kon cep ta kri ze i psi hi ja trij ske in ter ven ci je, 1983.14. Ma nič na sta nja, 1984.15. In ter di sci pli nar ni pri stup u psi hi ja tri ji, 1985.16. Pa ra no id na sta nja, 1986.17. Po re me ća ji lič no sti, 1987.18. Re ak tiv ne psi ho ze, 1988.19. Psi ho te ra pi ja: ne do u mi ce i per spek ti­ve, 1989. 20. Al ko ho li zam: ak tu el ni pro ble mi, 1990.21. Psi ho te ra pi ja: dok tri na, eklek ti ka, in te­gra ci ja, 1991.22. Sud ska psi hi ja tri ja: sim po zi jum po sve­ćen dr V. Su bo ti ću, pr vom sud skom psi hi­ja tru, 1992.23. Mr žnja i men tal no zdra vlje, 1993.24. Psi hi ja tri ja u dru gim me di cin skim di­sci pli na ma, 1994.25. Brač ni i po ro dič ni po re me ća ji: pre ven­ci ja i te ra pi ja, 1995.

26. Shi zo fre ni ja, na pra gu tre ćeg mi le ni­ju ma: vre me sa daš nje, di le me, na ja ve za bu duć nost, 1996.27. Kog ni tiv ni pro ce si i mo guć nost kog ni­tiv ne te ra pi je, 1997.28. Men tal no zdra vlje i psi hič ki po re me ća­ji kod že na, 1998.29. Svest, spa va nje, sno vi: čo vek iz me đu stvar no sti i maš te na pra gu 21. ve ka, 1999.30. Pro ble mi men tal nog zdra vlja iz be glog, ra se lje nog i prog na nog sta nov niš tva, 2001.31. Nor mal no i po re me će no pol no po na­ša nje, 2002.32. Di le me i per spek ti ve psi hi ja tri je u no­voj epo hi, 2003.33. Po re me ća ji ras po lo že nja: od di jag no­sti ke do te ra pi je, 2004.34. O su i ci du, 2005.35. Ra ci o nal na te ra pi ja men tal nih po re­me ca ja, 2006.36. Ak tu el ni pro ble mi i tren do vi sud ske psi hi ja tri je u Sr bi ji, 2007.37. An tip si ho ti ci­pu t ka re in te gra ci ji, 2009.38. Ra ne psi ho ze­iza zov za pre ven ci ju, di­jag no sti ku i te ra pi ju, 2010.39. Stig ma kao pre pre ka u pre ven ci ji i le­če nju men tal nih po re me ća ja, 2011.40. Spek tar ank si o znih po re me ća ja – iza­zov sa vre me nog do ba, 2012.41. Ju bi lej 90 go di na Kli ni ke za psi hi ja tri ju i Kli ni ke za ne u ro lo gi ju – Is ku stva i no ve ten den ci je, 2013.42. Bi o e ti ka i psi hi ja tri ja, 2014.43. Bi po lar ni spek tar – iza zo vi i per spek­ti ve, 2015.

DOSADAŠNJI EDUKATIVNI SIMPOZIJUMI INSTITUTA-KLINIKE ZA PSIHIJATRIJU

7Psihijatrija u svetlu neuronauke6 Psychiatry in the spotlight of neuroscience 7

1. Fun da men tal trends in Cli ni cal Psychi­a try, 1976.2. Cur rent trends in Psychop har ma cot he­rapy, 1978.3. Be ha vi o u ral psychot he rapy, 1978.4. Fo ren sic Psychi a try, 1979.5. Nor ma lity and Psychi a try, 1979.6. Psychi a try and an tipsychi a try, 1980.7. In no va ti ons in gro up­the rapy, 1980.8. Abo ut Schi zop hre nia, 1981.9. Psycho pat ho logy of ne u ro sis to day, 1981.10. De pres sion, 1982.11. Psycho logy, psychi a try and in ter per so­nal re la ti ons, 1982.12. Psycho­or ga nic syndro mes, 1983.13. Con cept of cri sis, the rapy and psychi a­tric in ter ven ti ons, 1983.14. Ma nic sta tes, 1984.15. In ter di sci pli nary ap pro ach to Psychi a­try, 1985.16. Pa ra noid sta tes, 1986.17. Per so na lity di sor ders, 1987.18. Re ac ti ve psycho ses, 1988.19. Psychot he rapy: di lem mas and per­spec ti ves, 1989.20. Al co ho lism: cur rent pro blems, 1990.21. Psychot he rapy: doc tri ne, ec lec ti cism, in te gra tion, 1991.22. Fo ren sic Psychi a try: a sympo si um de­di ca ted to Dr V. Su bo tic, the first fo ren sic psychi a trist, 1992.23. Ha te and Men tal He alth, 1993.24. Psychi a try in ot her fi elds of Me di ci ne, 1994.25. Ma ri tal and fa mily di sor ders: pre ven­tion and the rapy, 1995.

26. Schi zop hre nia on the thres hold of the third mil len ni um: cur rent sta tus, di lem­mas, fu tu re per spec ti ves 1996.27. Cog ni ti ve pro ces ses and the po ten ti als of cog ni ti ve the rapy, 1997.28. Men tal he alth and psychi a tric di sor­ders in wo men, 1998.29. Con sci o u sness, sle ep, dre ams: man in­bet we en fan tasy and re a lity on the thres­hold of 21st cen tury, 1999.30. Men tal He alth di sor ders in mi grants, in ter nally dis pla ced and re fu gee po pu la­ti ons, 2001.31. Nor mal and de vi ant se xu al be ha vi o ur, 2002.32. Di lem mas and per spec ti ves of Psychi­a try in the new era, 2003. 33. Af fec ti ve di sor ders: from di ag no stics to the rapy, 2004.34. Abo ut su i ci de, 2005.35. Ra ti o nal the rapy of men tal di sor ders, 2006.36. Cur rent pro blems and trends in Fo ren­sic Psychi a try in Ser bia, 2007.37. An tipsycho tics − a road to wards re in te­gra tion, 2009.38. Early psycho ses − a chal len ge for pre­ven tion, di ag no stics and the rapy, 2010. 39. Stig ma as an ob stac le to pre ven tion and tre at ment of men tal di sor ders, 2011.40. An xi ety di sor ders spec trum − a mo­dern age chal len ge, 2012.41. A 90­year ju bi lee of the Cli nic for Psychi a try & Cli nic for Ne u ro logy – ex pe ri­en ces and no vel ten den ci es, 2013.42. Bi o et hics and Psychi a try, 2014.43. Bi po lar spec trum − chal len ges and per spec ti ves, 2015.

PREVIOUS SYMPOSIA ORGANIZED BY THE INSTITUTE/ CLINIC FOR PSYCHIATRY

8 Psihijatrija u svetlu neuronauke8 Psychiatry in the spotlight of neuroscience 9

PROGRAM - 01.11.2017.

08:30h - 09:30h

09:30h - 10:00h

10:00h - 10:30h

10:30h- 11:00h

13:00h- 13:30h

11:30h- 12:30h

12:30h- 13:00h

14:30h- 15:15h

15:15h- 17:30h

17:45h- 18:30h

11:00h- 11:30h

13:30h- 14:30h

-I-

-I-

Registracija

Pred­se­da­va­ju­ći:

Pozdravna­reč

Plenarno predavanje

Plenarno predavanje

Plenarno predavanje

Satelitski simpozijum PFIZER

Predsedavajući:­

Plenarno predavanje

Satelitski simpozijumEUPHARM

Simpozijum

Neurobiološke osnove psihopatologije

Satelitski simpozijum KRKA

Kafe pauza

Ručak

A.­Jo­va­no­vić,­N.Ma­rić

A.­Jo­va­no­vić

P.­Falkai­(Nemačka)­WFSBP guidelines for treat-ment of schizophrenia – special aspects of long term pharmacologic and non-pharmacologic in-terventionsD.­Bugarski­Kirola­(SAD)­­Silver linings play-book – the positive side of the negative trials

G.­Knežević­Da li postoji dispoziciona uslovl-jenost amoralnog ponašanja?

Lyrika-anksioznost i šta još…? Milan­Latas­i­Vladimir­Janjić­

B.­Batinić,­S.­Milovanović

N.­Vasić­(Nemačka)­Commonalities and differ-ences between general and forensic psychiatry – what should be considered in the practice?

Terapija pacijenata sa shizofrenijom: da li dobro može biti i bolje? A.­Damjanović­i­M.Ivković

Depresija i anksioznost - upali svetlo i dodaj boje N.­Marić­i­Č.­Miljević

•­E.­Stefanova­Biomarkeri kognitivnih poremećaja u starijem životnom dobu – aktuelnosti •­N.­Marić­Anti NMDA-r encefalitis – hirurgija kao kauzalni tretman u psihijatriji •­M.­Ivković­Bipolarni poremećaj u svetlu neuroi-munologije •­B.Batinić­Neurobiološke osnove impulsivnog/kompulzivnog ponašanja –psihofarmakološke intervencije •­D. Duišin Neurobiološke osnove rodne disforije – aktuelni hipotetički modeli

Predsedavajući:­ A.­Damjanović,­M.­Ivković-I-

9Psihijatrija u svetlu neuronauke8 Psychiatry in the spotlight of neuroscience 9

08:30h - 09:30h

09:30h - 10:00h

10:00h - 10:30h

10:30h- 11:00h

13:00h- 13:30h

11:30h- 12:30h

12:30h- 13:00h

14:30h- 15:15h

15:15h- 17:30h

17:45h- 18:30h

11:00h- 11:30h

13:30h- 14:30h

-I-

-I-

Registration

Chairs:

Welcome note

Plenary lecture

Plenary lecture

Plenary lecture

Satellite symposiumPFIZER

Chairs:

Plenary lecture

Satellite symposium EUPHARM

Symposium

Neurobiological bases of psychopathology

Satellite symposium KRKA

Coffee break

Lunch

A.­Jo­va­no­vic,­N.Ma­ric

A.­Jo­va­no­vic­(Serbia)

P.­Falkai­(Germany)­WFSBP guidelines for treat-ment of schizophrenia – special aspects of long term pharmacologic and non-pharmacologic in-terventionsD.­Bugarski­Kirola­(USA)­­Silver linings play-book – the positive side of the negative trials

G.­Kneževic­(Serbia)­Is there a dispositional con-ditioning of amoral behavior?

Milan Latas and Vladimir JanjicLyrica-anxiety and what else…?

B.­Batinic,­S.­Milovanovic

N.­Vasic­(Germany)­Commonalities and differ-ences between general and forensic psychiatry – what should be considered in the practice?

Therapy in schizophrenia – if good could become better? A. Damjanovic and M. Ivkovic

Depression and anxiety – turn the light on and enhance colours­N.­Maric­and­Č.­Miljevic

•­E.­Stefanova Biomarkers of cognitive disorders in elderly – current trends•­N. Maric NMDA-r encephalitis – surgery as causal treatment in psychiatry•­M. Ivkovic Bipolar disorder in the light of neuro-immunology•­B. Batinic Neurobiological basis of impulsive and compulsive behavior – implications for psy-chopharmacological interventions•­D. Duišin Neurobiological basis of gender dys-phoria – current hypothetical models

Chairs: A.­Damjanovic,­M.­Ivkovic-I-

THE PROGRAM - 01.11.2017.

10 Psihijatrija u svetlu neuronauke10 Psychiatry in the spotlight of neuroscience 11

PROGRAM - 02.11.2017.

09:30h - 10:15h

-I-

10:20h - 10:45h Predavanje

Predavanje10:45h- 11:10h

13:00h- 14:00h

11:45h- 12:30h

12:30h- 13:00h

11:15h- 11:45h

14:00h- 17:00h

17:00h- 17:30h

-I-

-I-

Satelitski simpozijum ACTAVIS

Pred­se­da­va­ju­ći:

Pred­se­da­va­ju­ći:

Simpozijum

Doprinos mladih razvoju psihijatrije i neuronauka u Srbiji

Zatvaranje

Pred­se­da­va­ju­ći:

Plenarno predavanje

Quetiapin u terapiji bipolarnog afektivnog poremećaja­G.­Mihajlović­i­M.­Ivković

A.­Damjanović­Da li filozofija (ne)opravdava biološku psihijatriju

I.­Filipčić­(Hrvatska)­Multimorbiditeti u psihi-jatriji - CIP centar integrativne psihijatrije

Bogatija receptorska aktivnosti –uspešnije lečenje afektivnih i psihotičnih poremećaja N.­Marić­i­M.Latas

J.­Hall­(Velika­Britanija)­Schizophrenia - a fearful madness

M.­Latas,­Z.­Pavlović

B.­Dinjić,­Kostić­i­M.­Mihaljević

M.­Latas,­Z.­Pavlović

Kafe pauza

Ručak

Satelitski simpozijumGOODWILL

•­M.­Nešić Glukokortikoidna signalizacija, crte ličnosti i skorašnji stresogeni dogadjaji u strukt-uralnom modelu podložnosti za depresiju•­M.­Kostić Uticaj kumulacije 5-HTTLPR, BDNF Val66Met i COMT Val158Met polimorfizama na strukturu mozga kod pacijenata sa depresivnim poremećajem•­Z.Stojanović EKT kod osoba sa terapo-rezistent-nom depresijom: srednjoročni efekti na afekat i kogniciju•­B.­Dunjić­Kostić Alteracije citokina u shizofreniji i depresiji•­M.­Borovčanin Galektin-3 i interleukin-33 kao novi marker inflamacije u shizofreniji•­M.­Mihaljević­Udruženost uticaja rizičnih vari-jnati FKBP5 gena i traume u detinjstvu na rizik od psihotičnog poremećaja•­S.­Andrić­Petrović Deficit socijalne kognicije u psihijatrijskim poremećajima – fokus na psihoze•­M.­Pantović­Stefanović Shizoafektivni kontinuum - stari koncept u novom svetlu

11Psihijatrija u svetlu neuronauke10 Psychiatry in the spotlight of neuroscience 11

09:30h - 10:15h

-I-

10:20h - 10:45h Lecture

Lecture10:45h- 11:10h

13:00h- 14:00h

11:45h- 12:30h

12:30h- 13:00h

11:15h- 11:45h

14:00h- 17:00h

17:00h- 17:30h

-I-

-I-

Satellite symposium ACTAVIS

Chairs:

Chairs:

Symposium

The contribution of youth to development of psychi-atry and neuroscience in Serbia

Closing

Chairs

Plenary lecture

Quetiapine in the treatment of bipolar affective disorder G. Mihajlovic and M. Ivkovic

A. Damjanovic Biological psychiatry is (not) justifiable by philosophy?

I. Filipcic Multimorbidities in psychiatry – CIP center for integrative psychiatry

Rich receptor activity –improved therapy in affective disorders and psychosisN. Maric and M.Latas

J.­Hall­(UK)­­Schizophrenia − a fearful madness

M.­Latas,­Z.­Pavlovic

B.­Dunjic,­Kostic­and­M.­Mihaljevic

M.­Latas,­Z.­Pavlovic

Coffee break

Lunch

Satellite symposiumGOODWILL

•­M.­Nešić Glucocorticoid signalization, personal-ity traits and recent stressful events in a structural model of vulnerability to depression•­M.­Kostić The effect of cumulation of 5-HT-TLPR, BDNF Val66Met and COMT Val158Met polymorphisms on brain structures in patients with depression•­Z.­Stojanović ECT in patients with treatment resistant depression: medium-term effects on affect and cognition •­B.­Dunjić­Kostić Cytokine alterations in schizo-phrenia and depression•­M.­Borovčanin­Galectin-3 and interleukin-33 as new markers of inflammation in schizophrenia•­M.­Mihaljević­Joint effect of the risk FKBP5 genetic variants and childhood trauma on risk for psychosis•­S.­Andrić­Petrović Social cognition deficits in psychiatric disorders – focus on psychoses •­M.­Pantović­Stefanović Schizoaffective continu-um - old concept in a new framework

THE PROGRAM - 02.11.2017.

12 Psihijatrija u svetlu neuronauke12 Psychiatry in the spotlight of neuroscience 13

NOTES

13Psihijatrija u svetlu neuronauke12 Psychiatry in the spotlight of neuroscience 13

NOTES

PSYCHIATRY­IN­THESPOTLIGHT­OF­NEUROSCIENCE

XLIV­EDUCATIONAL­SYMPOSIUMCLINIC­FOR­PSYCHIATRY

CLINICAL­CENTRE­OF­SERBIA

Programme

15

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