Presented by :Md.Waliullah Wali

Topic: Cancer genome databases Ecological databases

CONTENTS

IntroductionCOSMIC cancer database

Types of dataSearching Process

Ecological databasesBioOne

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Searching ProcessBrief description

Introduction

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E.g. nucleotide sequence database

A database is a collection of information that is organized so that it can easily be accessed, managed, and updated.

The database which store biological data is called biological database.

Introduction

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Biological databases are libraries of life sciences information, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis.

Information contained in biological databases includes gene function, structure, localization, clinical effects of mutations as well as similarities of biological sequences and structures.

Cancer genome databases

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COSMIC cancer database

COSMIC cancer database

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COSMIC is an online database of somatically acquired mutations found in human cancer.

The database is freely available.

COSMIC cancer database

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Types of dataExpert curation dataGenome-wide screen data

COSMIC cancer database

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Expert curation data Manually input by COSMIC expert curators. Consists of comprehensive literature curation

followed by subsequent updates. Includes additional data points relevant to each

disease and publication. Provides accurate frequency data as mutation

negative samples are specified.

COSMIC cancer database

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Genome-wide screen data Uploaded from publications reporting large scale

genome screening data or imported from other databases such as TCGA and ICGC.

Provides unbiased molecular profiling of diseases while covering the whole genome.

Provides objective frequency data by interpreting non mutant genes across each genome.

Facilitates finding novel driver genes in cancer.

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Enter into -COSMIC cancer database

by typing http://cancer.sanger.ac.uk/cosmic in the address bar of Browser

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Searching Process

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Examples

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Examples

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Examples

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Examples

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Ecological databases

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Ecological databases

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Ecological databases is a source for finding ecological datasets and quickly figuring out the best ways to use them.

BioOneDataONEGEOBASE

BioOne

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BioOne is a nonprofit publisher that aims to make

scientific research more accessible.

BioOne was established in 1999 in Washington, DC.

BioOne is Complete and open-access.

It serves a community of over 140 society and

institutional publishers, 4,000 accessing institutions,

and millions of researchers worldwide.

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Enter into -BioOne Ecological database

by typing http://www.bioone.org/ in the address bar of Browser

BioOne

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Advanced Search

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Examples

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Examples

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BioOne

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BioOne

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http://www.elementascience.org/

Thank you All

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