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Seizure semiology
Moahmed HamdyAssistant Professor of neurology
Alexandria university
• Diagnostic protocols rely on – clinical semiology,– optimized MRI sequences, – video-telemetry, – Functional neuroimaging, – neuropsychology and neuropsychiatry
assessments and, at times, – invasive EEG monitoring.
Pitfalls of neuroimaging alone
• In adults, 25% of pathologically confirmed cases of focal cortical dysplasia are reported to be MRI-negative prior to surgery (high resolution 3 tesla)
Pitfalls of neuroimaging alone
• Increased signal on FLAIR indicative of HS is not always accompanied by hippocampal atrophy,
• Neoplasms are the structural substrate in 3-4% of patients with epilepsy in the general population
• Although MRI-defined structural lesions are a strong predictor of the seizure onset zone, there are reports of well-documented cases in which resections of EEG-defined seizure onset regions that spared structural lesions have resulted in seizure freedom
• Diagnostic protocols rely on – clinical semiology,– optimized MRI sequences, – video-telemetry, – Functional neuroimaging, – neuropsychology and neuropsychiatry
assessments and, at times, – invasive EEG monitoring.
Semiology is the 1st and the most important step
• Questioning the patient and family• Direct observation while hospitalization• Video-EEG monitoring
• The overall pattern of ictal semiology• The initial subjective phenomenon (aura)
and/or objective phenomenon which sometimes make it possible to confirm specific topographic origin
• the spatial and temporal articulation of the different ictal phenomenae.
• The post-ictal phase (focal deficit)• Conciousness during the attack
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Somatosensory phenomena
well localized, discriminatory, and spread relatively slowly (like a sort of ‘jacksonian march’)
• parietal lobe (primary somatosensory cortex, S1)
ill-defined, often accompanied by pain, spread within seconds,
• posterior insula-parietal operculum (supplementary somatosensory area, S2) and may be contra- or ipsilateral
Lateralized ictal headache
• Ipsilateral temporal or occipital
Post ictal headache
• Non localizing
Special senses
Gustarory aura
• Insular region
Visual aura
• Contralateral occipital cortex
Elementary auditory
• Primary auditory cortex
Complex auditory
• Temproparietal junction
Olfactory aura
• Anterior mesiotemporal (uncinate)
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Psychic manifestations
Deja vu
• Mestiotemporal without lateralization
Forced thinking
• Frontal or mesiotemporal of the dominant hemisphere
Ictal fear
• Amygdala
Ictal autoscopy
• Non dominant parietal lobe
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Head and limb movement
Nonversive head turning
• Ipsilateral temporal lobe
Forced (versive) head turning
• Contralateral frontal lobe
Focal clonic movement
• Contralateral frontal lobe
Hyperkinetic seizures
• frontal lobe
Gyratory seizures
• Contralateral frontotemporal
Todd’s paresis
• contralateral
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Eye and eyelid movements
Unilateral blinking
• Ipsilateral temporal or frontal
Ictal nystagmus
• Contralateral frontal or occipital
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Dystonic posturing
Unilateral limb dystonia
• Contralateral temporal or frontal
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Automatism
Unilateral automatism
• Ipsilateral temporal or orbitofrontal
Postictal nose wiping
• Ipsilateral temporal
Rhythmic ictal non clonic hand movement
• Contralateral temporal lobe
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Behavioral and phasic manifestations
Post ictal dysnomia
• Dominant hemisphere
Behavioral arrest
• Temporal, or orbitofrontal region
From symptom to localization or lateralization
• Sensory Phenomena• Psychic Manifestations• Head and Limb Movements• Eye and Eyelid Movements• Dystonic Posturing• Automatisms• Behavioral and Phasic Manifestations• Autonomic Manifestations
Autonomic manifestations
Ictal spitting
• Non dominant temporal lobe
Ictal nausea and vomiting
• Anterior insula
Ictal laughing
• Hypothalamic hamartoma in children and frontal cingulus in adults (non lateralizing)
Ictal weeping
• Non lateralizing mesiotemporal
Vertigo
• Insular-tempro-parietal junction
viscerosensory
• mesiotemporal
Thank You