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ANATOMY Unit 3 Notes: Hematopoiesis & Hemostasis

Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

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Page 1: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

ANATOMY

Unit 3 Notes:Hematopoiesi

s & Hemostasis

Page 2: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(1) Hematopoiesis• The process of blood cell formation and

development.

• All blood cells originate from the stem cell the Hemocytoblast.

• If it becomes a red blood cell:– Hemocytoblast Erythroid Stem Cell RBC

• If it becomes a Lymphocyte white blood cell:– Hemocytoblast Lymphoid Stem Cell Lymphocyte

• If it becomes a Non-Lymphocyte white blood cell:– Hemocytoblast Myeloid Stem Cell Neutrophil,

Basophil, Monocyte, Eosinophil

Page 3: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes
Page 4: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(2) Red Blood Cell Development

• As red blood cells develop they increase hemoglobin production.

• Once hemoglobin production reaches maximum, ALL organelles are ejected.– This gives red blood cells their biconcave

shape.– This also means red blood cells contain no

nucleus or anything!

Page 5: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes
Page 6: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(3) Making More RBC’s

• Red Blood Cells are produced within your bone marrow.

• Erythropoietin:Protein released from the kidneys which stimulates the production of RBC’s from the bone marrow.

• Cause for Release of Erythropoietin:– Low RBC count– Low oxygen levels

• Body stops producing / releasing erythropoietin when RBC / oxygen numbers are back at homeostasis.

Page 7: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes
Page 8: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(4) Hemostasis

• The process of blood clotting.

• Occurs in 3 Phases:– Vascular Phase

• Goal: Constrict the blood vessels as much as possible to decrease blood flow.

– Platelet Phase:• Goal: Stick platelets to sides of torn blood vessels to

patch up hole.

– Coagulation Phase:• Goal: Form the final mesh-net that will full cover the hole

and seal up the blood vessels.

Page 9: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(5) The Vascular Phase

• Blood vessel tears.

• Serotonin is released from torn vessel cells.

• Serotonin triggers vasoconstriction of blood vessels.

• Blood flow temporarily slowed or constricted.

Page 10: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(6) The Platelet Phase(This begins at the same time as the Vascular Phase.)

1. The same torn vessel cells release Von Willebrand Factor.

2. Free-Floating platelets adhere to Von Willebrand Factor.

3. Adhered platelets release Thromboplastin AND Thromboxane.

4. Thromboxane causes further vasoconstriction of blood vessels.

Page 11: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(7) The Coagulation Phase Pt 1

THE EXTRINSIC PATH1. Thromboplastin binds

with Calcium and Phospholipids.

2. Thromboplastin + Calcium + Phospholipid = “Proconvertin Enzyme”

3. Proconvertin binds with Stuart Prower Enzyme

4. Proconvertin + Stuart Prower = “Prothrombin”

THE INTRINSIC PATH1. Thromboplastin binds

with Calcium and Anti-Hemolytic Cofactor.

2. Thromboplastin + Calcium + Anti-Hemolytic Cofactor = “”Prothrombin”

Page 12: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(8) The Coagulation Phase Pt 2

1. Prothrombin binds with Proaccerin Cofactor.

2. Prothrombin + Proaccerin Cofactor = “Thrombin”

3. Thrombin binds with Fibrinogen.

4. Thrombin + Fibrinogen = “Fibrin”.

*Fibrin is the mesh net that finally seals up the wound.

Page 13: Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes

(9) After Coagulation

1. Contractile proteins in platelets bring edges of wound and tissue together to help close up hole.

2. Plasmin Enzyme is slowly released from platelets.

3. Plasmin will begin to degrade clot tissue to help naturally remove scab from the body.