PHCARE 4

DRUG LITERATURE

“COMPILATION OF

MOA PRESENTATIONS”

PRESENTATIONS FROM CLASS

11 AM -12 NOON FRIDAY; BLOCK B

Drugs Affecting the

Digestive System

Blocker

Increased gastric acid stimulation

G

cellACh

Stimulates

gastric acid

secretion

Katrina Leah G. EgargoH2 Receptor Antagonist

Ranitidine

PROTON PUMP INHIBITORSAcid is required to convert a PPI into its active formPPIs only bind to active proton pumps

Unstimulated proton pumps remain

PPI

PPIH+

H+

Quinonez, Rizza Dawn Andrea B. BS Pharmacy IV-B

Drugs Affecting the

Endocrine System

http://www.intechopen.com/books/diabetes-mellitus-insights-and-perspectives/gpr119-agonists-a-novel-strategy-for-type-2-diabetes-treatment

STEPHANIE SHEEN G. IYOG

THIAZOLIDINEDIONE

Drugs Affecting the

Urinary System

Lagura, Anne Rose O.Loop Diuretics

SHIRLY ANN BONGCAWEL

Drugs Under Analgesics

Analgesic (Acetaminophen)

Palomar, Gilian May L.

MULLIT, STEPHANIE P.

COX-2 SELECTING

INHIBITOR

COX-2:

Analgesic

Antipyretic and

Anti-Inflammatory Effect

Name: Angel Mae M. Rizaga

Drug Classification: Nonsteroidal Antiinflammatory Drugs

Drugs Affecting the

Nervous System

Sinemet By mouth

Blo

od

Bra

in B

arrie

rL-Dopa

Systemic

Dopa

decarboxylaseDopamine

no effect/toxic

CARBIDOPA

COMT

3-O-methyldopa

COMT

INHIBITOR

L-Dopa

Dopa

decarboxylase

Dopamine

(in substantia nigra)

Cerebral Cortex

Motor Movement

Homovanillic

acid

MAO and

COMTMAO Inhibitor

and COMT

INHIBITOR

Levodopa and Carbidopa (SINEMET) an Anti-Parkinson Drug:

Mechanism of Action presented by Joel Andrada Jr.

OPIOID ANTAGONIST

(-)

(+

)

Basher, Anna Norlayla

OPIOID AGONISTBy: Aleja Mae D. Capuyan

MT

X

Mayleen S.

Bacalso

Folic acid

Analog

Drugs Under Antiviral,

Antimicrobial and Antifungal

BINDS

TO FORM

S

RESULTS

TOINHIBITION

DELA RAMA, BLEZZY AMY R.

CLASSIFICATION: ANTIBIOTIC

NUEZ, MARIA NESEN C. BLOCK-B

MECHANISM OF ACTION OF ANTIMICROBIAL DRUGS

Bifunctional

alkylating agent

can cause

intrastrand

linking and

cross-linking

Prepared by: Eva Marie C. Bundoc

KAREN MAE L. GERUNDA,

CEPHALOSPORINS

Anti-tubercular agents- Isoniazid GAGWIS,

MARIA ALYSSA C.

ACTIV

ATE

INACTIVATE

INACTIV

ATE

INACTIVAT

E

P-Aminobenzoic

acid

Dihydrofolic

acid

Tetrahydrofolic

acid

Purines

Sulfonamides

(compete with

PABA)

Dihydropteroat

e synthase

Dihydrofolate

reductase

Trimethoprim

Proguanil,

Pyrimethamine

By: Zetieraizah Ann Basher

Drugs Affecting the

Cardiovascular System

ACE

INHIBIT

OR

HALIMA B.

MUÑOZ

ACE INHIBITOR

ANGIOTENSIN RECEPTOR

BLOCKERSSWEETIE R. LENTIC

Angiotensin

Receptor

Blockers

AT1 AT2

ARB

Vasoconstriction

Aldosterone secretion

Catecholamine release

Cell growth

BLOOD PRESSURE

Vasodilation

Inhibit cell

growth

CALCIUM CHANNEL BLOCKER MOA

CA2+

L- type calcium

channel

Reduce influx of calcium

during depolarization

Decrease contractile force

Decrease blood pressure

Control voltage

dependent

calcium influx

into cardiac and

vascular smooth

muscle.

Inhibit depolarization of

induced calcium entry into

muscle cells into cardio

vascular system

Kevin Guy

Villarin

Janine L. Rosalijos

CAPALAN, FARMINAH A.

“C E N T R A L A L P H A - 2 A G O N I S T”

-

Alpha 1 Adrenergic Receptor

Antagonists

Type 1 Alpha Adrenergic

Receptor

Smooth muscle

contraction

(Benign Prostatic

Hyperplasia)Non selective Alpha 1

blocker

Hypertension

Vascular Resistance

in arterioles

Increase in venous capacity

and lower blood pressure

Alpha 1A

Receptor:

(Bladder,

Neck and

prostate)

Alpha 1B :

Relaxation

of muscle in

smooth the

arterioles

Urinary Obstruction

JONNA LIZA C. RANOCO

Alpha 1 Adrenergic Antagonist

Both Selective and

Non selective agents

are used for the

symptomatic relief of

PROSTATIC

HYPERTROPHY

α-Blockers for

HTN

Doxazosin

Prazosin

Terazosin

α- Blockers

for BPH

Alfusozin

Doxazosin

Tamsulosin

BETA-BLOCKERS (SELECTIVE)

FIGURE LEGEND:

SCHEMATIC DIAGRAM OF CARDIOPROTECTIVE SIGNALING PATHWAYS AND THEIR ACTIVATION BY

BETA-3-ADRENOCEPTOR ACTIVATION WITH NEBIVOLOL

AKT = PROTEIN KINASE B; CX43 = CONNEXIN-43; ENOS = ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ERK = EXTRACELLULAR SIGNAL-REGULATED KINASE; GP130 = GLYCOPROTEIN 130 RECEPTOR;

GPCR = G-PROTEIN–COUPLED RECEPTOR; GSK-3Β = GLYCOGEN SYNTHASE KINASE-3-BETA; INOS =

INDUCIBLE NITRIC OXIDE SYNTHASE; JAK = JANUS ACTIVATED KINASE; KATP = ATP-DEPENDENT

POTASSIUM CHANNEL; MPTP = MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NNOS =

NEURONAL NITRIC OXIDE SYNTHASE; NO = NITRIC OXIDE; P70S6K = P70S 6 KINASE; PI3K =

INOSITOL-TRIPHOSPHATE KINASE; PKC = PROTEIN KINASE C; PKG = PROTEIN KINASE G; ROS =

REACTIVE OXYGEN SPECIES; STAT3 = SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION

3; TNF = TUMOR NECROSIS FACTOR; TNF-R = TUMOR NECROSIS FACTOR ALPHA-RECEPTOR.

NURSAHAYA L. LIPAE

NAME: KATRINA MAY C. PUTOT

DRUG CLASSIFICATION: VASODILATORS

Mechanism of Action of Alpha-2 Adrenoceptor

Agonist

Prepared by : Rachel N. Nabuya

Delator, Mylyn

PhCare 4 F 11:00-12:00

HMG-CoA REDUCTASE

INHIBITOR (STATINS)

Bronchoconstrictio

n

Cardiac muscle

relaxation

Non Selective Beta BlockersSalizon, Mary Antonette G.