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Fasting Ramadan & Diabetes
Do It Right
Mohammad Daoud, MDConsultant Endocrinologist
KAMC –NGHA Jeddah- Saudi Arabia
DM & Fasting Ramadan Frequently asked questions
Can a diabetic patient fast Ramadan, safely?
What are the risks & benefits ?
What about diet and exercise?
How to adjust Medications ?
Remember…
Most of the data are “Expert opinion “ based
Avoid use of the terms “indications” or “contraindications” for fasting
Focus on better risk stratification and best medical advice that can be provided to the patient
Working with patients’ “Choice to Fast ” to make their fasting as safe as possible
Sura Al-BaqaraVerse 183 /185
O you who have believed, fasting is decreed / prescribed upon you as it was decreed upon those
before you that you may become righteous (may ward off (evil)
ا� ن�و م� م�� م ذ�ي � م ٱ م�ا ن�ي م�ا �� ـ م� مي ي�ا ص� ٱل م م� ي� ي ي� ي� ت� م� م� ن�و �� م م� م� �ن �� م �م م م� ن� �ذ م م! ذ� م ذ�ي � م ٱ م�ى م# م$ ذ� ن% م&ا م% (١٨٣)
* ن, م& ن- م. �م م/ م0 م1 م�2 ٱ ن� �ن ذ�� م3 ذ1 م4 م& م/ ذ�* م!ا م0 ن6 م م7ٱ 8� م3 ن� م ٱ م م� :; ت �� م� م. م= م7 ذ< ��ا م � م 83? ت ن@ ن� م�� م0 ن� م ٱ ذ, ذ/. Aم Bذ ن��ن ـ8 ذ� � م ٱ م� مDا م� Eم ن0 م1 ي� م4 ي�ا ي�ن ي�ض�ا ت�ي * ي� م0 Gم ن�� H; �يا م م�� م م� IJ ت 3� م �ذ م/ 0; ت م6 Kم �ى �م م# م7 ي� م�� �ي �م يل ٱ م م� �ت م� ت�ي مي ي!ا ي� ي� �ي م� يل ٱ م م� �ت م" # ي ٱل م� ت�ي �ى مي �م م# م, �� م ٱ ا� ن70 م م� ن� ذ م7 Iم م�3 �ذ م ٱ ا� ن�و ذ& م� ن� ذ م7
م� ن70 �ن م2 م� م� ن� �م� �م م م7 م� �ن L� م3 م@ م�ا (١٨٥)
Fasting Ramadan
Muslims are almost approaching 2 billions persons
≈ 25% of Earth’s population…increasing
Like wise …DM-type 2 prevalence is
increasing
6
A large number of Muslim patients with diabetes fast during Ramadan
1The Pew Forum on Religion & Public Life. http://www.pewforum.org/The-Future-of-the-Global-Muslim-Population.aspx (Accessed March 2013); 2Al-Arouj M et al. Diabetes Care 2010;33:1895–902; 3Salti I et al. Diabetes Care 2004;27:2306–11; 4IDF Diabetes Atlas 5th edition. www.idf.org/diabetesatlas/5e/the-global-burden (Accessed March 2013); 5Whiting DR et al. Diabetes Res Clin Pract 2011; 94: 311–21; 6Beshyah SA. Ibnosina J Med Biomed Sci 2009;1:58–60
• The global prevalence of diabetes is projected to increase in emerging economies, including those with large Muslim populations4,5
• The pattern of daytime fasting and night-time meals and use of anti-diabetic treatment increases the risk of complications, including hypoglycaemia in patients with diabetes2,3
• Although the consensus from religious and medical leaders is that Muslims with diabetes are generally not obliged to fast6 many choose to do so2,3
1.6 billion(2010)
2.2 billion(2030)
Global Muslim population1
> 50 million people with diabetes are estimated to fast during Ramadan worldwide2,3
Fasting
Occurs during the month of Ramadan
and
Voluntary fasting ( ex: 1-2 days /wk; Monday and Thursdays 13th - 15th o days of Lunar months …)
Fasting Ramadan
Time of the year ...Never the same # of hours fasted Varies greatlyClimate ; Winter Vs. Summer
2015 Ramadan ; Summer June-July about 15 hours
(Fajr 4:14 to 4:25 am …Sunset 7:10 to 7: 10 pm)
Pathophysiology of fasting in Normal Individuals
Pathophysiology of fasting in Diabetes
Fasting Ramadan
Physiologic changes:
↓ Glucose and insulin levels
↑Glucagon / Catechol-amines → ↑Gluconeo-genesis ↑ Glycogeno-lysis
Free fatty acids → Ketones(Ketones are fuel by skeletal /cardiac muscles, liver, kidney, and adipose tissue, thus sparing glucose for continued utilization by brain and RBCs)
Fasting Ramadan and DMPatho-Physiologic changes:
Defected secretion of insulin :Risk of hyperglycemia /DKA
Defected secretion of Glucagon / Catecholamines :
Risk of hypoglycemia
EPIDIAR study group Results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study. , Salti Iet al -Diabetes Care 2004;27:2306–2311
EPI.DIA.R trial (EPIdemilogy DIAbetes in Ramadan)
Multi-country epidemiological study (Algeria, Bangladesh, Egypt, India, Indonesia, Jordan, Lebanon, Malaysia, Morocco, Pakistan, Saudi Arabia, Tunisia & Turkey)
12,273 diabetic patients
Individuals who fast during Ramadan showed a high rate of acute complications
Diabetes Care, volume 28, NUMBER 9, September 2005
How Many Diabetics Fast?
Type 1 DM Type 2 DM
≈ 43% ≈ 79%
Salti I, et al. EPIDIAR study. Diabetes Care 2004;27:2306
50% … did not change their lifestyle
Lifestyle changes involved :Physical activitySleep duration
Food, sugar, and fluid intake
Only 25% on OADs adjusted Rx 1/3 rd on insulin
adjusted Rx
Fasting Ramadan and DM
Risk stratification Fatwa : Is it due for a
review?
والشرع Fiqh and Medicineالطب
www.fiqhacademy.org.sa
اإلسالمي الفقه مجمعالدولي
اإلسالمي الفقه لمجمع عشرة التاسعة الدورة والتوصيات القراراتالشارقة - إمارة )الدولي المتحدة ( العربية اإلمارات دولة
26-30 ( إبريل ( األولى 1 -5- م / 2009نيسان 1430جمادى
Fiqh Islamic Academy الدولي اإلسالمي الفقه مجمع
Patients are divided into groups according to risk:
First group: Very high risk
Second group: High risk
www.fiqhacademy.org.sa
1st and 2nd groupsshould not fast
حصول إ من التأكد على مبني والثانية األولى الفئتين حكم نالطبيب يقدره ما بحسب بحصوله الظن غلبة أو البالغ الضرر
المختص،�� تنطبق الثقة الذي المريض على شرعا فيتعينفيهما الواردة الحاالت إحدى له عليه يجوز وال يفطر أن
نفسه الصيام عن للضرر درءا ، ،
( : تعالى (النساءلقوله: ( رحيما بكم كان الله إن أنفسكم تقتلوا (وال
المجمع بالصيام ويؤكد تضرره مع صام من أنصومه فإنه صحة مع يأثم
Very High Risk
High RiskDIABETES CARE, VOLUME 33, NUMBER 8, AUGUST 2010
Note: This classification is based largely on expert opinion and not on scientific data derived from clinical studies
Fiqh Islamic Academy الدولي اإلسالمي الفقه مجمع
www.fiqhacademy.org.sa
Third group: Moderate risk
Fourth group: low risk
3rd and 4th groupsshould fast
المجمع هاتين ورأى لمرضى اإلفطار جواز بعدمال الفئتين الطبية المعطيات كون إلى استنادا ،
بصحتهم ضارة مضاعفات احتمال إلى تشيرمن يستفيد قد منهم الكثير إن بل وحياتهم
وأن الحكم بهذا االلتزام األطباء داعيا ، الصيامحدة على حالة لكل المناسب العالج يقدروا
Moderate Risk
Low Risk
DIABETES CARE, VOLUME 33, NUMBER 8, AUGUST 2010
Note: This classification is based largely on expert opinion and not on scientific data derived from clinical studies
Fasting Ramadan Risks
Risks associated with FASTING in patients with diabetes
Diabetes Care, volume 28, NUMBER 9, September 2005
1. Hypoglycemia
2. Hyperglycemia : DKA / HHS
3. Dehydration and thrombosis
4. Hospitalizations
EPIDIAR study: fasting during Ramadan increases the risk of severe hypoglycaemia and hyperglycaemia in
patients with T2DM30
1Salti I, et al. Diabetes Care 2004;27:2306–11; 2Al-Arouj M, et al. Diabetes Care 2010;33:1895–902
Inci
denc
e (e
vent
s/10
0 pa
tien
ts/m
onth
)
Series10
1
2
3
4
0.4
3
Series10123456
1
57.5-fold increase*
5-fold increase
P<0.0001 P<0.0001
EPIDIAR = EPIdemiology of DIAbetes and Ramadan; T2DM = type 2 diabetes mellitus
11,173 patients with T2DM; 78.7% chose to fast for at least 15 days during Ramadan1
Higher risk of severe Hypoglycemic events†
in overall population during Ramadan‡1,2
Higher risk of severe Hyperglycaemic events†
in overall population during Ramadan‡1,2
Pre-Ramadan
During Ramadan†Events requiring hospitalization in overall population with T2DM; ‡compared with previous months
* There was a 7.5 fold difference of hypoglycaemia in overall population fasting during Ramadan. For patients who fasted for > 15 days difference was, 6.7 fold
Probably
Under-estim
ated
Fasting RamadanHyper- glycemia Risk
Higher risk of hospitalization in both types of DM
Type 2DM 5 X increase in incidence of severe
hyperglycemia
EPIDIAR study group / Diabetes Care 2004;27:2306–2311
Type 1 DM 3 X increase
More DKA with prior poor control
Fasting RamadanHyper- glycemia Risk
Benghazi Diabetes and Endocrine Centre (BDEC)
493 T2DM patients fasting during Ramadan
10.7% experienced hyperglycemia
Nearly 20% of SU-Treated Muslim Patients With Type 2 DM Experienced Symptomatic Hypoglycemia During
Ramadan Fasting1
Mean daily doses of SUs were: 2.8 mg for glimepiride, 129.3 mg for gliclazide, 10.7 mg for glibenclamide (glyburide), and 6.6 mg for glipizide.SU=sulfonylurea.1. Aravind SR et al. Curr Med Res Opin. 2011;27(6):1237–1242.
16.814.0
25.627.6
19.7
0
5
10
15
20
25
30
Patie
nts,
%
GlimepirideGliclazideGlibenclamideGlipizideOveralln=428 n=386 n=535 n=29 n=1378
Incidence of Symptomatic Hypoglycemia During Ramadan in 2009
by Treatment Group
6.7% of SU-Treated Muslim Patients With Type 2 DM Experienced Severe Hypoglycemia During Ramadan
Fasting1
Incidence of Severe Hypoglycemia During Ramadan in 2009by Treatment Group
SU=sulfonylurea.1. Aravind SR et al. Curr Med Res Opin. 2011;27(6):1237–1242.
5.1
2.6
10.8
6.9 6.7
0
2
4
6
8
10
12
Patie
nts,
%
GlimepirideGliclazideGlibenclamideGlipizideOverall
n=428n=386
n=535 n=29 n=1378
Dehydration Orthostatic hypotension esp. with
autonomic neuropathy Syncope, falls, injuries, and bone
fractures
-Adjust patients' BP medication -Drink sugar free / caffeine free drinks frequently
throughout the evening and before dawn.
Fasting Ramadanother risks
Thrombosis ? Volume contraction / Increased blood viscosity
may exacerbate the hyper- coagulable state **
Increased incidence of retinal vein occlusion #
No data concerning the effect of fasting on mortality
Fasting RamadanOther risks
**24Akhan G, Kutluhan S, Koyuncuoglu HR. Is there any change in stroke incidence during Ramadan? Acta Neurol Scandin 2000;101:259–261#25 Alghadyan AA. Retinal vein occlusion in Saudi Arabia: possible role of dehydration.Ann Ophthalmol 1993;25:394–398@Temizhan A, et al B. Is there any effect of Ramadan fasting on acute coronary heart disease events? Int J Cardiol 1999;70:149–153
DM and Fasting RamadanManagement
Pre Ramadan assessment Individualization Frequent monitoring of glycemia Nutrition & Exercise Breaking the fast Medications adjustment
Diabetes Care, volume 28, NUMBER 9, September 2005
Pre-RAMADAN assessment
Medical Assessment:1-3 months before RAMADANSpecific attention to the:
Well-being of the patientGlycemia, BP and lipids
Specific medical advice for those who wish to fast against medical recommendations
Necessary changes in the diet or medication regimen should be made
Diabetes Care, volume 28, NUMBER 9, September 2005
Pre-RAMADAN assessment
Educational Counseling: Educate the patient and his family on:
Signs & symptoms of hypoglycemiaBG monitoring ; risk of
hypoglycemia,even not fasting !!?Meal planningPhysical activityMedication administrationManagement of acute complications
DM and FastingManagement
-Decide on fasting Vs. non fasting
-Diet: assess pattern / amounts of food intake /habits ; to be able to match with a good Rx plan
Pre Ramadan fasting experience / prior Rx plan success
DM and FastingTrial fast in pre-Ramadan period
For 3 consecutive days before Ramadan should be advisedEx: Fasting the 13th, 14th, and 15th day of Shaban.
Can assess the risks of hypo- and hyper glycemia
Can help as a guide for medications adjustments
DM and FastingBGM
Frequent monitoring of glycemia: esp. in the first few days esp. with Insulin use or insulin secretagogues
To verify Safe DM control:Early morning , noon ,late afternoon , before sunset
To verify Adequate DM control:After Iftar , late night and before Sohour
BGM for high risk groups
Consider BGM done at the following times
1. Pre-Suhur2. 2 hours post-Suhur3. Midday4. Pre-Iftar5. 2 hours post-Iftar6. Whenever symptoms of hypoglycemia occur7- Midnight blood glucose if needed Management of Type 2 diabetes in Ramadan: Low-ratio premix insulin working group practical advice
NutritionAim to not overeat
-Healthy and balanced diet-Avoid large quantities of fried foods and CHO-meals
- Sohour (pre-dawn meal): - Delay as late as possible - Use “complex” carbohydrates
-Aim at maintaining a constant body mass
- Plenty of fluid during non-fasting hours
Dietary Patterns & Glycemic Control and Compliance
to Dietary Advice Among Fasting Patients With DM During Ramadan
Positive pattern CHO intake < 50 % of energy;
Distributed (i.e:3-4 meals)= Effective diet assuring
normoglycemia
= Better DM control
Diabetes Care 2014;37:e47–e48 | DOI: 10.2337/dc13-2063
Dietary Patterns & Glycemic Control and Compliance
to Dietary Advice Among Fasting Patients With DM During Ramadan
Diabetes Care 2014;37:e47–e48 | DOI: 10.2337/dc13-2063
Activity/Exercise
-Maintain Normal levels of physical activity/ safe timing
-Avoid Excessive physical activity : Higher risk of hypoglycemia (especially before Iftar)-Avoid late daytime (close to Iftar time) sleeping
-High risk of hyperglycemia in poorly controlled DM 1
-Prayer activity is generally safe including Ishaa’ and Taraweeh
- BG ≤ 60 mg/dl [3.3 mmol/l])
- BG < 70 mg/dl (3.9 mmol/l) early in the day
Stop fasting even if the hypoglycemia occurs close to the time of Iftar
- BG > 300 mg/dl ( 16.7 mmol/l) ; esp. Type 1 DM
ketones in blood or urine should be checked
- Sick days / Unusual symptoms (Vomiting, SOB,…)
Frequent Monitoring KeyBreak the Fast if Necessary
DM and Fasting Adjustment of Medications
DM and FastingDM Type 1
Don’t Fast ?
Fasting at Ramadan carries a very highrisk for people with type 1 diabetes
Still with the new safer formulation of insulin ; Fasting maybe possible but
with possible compromise of inadequate control
DM Type 1
If the patient Insists on fasting :Basal-bolus regimen
(or Insulin pump) is the preferred protocol of
management
Tends to be safer, with fewer episodes of hyper- and hypoglycemia
Lispro Compared with Regular Human Insulin During Ramadan
Kadiri A et al. Diabetes Metab (Paris) 2001;27:482-6.
0
3
5
4
1
2
Fasting 1-h 2-hPostprandial time
*
HumalogRegular insulin
* P = 0.026
0
3
5
4
1
2
Fasting 1- 2-Postprandial time
*
HumalogRegular insulin
* P = 0.026
Postprandial Blood GlucoseB
lood
glu
cose
exc
ursi
on (m
mol
/L)
Lispro Compared with Regular Human Insulin During Ramadan
Kadiri A et al. Diabetes Metab (Paris) 2001;27:482-6.
Epi
sode
s of
hyp
ogly
cem
ia
Hypoglycemia by Time of Day
0
5
10
15
20
000
Insulin LisproRegular insulin
Sunrise meal
Sunrise meal
Sunset meal
2-h 6-h 2-h 6-h
27
5
12
27
11
5
2
43
0
5
10
15
20
000
Regular insulin
Sunrise meal
Sunrise meal
Sunset meal
2-h 6-h 2-h 6-h
27
5
12
27
11
5
2
43
Premix analogue (Vs. human premix insulin)
Better average glycemic control
Better meal time flexibility
Less likely to cause post-prandial hypoglycemia
DM and FastingType 2 DM
Diet-controlled / Metformin Low risk of Hypoglycemia
Fasting is of benefit /Safe
Change dosing schedule to after sunset meal (2/3) and before dawn meal (1/3)Or Full dose at Iftar (ex:Metfromin XR)No need to decrease dose if Solo
Type 2 DMSulfonylureas
Risk of hypoglycemia If well adjusted …can fast with least possible
risk
Avoid use of Chlorpropamide ,Glyburide /Glibenclamide
Gliclazide, Glimepiride and Glipizidehave lower risk
Short-Acting Insulin Secretagogues
Repaglinide and Nateglinide
Taken twice daily before the sunset and predawn meals.
Repaglinide Vs Glibenclamide : less hypoglycemia *
*Mafauzy M. Repaglinide versus glibenclamide treatment of type 2 diabetes during Ramadan fasting. Diabetes Res Clin Pract 2002;58:45–53
Type 2 DMSafer New Choices
Glitazones ;PioglitazoneGlucosidase inhibitors
Acarbose,miglitol, and voglibose Bromocriptine
GLP-1 Agonists : Exenatide and Liraglutide,… DPP-4 -I : Sitagliptin, Linagliptin ,…
No hypoglycemia on its own Provides an excellent choice in
Ramadan
DPP-4 I vs SU
Patients (1066) on SU (with or without Metformin) Randomized just before Ramadan to:
Sitagliptin Vs SU Hypoglycemia:
4.8 %: Sitagliptin group 14.3 %: SU group
Had to break fast: 6.3 %: Sitagliptin group 10.3 %: SU group
Al Sifiri S, et al. Int J Clin Pract. 2011;65:1132
Incidence of symptomatic hypoglycemia in Muslim patients with Type 2 DM (Ramadan)
The International Journal of Clinical Practice ,November
2011,65,11,1132-1143 Sitagliptin
Gliclazide MR
Conclusions: Among > 1000 patients
The incidence of Hypoglycemiawas lower with Gliclazide relative to the other sulphonylurea agents and similar
to that observed with Sitagliptin
Before Ramadan During RamadanPatients on “Diet and Exercise”
- No change- Modify time /intensity of exercise- Ensure adequate fluid intake
Metformin -Iftar: 1,000 mg-Sohour: 500 -1000 mg
DPP4 inhibitor As usual at night
Glitazone As usual at nightGlinide As usual at night
Treatment Recommendations
Before Ramadan During RamadanSulfonylurea Once Daily: Morning dose.e.g., Gliclazide MR
Iftar: Full Morning Dose May cut down by 20-30%
Sulfonylurea Twice Daily: Morning & Evening dose.e.g., Gliclazide 80-160 mg BD
-Iftar: Full Morning Dose-Sohour: ½ Evening Dose (or skip ?)
Treatment RecommendationsMajority of our type 2 diabetic patients are treated
with Sulfonylurea & Metformin
Patients Treated With Insulin
-RAI analog Vs. Regular Insulin Less hypoglycemia and smaller postprandial glucose excursions
-Long acting Basal insulin (Glargine ) with RAI analog at Iftar and RAI analog at Sohour
Before Ramadan During RamadanPremixed insulin 30 Morning: (ex: 30 U)Dinner: (ex :20 U)
Iftar: Full Morning Dose (30 U)Sohour: ½ Dinner Dose (10 U) (? 50% reduction at Sohour ?)
Consider switching patients who are on either:
Mixed or intermediate-acting insulins to basal insulin
Split Mixed (R+N)R+0+RN+0+N
R+0+50 % of RN+0+50% of N (50% reduction at Sohour)
R+R+R0+0+N
R+R+50% of R0+0+50% of N (50% reduction at Sohour)
Treatment Recommendations
Before Ramadan
During Ramadan
Rapid-acting insulin;Ex: Aspart
Usual dose of should be taken with sunset meal
RAA insulin can work immediately after meals.Decrease predawn dose in half (?omit )
Basal AnalogueEx: Glargine
At the same time Up to 20-40 % dose reduction
Treatment Recommendations
DM and Fasting RamadanCONCLUSIONS
Fasting carries a risk for many patients
(DM 1 > DM 2)
Commonest concerns :Hypoglycemic and Hyperglycemic
Risk assessment = Advice who
should be exempted /shouldn’t fast
DM and Fasting RamadanCONCLUSIONS
Fasting Can Be Accomplished, but Care Must Be Taken
-Majority of DM patients can fast safely -If patients insist on fasting ;Work with
them -Adjusting medications is an Art >>
Science-Certain agents provide safer control
( ex: Incretins; GLP-1 R agonists and DPPr i ,MFN, Acarbose ,Glinides)
DM and FastingCONCLUSIONS
Education
Diet control
Daily activity
Drug regimen adjustment
Conclusion
Until guidelines are available, the most important management strategy for
health-care providers is
IndividualizedStructured education
Before and during Ramadan
Ramadan Kareem
References 1-Recommendations for Management of Diabetes During Ramadan , DIABETES CARE, VOLUME 33, NUMBER 8, AUGUST 2010
2-Recommendations for Management of Diabetes During Ramadan DIABETES CARE, VOLUME 28, NUMBER 9, SEPTEMBER 2005 2305
3-Dietary Patterns and Glycemic Control and Compliance to Dietary Advice Among Fasting Patients With Diabetes During Ramadan Diabetes Care 2014;37:e47–e48 | DOI: 10.2337/dc13-2063
4-Incidence if hypoglycemia among Muslims fasting Ramadan : SU vs Sitagliptin ,Al Sifiri S, et al. Int J Clin Pract. 2011;65:1132
5- Long-acting oral hypoglycemic agents (OHA) must be used more caution Hassan Chamsi-Pasha and Khalid S. Aljabri. Avicenna J Med. 2014 Apr- Jun; 4(2): 29–33
References 6- Salti I, Bénard E, Detournay B, Bianchi-Biscay M, Le Brigand C, Voinet C, et al. A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: Results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study. Diabetes Care 2004;27:2306–11
7- Karamat MA, Syed A, Hanif W. Review of diabetes management and guidelines during Ramadan. J R Soc Med. 2010;103:139–47
8- Management of Type 2 diabetes in Ramadan: Low-ratio premix insulin working group practical advice ,Indian J Endocrinol Metab. 2014 Nov-Dec; 18(6): 794–799.Mohamed Hassanein, Mohamed Belhadj,1 Khalifa Abdallah,2 Arpan D. Bhattacharya,3 Awadhesh K. Singh,4 Khaled Tayeb,5 Monira Al-Arouj,6 Awad Elghweiry,7 Hinde Iraqi,8 Mohamed Nazeer,9 Henda Jamoussi,10 Mouna Mnif,11Abdulrazzaq Al-Madani,12 Hossam Al-Ali,13 and Robert Ligthelm