PathophysiologyMohannad Soliman - 1074

In the absence or low of insulin, glucose cannot enter the cell. (Type 1 Diabetes)

Insulin enables glucose uptake by adipose tissue and resting skeletal muscle.

Type 1 Dieabetes liver cell.A hepatocyte in the fasted state

makes glucose and transports it out into the blood.

Normal liver cell.Insulin acts indirectly to alter glucose uptake in

hepatocytes: in fed state liver cells take up glucose.

MANAGEMENT OF ACUTE PATHOPHSIOLOGY

Usually admitted to intensive care unit of hospital for care since client is in life-threatening

condition: unresponsive, may be on ventilator, has nasogastric suction.

- Vigorous fluid replacement

- Give insulin IV *Regular insulin (Short acting,soluble,crystalline zinc insulin).

- Lower glucose with regular insulin until glucose level drops to 250 mg/dL

- Potassium, sodium chloride given IV

-Dextrose is given when blood sugar reaches around 250mg/100ml to prevent hypoglycemia

-Treat precipitating factors.

Long Term

Inhibit NO

“vasomotor tone”vascular endothelial cells

sorbitolaccumelates in non depending insulin cellslens,barin,nerves

Hypertension

Glaucoma

e.g. Cataract

*High levels of blood sugar resulting from diabetes can affect your ability to see by causing the lens inside the eye to swell, which can result in temporary blurring of eyesight.

MYOCARDIAL INFARCTION

HEART FAILURE+ imparid oxygen

HYPERPLASIA e.g prostate