OVARIAN CANCER AWARENESS

MYRIAD GENETICS PRESENTS

OVARIAN CANCER AWARENESS

SEPTEMBER DAILY AWARENESS

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3

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SEPTEMBER 1

1 in 72 women will develop ovarian cancer in their lifetime.1

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SEPTEMBER 2

1 in 7 ovarian cancers are due to BRCA mutations.2

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SEPTEMBER 3

Lynparza (olaparib) is the first and only FDA-approved PARP inhibitor for use in patients with ovarian cancer who have a BRCA mutation and have been treated with three or more prior lines of chemotherapy.3 Hear about one patient’s journey with BRCA-associated ovarian cancer: Katya

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SEPTEMBER 4

Pap tests/cervical smear tests are not a screening test for ovarian cancer.4

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SEPTEMBER 5

Almost half (44%) of women with BRCA mutation-associated ovarian cancer have NO family history of breast or ovarian cancer.2

44%

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SEPTEMBER 6

Up to 5% of endometrial cancers are due to a hereditary (inherited) cause. The most common hereditary cause of endometrial cancer is Lynch syndrome, which also increases the risk of developing colorectal and ovarian cancer.5

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SEPTEMBER 7

There are other genes that increase the risk of ovarian cancer beyond BRCA1 and BRCA2, such as BRIP1, MSH6, and RAD51D. Learn more about these and other hereditary ovarian cancer genes here.

OVARIAN

BRCA1

BRIPI

MSH2

MSH6

PMS2RAD51D

RAD51C

EPCAM

TP53 BRCA2

MLH1

STK11

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SEPTEMBER 8

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Women with a BRCA mutation have up to a 44% risk of developing ovarian cancer by age 70 (compared to the average woman’s risk of 1.4%.)6

Breast cancer by age 50

Breast cancer by age 70

Ovarian cancer by age 70

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SEPTEMBER 9

Symptoms of endometrial cancer can include vaginal bleeding, spotting, or discharge that is not normal for you. Any vaginal bleeding occurring after menopause should be further evaluated to rule out endometrial cancer.7

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SEPTEMBER 10

People who have a first-degree relative (parent, sibling, or child) with a BRCA mutation have a 50% chance to inherit the same mutation.5

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SEPTEMBER 11

There is no proven early detection test for ovarian cancer. Women at increased risk of developing this cancer, such as those with an inherited gene mutation, may be recommended by their doctor to undergoing screening for certain markers in the blood (such as CA-125) or by ultrasound.8

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SEPTEMBER 12

The average woman’s risk of developing endometrial cancer is 2.7%. That risk increases to up to 71% in women with a hereditary endometrial cancer syndrome like Lynch syndrome.9

2.7%

71%with hereditary endometrial cancer syndrome

the average woman’s risk

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SEPTEMBER 13

While ovarian cancer is often called the “silent killer”, there are some symptoms to watch out for. These can include bloating, pelvic or abdominal pain, difficulty eating or feeling full quickly, urinary symptoms such as urgency or frequency, fatigue, indigestion, back pain, pain with intercourse, constipation, and menstrual changes. If these symptoms persist for more than two weeks, see your physician.4

FATIGUE

UPSET STOMACH

BACK PAIN

CONSTIPATION

MENSTRUALCHANGES

ABDOMINALSWELLING WITH

WEIGHT LOSS

RECOGNIZE THE SYMPTOMS

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SEPTEMBER 14

There are preventive measures available for women at increased risk of ovarian cancer. Oral contraceptives reduce the risk of ovarian cancer by up to 50%, and surgical removal of the ovaries and fallopian tubes reduces risk by up to 96%. Tubal removal alone and breastfeeding may also reduce the risk of developing ovarian cancer.4

50%

oral contraceptives reduce the risk by up to

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SEPTEMBER 15

Risk factors for ovarian cancer include: a family history of breast/ovarian cancer, a mutation in a hereditary cancer gene, a personal history of breast cancer, a personal history of colon cancer, having no children, possibly infertility, beginning menstruation at an early age (before age 12), a later age of menopause (after age 55), and increasing age.4

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SEPTEMBER 16

The National Comprehensive Cancer Network (NCCN) and the Society of Gynecologic Oncology (SGO) recommend that ALL women with ovarian cancer receive genetic testing, regardless of family history.10

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SEPTEMBER 17

There are 3 major types of ovarian cancer: epithelial, germ cell, and sex-cord stromal cell. Epithelial ovarian cancer represents around 90% of ovarian cancers.4

EPITHELIAL

Represents around 90% of ovarian cancers; common

among women over the age of 60 but can develop at

any age.

GERM CELL

Represents 5% of ovarian cancers; usually only impacts 1 ovary in adolescent and young women.

SEX-CORDSTROMAL CELL

Represents less than 5% of patients; tumors occur with equal

frequency among pre- and post-menopausal women.

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SEPTEMBER 18

Hereditary cancer genetic testing is broadly covered by the vast majority of health insurance plans. In fact, most patients with ovarian cancer pay $0 out of pocket for genetic testing.11

$0 pay for genetic testing

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SEPTEMBER 19

BRCA mutations can be inherited from either the mother’s or the father’sside of the family.5

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SEPTEMBER 20

Risk factors for endometrial cancer include: a family history of endometrial cancer, a mutation in a hereditary cancer gene, increased age, beginning menstruation at an early age (before age 12), a late age of menopause (after age 55), exposure to estrogen-only hormone replacement therapy, obesity, polycystic ovary syndrome (PCOS), and exposure to tamoxifen.9

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SEPTEMBER 21

Early detection of ovarian cancer is key, and more research is needed to develop effective screening tools. When caught in its early stages, 92% of women with ovarian cancer will survive five years, compared to only 28% of those who are diagnosed after the cancer has spread to other organs. Unfortunately, only 15% of ovarian cancer is currently diagnosed at an early stage.4

92%of women with ovarian cancer will survive 5 years

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SEPTEMBER 22

Patients with BRCA mutation-associated ovarian cancer may respond better to platinum-based chemotherapy, as well as other classes of drugs; for example, PARP inhibitors.2

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SEPTEMBER 23

A family history of ovarian cancer is important for men to know about as well. Not only could a hereditary ovarian cancer syndrome impact their female relatives, men with a BRCA mutation are also at increased for cancers of the prostate, pancreas, breast, and melanoma.

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SEPTEMBER 24

Only 25% of patients newly diagnosed with ovarian cancer know their BRCA status12, even though the National Comprehensive Cancer Network (NCCN) has recommended BRCA1 and BRCA2 testing for all patients with epithelial ovarian cancer since 2008. If you’ve had ovarian cancer, talk to your doctor about whether genetic testing is right for you.

Only 25% of patients newly diagnosed with ovarian cancer know their BRCA status

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SEPTEMBER 25

Women with Lynch syndrome have a high risk of developing a second cancer such as colon cancer or ovarian cancer. Up to 30% will develop a second cancer within 10 years of their first cancer diagnosis, and up to 50% will within 15 years.13,14

30% will develop a second cancer within 10 years

50% will develop a second cancer within 15 years

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SEPTEMBER 26

Ovarian cancer is a deadly disease. This year, there will be more than 21,000 new cases of ovarian cancer diagnosed and about 14,000 deaths from ovarian cancer.1

More than 21,000

new cases of ovarian

cancer diagnosed

About 14,000 deaths

each year from

ovarian cancer

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SEPTEMBER 27

BRCA mutations are not only found in younger patients; 66% of women with BRCA mutation-associated ovarian cancer are diagnosed after the age of 50.15

66%of BRCA-positive women are diagnosed after age 50

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SEPTEMBER 28

1 in 4 patients with endometrial cancer are at risk for hereditary cancer and should undergo genetic testing. Approximately 24% of patients with endometrial cancer are diagnosed before the age of 50, which is one of the clinical testing criteria recognized by the National Comprehensive Cancer Network (NCCN).9,16

at risk for hereditary cancer

24% with endometrial cancer are diagnosed before the age of 50

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SEPTEMBER 29

Are you at risk for hereditary gynecologic cancer? Take the hereditary cancer quiz here to find out. Red flags for hereditary cancer include rare cancers (such as ovarian cancer), cancer that occurs at an earlier age than in the general population (such as breast or colon cancer in a 30-year-old), more than one type of cancer occurring in one person (such as a woman experiencing both breast and ovarian cancers or cancer in both breasts), and multiple people on the same side of the family with similar or related types of cancer (for example, several relatives with breast cancer).

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SEPTEMBER 30

Knowledge is power - talk to your doctor about your personal or family history of ovarian cancer. Find a health care professional here.

View full interactive calendar here.