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Liver Lovin’with Camille Freeman
Where is the liver located?
"Hepatic structure2" by Originally by Frevert U, Engelmann S, Zougbédé S, Stange J, Ng B, et al. Converted to SVG by Viacheslav Vtyurin who was hired to do so by User:Eug. - Based on the research article "Intravital Observation of Plasmodium berghei Sporozoite Infection of the Liver", PLoS Biology, doi:10.1371/journal.pbio.0030192.g011. Licensed under CC BY 2.5 via Wikimedia Commons -http://commons.wikimedia.org/wiki/File:Hepatic_structure2.svg#mediaviewer/File:Hepatic_structure2.svg
"2104 Three Major Capillary Types" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC BY 3.0 via Wikimedia Commons -
http://commons.wikimedia.org/wiki/File:2104_Three_Major_Capillary_Types.jpg#mediaviewer/File:2104_Three_Major_Capillary_Types.jpg
"2423 Microscopic Anatomy of Liver" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC
BY 3.0 via Wikimedia Commons -https://commons.wikimedia.org/wiki/File:2423_Microscopic_Anatomy_of_Liver.jpg#/media/F
ile:2423_Microscopic_Anatomy_of_Liver.jpg
Hepatic Portal Vein
Major Functions of the Liver
Formation & secretion of bileNutrient & vitamin metabolism
Storage
Detoxification
Synthesis of hormones and plasma proteins
Immunity
Bile
• Water
• Pigments
• Bile acids
• Other: cholesterol, fatty acids, inorganic salts, hormones…
Image by Boumphreyfr - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=7006980
Figure 1
Cell Metabolism 2009 10, 162-164DOI: (10.1016/j.cmet.2009.08.005)
Copyright © 2009 Elsevier Inc. Terms and Conditions
Herbal Notes
• Saponins: may bind to bile salts, increase fecal excretion
• Cholagogues
• Choleretics
• Bitters
• Cynara scolymus
• Chelidonium majus
• Mentha spp?
• Curcuma longa
• Berberis vulgaris, B. aquifolium, Chionanthus, Taraxacum radix
Major Functions of the Liver
Formation & secretion of bile
Nutrient & vitamin metabolism
DetoxificationSynthesis of hormones and
plasma proteins
Immunity
Detoxification
• Phase I: CYP450 enzymes can make substances more toxic than the parent molecule
• Phase II: sulfotransferase, methyltransferase or glutathione-S-transferases make molecule more easily excreted in urine/bile• Nrf2 is a transcription factor that
regulates genetic expression of many phase II enzymes. When Nrf2 is upregulated, phase II detoxification increases
Herbal Notes
• May increase phase II:• Curcumin, garlic, green tea,
rosemary, schisandra, broccoli sprouts
• Hepatoprotective/antioxidant:• Silybum
• Cynara
• Ginkgo (?)
Major Functions of the Liver
Formation & secretion of bile
Nutrient & vitamin metabolismStorage
Detoxification
Synthesis of hormones and plasma proteins
Immunity
• Stores glucose as glycogen
• Makes new glucose/releases glucose into blood
• Builds new proteins
• Re-packages fats and cholesterol
• Synthesizes cholesterol
• Stores B12, D, etc.
Major Functions of the Liver
Formation & secretion of bile
Nutrient & vitamin metabolism
Storage
Detoxification
Synthesis of hormones and plasma proteins
Immunity
• Acute phase proteins
• Sex Hormone Binding Globulin (SHBG)
• Albumin
• Complement proteins
• + more!
Major Functions of the Liver
Formation & secretion of bile
Nutrient & vitamin metabolism
Storage
Detoxification
Synthesis of hormones and plasma proteins
Immunity
• See previous slide for image citation
Transaminases
•ALT: alanine transaminase
•AST: aspartate transaminase
Measured by liver function tests
Herbal Ideas
• Thuja occidentalis & Echinacea purpureastimulate Kupffer cell phagocytosis in vitro
• Silybum may decrease fibrotic activity by decreasing stellate cell activation
• Cynara appears to reduce AST/ALT (preliminary evidence)
The Rhythms of the Liver
• Hepatocytes express many genes rhythmically
• Must be entrained to body’s circadian rhythm using zeitgebers
Strategies to Support the Liver
• Use hepatoprotective herbs
• Strengthen integrity of epithelial mucosa in GI
• Maintain regular movement through the GI
• Encourage bile production & secretion
• Promote healthy microbiota in colon
• Decrease inflammatory inputs
• Follow a daily, predictable rhythm
Liver Overview
Hepatic vein
• Nutrients• Bilirubin• Drugs• antigens
• Hormone/drug metabolites
• Nutrients (esp. fatty acids)
• bilirubin
• Glucose• Plasma proteins• Urea• Vitamin D• Metabolites for
excretion
• Bile salts• Bilirubin• Water/ions• Phospholipids