Monoclonal gammopathies of undetermined significance

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Monoclonal Gammopathies Of Undetermined Significance

Monoclonal Gammopathies Of Undetermined SignificanceBy: Dr. Chirag Parmar

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Since Antiquity

Plasma cell dyscrasias have been with us since Antiquity. Archeologists have been able to tell us of individuals that suffered MM in Ancient Egypt, medieval Europe and pre-Columbus America

IntroductionThe real incidence of monoclonal gammopathy is unknown; however, it increases with age, with most cases being identified in the 7th or 8th decade of life. The presence of a monoclonal protein is indicative of an underlying clonal plasma cell or B cell disorder.These disorders encompass a spectrum of disease entities ranging from clinically benign monoclonal gammopathy of undetermined significance (MGUS) to clinically significant diseases such as multiple myeloma and plasma cell leukemia..

DefinitionMonoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, pre-malignant clonal plasma cell proliferative disorder.

MGUS is defined by the presence of: serum M protein