RED YEAST RICE

FOR YOUR HEALTH

What is red yeast rice• Red yeast rice is a traditional Chinese food product which has been a dietary staple i

n many Asian countries for centuries. It is produced by the fermentation of “red yeast” (Monascus purpureus) on a substrate of pre-cooked rice. Monacolin K is assumed to be the main active compound of red yeast rice involved in blood LDL cholesterol maintenance (EFSA journal, 2011a).

• Red yeast rice has been used in Chinese medicine to strengthen the spleen, promote or improve digestion, eliminate dampness and phlegm, promote or improve blood circulation, and remove blood stasis. During the Ming Dynasty, red yeast rice was described as “sweet in flavor and warm in property.”

• Most important, red yeast rice is currently the most effective naturally occurring statin. it has been used with diet, exercise, and medical care to lower cholesterol and triglyceride levels. It may reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, and may also increase levels of "good" cholesterol (high-density lipoprotein, or HDL).

What can red yeast rice help

• Hyperlipidemia• Diabetes• Hypertension• Cancer

Hyperlipidemia• Monacolin K competitively inhibits HMG-CoA reductase, the enzyme that catalyzes H

MG-CoA to mevalonate and then to cholesterol, which results in decreased very low density Lipoprotein and plasma triglycerides, as well as low density Lipoprotein.

• The efficacy of the treatment on lipid modification was comparable with that of the prescription drug products pravastatin, simvastatin, lovastatin, atorvastatin, or fluvastatin. When compared with nonstatin drug therapy, red yeast rice was superior to nicotinate and fish oils.

• Animal data• In the late 1970s, it was discovered that Monascus metabolites inhibited HMG-CoA re

ductase, the rate-limiting step in cholesterol biosynthesis. Monacolin K was also found to suppress aortic atherosclerotic plaque formation and lipid accumulation in the animal livers. The dose of 0.4 and 0.8 g/kg in 1 report reduced serum cholesterol levels by 44% and 59%, respectively.

•Clinical data•Many Chinese studies evaluating Monascus are available. One major randomized, multicenter trial involved 446 hyperlipidemic patients with cholesterol levels greater than 230 mg/dL. At the end of an 8-week treatment, total serum cholesterol was reduced an average of 23%, triglycerides were reduced by 37%, LDL cholesterol was reduced by 29%, and high-density lipoprotein (HDL)–cholesterol levels were increased by 20%.

1 total serum cholesterol

2 triglycerides

3 LDL cholesterol

4 high-density lipoprotein (HDL)–cholesterol

Diabetes•The postulated mechanism of action involves the release of acetylcholine from nerve terminals, which in turn stimulates muscarinic receptors in pancreatic cells, increasing insulin release and resulting in lower plasma glucose.

•Animal data•Red yeast rice decreased plasma glucose in a dose-dependent manner in rats. An increase in plasma insulin or C-peptide was also observed and similar results were documented in streptozotocin-induced diabetic rats. Another study found that red yeast rice improved insulin sensitivity in rats and delayed development of insulin resistance.

Hypertension•An aqueous extract of M. purpureus prevented and reversed fructose-induced hypertension in rats.

Cancer•The mechanism of action may involve monacolin K and red yeast pigment fraction inhibiting denovo cholesterogenesis that is required for tumor growth. Monacolin K is an effective anticancer agent that blocks the mevalonate biosynthesis pathway, inducing suppression of cancer growth. •Red yeast rice inhibited proliferation and stimulated apoptosis perhaps through caspases and poly (ADP-ribose) polymerase cleavage in human colon adenocarcinoma cell lines. Proteomic studies found monacolin K to inhibit cell proliferation through multiple protein expressions (a total of 20 proteins), including peroxiredoxins, cytoskeleton proteins, chaperone proteins, and energy-producing enzymes. Monacolin K may also alter the expression of some redox-related enzymes. Monascus fermented red yeast rice have documented antiproliferative effects against tumor cells.

Formation of red yeast riceRed yeast rice is available in a capsule formulation. Other forms of red yeast rice may also be available, such as tablets, teas, tinctures, and topical forms.

Dosage•No dosage standards have been established for red yeast rice. Adult dosages used in clinical studies range from 1.2-2.4 g per day to 0.8 g/kg/day. In Asian countries the average daily intake of red yeast rice is 14-55 grams.•Red yeast rice should better be taken with food to reduce stomach upset.

CautionYou may not be able to use this product if you have:•asthma;•kidney disease;•pregnant, breast feeding;•drink more than 2 alcoholic beverages per day;•a serious infection, disease, or medical or surgery condition.Avoid using red yeast rice with cholesterol-lowering (statin) medications, which can increase risk of liver damage and rhabdomyolysis.

Storage•Store red yeast rice in a sealed container as directed on the product label, away from moisture, heat, and light.

Some existing brands and products

What we can offer for you•Wuxi Cima Science Co.,Ltd, the professional manufacturer of Red Yeast Rice for nearlly 10 years. •We supply all kinds' specification of Red Yeast Rice Extract and their corresponding OEM products, such as Red Yeast Rice capsules and tablets.•Our products advantage: •100% Natural solid-state fermentation & 100% No Citrinin & 100% High assay of acid form of Monacolin K (Mevinolinic acid in the range of 60-85%) &100% GMO Free & NO-irradiation & Low aflatoxin content & Low pesticide residue.Note : Not all red yeast rice sold on the market are of high quality. Some of them contain citrinin, a compound formed during production and potentially toxic for your health.

Series Specification RemarkCS-RYR Total Monacolin K 0.4%-5.0%, Citrinin Free CS-DCRYR Total Monacolin K 0.4%-3.0%, Citrinin Free DCCS-WSRYR Total Monacolin K 1.0%-3.0%, Citrinin Free Water solubleCS-RYRG Total Monacolin K 0.4%-3.0%, Citrinin Free GranularCS-SRYR Total Monacolin K 0.4%-3.0%, Citrinin Free Superfine

Specially• 1. 100% Water soluble Red Yeast Rice (100% be solved in cool water easily and the

solution is transparent absolutely) for beverage, fruit drink or tea bag.• 2. DC grade Red Yeast Rice for tablets. • 3. Red Yeast Rice Granular for capsule filling.• 4. Superfine red yeast rice for softgel or food ingredient.• 5. A typical formula include: Red Yeast Rice Extract; Salvia miltiorrhiza Bge Extract;

Hawthorn Fruit Extract; Catsia tora Linn Seed Extract. This capsule really have a good function to to promote HMG-CoA reductase inhibition action which may help to promote healthy cholesterol levels, lower blood pressure, and prevent myocardial infarction, general according to our experiments. It do really good for your circulatory system, and also it is 100% Citrinin free to ensure there is no any side effect for this capsule.

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