SANGUINARIA CANADENSIS

IntroductionChemical Constituents

SolubilityUses

Mechanism of Action

Side EffectsToxicityDosage

Contraindications

INTRODUCTIONFamily: Papaveraceace

Botanical Name: Sanguinaria canadensis

English Name: Bloodroot

Urdu Name: Arq ud Daam

Part Used: Dried roots and rhizomes

CHEMICAL CONSTITUENTSSanguinarine (Main Constituent)

BerberineCoptisine NarceineProtopine

ResinSanguidaridineSanguidimerine

SanguilutineSanguirubineChelerythrineChelidonine

SOLUBILITY

Insoluble In

Water

Soluble In

Methanol

Soluble In Ether

Soluble In

Benzene

USESSanguinarine, Chelerythrine, Berberine And

Chelidonine Are Used As Anti-inflammatory

Chelerythrine Is An Antibacterial

For Staphylococcus Aureus

Sanguinarine Is Used As Anti-cancer.

Mainly Used For Treatment Of Breast

Cancer

Berberine Is Used As

Antiarrhythmic

USESNarceine Is

Used As Psychoactive

Drug

Protopine And Narceine Is

Used As Analgesic

Narceine Is Used To Induce Vomiting To

Expel Any Toxic Substance That Is

Swallowed

Sanguinarine Is Used As Anti-

bacterial For Helico Pylori To Treat

Gastritis

USESExtract Is Used

As Blood Purifier

Coptisine Is Used as Heart

protective agent

Protopine Is Used To Smooth

Muscle Relaxant

MECHANISM OF ACTIONBerberine Treat Arrhythmia By Inhibiting Potassium Channels Which Increases The Cardiac Action Potential

Sanguinarine, Chelerythrine, Berberine And Chelidonine Inhibits Pro Inflammatory Cytokines And Prostaglandins Which Induce Inflammation

Coptisine Block The Enzyme Mono Amine Oxidase A, Which Degrades The Neurotransmitter Serotonin And Keeps The Brain Functions Normal, To Avoid Degradation Of Neurotransmitter To Keep Brain Function Normally.

MECHANISM OF ACTIONNarceine And Protopine Acts On CNS Receptors For Pain To Relieve Analgesia

When Narceine Is Administered, The Immune System In Response To A Narcotic Release Histamine. High Level Of Histamine Causes Psychoactivation.

Narceine Causes Inflammation Of GIT Due To Which Vomiting Occurs

Berberine And Sanguinarine Inhibit The Bacterial Growth By Inhibiting The Ribosomes Forming Protein And Thus Treat The Gingivitis And Gastritis

MECHANISM OF ACTIONSanguinarine causes cell death by inducing release of autolytic enzymes

Sanguinarine has wide range of anti bacterial effects and anti inflammatory, so extract may be used as blood purifier

Coptisine inhibit inducing the release of the autolytic enzymes of cardiac muscles to prevent apoptosis, thus may act as heart protective agent

Protopine inhibit the intracellular Ca+2 release, allows the smooth muscles to remain relax and thus it acts as smooth muscle relaxant

SIDE EFFECTS

Causes Localized

Tissue Damage

Sanguinarine Inhibits The

Platelet Aggregation

When Taken Orally And

Swallowed, It Cause

Vomiting

May cause relaxation of

smooth muscles

TOXICITY

DOSAGE10-20 Drops May Be

Mixed In 6ml Of Water & Take After Every Two Hours Or Six

Hours

Blood root Tea: Boil 1 tea spoon of rhizome to a cup of water for 20 minutes. Drink 3

times daily.

Blood root Tincture: 1-2 ml

of tincture. 3 times a day

For Gingivitis Treatment, Oral

Rinses May Contain 300µg Of The Extract

CONTRAINDICATIONS

Use Of Sanguinaria Canadensis May Be Avoided During Pregnancy And Breast Feeding

Large Doses Must Not Be Taken

Must Not Be Taken Orally In The Form Of Paste

Must Be Avoided If Suffering From Diarrhea

Must Not Be Used Undiluted

Use Must Be Avoided If The Suffering From Antral Gastritis Or Jejunitis

CONTRAINDICATIONSCaution Is Advised When Taking Bloodroot With Any Agent With Similar Effects Due To Having Increased Side EffectsBlood root effect glaucoma treatment, don't use if you have glaucoma unless health care professional monitor your eye.

Patients using tobacco should use blood root cautiously because sanguinarine may cause leukoplakia and lesions.

Blood root can be used on skin but is unsafe when taken by mouth during pregnancy because it stimulate menstruation and there is risk of abortion.

It is unsafe when taken by mouth during breast feeding beacause the content harmful for the child are diffused into milk

End