MSK Section Research Meeting7-21-06

2005-2006 Academic Year Publications

• MR arthrography of the knee: how, why, when• MRI findings of femoral diaphyseal stress injuries in athletes. • Acromioclavicular joint osteoarthritis: comparison of findings derived

from MR imaging and conventional radiolgraphy.• Fresh Osteochondral Allografts. • Posterior cruciate ligament recess and normal posterior capsular

insertional anatomy: MR imaging of cadaveric knees.• MR imaging of the hip abductors: normal anatomy and commonly

encountered pathology at the greater trochanter.• MR imaging of the finger tendons: normal anatomy and commonly

encountered pathology. • Paraspinal muscle vasculature contributes to posterolateral spinal

fusion. • Normal MR Imaging Anatomy of the Elbow. • MR Imaging of the Rotator Cuff Interval. • Magnetic resonance imaging of the hip.

2005-2006 Academic Year Publications

• Pellegrini-Stieda disease: a heterogeneous disorder not synonymous with ossification/ calcification of the tibial collateral ligament – anatomic and imaging investigation.

• Inflammation of Hoffa’s Fat Pad in the Setting of HIV: MR Imaging Findings in 5 Patients.

• Painful stress fractures in the fabella in patients with total knee arthroplasty.

• Hyperplastic callus formation in osteogenesis imperfecta type V• Magnetic resonance imaging of para-acetabular insufficiency fractures in

patients with malignancy• MRI of anterior tibiotalar impingement• Radial and ulnar bursae of the wrist• Deep and superficial infrapatellar bursae of the knee • Pattern of osteophytes and enthesophytes in the proximal ulna• Imaging findings in asymptomatic patients with femoral diaphyseal stress

injuries• Hypoplasia of the glenoid neck of the scapula

2005-2006 Academic Year Publications

22 Peer Review Publications

(20 Peer Review Publications 2004-2005)

(21 Peer Review Publications 2003-2004)

Collaborators

• Graeme Bydder– Ultrashort TE Imaging

• Parviz Haghighi– Pathology

• Rob Pedowitz– Orthopedic surgery

Fellow Requirements

• One didactic lecture

• One research project– 2 weeks to choose a project– After 2 week time period, project will be assigned

• Case preparation– Divide into individual cases and label folder with diagnosis– Folder should contain a word document

• Origin of case (telerad location/ VA/ Thornton/ Scripps/ Hillcrest)• Identifying info of patient• Pertinent history

– All cases should be loaded into MIRC server (Amil will direct) as well as computer in telerad room

Projects

• Writing– Case reports– Pictorial essays– Chapters

• Doing and Writing– Retrospective review– Prospective studies– Lab projects– Imaging projects

IRB Approval

• Required for:– All review of medical records– All retrospective review– Any study involving patients/ informed consent

• Website: http//medicine.ucsd.edu/humsub/

• Types of approval:– Regular– Expedited

• UCSD and VA approval– Share a common IRB committee– Once UCSD IRB approval acquired, must pass an administrative

approval by VA R&D committee

Steps to Begin Project• Idea!!

• Verify the validity and novelty of the idea– Literature search (PUB MED)– Key articles (E-journal www.ucsd.edu)– Establish target journal– Discuss authorship and work responsibilities

• Study design– Objective– Basic materials and methods

• Data analysis– Good idea to touch base with statistician to be sure design is statistically valid– Paul Clopton (VA extension 3534)

• Write– According to target journal instructions to authors

• Submit

Authorship

• If you write and submit the article to the journal, you will be the first author

• If you do not submit the article to the journal, you WILL NOT be the first author unless arrangements have been made and approved by the lead author

• With authorship comes the burden of justification for your role in a project

Study Design: Cadaveric Projects

• Contact person Deb Trudell (VA extension 7058)

• Protocol Description Worksheet– Study description– Specimen request– MR technique (very specific)

• Imaging time– Wednesday 9 pm start time– Sunday 5 pm start time

Imaging Policy

• All MR images obtained for studies must be put in jpeg format the night of imaging, placed in a folder on the Neuroradiology PACS station on your VA sign in

• Request 2 CD’s of the data to be written by Mike Olds (leave note on his door)

• One CD for your records which should be placed on the Research computer in a folder with the project name

• One CD should be submitted to lead author

• Any photographs of gross anatomy/ dissections, etc for projects should be placed on the Research computer with a CD submitted to lead author

Meeting Presentation

• Funding for abstract presentation at major scientific meetings

• Deadlines:– ARRS October 1, 2006 Deadline

• (Meeting May 6-11, 2007 Orlando)

– SSR October ? deadline • (Meeting March 2007, Orlando)

– ISMRM ?? Deadline October• (Meeting May 19-25, 2007 Berlin)

– RSNA April 15• (Meeting Nov-Dec. 2007, Chicago)

– International Skeletal Society ?? deadline• (September 2007, Budapest)

Amil Research

• Radiology projects:– Accessory muscles of the ankle – Accessory muscle of the wrist or knee – MR arthroscopic correlation

• Computer projects: – PowerPoint to flash conversion – Friday conference on the internet – Resident musculoskeletalradiology curriculum online – Structured reporting MIRC

Amil Research

• Educational projects: – Fractures – Arthritis – Hardware Post op complications – Incidental findings – Skeletal scintigraphy

Tudor Research• Review article

– Bone within Bone appearance

– HIV Manifestations in MSK

– Periosteal reaction (possible poster)

– MSK findings of illicit drugs (possible poster) Rick Arigo

– Radiologic MSK anthropology (possible poster)

– Atlanto occipital atlas dissociation (possible poster) Toni Roth

– Fat in tendon sheaths: Predictor of adjacent fractures (possible poster) Ugne Skripkus

– Foreign bodies (possible poster)

– Rice bodies (possible poster)

– Corner fractures of the cervical spine Debra Chang

Tudor Research• Metatarsal head shape (Hamid Torshizy)

• Stress fracture atlas (Luke Hiller)

• C1 CPPD (Luke Hiller)

• Border jumper injuries

• Ligaments that ossify (Post tib fib) / Retrospective review of ankle fractures (James Chang)

• Cross sectional criteria for protrusio

• Bone formers and THR: Does DISH improve noncemented THR outcome

• 3D reformats: Do these help the orthopedist

Don’s Research

•    SNAC wrist Debra Chang

•    Spring ligament anatomy Dean Bruce

CBC Research:Writing

• Chapters– Post-operative Elbow (Co-Authors: Steinbach/ Beltran/ Morrison/

Chung) Debra Chang– Post-operative Wrist and Hand (Co-Authors: Steinbach, Beltran/

Morrison/ Chung) Nick Panchal • Clinical

– Hoffitis in HIV patients• Torshizy

– MR imaging of the hip• Hong

• Research– MR imaging and MR arthrography in cadaveric specimens with

existing meniscal tears and created lesions

Accepted for Publication

Accepted for Publication

CBC Research:Anatomic Pathologic Correlation

• 1st MCP anatomy• Anatomy of the thenar eminence• Anatomy of the hypothenar eminence• Reflected Head of Rectus Femoris and Assoc Pathology• Standard MR imaging versus of MR arthrography for evaluation of

radial and ulnar collateral ligament injuries in the thumb (created lesions in cadavers)

• MR classification for finger OA– Aguiar

• DIP and PIP anatomy– Aguiar

• Muscular attachment to humerus– Inferior aspect of Intertubercular sulcus

• Posteromedial knee anatomy (bursa)

Accepted Presentation ISS/ RSNA 2006Accepted Presentation ISS/ RSNA2006

MSK Imaging Research Group

• Imaging of the Calcified Layers of Cartilage with UTE Application– Multiple phases of data collection/ analysis to work

toward several goals• UTE optimization at 3T• Comparison of UTE to standard clinical sequences for

evaluation of the deepest layers of cartilage• Characterization of patterns of OA in the setting of deep layer

lesions (association with T2 mapping and dGEMRIC type techniques)

• Clinical applications• Biomechanical correlation

Translational Cartilage Research

• Radiology– Christine Chung (Associate Professor Radiology)– Graeme Bydder (Professor Radiology)– Donald Resnick (Professor Radiology)– Shantanu Sinha (Professor Physics)– Robert Orth (Radiology Resident)– Hamid Torshizy (Medical student)– Richard Znamirowski (MRI technologist)– Nick Pinto (MRI technologist)– Deb Trudell (Research assistant and MRI

technologist)

• Bioengineering– Robert Sah (Professor Bioengineering)– Won Bae (Assistant Research Assistant)– John Lee (NIH funded medical student)

Translational Cartilage Research

• Orthopedics– William Bugbee (Assistant Professor Orthopedics)– Robert Pedowitz (Associate Professor Orthopedics)

• Pathology– Parviz Haghighi (Professor Pathology)– Darryl D’Lima (Director Orthopedic Research Center

Scripps Clinic)– Jianfen Chen (Research assistant)

• Statistics– Tanya Wolfson (Staff Statistician)

MSK Imaging Research Group

• Lab meetings Wednesdays 3 pm VA conference room

• Physics meetings will begin August– To follow clinical conference 7:45 – 8:30