The 7 discoveries that will enable you

to live healthier

for longer.

Dr Paul Clayton: Former Chair of the Forum on Food and Health at the Royal

Society of Medicine.

“The so-called ‘age-related’ diseases take from 10 to 20 years to surface as overt, debilitating, life-threatening illnesses – heart disease, stroke, cancer, diabetes, dementia.

That’s equally true of life-diminishing conditions like arthritis, chronic tiredness and erectile dysfunction.

At that point pharmaceutical treatment is largely treating the symptoms not the causes.

If you want to be healthier for longer, the time to take positive preventative action is in your early 50’s or even before.

Thanks to recent discoveries we now know the best way to slow ageing and maximise the chance of continuing full health. I call them ‘The 7 Pillars of Health’

Preventative Healthcare is the key

Certain nutrients can upregulate or turn on ‘good’ genes – like tumour suppressor genes. And others can down-regulate or turn off ‘bad’ genes – such as oncogenes which have the potential to cause cancer.

It’s called ‘gene expression’, part of a new science called Epigenetics. There are foods and nutrients you can include in your diet that can express genes to promote health and even slow biological ageing.

One of the leading researchers in this area is Dr Cynthia Kenyon working at Cambridge University on ageing mechanisms. She says: “The idea that ageing was subject to control was completely unexpected”

1. Turn on ‘good’ genes, turn off ‘bad’ genes

A study at the University of California at San Francisco showed that hundreds of genes in people who were put on a largely plant based diet were modified, leading to a lower cancer and heart disease risk.

Plant derived nutrients that up-regulate genes to promote health include the polyphenols in green tea , lycopene, lutein and genistein, which is a compound in soy.

Other nutrients that have been shown to positively activate gene expression are:

Choline, folic acid, B6 and B12, a B vitamin called betaine, vitamin D3 and minerals that include zinc and selenium.

Nutrients that encourage gene expression: Betaine, B6, B12, folic acid, vitamin D, zinc, selenium, lycopene, lutein, green tea polyphenols and genistein.

Promoting gene expression

Chromosomes are condensed rods of DNA and have 4 ‘arms’. At the end of each arm is a telomere – a tiny protective ‘cap’ often likened to the plastic end of a shoe lace.

Each time a cell divides to make a new copy the telomere gets fractionally shorter. When the end of the telomere is finally reached, the cell dies. So scientists believe the length of your telomeres may be a good marker of biological ageing and mortality.

Research shows that the rate at which telomeres become shorter can be slowed down with an anti-oxidant and anti-inflammatory rich diet .

2. Slow down the shortening of telomeres

Anti-inflammatory and anti-oxidant nutrients: Omega 3, vitamins C and E, beta carotene, curcumin and polyphenols in green tea and grapeseed extract

Your body is made of organs, organs are made of tissue and tissues are made of cells. You make billions of new cells every day!

Since cells are constantly dying and being replaced, the foundation of a healthy body is to ensure every part of every new cell has the nutrients it needs to regenerate itself and function at peak effectiveness. Other nutrients help slow cell breakdown.

We talk about ‘age related’ illness like heart disease, diabetes, dementia and chronic tiredness, but the passing of the years has much less effect than sub-optimal nutrition and lifestyle.

3. Build healthy cells

Encasing each cell is a membrane made up of proteins, cholesterol and fatty acid. These fats give the membrane its flexibility and structure.

If your diet has insufficient high quality fatty acids in it, the membrane has to build itself with low quality fats. It becomes stiffer, less permeable and less able to allow essential nutrients in or wastes out.

Omega 3 fish oils help build healthy, flexiblecell membranes. Some 50% of the eye’s photoreceptors are made up of Omega 3 oils as are over 40% of brain cell fats.

As the brain is high in fats, it is vulnerable to oxidation and inflammation - so it needs anti-oxidant and anti-inflammatory protection.

Omega 3 fish oil makes healthy cell membranes

Anti-oxidant and anti-inflammatory nutrients: Omega 3, vitamins C and E, beta carotene, curcumin and polyphenols like green tea and grapeseed extract

membrane

Because cell membranes have a high unsaturated fat content they are very vulnerable to free radical damage. Free radical damage occurs when fats react with oxygen – and you can see the process when a fat like lard becomes rancid. The illustration left represents how free radicals can attack and damage a cell.

Nutrients that can provide protection are called anti-oxidants. They create a “shield” that “quenches” or absorbs free radicals.

There is evidence that polyphenols called anthocyanins found in coloured berries – like blueberries, bilberries, raspberries and black currants - are especially powerful neuro-protectors. They help protect brain cells.

Anti-oxidants neutralise free radical damage

Anti-oxidant and anti-inflammatory nutrients: Omega 3, vitamins C and E, beta carotene, curcumin and polyphenols like green tea and grapeseed extract

Each cell membrane must do something else that is vital. Cells need to sense each other’s boundaries. They do that by what is called ‘cell signalling’. When they cannot signal their boundaries, the result can be uncontrolled cell growth – cancer.

Researchers have found that vitamin D, the carotenoids lycopene and lutein and choline are important to ensure normal cell signalling and, by extension, cutting the risk of cancer.

Pub Med, the on-line publishing arm of the American National Institutes of Health, confirms that carotenoids ‘can be useful in the prevention of cancer and other degenerative diseases.’1

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The importance of effective cell signalling

Nutrients that support normal cell signalling : vitamin D, lycopene, lutein and choline

Inside each cell are a nucleus and several mitochondria - which are normally likened to miniature ‘power plants’. Heart, brain and muscle cells have the most mitochondria, because they have high energy demands.

Inside mitochondria, the energy from food is transferred to energy storage molecules such as ATP. The nutrient Coenzyme Q10 or CoQ10 is vital in this process. A lack of CoQ10 – which declines with age - is a cause of lack of energy

Anti-oxidants are needed for protection because oxidative damage to mitochondria is contributes to accelerated ageing.

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Protect your mitochondria

Nutrients that support your mitochondria and energy production: Co Q10, B vitamins, vitamins C and E, magnesium, zinc, chromium, beta carotene, and polyphenols

During the continual process of cell replication, mistakes and damage to DNA occasionally, but inevitably, occur.

If a cell has accumulated a lot of DNA damage, it can trigger the start of a cancerous tumour where cells do not stop growing and dividing.

Researchers have discovered that selenium, zinc, the carotenoids lutein and lycopene, and a compound called isothiocyanate found in cruciferous vegetables are among compounds important in the DNA repair mechanism.

Cumulative DNA damage is thought to further contribute to the ageing process, and is involved in certain diseases including cancer.

Support your DNA repair mechanism

Nutrients that support DNA repair: lutein, lycopene, selenium, zinc and isothiocyanates

What is called ‘chronic, sub-clinical inflammation’ is now known to be a major cause of the degenerative killer diseases.

This type of inflammation builds up in tissues over time, but you can’t see or feel it – which is why Time Magazine calls it ‘the silent killer’.

New Scientist recently confirms it’s involved in: …”muscle wasting and glaucoma, Alzheimer’s and Parkinson’s, osteoporosis and arthritis, heart failure and high blood pressure, cancers, and lung, liver and kidney and skin disorders.”

Inflammation increases with age and affects most people after the age of about 50. Risks rise further if you are a city dweller exposed to air pollution from particulates, living a low-energy lifestyle and consuming processed foods.

4. Reverse ‘chronic’ inflammation

The body uses fatty acids from the food we eat to make the hormones called eicosanoids that control the inflammatory response.

Omega 6 fatty acids, found in polyunsaturated plant oils like safflower, sunflower, palm and corn oil, increase the level of hormones that promote inflammation. These oils are frequently used in processed foods because they are cheap. They are also put into feeds for animals intensively raised for meat consumption.

Omega 3 fatty acids (from oily fish) have the opposite effect, producing eicosanoids that reduce inflammation.

Processed foods often contain excess levels of

pro-inflammatory Omega 6

Reduce pro-inflammatory foods

Reducing Omega 6 intake and increasing your Omega 3 intake produces a healthier Omega 3/6 balance.

The American Cancer Institute now recommends nine portions of fruits and vegetables a day!

Fruits and vegetables not only promote positive gene expression, they contain, amongst other compounds, flavonoids - polyphenol molecules. These exert powerful anti-inflammatory effects in the body.

Flavonoids also help block the potentially highly destructive action of enzymes called MMPs which are directly responsible for the tissue damage that turns chronic inflammation into overt disease – and creates an environment where cancer can spread.

So increase your fruit and veg intake.

Increase anti-inflammatory foods

If 9 portions is a challenge, take a supplement that contains flavonoids and plant derived nutrients like lycopene, lutein and grapeseed extract.

When cells are damaged by inflammation they produce toxic compounds that trigger the release of excess free radicals.

The resulting oxidative stress further damages those cells, and this process releases a second wave of inflammatory compounds.

This vicious circle drives both degenerative disease and the ageing process itself.

That’s why your diet should contain high levels of both anti-inflammatory andanti-oxidant foods and nutrients.

Dark berry fruits, vegetables like kale, spinach, and broccoli and spices like turmeric (curcumin) are all high in both anti-inflammatory and anti-oxidant compounds.

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Inflammation and Free Radical damage – a vicious circle

If there is an excess of sugar in the body, protein molecules can react with sugar molecules and form cross-links with other proteins. This is called glycation and once a protein is glycated it is damaged and unable to perform its proper function.

Collagen is the most abundant protein in the body and when collagen is glycated the result is reduced flexibility of organs, hardened arteries, hypertension, impaired muscle function and kidney damage. Externally it manifests as loss of elasticity, wrinkles and accelerated skin ageing.

Internally excess glycation is linked to damage to the lining of blood vessels (and hence heart disease), the stiffening of the lens of the eye and the formation of cataracts. Glycemic stress is linked to Alzheimer’s and glycation contributes to accelerated ageing.

5. Prevent ‘sugar coated’ cell damage

Normal skin has neat, regular

collagen bonds – a bit like

undamaged chainmail

When skin becomes glycated the

bonds in collagen become

irregular and cross-linked leading

to internal and external ageing.

Whole fruits – or liquidising whole fruits – are better than fruit juices which are light in fibre and heavy in fructose. And cut down on confectionary and baked goods.

In addition, when foods containing proteins are cooked at high temperatures, the protein binds with sugars in the food to produce toxic pro-inflammatory compounds.

Avoid deep-frying and grilling, including chips, French fries and crisps, and many processed foods which are often prepared using very high temperatures. Prefer steaming and microwaving.

Reduce glycation

Spices like ginger, turmeric, thyme, rosemary and basil have an anti-inflammatory effect and can help neutralise glycation. Include them in your

cooking. And rub meat to be grilled with rosemary or thyme..

Your immune system defends you against pathogen invaders like viruses and bacteria and against internal ‘rogue’ cells. Unfortunately it declines in effectiveness as we age, which is why extra support is important.

Foods that support the immune system include mushrooms (especially shiitake and maitakemushrooms), dark berry fruits, cabbage, spinach, broccoli and kale, pumpkins, citrus fruits for their vitamin C content, green tea, garlic, and wheat germ which is high in vitamin E.

6. Support your immune system

Nutrients that support the immune system: vitamins A, D and E selenium, zinc, green tea extract, flavonoids, curcumin, beta carotene and lycopene.

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If you have an illness like measles your Acquired Immune System creates antibodies which normally protect you from catching the same illness again.

You also have a second (Innate) Immune System, consisting of Natural Killer cells, macrophages and neutrophils. These patrol the body and normally neutralise the threats from viruses, bacteria and ‘rogue cells’ by killing them.

A natural ingredient, called 1-3, 1-6 beta glucans is proven to modulate the Innate Immune System by increasing the number and activity level of your Natural Killer cells.

When the Canadian Dept. of Defence tested over 100 immune system enhancers, a 1-3. 1-6 beta glucan called Wellmune was the top rated.

A macrophage enveloping and killing virus

Boosting your Innate Immune System

The microbes in your gut are called your microbiome. These microbes make some essential vitamins like B vitamins and Vitamin K. They are also vital part of your immune system.

If the numbers and range of these ‘friendly’ microbes is reduced –for example if you are on antibiotics or have a sub-optimal diet – you become much more vulnerable to pathogens like C difficile and salmonella.

Diseases as widely different as asthma, diabetes, obesity, cancer, and heart disease have been shown to be influenced by the microbiome.

If the microbiome is not properly nourished the gut becomes more permeable which can allow toxins to leak into the blood stream triggering inflammation that affects the entire body.

7. Feed your 100 trillion ‘guest’ microbes!

Different gut microbes need different types of ‘food’ to feed on and thrive.

These include prebiotic fibres found in peas, beans, lentils, oats, in fibrous fruits like figs, apples, dates, prunes and in vegetables like asparagus, leeks, garlic, onions, broccoli, cabbage and root vegetables.

Your microbiome also benefits from fermented probiotic foods like sauerkraut, tempeh, buttermilk, sourdough bread and miso soup.

You can boost the numbers and range of beneficial microbes by eating probiotic yoghurts that contain strains of ‘friendly’ bacteria like L. plantarum

and Bifidobacteria and Akkermansia.

Ensuring a healthy microbiome

On average we are living longer – but too often the later years are characterised by illness.

We now know that the causes of these illnesses are all interconnected. It looks complicated but two common problems underlie all of them. Lack of physical activity and sub-optimal nutrition - because your nutritional needs increase over time.

The solution then is clear. By increasing the level of the foods and nutrients we have highlighted in this presentation you can dramatically reduce the risk and threat of so-called ‘age related diseases’. And slow biological ageing.

The 7 interconnected causes of ageing and illness

Summarised opposite is the simplest yet most comprehensive plan to maximise your health, counteract the threats that lead to illness and slow biological ageing.

Achieving all 7 parts of the plan depends on regular exercise and optimum nutrition:

• Increased intake of the fruits, vegetables mushrooms, whole grains and nuts and a reduced intake of refined grains, sugar and processed foods. (Just because you’ve heard it before, doesn’t make it less true!)

• Increased pre and pro-biotic foods

• Oily fish 3 times a week

• A nutritional supplement that includes the range and level of nutrients that fully

supports this 7 step plan.

1. Promote positive gene expression

2. Slow the reduction in telomere length

3. Build healthy cells and support DNA repair

4. Reduce internal chronic inflammation

5. Reduce glycation

6. Support your immune system

7. Feed your microbiome

The Seven Pillars of Health

Counteracting all seven causes of ageing requires consistent levels of a wide range of nutrients. And those needs increase over time. (So the American Cancer Society recommends 9 portions of fruits and vegetables a day).

Yet the average person burns 1,000 calories a day less than 60 years ago! So we’ve had to reduce our calorie intake - but less food means less nutrition.

To compound the problem, the nutritional value of many foods has declined over the same period.

A simple one-a-day A-Z vitamin pill might be enough if you are under about 40. But it won’t include the other nutrients that support the 7 pillars of health as you get older.

Why would you need a supplement?

Even a conscientious person will struggle to obtain the range and levels of the preventative nutrients we have identified, day-after-day.

In formulating Nutrishield we have drawn on over 35 years and 10,000 peer reviewed studies to design the combination of nutrients -in optimum, synergistic and safe amounts - that support the full, healthy functioning of brain and body. It’s a heart, brain, skin, joint and eye supplement all in one.

Coupled with a sensible diet and moderate exercise, it gives you the foundation for long term health and energy.

It works: independent tests show NutriShielddramatically reduces inflammatory markers at the cell level. And 87% of our customers come from word of mouth recommendation.

The most comprehensive supplement

1. A full range of vitamins and minerals 2. Polyphenols that include curcumin,

green tea, bilberry and grapeseed extract

3. Omega 3 fish oil4. Lycopene, lutein and beta carotene5. Glucosamine 6. CoQ 107. Soy isoflavones, genistein and betaine

Links

www.nutrishield.com

If you order today we will also send you a colour cookbook that shows how to include the foods

discussed in this report.

www.immunoshield.comincludes Wellmune 1-3, 1-6 beta glucans

You will find articles and scientific references for all the statements made and nutrients mentioned at

www.nutrishield.com/the-library

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