Data Virtualization Modernizes Biobanking

Data Virtualization Modernizes Biobanking

Speakers

Lori Ball

COO & President, Integrated Solutions

William Barnett

Chief Research Informatics Officer

Suresh Chandrasekaran

Senior Vice President

Ravi Shankar

CMO

Comprehensive Sample Management

Data Virtualization in Healthcare

Integrated Biobank Visual Analytics

Solution Development

Lori A. BallCOO & President,

Integrated Solutions

Comprehensive Sample Management Solutions

www.biostorage.com

Biorepository and Biobanking Sample Storage –Onsite and Offsite

Supply Chain Services – Logistics and Relocation

Technology Solutions - ISIDOR®

Business Continuity / Disaster Recovery

Bioprocessing Solutions – Sample Preparation /Genomics/Cell Services

Project Management Services

Millions SamplesStored around world

>200 sample types

>275 Clients 18 of the top 20 global biopharma companies

4 global site locations(US, Europe, Singapore, China)

+27ºC to -190ºC storage temperatures

Thousands ft² facility space

TechnologyUS FDA 21 CFR Part 11 compliant

QualityCAP, GxP, NRC,IATA, CCSF

5

Healthcare Industry Trends Impacting Biobanking

Industry focus on precision medicine1

Bioscience research budget challenges2

Expansion in global clinical trials3

Growing industry and research collaborations

4

Increasing need for more transparent and standardized informed consent tracking

5

Growing demand for integrated sample and research data

6

Research organizations are beginning to intelligently apply data integration and visual analytics tools in ways that enable researchers to both explore and interact with aggregate data. 1

Source: 1 2020 Vision: Fulfilling the Future of Clinical Research, Applied Clinical Trials, Feb 2015.

Development of effective data management systems is the #1 challenge facing individuals managing biobanks today.1

Source: 1 PharmaVoice, “The Internet of Things”, March 2015

Data Integration(physical & virtual)

Virtualization

Valorization

Visualization

Cloud Storage: SAS, SQL, Oracle, ERP

ConsolidatedData Center / Logical Data Warehouse

Biobanking Industry Data Integration Challenges

ISIDOR® Technology Solutions

A transformational and scalable informatics platform

which integrates research and sample data to advance

bioscience discoveries.

How Data Virtualization Works and the Value it Delivers in Healthcare

Suresh Chandrasekaran | Senior Vice President, Denodo

Denodo at a Glance

© Copyright Denodo 2015 9

Denodo offers unified access to corporate data assets, flexible integration and management of data of all kinds, and real time data delivery for applications and analytics in a single solution that doesn't need to move data from their original physical repositories.

Headquarters

Palo Alto, CA

Denodo Offices, Customers, Partners

Global presence throughout North America, EMEA, APAC and Latin America

Leadership

Longest continuous focus on data virtualization and data services. Product leadership. Solutions expertise.

Customers

250+ customers,

including many F500 and G2000 companies across healthcare, life sciences, technology, media, telecommunications, insurance, financial services, consumer/retail, energy and public sector.

What is Data Virtualization?


Data Virtualization combines disparate data sources into a single “virtual” data abstraction

layer (aka information fabric) that provides unified access and integrated data services to

consuming applications in real-time (right-time).

Connect &

Virtualize

Combine &

Integrate

Publishas a Data Service

Local Database XML Documents

Name | Description | Price Name | Description | Price

U

∞

Name | Manufacturer | Score

Name | Description | Manufacturer | Price | Score

Application

Browser

ResultsSQL Query

Base ViewBase View

Base View

Derived ViewData Service

(SQL, SOAP, REST, Widgets…)

DV Enables Agile Info ArchitectureMany to Many

Agile BI &Agile Apps

Data Services

Any Data, Anywhere

IntegrateNew Sources

OptimizedPerformance


DV Has Several Uses in Life Sciences


Disparate DataAny SourceAny Format

Data VirtualizationRight Informationat the Right Time

Business SolutionsAccess Information-as-a-Service

Research

Scientific Knowledge BaseCompetitive Intelligence Portal

Drug Development

Clinical Data CollectionCompliance Reporting

Commercial

Sales & Marketing AutomationSingle View of Physician

Scientific Clinical

Intellectual Property

BusinessData

Pharma Relationship Map

Research, Trial

Bioinformatics,Clinical

Internal

External

Patent Data Financial Data

Patent Issues Competitive Info

Drug

CEME

Company

Disease

Biosample and Research Intelligence Example


Access heterogeneous data sources

Create logical abstraction layer

Deliver canonical business views

Data services – access anywhere

Agile data integration and quality

Minimize replication (cost, time)

Enterprise to cloud scalable, secure

TrialCRO

Samples

Clients

Consent

Data Virtualization Layer

Bu

sin

ess N

eed

(Canonic

al Vie

ws)

Real W

orld

(Sourc

e D

ata

Vie

ws)

Clinical Trial Data

CTMS

Biorepository Data

SMS

Researcher Data

Laboratory Data

SDMS

LIMS

Biobank Data

SMS

Hospital / Clinic Data

SDMS

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Indiana CTSI Integrated Biobank

Visual Analytics

William K. Barnett


Indiana CTSI and

Regenstrief Institute


www.indianactsi.org

The Indiana CTSI:To transform the participating institutions to create an environment that facilitates the

conduct of clinical and translational science research.

• One of 62 national translational institutes, funded by the NIH

• A Statewide collaboration among Indiana U., Purdue, and Notre Dame to

advance translational research

• Partnerships with healthcare providers to improve care

• Partnerships with industry to speed discovery to market


www.indianactsi.org

Goals of the Indiana CTSI

• Accelerate translational research

• Train a new cadre of translational researchers

• Foster robust community engagement

• Build facile research resources and technologies

• Leverage the Indiana and national partnerships


www.indianactsi.org

Informatics Programs

• Community portals such as IndianaCTSI.org

• Research systems such as our clinical research and trials

management systems

• Data collection and management systems, including biobanks

and registries

• Systems Integration – instruments, research process

• Data integration and analytics


www.indianactsi.org

Biobank Integration and Analytics

• Biospecimens and their affiliated

demographic, phenotypic, and

genotypic data are a critical research

assets

• We collect biospecimen data through

the Indiana Biobank, research biobanks

at IU, and biospecimen registries at IU

and elsewhere.

• As we move to precision medicine,

comparing and integrating these data

will be a key element in improving care.


www.indianactsi.org

Towards Integrated Visual Analytics

• Many biorepositories on different platforms.

• Goal to eliminate redundancies and identify opportunities

for research.

• BioStorage already provides redundant specimen storage

for many of our biorepositories.

• This ISIDOR® project is a proof of concept to visualize

aggregate specimen data.


www.indianactsi.org

informatics platform integrates research and sample data

Enhance

Sample & Data Optimization

Accelerate

Medical Research

Improve

Sample & Data Sharing

• Project Vision: To create an environment where sample assets and data sharing

across the enterprise enhances opportunities to support and accelerate research


www.indianactsi.org

Use Case 1: Visualizing Tissue Availability

for Research

• Background: IU Simon Cancer Center (IUSCC) Tissue Procurement

and Distribution Facility has the responsibility to collect and distribute

biospecimens to support cancer research. As such, the IUSCC would

like to make biospecimen data available to as widely as possible to

the IU research community.

• Problem solved: Enabling researchers to visualize the availability of

specific subsets of samples and publicizing this within a shared

database enables improved sample asset sharing across the

research enterprise.


www.indianactsi.org

Use Case: Visualizing Tissue Availability for Research


www.indianactsi.org

Use Case 2: Enabling Research Study

Feasibility

• Background: An investigator with a research idea must first determine

if the study is feasible based upon availability of viable samples which

meet the study requirements.

• Problem solved: The researcher’s ability to isolate data about the

availability of different types of tissue and matching bio-

macromolecules is crucial for planning the types of experiments that

can be performed.


www.indianactsi.org

Use Case: Enabling Research Study Feasibility


www.indianactsi.org

Use Case 3: Tracking Multi-Center Study

Collections

• Background: In a multi-center clinical study, research labs from

multiple research or clinical institutions will be accruing participants

and collecting specimens to meet research goals. One challenge is

the need to accurately track the number and source of samples from

each participating center.

• Problem solved: The development of a centralized dashboard for

querying and reporting sample collections within a multi-center study

will enable researchers to identify if the overall study collection goals

are being met, and whether each study center is contributing as

planned.


www.indianactsi.org

Use Case: Tracking Multi-Center Study Collections


www.indianactsi.org

Use Case 4: Disease Sample Collections

• Background: Researchers often need access to biological research

samples and data that may not exist within their internal biobanks or

databases that are managed by research foundations, government

agencies and epidemiological biobanks that relate to specific medical

conditions, diseases and populations.

• Problem solved: A visual dashboard for querying and reporting the

demographics of samples collected within a research foundation,

demographic and phenotypic data on these normal volunteer samples

support research programs.


www.indianactsi.org

Use Case: Disease Sample Collections


www.indianactsi.org

Business Benefits

• Optimized operations with better data management tools

• Acceleration of research by rapid, user-defined querying

• Increase grant competitiveness and sponsor partnerships


www.indianactsi.org

Roadmap

The Indiana CTSI sees data integration as a key component

to the next wave of research that will move discoveries to

healthcare improvements, particularly in areas such as:

– Precision Medicine

– Epidemiology and Population Health

– Heath Services Research

– Quality Studies


www.indianactsi.org

Reflections

A journey of many steps and many partners

Careful planning leads to responsive and useful analytics

The tools are only as good as the data

Speakers

Lori Ball

COO & President, Integrated Solutions

William Barnett


Suresh Chandrasekaran

Senior Vice President

Ravi Shankar

CMO

Panel

Next Steps

To learn more about ISIDOR Technology solutions, visit http://www.biostorage.com/isidor/

To learn about agile data solutions for life science organizations, download http://bit.ly/1QKCdyZ

To learn more about Indiana CTSI and their translational research, visit http://www.indianactsi.org

http://www.biostorage.com/isidor/

http://bit.ly/1QKCdyZ

http://www.indianactsi.org/

© Copyright Denodo Technologies. All rights reservedUnless otherwise specified, no part of this PDF file may be reproduced or utilized in any for or by any means, electronic or mechanical, including photocopying and microfilm, without prior the written authorization from Denodo Technologies.

Thanks!

Lori Ball William Barnett Suresh Chandrasekaran

[email protected] [email protected] [email protected]

www.biostorage.com www.indianactsi.org www.denodo.com

http://www.biostorage.com/

http://www.indianactsi.org/

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