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toxicolo gy

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toxicology

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4

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Routes of absorption

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Dermal route Gastrointestinal tract route

Respiratory route

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• 0ther routes of absorption

IntraperitonialIntramuscularIntravenousSubcutaneousConjunctive instillationRectal

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iv > inhale > ip > im > ingest > topical

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skin surface area 1.5-2 m2Distance from blood vessels:100 micronsSkin thickness 3mm

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Brick and mortar model of stratum corneum

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Penetration rate In various parts of body

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Skin areaTemperatureNature of exposure(vapour deposition

compared to direct liquid contact, formulation)

Thickness of horny layerDamage to skinCo-exposure of other

solvants(acetonitrile,dimethylsulfoxide)

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Concentration of toxicantExposure duration

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AmmoniaCalcium oxide ChlorinePhosphorusHclH2so4Boric acidDetergentsChromium

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CobaltAbietic acid