“PREVENTION OF ACUTE GI DISTURBANCES WITH A FUNCTIONAL FOOD FORMULATION DESIGNED TO SUPPORT

AND MAINTAIN INTESTINAL BARRIER FUNCTION DURING SPORTS PERFORMANCE”

N. Sponsiello –S.Belgeri -R .Conte – D. Carandini – M. Salamone

7 Settembre 2014- Sana Pad. 35 Sala Benessere ore 12:00

To train your gut is possibleProf. Nicola Sponsiello Dott. Stefano BelgeriDott. Roberto Conte Dott. Daniele CarandiniDott. Maurizio Salamone

Gastrointestinal sympoms reported during/after prolonged and intense physical exercise

Upper GI tract Lower GI Tract

Delaied gastric emptying(GE) Abdominal pain

Gastroesofageal reflux nGER Bloating/borborigms/gas

Gastric burns Diarrhea

Dizzines/Nausea/Vomiting Blood in faecis

Eruttations Acute pain at right/left side

GI PROBLEMS IN THE LAST 2 YEARS COMPETITIONS AND DROPOUTS FOR GI REASONSGrafico 3

How many competitions with GI disturbances or dropouts for GI problems in the last 2 years

HEALTH

SPORTRESULTS

Is it possible to train our gut as well as we train our muscles?

Intestinal ecosystem

Nutrientsabsorption and digestion

Intollerances and allegies

Inflammation

Digestive tract

Strenght

Resistence

Flexibility

Bones and muscles

Stress management

Concentration

Motivation

Psyche

Primary objectiveVerify if a mix of nutrients formulated to mantain and rebalance gastrointestinal barrier

can reduce gastrointestinal side effects induced by physical stress due to intense and prolonged exercise in healthy adults

- Quality of life, energy and resistance;- Frequency of gastrointestinal tract problems and aspecific symptoms

Secondary objectives

% dropouts due to digestive tract disorders in treatment group compared to controls

Objectives of the observational study:

50 enrolled athlets among 705 athlets at the start (7%)

47 athlets trained their gut with Nutrimoniumfor a months before the race

Technic and scientific support from Metagenics medical division

Collaboration and synergy with Sport doctors and race organizzation

Athlets used Nutrimonium 1 months before the race and during the race

Study in number:

FORM 1N=47

FORM 2N=47

FORM 3N=41

Study design

and start up

• Study design• Forms elaboration• Athlets enrolling and first form• Evaluation of possible sinergic activities with other interventions and researches

1 month

of treatme

nt during

training

• Shipment of 1 month treatment (28 sachets) to enrolled athlets• 2 form

Treatment

during the race

• Delivery of the race-treatment with the official race bag• 3 form after the race

Operational phases of the study:

Analisi, valutazione e pubblicazione dei dati ottenuti.

The race starts under heavvy rain:

Metagenics hero:

Results I

• 24 athlets on 47 enrolled reports 1 or more benefits related with the treatment (51 %) during training and during the race

Instestinal and general benefits

• 11 athlets on 47 enrolled reported more energy and physical resistance during the month of training (23,4%)

More energy and resistance

• 1 athlet on 43 that completed the 3rd form dropout for gastrointestinal problems (6 /140 in the control group)

Dropouts for GI disorders

NORMAL GUT HABITS

YES

NORMAL GUT HABITS

BLOATING AND ABDOMINAL PAIN

YES

BLOATING AND ABDOMINAL PAIN

BENEFITS AND COMPLIANCE

Regular use of formula during the study

Benefits in comparison to previous month

Side effects linket do thetreatment

Treatment interrupted beforeThe competition

YES

COMPETITION

Time 0 After 30GG delta %

NUMBER OF ATHLETS 47 (41M+6F) 47 (41M+6F)

AVERAGE WHEIGHT in Kg 72,1 70,9 -1,2REGULAR GUT TRANSIT 83,3% 96,6% +13,3DIARRHEA 6,3% 8,5% +2,2CONSTIPATION 4,2% 2,1% -2,1FREUENT ABDOMINAL PAIN 8,3% 8,5% +0,2BLOATING 27,1% 14,9% -12,2ESOFAGITIS, GASTRIC PAIN, GER 2,1% 2,1% 0DISPEPSIA OR SLOW DIGESTION 8,3% 6,4% -1,9GI PROBLEMS BEFORE/DURING TRAINING 97,0% 70,2% -26,8BENEFITS VS. MONTH BEFORE 51,1%SIDE EFFECTS 14,9%TREATMENT INTERRUPTED 14,9%GENERAL HEALTH CONDITIONS AND QUALITY OF LIFE (SCALE 1 TO 10) 8,1 8,4 +0,3

Results II

+3,7

Results III

NUTRIMONIUM % CONTROLS % RACE %

RECEIVED FORMS 47 140 705

DROPOUTS 24 51,1% 52 37,1% 322 46,2%

DROPOUTS FOR GI PROBLEMS 1 4,2% 6 11,5% 0,0%

3 TIMES (in %) MORE DROPOUTS FOR GI PROBLEMs IN CONTROL GROUP COMPARED TO Nutrimonium group

“I had diarrhea form Loson hill up to Cogne probably due to a very bad teà that I get at the recovery point!!!Then I get my Nutrimonium in the morning and everything was all right up do Donnaz except for some pain at the knee!! I felt really good.I run 150 km in 3 hours!!!”

“I was very afraid of a digestive block due to the physical stress combined with the night cold of the mountains Furthermore I had to drink iced drinks and water. (for me it is a frequent problem). Ma everithing went quite right..

“At all times during the race my gut worked very well.I was really surprised about that considering my previous experiences

Take home messages…

It’s possible to train our gut order to have it ready to cope with physical stress and prolonged and intense exercise.

We tested with succes efficacy of a nutritional integrative formulation called Nutrimonium in healthy athlets running the hardest ultra-marathon of the world: Tor de Geants;

24 athlets/47 enrolled reported benefits Less dropouts in Nutrimonium group vs. controls