Global medtech R&D expenditure is forecast to grow by

3.3% (CAGR) to $25.3B

Roche will lead the In Vitro Diagnostics market with sales of $9.9B,

commanding an 18% market share

Medtronic to remain No.1 Cardiology company with global sales

of $10.4B and a market share of 21%

Synthes acquisition will vault Johnson & Johnson to the No. 1 position

in the Orthopedics market with an expected market share of 30%

Worldwide medtech sales forecast

to total

$440B

MedTech

Source: EvaluateMedTech World Preview 2018

in 2018

3 21

Top 20 Medtech Companies

Top 15 Categories & Total Market

Medtech R&D Spend 2011/18 (millions)

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

Ear, Nose & Throat (ENT)6.0%

Neurology6.1% In Vitro Diagnostics (IVD)4.4%

Dental4.4%

General & Plastic Surgery5.7%Diabetic Care4.3%

Nephrology2.8%

Healthcare IT3.3%

Cardiology4.3%

Ophthalmics5.7%

Endoscopy5.5%

Diagnostic Imaging3.5%

Drug Delivery 3.6%

Wound Management4.6% Orthopedics3.1%

mddionline.com

Medtech R&D ($m) Company 2011 2018 CAGR 11-18

1 Johnson & Johnson 1,751 2,072 +2% 2 Siemens 1,674 1,987 +2% 3 Medtronic 1,490 1,814 +3% 4 General Electric 949 1,166 +3% 5 Philips 986 1,101 +2% 6 Roche 1,018 1,047 +0% 7 Boston Scientific 895 997 +2% 8 Abbott Laboratories 851 996 +2% 9 St. Jude Medical 705 873 +3% 10 Covidien 554 798 +5% 11 Danaher 419 615 +6% 12 Stryker 462 589 +4% 13 Becton Dickinson 476 544 +2% 14 Terumo 308 458 +6% 15 Edwards Lifesciences 246 428 +8% 16 Essilor International 211 343 +7% 17 Olympus 320 338 +1% 18 B. Braun Melsungen 250 327 +4% 19 Intuitive Surgical 122 317 +15% 20 Zimmer 239 292 +3%