Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd

Autogenous Vaccines in Principle and PracticeAn opportunity in Asia?

Tim Wallis BSc PhD

Ridgeway Biologicals Ltd, Units 1-3 Old Station Business Park, Compton, Berkshire, U.K.

www.ridgewaybiologicals.co.uk

Why do we need autogenous vaccines?

• Bacteria are continuously evolving– emergence of new variants– resulting in conventional vaccine breakdowns

• Changes in farming practices create newly susceptible populations– emergence of “new pathogens”– new fully licensed products take 5yrs to develop

• Fully licenced vaccines – not always available

• Autogenous vaccines can provide a rapid solution– reduce dependence on antibiotics

Autogenous (emergency) vaccines- definitions

• Derived from pathogens isolated from the target farm/production system

• Inactivated vaccines• Used where fully licensed products have proved ineffective or

are unavailable• Have to be manufactured in premises licenced by regulatory

authorities– Using QA assured manufacturing/QC processes

• Used under the supervision of veterinary surgeon

High specification manufacturing facilityResourced with committed team

Strong Customer focusHighly skilled workforceResponsive vaccine manufacturing processesAdaptable production schedulingRobust Quality Assurance

“near cGMP”Strong R&D ethos

Pathogen submission/strain analysis

Isolation of pathogens pre- and post-saleGood liaison: Veterinary surgeon Expert local diagnostic laboratory

BacteriologyMolecular biologyCell cultureVirology

Vaccine manufacturer

Autogenous vaccine products: poultry

• Pasteurella sp• Riemerella anatipestifer• Erysipelothrix rhusiopathiae • Salmonella sp • Mycoplasma gallisepticum• Mycoplasma synoviae• Gallibacterium anatis• Ornithobacter rhinotrachealis• E.coli• Avian Influenza• Newcastle disease

LayersBroiler breedersTurkeysDucksGeeseGame birds

Multivalent vaccines can simplify vaccination programs

Vaccines adjuvated with oil or alhydrogel

Autogenous Vaccine products: Pigs

Actinobacillus pleuropnumoniaHaemophilus parasuisSalmonella speciesStreptococcus suisBrachyspira hyodysenteriaeMycoplasma hyosynoviae/hyorhinis/hyopneumoniaePRRSSwine flu

Autogenous vaccine products: aquatic species

Vibrio speciesTenacibaculum maritimus Flavobacterium psychrophilumYersinia ruckeriPseudomonas anguillosepticumPhotobacterium damseliaeAeromonas salmonicidaStreptococcus speciesNodavirusViral Haemorrhagic Septicaemia

Atlantic Cod SalmonTroutSea BassTilapiaOlive flounderCleaner fishDisplay fish

Understanding route to Asian market

Better understand: Veterinary medicines regulations State Veterinary health service provisionIdentify lead: Veterinary Diagnostic LaboratoriesUnderstand disease issues of main: Poultry broiler breeders Table egg producers Commercial duck producers Pig integrators Aquaculture sectorsTarget market prioritiesDevelop the supply chain Logistically possible?

Autogenous vaccines: Summary (1)

• Fully licenced vaccines are not always available for the diseases of minor species

• Microbial pathogens are continuously evolving leading to the emergence of new strains

• Conventional vaccines are not always able to provide cross-protection against all variants of pathogens

• Autogenous vaccines are derived from farm-specific pathogens and can control new outbreak strains

• High quality products manufactured in regulated premises with defined and controlled processes

Autogenous vaccines: Summary (2)

• Formulated to the specific requirements of each client – planning is required as they are bespoke products

• Rapid, adaptable response to new emerging infections

• Valuable resource for controlling infectious disease– can help reduce dependence on antibiotics

• Not an alternative to good management, good nutrition and other prophylactic measures

Thanks for listening