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1976 Swine Flu Vaccine Debacle and U.S. Vaccine Strategy for Avian Flu: History Repeating Itself?
Jacqueline Doamekpor
Advisor: Jonathon Erlen, Ph.D.
Presentation Outline
I. Research Objectives and MethodologyII. General Information about Influenza
Viruses, Vaccines, and Disease Terminology
III. Profile of Swine Flu Vaccine Program of 1976
IV. Mistakes of Swine Flu Program/Lessons learned
V. Profile of Avian Influenza Outbreak/U.S. Vaccine Strategy for Avian Influenza
VI. Potential Obstacles in my Project
Research Project Objectives
1. Thoroughly research background information on President Ford’s swine flu vaccine program and current Avian flu outbreak/U.S. vaccine strategy for avian flu
2. Identify reasons why the swine flu vaccination program failed
3. Compare and contrast the vaccine strategies for 1976 swine flu and avian flu to see whether the poor decision-making elements which led to the failure of 1976 vaccine program are also present in the U.S. government’s (CDC and HHS) mobilization of current vaccination strategies against avian flu
Research Methodology
Objective 1 and 2: Obtain thorough background info by using journal articles (etc. JAMA, WHO, CDC), books, newspapers, videos, primary sources
Objective 3: Research/Develop criteria for evaluating effectiveness of vaccine programs Evaluate swine flu vaccine program and
US vaccine program
Why Should I Care?
1. Understanding the failure of the swine flu vaccine program and applying the lessons learned from the situation to management of the avian flu threat are critical if the U.S. wants to have an effective avian flu vaccination strategy
2. A form of the H5N1 virus which is transmissible from human to human could be devastating to the U.S. if there is no effective vaccine strategy in place (CDC)
3. If the U.S. government wants to protect its citizens against avian flu without wasting millions of dollars, it must avoid committing the errors associated with the swine flu vaccine strategy
General Info about Influenza Viruses: Types There are three types of influenza viruses: A, B, and C:
Type A = main focus of research Widely considered the most dangerous type because of its ability to infect a
wide variety of mammals and birds Birds are only infected with type A
Causes the most cases of the flu in humans and is the type most likely to become epidemic
Type B Infects humans and birds Produces a milder disease than type A, but can also cause epidemics
Type C Infects only humans Produces either a very mild illness indistinguishable from a common cold or
no symptoms at all Does not cause epidemics
Influenza A Viruses: Subtypes/Strains
Subtypes of influenza type A viruses (e.g. swine flu and avian flu) are named according to two specific surface proteins: hemagglutinin (HA) and neuraminidase (NA)
Hemagglutinin allows the virus to “stick” to a cell and initiate infection
Neuraminidase helps newly constructed viruses exit host cell
Subtypes could also named by geographical region
Avian Flu Virus(www.rkm.com.au/.../ VIRUS-FLU-structure-L-500.jpg)
Influenza A Viruses: Subtypes/Strains (cont.)
Currently, 16 known variants of HA protein and 9 known variants of NA protein
Swine flu virus = H1N1 New Jersey strain Variant 1 HA and variant 1 NA
Avian flu virus = H5N1 Variant 5 HA and variant 1 NA
Disease Terminology
Endemic = “native to,” infection that can be maintained in a certain population without external input
Epidemic = occurrence of disease within a specific geographical area or population that is in excess of what is normally expected (example with chicken pox)
Pandemic = an epidemic which spreads worldwide, or over a large region (e.g. bubonic plague, Spanish flu)
How Vaccines Prevent Disease Vaccines contain weakened or killed viruses or bacteria specific
to the disease that is to be prevented Sometimes live pathogens for stronger immune response
Vaccines help your body recognize and fight these germs and protect you each time you come in contact with someone who is sick with any of these diseases
First: Vaccine usually given by a shot Next: Over the next few weeks, the body makes antibodies and
memory cells against the weakened or dead pathogens in the vaccine
Then: The antibodies can fight the real pathogens if the person is exposed to the germs and they invade the body
The antibodies will help destroy the germs and the person will not become ill
Finally: Antibodies and memory cells stay on guard in the body for years after vaccination
Antivirals
Four antiviral medications have been approved by the U.S. Food and Drug Administration (FDA) for treatment of influenza:
Amantadine Rimantadine Zanamavir Oseltamivir (commercially known as Tamiflu) All must be prescribed by doctor and taken for 3-5 consecutive days Four antiviral medications are effective only against influenza viruses
Benefits of antivirals Antivirals can reduce influenza symptoms and may shorten duration of illness by 1 or 2 days Makes people less contagious Antivirals should be taken within 2 days after symptoms emerge to be effective
Setbacks Influenza strains can become resistant to these drugs, and drugs may not always be effective They will not help symptoms associated with the common cold or many other influenza-like illnesses caused
by viruses that circulate in the winter Antiviral use during flu epidemic
Public health practice is to combine the use of influenza vaccine and antiviral medications E.g. If outbreak at nursing home, residents and staff are vaccinated and also given antiviral
medications to prevent influenza until the vaccine takes effect (about 2 weeks) This practice continues as long as influenza is occurring in that setting
Potential for an Influenza Pandemic Flu viruses species-specific = each strain only infects a certain species All influenza viruses have the potential to change, or mutate
Influenza virus strain which normally infects specific non-human species could mutate into form which spreads easily amongst humans
Flu viruses lack a “proofreading” mechanism, so small errors that occur when the virus replicates are not corrected
As a result, their genetic composition constantly changes in small ways. Updated influenza vaccine needed each year
Little or no immune protection against them in the human population. If an avian virus were able to infect people and gain the ability to spread
easily from person to person, an “influenza pandemic” could begin An influenza pandemic is a global outbreak of influenza and occurs
when a new influenza virus emerges, spreads, and causes disease worldwide
Past influenza pandemics have led to high levels of illness, death, social disruption and economic loss.
Past Influenza Pandemics
There were three influenza pandemics in the 20th century, and all of them spread worldwide within 1 year of being detected:
1. Spanish flu (1918-19), most severe Killed 20-100 million worldwide ~675,000 died in US H1N1
2. Asian flu (1957-58) Killed 1-4 million people worldwide including 70,000 in
US H2N2
3. Hong Kong flu (1967-68) Killed 750,000 to 2 million people worldwide including
34,000 in US H3N2
Spotlight on Spanish Flu Pandemic (1918-19) So devastating that it is commonly used as a basis of
comparison for all modern pandemics According to HHS, approximately 20-40% of the
worldwide population became infected with the Spanish influenza virus 20-100 million people died 500,000-675,000 died in US
Global mortality rate = 2.5-5% of human population 25 million killed in its first 25 weeks, while AIDS killed 25
million in its first 25 years Caused by an H1N1 influenza A RNA virus which was
endemic to pigs Through mutation gained ability to infect people
Spanish flu Sanatorium in U.S. during 1918 Pandemic
Spotlight on Spanish Flu Pandemic (1918-19) cont. True origin unknown
Did not originate in Spain/Name from less censored Spanish media during WWI
Spanish flu strain was unusual because most victims were previously young and healthy victims
Common influenzas kill mostly newborns and the old and infirm Upon infection, the Spanish flu virus killed victims within a short
time period: victims who felt well in the morning would become sick by noon
and dead by nightfall, pneumonia By April 1919, pandemic had mysteriously ceased
No vaccine created Overarching fear of similar pandemic recurring during swine flu
and avian flu outbreaks
How the Swine Influenza Panic of 1976 Began Feb. 4, 1976, Army recruit died at Fort Dix, N.J.
(recruit training camp) during an epidemic of respiratory infections following the holidays
Throat washings were taken from 19 ill soldiers Majority tested positive for that winter's dominant
strain of the influenza virus: A/Victoria But four samples had inconclusive test results, and
New Jersey public health officials sent them to the CDC to be identified
CDC Report and Its Significance On Feb. 12, 1976, the CDC delivered a chilling report:
The four samples from Fort Dix (which included one from the dead soldier) contained influenza A H1N1 virus which was endemic to pigs a.k.a swine flu
Further studies of Fort Dix's soldiers showed that about 500 had been infected with swine flu
Officials also noted that the recruits were infected via human-to-human transmission
Could easily lead to pandemic Spanish flu pandemic of 1918 was also caused by influenza A
H1N1 virus endemic to pigs Spanish flu virus (H1N1) and swine flu (H1N1) in four samples
are not identical but antigenically related to each other Fear of 1918 pandemic recurring Within days of identifying the swine flu strain, federal health
officials met at the CDC to discuss what to do
Ford’s National Influenza Immunization Program (NIIP) On March 24, 1976, the Ford
Administration officially launched the National Influenza Immunization Program (NIIP), which was one of the most aggressive and universal vaccination programs in recent U.S. history
Objective: “to inoculate every man, woman and child in the United States against swine flu”
$135 million appropriation from Congress
Early production of swine flu vaccine was possible because there was sufficient time between the period when the initial isolates were discovered and the beginning of the upcoming flu season
On October 1, 1976, the first vaccines were given
Obstacles Facing NIIP
Pharmaceutical companies undertook crash programs to make enough of the vaccine by the start of flu season in October
But the Fort Dix bug grew poorly in chicken eggs (the growth medium for the influenza virus used in vaccine) This meant that yields ~50% of what was planned In addition, one company used the wrong virus and
had to start over
Obstacles Facing NIIP (cont.)
Within the first two weeks of the program’s initiation, three elderly people who had been vaccinated by the same clinic in Pittsburgh died
On October 12, Pittsburgh health officials closed down the immunization program in Allegheny County pending an investigation of the recent deaths
By the end of October, a total of 41 recently vaccinated people had died across US
54 cases of Guillain-Barré syndrome (GBS) were reported in 10 states among people who had received the swine flu vaccine GBS is a serious neurological disease which is
characterized by paralysis, loss of muscle control, and muscle weakness
Suspension of NIIP
December 1976, the GBS cases led to a suspension of NIIP Never restarted
In its entirety, Ford’s program only lasted for two and a half months
After NIIP ended, the federal government was bombarded by lawsuits from people requesting compensation because they contracted Guillain-Barré syndrome (GBS) after being vaccinated
One final blow: a pandemic of swine flu never materialized
Some Mistakes from NIIP
1. Failure to deal with uncertainties in a tentative manner Idea that a swine flu epidemic was unlikely never received a full airing or a fair
hearing, even though numerous experts held this view Notion that an epidemic was likely enough to warrant nation-wide vaccination grew
from dominant opinion to unquestioned gospel2. Vaccine given too early
A few experts suggested the vaccine be made and stockpiled but used only if there was more evidence of an epidemic
Considered but rejected early on Argument against stockpiling was that the influenza vaccine had few, if any,
serious side effects, and that it would be far easier (and more defensible) to get it into people's bodies before people started dying
3. Effective communication from scientifically qualified persons lacking Prevailing perception that the program was motivated by politics rather than
science
Contributing Factors Sensationalism in media (e.g. 1918 photographs during news broadcasts)
Mistakes of NIIP (cont.)
Still researching!
What is Avian Influenza?
It is an infectious disease that is endemic in birds–rarely afflicts humans but this has occurred recently
highly contagious among birds, and can be fatal to them Caused by an Influenza A H5N1 virus Prior H5N1 strains have existed, but they were significantly different
from the current H5N1 strain on a genetic level Current H5N1 strain is a fast-mutating, highly pathogenic avian
influenza virus (HPAI) found in multiple bird species
The H5N1 strain of the influenza virus, gold globulesCourtesy of BBC News
Avian Flu Timeline
MAY 1997, HONG KONG: H5N1 Bird flu virus is isolated for first time from human patient
Entire chicken population slaughtered in Hong Kong 2003, ASIA: Bird flu virus continues to spread in humans and birds JAN 2004: WHO confirms H5N1 infection in 11 people
The virus has wreaked havoc among poultry in Thailand, Vietnam, Japan and South Korea, and has also appeared in a duck farm in China
NOV. 2004: WHO warns that H5N1 bird flu virus might spark a pandemic, and is concerned that "much of the world is unprepared for a pandemic" and needs to enhance preparedness to reduce its potential impact
NOV 2005: The WHO's official count of human cases of H5N1 reaches 122, with 62 deaths, in Vietnam, Thailand, Indonesia, and Cambodia
PRESENT: WHO has confirmed a total of 229 human cases of H5N1 flu; 131 have been fatal
Avian Influenza in Birds
Avian influenza viruses occur naturally among birds
Wild birds worldwide carry the viruses in their intestines, but usually do not get sick from them
Avian influenza is very contagious among birds and can make some domesticated birds (chickens, ducks, and turkeys) very sick and kill them
Infected birds shed influenza virus in their saliva, nasal secretions, and feces
Susceptible birds become infected when they have contact with contaminated secretions, excretions or surfaces
Domesticated birds may become infected with avian influenza virus through direct contact with infected waterfowl or other infected poultry, or through contact with surfaces or materials that have been contaminated with the virus
Avian Influenza in Birds (cont.)
15 different subtypes of influenza virus circulating in bird populations
Infection with avian influenza viruses in domestic poultry causes two main forms of disease: Low pathogenic form = may go undetected and
usually causes only mild symptoms (e.g. ruffled feathers and a drop in egg production)
Highly pathogenic form = spreads more rapidly through flocks of poultry
May cause disease that affects multiple internal organs and has a mortality rate that can reach 90-100% within 48 hours
Avian Influenza in Humans
H5N1 virus does not usually infect people, but infections with these viruses have occurred in humans
All of human cases during current outbreak have resulted from people having direct or contact with H5N1-infected poultry (slaughtering or de-feathering infected birds) or H5N1-contaminated surfaces
In all human cases of current outbreak, avian influenza has been spread from birds to humans
There have no incidences of human-to-human transmission
Experts say avian flu is not a food-borne virus, so eating poultry is safe
Global Impact of Avian Flu
Countries affected by human cases: Azerbaijan, Cambodia, China, Djibouti, Egypt, Indonesia, Iraq, Thailand, Turkey, and Vietnam
As of July 4, 2006: 229 cases total, 131 of these fatal
Tens of millions of birds have died of H5N1 influenza
Collectively, hundreds of millions of birds have been slaughtered and disposed of to limit the spread of H5N1 in the following countries:
Korea, Vietnam, Japan, Thailand, Cambodia, Laos, Indonesia, China, Malaysia, Russia, Kazakhstan, Mongolia, Turkey, Romania, Croatia, Ukraine, Cyprus, Iraq, Nigeria, Egypt, India, France, Niger, Bosnia, Azerbaijan, Albania, Cameroon, Myanmar, Afghanistan, Israel, Pakistan, Jordan, Burkina Faso, Germany, Sudan, Ivory Coast, Djibouti. Austria, Bulgaria, Czech Republic, Denmark, Greece, Hungary, Iran, Italy, Kuwait, Poland, Serbia and Montenegro, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Kingdom
Millions of birds have also been vaccinated
HHS map of Avian Flu Outbreaks in Birds and Humans as of 6/6/06
WHO Pandemic Phase Chart
WHO Statistics on Avian Flu Victims Age of victims
Half of the cases occurred in people under the age of 20 years 90% of cases occurred in people under the age of 40 years.
Overall Mortality Rate = 56% Highest mortality rates in persons aged 10-39 years Case-fatality profile by age group differs from that seen in
seasonal influenza, where mortality is highest in the elderly. The overall case-fatality rate was highest in 2004 (73%),
followed by 63% to date in 2006, and 43% in 2005. Seasonal Effects
Cases have occurred all year round Incidence of human cases peaked during the winter and spring
in the northern hemisphere
Symptoms of Avian Flu (WHO)
Incubation period = ~7 days Symptoms range from typical flu-like symptoms to life-
threatening symptoms Minor Symptoms:
Fever higher than 100.4°C Cough Lower respiratory tract infections Bleeding from nose and gums Diarrhea, vomiting Abdominal and chest pain
Possibly Fatal Symptoms: Pneumonia (often fatal) Multi-organ failure
How would an Avian Flu pandemic materialize? Current H5N1 strain is responsible for bird-to-bird and bird-to-
human transmission of avian flu NO reported cases of human-to-human transmission
In order for pandemic to occur, H5N1 strain must mutate into strain which is transmitted readily amongst humans
Very good chance that this will happen, but not definite Every time bird or human is infected with avian flu, the virus
mutates Most mutations will not significantly affect virus’ capability to
infect However, a small percentage of mutations could alter the avian
flu virus enough so that it can be transmitted amongst humans
"Everything you say in advance of a pandemic is alarmist; anythingyou do after it starts is inadequate." - US HHS Secretary Michael O. Leavitt
How would a pandemic of avian flu be controlled? Same way flu epidemic would be controlled:
combination of antivirals and vaccines Current avian flu virus that has caused human
illness and death in Asia is resistant to amantadine and rimantadine
Experts believe oseltamavir (Tamiflu) and zanamavir would probably work (additional studies still need to be done to demonstrate their effectiveness)
The mass administration of antiviral drugs to the general population is not recommended by WHO, as this could accelerate the development of drug-resistant strains
Avian Flu Vaccine Production
Scientists can only start producing a vaccine when an avian flu virus strain emerges, which causes human-to-human transmission of avian flu Such strain has not emerged yet Currently, there is only the H5N1 strain which
causes bird-to-human transmission Once an avian flu strain emerges and causes
human-to-human transmission vaccine can be made to directly combat this strain: at least 6 mts
Scientists are testing a recently created vaccine from the circulating H5N1 strain Only partial protection during pandemic
U.S. Vaccine Strategy
Need to research!
Obstacles in Research
Hard time finding primary sources in researching swine flu
Defining clear cut criteria to use as means of comparison between two vaccine programs
Bibliography
Luke, Catherine. and Subbarao, Kanta. Vaccines for Pandemic Influenza. Emerging Infectious Diseases (www.cdc.gov/eid). Vol. 12, No. 1. January 2006
Neustadt, Richard and Fineberg, Harvey. The Swine Flu Affair: Decision-Making on a Slippery Disease. U.S. Dept. of Health, Education, and Welfare, 1978.
Osborn, June. History, Science, and Politics: Influenza in America: 1918-1976. Prodist: New York, 1977.
Pandemics and Pandemic Threats Since 1900. http://www.pandemicflu.gov/general/historicaloverview.html
Sencer, David. and Millar, J. Donald. Reflections on the 1976 Swine flu Vaccination Program. Emerging Infectious Diseases. Vol. 12. No. 1, January 2006.
Vaccine Distribution. U.S. Dept. of Health and Human Services. http://www.hhs.gov/pandemicflu/plan/sup6.html#S6-II
World Health Organization, Division of Communicable Disease Control.Avian Influenza. http://www.emro.who.int/pdf/dcdnewsletter7.pdf
World Health Organization. Avian Influenza Fact Sheet. http://www.who.int/mediacentre/factsheets/avian_influenza/en/#history
World Health Organization. Cumulative Number of Confirmed Human Cases as of June 6, 2006.http://www.who.int/csr/disease/avian_influenza/country/cases_table_2006_06_6/en/index.html
World Health Organization. Ten Things You Need to Know About Pandemic Influenza. http://www.who.int/csr/disease/influenza/pandemic10things/en/index.html
Acknowledgments
I would like to thank the Honors College for giving me this awesome opportunity.
Thanks to all of you for listening and being a great audience.
Good luck to all the Brackenridge Fellows with your research projects!
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