—— Hardware, Software, & now Middleware – The …...Hematology Lab Vancouver General...

Hematology Lab Vancouver General Hospital

May 12, 2015jim yakimec RT, BSc (MLS)

—— Hardware, Software, & now Middleware –

The experience at Vancouver General Hospital ——

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• Discuss autoverification• Discuss middleware• Reason for this project• Our experience / timeline

• Sysmex XE2100, XN, Coagulation, Auto Immune

Outline

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• Academic Health Science Centre• Fully affiliated with the University of BC• BCIT Med. Lab. Science training site• Programmes in

– Neurosurgery, Orthopedic, General– Solid organ transplant centre– Leukemia & Bone marrow transplant centre – Trauma centre

About Us……..

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Daily Workload:• Mon-Fri: approximately 1100 – 1200 CBCs

• Day shift: ~800• Evening shift: 200 • Night shift: 120

Manual slide review rate daily: ~ 140 slides

Approximately 20 CSF/ body fluid cell counts & differentials

~450 INR / APTT

Hematology

Laboratory

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autoverification

Labs are continually challenged to decrease turnaround time while handling higher volumes and maintaining high data quality despite labour shortages and tightening budgets.

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Benefits of Middleware vs

LIS for Auto-

Verification Rules

• Lab control of process• Lab has understanding of what exactly needs to be done• Complete audit trail available• May be programmed within lab by lab people• MW able to be have much more complex rules therefore higher rate of AV

June 2011 Feature StoryMinting QC and efficiency gains with middlewareAnne Paxton,

Seattle

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Our Goals• Gain efficiencies in workflow by

– Integration of CBC analyzer, diff keyboard, CellaVision into one ‘IT’ platform• More powerful rules written• ‘one stop shopping’ for Inquiry of previous results

– Continually critiquing process / reduce repetitive tasks• Decrease number of reporting errors• Minimize misinterpretation of results handling• Further improve TAT of CBC results• Adopt a paperless system

LEAN attributes

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Before / After Implementation

Turnaround Time Report

Test code: HB

VGH Inpatient Locations –

All Priorities VGH ED Locations

Jan 2011 (Before) Apr 2011 (After) Sept 2011 (ED locations)

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Research: • Although Sysmex WAM appeared to be the most logical, due to costs, alternatives

had to be investigated.

• CAP today magazine annual March issues have a feature on Middleware• Chemistry VGH had middleware, our LIS analyst noted the deficiencies, that ‘brand’

not pursued• Sent off an email to Data Innovations to start the ball rolling• visited AACC congress• Customer interviews

• Initial webinar:– overview of the product & functionalities

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• Self built and went ‘live’ in 6 mos• LIS: Sunquest• A lot of set up was self-taught• Very easy to tweak rules• Always had very good support • Easy Maintenance• Overall very favorable opinion

DI Customer Call: Mid America Clinical Laboratories:

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• Had DI for 8 yr, all instruments running through it• LIS: ultra GE• Rules: Training course. 1000+ rules• Quality of Training: Quite good• Recent Software Improvements:

Rule values contained in tables

Further improved rule writing• Generally the IT dept can solve all the IT issues• Overall very satisfied

DI Customer Call: Toronto Metro Labs

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• VGH on-site visit install from DI to establish connectivities and 4 short training classes

October 12 -

14, 2010

October 4 –

7, 2010

•Training Classes in Vermont

•Emphasis on rules writing with hands‐on 

practice

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IF: {Test Resulted} {Value List:TestCode}THEN: {Hold all Tests

for Verification} {AND} {Add Test Error Flag Display Name of} {Value List:TestCode} "Verify All Results / Slide Review Required"

‘out of box’

rules holding all tests for verification much customization required

Our approach…

For rules that trigger, a test “ACTION”

will be added, the Test ACTION is held for verification.

Actions required will be in the Test Comment field. To view complete Test comment, place mouse over comment and hover.

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“ACTION”

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Approach with an attempt to:

reduce reporting errors

streamline workflow

increase TAT

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WBC 250.0 –

450.0 rule

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PLT_Clumps? above threshold

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Example: Critical Results Rule

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Critical Results ‘in practice’

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Delta rule “in practice”

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Outpatient / critical result phone criteria

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• The nonLIS

comment

is always added within DI and auto-results as HIDE:– examples of use:

• eg. MCV delta: type in ‘ABO chk’d’• eg.

plt: type in ‘no clot’, etc, etc

Lab-Use only

Comments

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Differential keyboard

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• Cellavision Sunquest interface took ~ 4 mos (2008)

• Cellavision DI interface took ~ 2 wks

• Workarounds resolved

• July 2014, Everett, WA –• Aug 1st, Seattle Children’s Hosp

1.WBC, RBC, PLT commenting

2. Corrected WBC for NRBCs

3. Zero neutrophils

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Added functionalityConfirm Cell Counter icon -autodiff

is released to LIS

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WBC CONFIRM

Hemogram & Auto differential populate CellaVisionallowing for quick autodiff and PLT approximation / verification.

→ WBCCONFIRM

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Comments

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Click on comment

Click on Append

Click on ‘writing tablet’

Comments appear here Append

……………sssss

..

Comments become their own testcode.

Each phrase code is then mapped –not recommend to use free-text.

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If CC-WBC Conc

>0.46 & WBC Collect is Numeric, then add cWBC

(corrected WBC) and set = WBC*100/(100+ %nrbc+%micromegakaryocyte), then calculate absolutes.

Corrects the WBC if NRBC >5%, if micromegakaryocytes

>5%.

Manual Differential

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If MANY, MKD poikilocytes

reported, test comment ‘Refer if not previously reported.’

If sickle cells reported, comment to do sickle test before reporting sickle cells.

Morphology

For English text codes defined in Sunquest. If tech can’t remember what the code is, they display in the Test Comment field.

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If Neutrophils

0.00, they will be reported as 0.00 (Sunquest keyboard did not report 0.00)

Absolute Neutrophil

0.00

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Issues encountered & resolution

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Issues Post “live”• Underwent a “lean” review, with minor tweaks to:

• improve rules• cut down # slides

• May 3, 2011 Sunquest LIS upgrade

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Reflex tests

~20 mos

ago, Combined MORFL & DIFMAllow reflex to occur & cancel

with “not indicated….”

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Auto-Suppression• Any result not reported will

auto-suppresses in LIS

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Bone Marrow Transplant / Oncology blast-flagged diffs

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Life….months after go-live

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Resulting Hematopathologist

Comments within DI middleware:

• Want an editable macro within IM– BioChem, Hem, AP, Micro applications (diagnostic comments,

pathology comments)

• Now standard in v8.13

PERL request

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• New LIS test built • Would be reflex-added by rule within IM

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Edit, add physician contact info….

Edit, by removing it completely ….

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Body Fluid / CSF

with keyboards

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Fluid cytospin

comments

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Keyboard rule ~ Fluid vs

CSF keyboard

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Coagulation

June 2013 -

3 sites

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Continue to learn complexities / possibilities available

Additional elements, eg, test user fields 01 through 15…

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• Significant change in interface to that of Sysmex XE2100• LIS XN-IC XN-IPU & CT90: replaces LASC• Repeat / reflex orders

» Required driver modification to capture [Specimen Action][Specimen Action] element to write rule to reject 1st run and re-run

• scattergrams

Sysmex

XN line –

July 2013

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SPH -

Sysmex

XN 3000with digital slide scannerDI-60

Other differences from the XN9000 interfacing: differential flagging – eg Present vs a number results from the XN9000 analyzers are routed through a central processor

called the XN-IC. This is a WAM unit with its functionality “turned” off. All test codes and flagging are converted to WAM syntax and sent to DI.

• This configuration interacts differently with DI than the XN9000, with direct instrument interfaces.

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IF:

( ( {Specimen Action} = "N" ) {AND} ( {Result Status} {On Any Test} = "P" ) )THEN: {Reject That Test} {AND} {Rerun That Test} {With Comment} "Sample rerun" {With Test Dilution} "1"

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Autoimmune Testing -

Luminex

–

Sept 2013

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Autoimmune Testing -

Luminex

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Take home lessons:• Don’t underestimate the time post “live” for ‘tweaking’ rules in 1st few months

• LIS Department integral in support of non-technical issues

• Recommend a test server

Continually linked to LIS Test environment

Test LIS upgrades (and DI rules) before migrating them to ‘live’ environment

• Is your lab able to execute such a project?

• End product is dependent on:

Perseverance

Capabilities

Imagination of ‘Super-Users’

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