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IMUNE
The International Medical University for Natural Education
1 IMUNE | Review article | August 6, 2020 | All rights reserved.
The Opposite of Sugar (first edition)
Published online: August 6, 2020
written by András Csikai
IMUNE mentor, herbalist, Only Nature Knows co-founder, QQC chief engineer
A brief review at the risks of refined sugar consumption and one natural herbal compound
which counteracts most of these undesired sugar induced side effects.
Taking a closer look at this herbal compound the exact reverse opposite of sugar reveals.
Abstract
First part: Sugar Induced Damages
Refined sugar is a concentrated substance. Excess refined sugar consumption has recognized as a cause and
cofactor of serious health problems all over the world. Refined Sugars cause or contribute to a wide variety of
inflammatory responses, liver diseases, cirrhosis, hepatitis, coronary heart disease and cardiovascular risks,
Type 2 diabetes, cancer, neurodegenerative diseases, depression and mood disorders (newest research) .
Second part: Defines the Sugar problem with TCM, spots the opposing element, names the herbs and the compound
which counteracts the Sugar Induced Damages
With the Traditional Chinese Medicine TCM five elements systematic correspondance I am going to spot the
opposite element of these aggrevated inflammatory symptoms and reveal a variety of herbs (Mahonia
aquifolium, Coptis chinesis, Phellodendron amurense and more) which can counteract the inflammation. I’m
going to show their sources and name the key compound (berberine) which counteracts Refined Sugars.
Third part: A collection of scientic studies proving that the compound counteracts all the Sugar Induced Damages.
With a collection of research articles, meta studies, systematic reviews I ’m going to prove that the compound’s
effects are the exact reverse opposite of Refined Sugar’s effects.
Where the compound (berberine) exerted: Anti-aging, Anti-Inflammatory, Anti-neuroinflammatory, Anti-
cancer, Antibacterial, Antidiabetic, Anti-fibrotic, Hypotensive, Antidepressant, Anti-arrhythmic,
Renoprotective, Neuroprotective and a lot more effects.
IMUNE
The International Medical University for Natural Education
2 IMUNE | Review article | August 6, 2020 | All rights reserved.
The Opposite of Sugar (first edition) Published online: August 6, 2020
written by András Csikai
IMUNE mentor, herbalist, Only Nature Knows co-founder, QQC chief engineer
A brief review at the risks of refined sugar consumption and one natural herbal compound
which counteracts most of these undesired sugar induced side effects.
Taking a closer look at this herbal compound the exact reverse opposite of sugar reveals.
Refined sugar other names: dextrose, sucrose,
table sugar, common sugar, white sugar,
granulated sugar, brown sugar, cane sugar Refined sugar is a concentrated substance. Excess refined
sugar consumption has recognized as a cause and
cofactor of serious health problems all over the world.
Especially in the developed countries where the majority
of the foods contain the sugar. For example the processed
foods including diary products, sweets, soda and SSB
(sugar sweetened beverages), fruit based products and
even many salty, canned foods, pastry, prepared foods,
semi-prepared dishes, cereals, kethup, all kinds of sauces
in the stores contain the added refined sugar as sucrose
or high fructose corn syrup. Because of these
circumstances most people cannot spend a single day in
their lives without eating some of these refined sugars.
Thus people have been exposed to sugar spikes from fetal
age in their mother’s womb. The existing opposite of the
concentrated substance sugar was not even introduced to
people’s system since they cannot get it from the stores
they weren’t educated in a way that they can do more to
their health.
Sugar is the generalized name for a class of chemically-
related sweet-flavored substances, most of which are
used as food. They are carbohydrates, composed of
carbon, hydrogen and oxygen. Simple sugars are
monosaccharides include glucose or dextrose and blood
sugar concentration or blood glucose level is the amount
of glucose (sugar) that is present in the blood. High Blood
Sugar hyperglycemia is a blood sugar that is higher than
130mg/dL after not eating or drinking for 8 hours. After-
meal hyperglycemia is when your Blood Sugar is higher
than 180mg/dL 2 hours after you eat. [1]
HCFS - High Fructose Corn Syrup
HCFS is a semi-synthetic sweetener made from corn
starch. It gives you more hunger after taking it, it has
similar and worse effects than Refined Sugars.
Damages and Diseases by Refined Sugar
The frequenty elevated or ongoing blood sugar can
cause nerve damages, blood vessel damages and organ
damages. [1]
The B cells in the pancreas create insulin to keep blood
glucose in a normal range. Elevated blood sugar levels
caused by sucrose led to the suppression or destruction
of pancreatic cells β-cells in pancreatic islets and this
contributes to the pathophysiology of type 2 diabetes.
[22]
While the blood sugar is elevated it will attack the cells of
your weakest organ. Could be the kidney cells
(pyelonephritis, glomerulonephritis), liver cells (fatty liver
disease and scarring, similar damages like alcohol
consumption), nerve cells, pancreatic cells, cells of the
blood vessels, heart tissue cells, cells of the reproductive
organs, tyroid cells...
Obesity is not a cause it is one of the wide variety of
symptoms Refined Sugars can cause. Focusing on obesity
instead of Sugar Induced Damages confuses people
because it supports a delusion that normal weight or light
weight people do not suffer from sugar damages
therefore they can eat it. Their weight gives them a false
sense that they eat right or their immunity is better and
they can assume that they probably do not suffer from a
fatty liver disease or a liver cirrhosis or prediabetes,
nephritis, diabetes or worse. They allow themselves to eat
the worst quality carbohydrates without thinking about
the health consequences. This false belief is supported by
the uneducated social environment and the media.
Medical doctors do not warn people about these dietary
risks and serious side effects and they avoid to make any
statement about sugar.
Non-Alcoholic Fatty Liver Disease NAFLD Just overeating can cause fatty liver disease. In Hungary
there is a traditional delicacy the goose liver when geese
get fatty liver disease and it is made in a spacial way.
Geese forcefully fed with corn then they held captive in
conditions where they are unable to
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move. Those geese are going to get the fatty liver disease
with 100% certainty their liver enlarges it becomes a large
piece of fat. Because the lack of the geese exercise the
process takes just 16-21 days. Their tasty fatty liver then
cooked (most of that liver is just fat and it melts in the
cookware) and served as a delicious Hungarian food
thereafter.
The liver uses fructose, to make fat. Too much refined
sugar and high-fructose corn syrup causes a fatty buildup
that can lead to liver disease. When fatty buildup happens
in the liver you do not necessarily see fatty buildup or
signs of obesity in other parts of the body. Some studies
have shown that sugar can be as damaging to the liver as
alcohol, even if you’re not overweight. It’s one more
reason to limit foods with added sugars, such as soda,
pastries, and candy. [32]
Dietary sugar consumption, in particular sugar-
sweetened beverages and the monosaccharide fructose,
has been linked to the incidence and severity of non-
alcoholic fatty liver disease (NAFLD) [6]
Non-alcoholic Liver Cirrhosis
With the continuous inflammation the next stage is when
the swollen fatty liver is hardening and scar liver tissue,
cirrhosis appears. Cirrhosis is an abnormal condition in
which healthy liver tissue is replaced by scar tissue. In
cirrhosis, those cells will not function the liver no longer
works well to digest food or protect us from toxins.
Eventually, liver failure will occur when most normal parts
of the liver have been replaced by scar tissue. Then the
only treatment is liver transplant.
Liver recovery difficult even with improved diet, but faster
if sugar intake is low [33]
Non-Alcoholic SteatoHepatitis NASH
Some individuals with non-alcoholic fatty liver
disease (NAFLD) can develop nonalcoholic steato-
hepatitis (NASH), an aggressive form of fatty liver disease,
which is marked by liver inflammation and may progress
to advanced scarring (cirrhosis) and liver failure. This
damage is similar to the damage caused by heavy alcohol
use. [8]
CHD Coronary Heary Disease, cardiovascular risks JAMA article in 2016 officially uncovered „Project 226”
the systematic misrepresentation of sugar consumption’s
dangers by Harvard University scientists who were paid
by the Sugar Research Foundation. [29] The sugar
industry sponsored it’s first CHD research project in 1965
to downplay early warning signals that sucrose
consumption was a risk factor in Coronary Heart Disease.
[29] The Sugar Research Foundation initially offered $500
to Professor Mark Hegsted (Harvard University)[51] and
$1000 to Dr. Robert McGandy (Harvard University)
nutritionists. “half to be paid when you start work on the
project and the remainder when you inform me that the
article has been accepted for publication.” [29] Their
falsified documents served as a basis and reference for
further dietary advices by nutritionists, medical doctors,
healthcare professionals and others worldwide for
decades. The directives of the whole healthcare industry
built on that, pharmaceutical developments, sales from
drugs and drug advices by medical doctors in the last 60
years (cholesterol drugs). They blamed fat and cholesterol
where the real correlating factors for CHD (professedly in
the document) is sugar consumption, blood sugar levels
and raised blood trygliceride levels.
A year after the uncover of Project 226 in 2017 The Lancet
wrote: Relationship between macronutrients and CHD is
„controversial” then they made a cohort study finding:
The high carbohydrate intake results higher risk of total
mortality while fat and total fat consumption were not
associated with Cardiovascular disease mortality,
myocardial infarction. [86]
If you eat a low fat diet studies have shown that the
quality of the carbohydrates you eat has a greater impact
on your health compared to a higher fat diet, means that
the damages from sucrose and HFCS are even more
severe with a low fat diet.
Prediabetes
Regularly eating foods with high sugar content can
overload the body's ability to produce enough insulin. It
can also limit the ability of cells to absorb the sugar. We
call that insulin resistance. Insulin resistance is the cause
of prediabetes. or glucose, they will gradually respond
less and less to insulin. [34] Insulin resistance when the
body does not respond properly to insulin. The pancreatic
B cells aren’t making enough insulin to keep blood glucose
in a normal range, blood glucose abnormally high which
damages cells. This highly increases the risk of serious
health problems, including type 2 diabetes and problems
with your heart, blood vessels, eyes, and kidneys.
Prediabetes diagnosed when Fasting plasma glucose
(FPG) 100-125mg/dL, Glucose tolerance test 140-
199mg/dL, A1C average estimated blood sugar over the
past 3 months 5.7%-6.4%.
Type 2 diabetes
Type 2 diabetes is the aggrevated version of the
prediabetic condition, when the destruction of pancreatic
cells β-cells are at a higher degree. Diagnosed when
Fasting plasma glucose (FPG) 126mg/dL or higher,
Glucose tolerance test 200mg/dL or higher, A1C average
estimated blood sugar over the past 3 months 6.5% or
higher. Raises your risk for heart disease, blindness,
nerve and organ damage, and other serious conditions.
Diabetic neuropathy
Diabetic neuropathy is the most common complication of
diabetes mellitus and up to 90% of patients with type 1
IMUNE
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and type 2 diabetes mellitus have neuropathy. Diabetic
neuropathy remains an unmet clinical problem and is
poorly relieved by conventional analgesics. Neuropathy is
diagnosed when diabetic patients complain of symptoms
and/or show signs of peripheral nerve dysfunction after
the exclusion of other etiologies such as
pain, paraesthesiae and loss of sensation43. It has been
shown that activation of polyol pathway plays a key role.
in the pathogenesis of diabetic neuropathy.Diabetic
neuropathy is a common complication of both type 1 and
type 2 diabetes, which affects over 90% of the diabetic
patients. Although pain is one of the main symptoms of
diabetic neuropathy, its pathophysiological
mechanisms are not yet fully known.
Diabetic nephropathy High blood sugar levels can damage the kidneys attacks it’s filtration system, damages the capillary walls and proteins might appear in the urine. Pyelonephritis, glomerulonephritis, proteinuria
Sugar cravings, dependency and withdrawal Studies shown that the same addictive behavior, anxiety
and withdrawal symptoms occured after excessive sugar
intake as with opioids, morphine or nicotine. „Repeated, excessive intake of sugar created a state in
which an opioid antagonist caused behavioral and
neurochemical signs of opioid withdrawal. The indices of
anxiety and DA/ACh imbalance were qualitatively similar
to withdrawal from morphine or nicotine, suggesting that
the rats had become sugar‐dependent.” [21]
„a diet of intermittent excessive sugar consumption
produces a state with neurochemical and behavioral
similarities to drug dependency” On top of that it causes
behavioral cross-sensitization to a low dose of ampheta-
mine [22]
Sugar increases inflammation
Low to moderate sugar-sweetened beverage
consumption impairs glucose and lipid metabolism and
promotes inflammation in healthy young men: a
randomized controlled trial [10] Raised inflammation
mark-ers in short-term exposed rats to 10% liquid sucrose
solution. [11]
Sugar consumption and elevated triglycerid levels
High blood lipids increase the clotting of blood „Yes.
Added sugars intake does appear to be connected
with increased triglyceride levels.” [49] Dietary glucose
caused increase in trygliceride production, dietary
fructose impaired the triglyceride removal from the blood
both caused elevated triglyceride levels. [105]
From the uncover of Project 226 the 2016 JAMA article
the systematic misrepresentation of sugar damages in the
50’s and 60’s we know that high triglycerides and
elevated blood sugar levels contribute to the
development of coronary heart disease while fat and
cholesterol is not relevant. [29]
Sugar consumption and High Cholesterol
Studies shown that the consumption of added sugar
lowered the HDL (good cholesterol) and increased the
LDL (bad cholesterol) in the blood. [36]
Sugar consumption and High Blood Pressure
Sugar-sweetened beverage consumption, a significant
source of dietary fructose, is associated with higher
serum uric acid levels and blood pressure in adolescents.
[26]
Sugar consumption and tooth decay
„Ancient Romans 'had perfect teeth' thanks to healthy
low-sugar diet” [52] (IMUNE Library) , There is a
decreasing diversity of oral bacteria with more
processed foods introduced to our society compared to
the hunter-gatherers. After the change to agriculture
and especially after the Industrial Revolution the
diversity of oral bacteria has decreased. Streptococcus
mutans creates lactic acid while metabolizing sugar,
lactic acid eats away the mineralized enamel surface of
teeth. Thus more sugar creates more lactic acid cases
more decay. [52]
Sugar and Cancer
Cancer cells consume 200 times more sugar than normal
cells also refined sugar makes cancer cells grow faster.
[37]
Fructose-rich sweeteners like high-fructose corn syrup
(HFCS) are particularly offensive, as cancer cells have
been shown to quickly and easily metabolize them in
order to multiply. [53]
Discovery of Tumor M2-PK Proves Cancer Cells Shift
From Oxygen to Glucose as Source of Energy M2-PK (also
known as PKM2) is an enzyme that is important in tumor
metabolism, discovered in 2010 by Harvard Medical
School. Tumor M2-PK helps cancer cells shift to greater
glycolytic pathways. It is only found in cancer cells and
not in normal healthy cells, making M2-PK an excellent
marker for monitoring excelled growth or tracking
improvement in treatment, depending if levels are high
or low. [53]
„The high fructose corn syrup and other refined sugars
are the major cancer-causing food. The brown sugar is
highly refined sugar with the removed molasses added
back in it for flavor and color. Refined sugars and foods
prepared with them lead to major insulin spikes. The
sugar is the best feed for the growth of cancer cells. So
the oncologists are using diabetes medication to fight
cancer cells. Also the majority of the sugar is made using
genetically modified (GMO) sugar beets in USA. Organic
honey, coconut sugar, or maple sugar may be better
alternatives.” [63]
Sugar and mood disorders Heavy sugar consumption is connected to increased risk
of depression. Poor glycemic control is associated with
more diabetes complications, depression, and worse
quality of life. Data suggest that greater glycemic
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variability may be associated with lower quality of life
and negative moods. Implications include replication of
the study in a larger sample for the assessment of blood
glucose fluctuations as they impact mood and quality of
life. [90]
Sugar and the growth of pathogenic microorganisms
Sugar supports the growth of bad bacteria in the bowel
flora, also the overgrowth of candida which can cause
candidiasis. Sugar supports bad bacteria in the mouth,
throat and all parts of the body. Parasites thrive on sugar
too. Candida infections were observed at increased
frequencies among subjects with high blood sugar
levels and PPDs ≥ 5. [64]
Sugar and premature aging, aging processes
Sugar-induced premature aging in the skin [43] „Excess
added sugar plays a central role in age related diseases
and in the process of aging.” [44] Further evidence exits
that the type and amount of dietary carbohydrate can
significantly affect the health and life span of elderly
people. [91]
Sugar and neurdegenerative diseases High-sucrose diet is a mild model of neurodegeneration in wild-type female rodents, as evidenced by exaggerated glucocorticoid expression, spatial learning deficits, irregularities within the insulin pathway, and increased β-amyloid production and Tau phosphorylation. [88] A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and neurodegenerative diseases such as Alzheimer’s disease (AD). Although the precise mechanism remains unclear, T2D can exacerbate neurodegenerative processes. Brain atrophy, reduced cerebral glucose metabolism, and central nervous system insulin resistance are features of both AD and T2D. [89] Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease. [92]
Regarding to the literatures refined sugars are able to severly decrease the quality of life and health for people. By
definition a poison is „a substance that is capable of causing the illness or death of a living organism when introduced or
absorbed.” Sugar shouldn’t be a poison in a society with a balanced diet, but in this society with these circumstances it
satisfies the definition. To consider Refined Sugars as poisonous substances is well founded.
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Applying the Five Element systematic
correspondence from Traditional Chinese
Medicine (TCM)
Your food is your medicine -> Everything you eat has a
property. If some foods or herbs has an effect there is
something else which has the opposite effect.
In TCM Sugar belongs to the Earth element which acts on
Stomach – Spleen. Overconsumption of Sugar can damage
the spleen and it will lead to more sugar cravings. Your
spleen is responsible for the digestion of your food, water
metabolism, menstrual cycles, and controls the overall
peace and harmony in our bodies. Spleen has a function
that keeps the organs at their place. [87]
TCM damaged Spleen may cause: Weight gain, Fatigue,
Depression, Problems with water metabolism, Sugar
cravings, Irregular menstruation, diarrhea, acne
In female genital area spleen damage, excessive
dampness can cause foul-smelling discharge. In the
intestines, it results in loose stools. Other symptoms of
dampness include: bloating, nausea, vomiting, dizziness,
heaviness feeling in the body or limbs and a thick greasy
tongue coating.
Additionally the excess dampness in the Earth element
creates moist in the lungs (METAL element) may lead to
sinusitis, phlegm-type asthma. This contributes to the
upper respiratory symptoms among children.
Excess Earth requests excess Fire weakening it and the
related organs Heart, Pericardium, Small Intestine, Blood
vessels. Inflammation also appears where the solution is
the Water element with it’s Cold nature controls the Fire
and washes away the dampness in the Earth.
We can separate the problem to at least two stages. 1.
The spleen imbalance created at young ages. 2. Then the
imbalance was sustained, inflammation aggrevated the
conditions since most foods people consume is sugars and
sweeteners , dairy products, processed foods, alcohol,.
Imbalance 2 is vast and it was sustained for decades.
To undo the damages we need to apply Anti-inflammatory
herbs first which corresponds to the Water element and
they are cold in nature.
Then we need to balance the Spleen to counteract the
excessive dampness and the damage dealt to the spleen.
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1. The spleen imbalance, damage at young ages. 2. Then the imbalance was sustained, inflammation aggrevated and
multiplied the conditions since most foods people consume is sugars and sweeteners , dairy products, processed foods, alcohol
To undo the damages we need anti-inflammatory herbs they belong to the water element and cold in nature. need to be such
as Coptis rhizome, Phellodendron amurense, Berberis vulgaris, Mahonia aquifolium, Hydrastis canadensis. Then we can
balance the spleen and repair it’s damages with Ginseng, Codonopsis, Chinese Yam, Poria, Jujuba..
A simplified model of the branches of traumas starting with the Initial spleen damage as the first bifurcation point, besides
a trauma can branch in more than two ways. The Initial damage to the spleen caused by Sugar upsets the control of the
metabolism, all kinds of inflammation appear all over the body, depending on personal weaknesses.
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Cool down the inflammation with cold herbs
TCM Water element cold and cooling means anti-
inflammatory effects oppose the heat and excess heat
which is connected to inflammation. Our bodies kept in
inflammation states with high blood sugar levels which is
known and common in our westernized diet. To conteract
a substance which causes heat we need cold herbs. It will
cool down that inflammatory process with the cold herb’s
anti-inflammatory effects.
Copis Chinesis is the rhizome of the Chinese goldthread.
This is one of the 50 fundamental herbs in TCM and it is
one of it’s coldest herbs. It is an „extremely bitter” herb
Not just clears the excess inflammation but removes the
Earth element’s excess dampness caused by sugar which
responsible for weight gain and a lot other undesired
effects discussed above. On top of that it is a strong
antimicrobial. Phellodendron cortex has similar effects.
Their color is the same yellowish which refers to the same
bitter substance they contain.
Coptis chinesis– Huang Lian rhizome
Phellodendron amurense cortex
Tasting and action
Traditionally used bitter tasting herbs remove heat and
toxins they are antimicrobial and have anti-inflammatory
properties. Regarding to TCM Coptis Chinesis rhizome is
extremely bitter TCM connects the bitter taste to the heart
and pericardium, cardiovascular system. TCM also says
bitter flavour goes directly to the heart. One of our biggest
problems with sugar is the increased risk of Coronary
Heart Disease CHD therefore bitter flavoured plants could
be the right direction to continue the research.
The common compound
Looking at the pharmacognosy of these herbs the
substance which is common in all of them and which is
responsible for that bitterness and the related anti-
inflammatory effects is BERBERINE. Berberine is an
extremely bitter yellow substance derived from the
rhizome of Coptis chinesis, root cortex of Phellodendron
amurense (from China), root cortex of Mahonia
aquifolium and herba or root of Hydrastis canadensis
(from North America) or root cortex of Berberis vulgaris
(from Europe). These are traditionally used herbs in herbal
medicines all over the world. About the berberine
containing herbs the extracted natural berberine works as
well as the whole herb.
Mahonia aquifolium – Oregon grape (root cortex)
Goldenseal root – Hydrastis canadensis
Berberine is a natural herbal compound available from
many different herbs.It is probably in your backyard or the
bush that you pass every day on the street where you live.
Mahonia species, Berberis species are widely available
and there are a lot herbs with Berberine in every country
around the world.
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Berberine
I will take a look at the state of the art scientific research
about berberine. It is one of the most studied natural
substances in the world.
Pharmacist say berberine is almost as strong as synthetic
medications. While Berberine’s side effects are negligible.
Berberine is an isoquinoline alkaloid, Berberine based
formulations, are widely used in traditional systems of
medicine including, Ayurveda and Traditional Chinese
Medicine. Berberine has demonstrated wide range of
pharmacological activities including; antihypertensive,
anti-inflammatory, antioxidant, antidepressant,
anticancer, anti-diarrhoeal, cholagouge,
hepatoprotective and above all, antimicrobial. Recent
studies, have thrown light on antidiabetic and
hypolipidemic activities of the alkaloid. Berberine has
been tested clinically in the treatment of oriental
sore, diarrhea, trachoma diabetes mellitus type-
2, hypercholesterolemia, and congestive cardiac failure
and more [58]
Scientific studies about Berberine
Anti-inflammatory effects Anti-inflammatory activity of berberine in non-alcoholic
fatty liver disease, [55] Natural compound BBR has
antioxidant and anti-inflammatory activities which might
contribute in part to its therapeutic efficacies against
diabetes mellitus and insulin resistance [54]
Non-Alcoholic Fatty Liver Disease There is evidence, berberine can significantly improve
blood lipids and liver function in patients with NAFLD and
has good advantage in reducing blood glucose in patients
with NAFLD, which might be a new choice for the
treatment of NAFLD (META study) [82] [84] [104] [108]
Prediabetes, Type 2 diabetes, Blood sugar lowering
and stabilizing effects There is strong scientific evidence from the highest quality
(systematic reviews) about the side effect free treatment
of Type 2 diabetes with Berberine. Berberine was able to
lower glucose levels in liver cells. [39] Recent studies
suggest that berberine could have a direct action on
carbohydrate metabolism in the intestines. It affects
glucose metabolism, increases insulin secretion,
stimulates glycolysis, suppresses adipogenesis, inhibits
mitochondrial function. [41] Enhances insulin sensitivity,
resuscitates exhausted pancreatic islets. Extra beneficial
effects on diabetic cardiovascular complications [14]
Lowering triglycerid levels Berberine partially mediated by the up-regulation of
lipolysis gene expressions and down-regulation of
lipogenesis gene expressions through activation of the
AMPK signaling pathway.[112] Lipid-lowering effect of
berberine in human subjects: berberine treatment
produced a mild weight loss and significant lipid-lowering
effects without side effects. [114]
Blood Pressure Lowering Berberine has a hypotensive effect, at least in part, via the
inhibition of ACE and direct release of NO/cGMP in the
vascular tissues[108]
Cholesterol lowering Human experiment shown lipid-lowering effects of
berberine with significant cholesterol level decrease 9% in
the 12 weeks 500mg berberine orally 3 times a day
continous consumption. A mild weight loss effect in obese
patients were present. [114]
Antimicrobial effects of Berberine Starting with the strongest antimicrobial activity S. aureus >P. aeruginosa S (sensitive) >E. coli S>P. aeruginosa R (resistant) >E. coli R>B. subtilis>Z. ramigera>C. albicans>S. cerevisiae>A. pullulans B (black)>A. pullulans W (white)>T. viride Br (brown)>M. gypseum>A niger>F. nivale>P. chrysogenum>T. viride G.
[107] Berberine has shown strong antibacterial effects while it’s effect on funguses was weaker.
Caries tooth decay Berberine shown bactericidal against oral bacteria responsible for dental caries. Streptococcus mutans and other streptococcus species. [117]
Neuropathy -Inflammation of the nerves Berberine suppresses diabetic neuroinflammatory
response, Berberine shown anti-neuroinflammatory
effects Using berberine to treat diabetic neuropathy in
rats induced by STZ and in diabetic patients demonstrated
that berberine could significantly improve the median
nerve, peroneal in nerve conduction velocity (NCV) [46]
Nephropathy – Inflammation of the kidneys Berberine reduced renal injury, Berberine attenuated the
systemic and renal cortex inflammatory response [47].
Berberine shown renoprotective, decreased renal
inflammation [48]
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Anticancer
There is strong scientific evidence about the effectiveness
of Berberine for cancer. Anti-tumor effects in a variety of
tumors in vivo, especially breast cancer and lung cancer.
Has positive effects on colorectal cancer and gastric
cancer Berberine exerted anti-tumor mechanisms was
anti-angiogenesis and there was a dose-response
relationship in these anti-tumor effects..[85]
Antianxiety
With the decrease of 5‐HT, NE, and DA levels, Binding with
GABAA receptor, Inhibition of glutamate receptors,
Increase in turnover rates of monoamines, Activation of 5‐
HT1A and inhibition of 5‐HT1A and 5‐HT2 receptors [59]
Alzheimer’s disease
Berberine prevents brain damages. Berberine could
impede the development of dementia via multiple
mechanisms: preventing brain damages and enhancing
cognition directly in the brain, and indirectly through
alleviating risk factors such as metabolic dysfunction, ,
cerebral ischaemia, mental depression, schizophrenia and
cardiovascular, kidney and liver diseases. This study [83]
provided evidence to support the value of berberine in the
prevention of dementia associated with metabolic
syndrome. [83]
Depression Berberine has effects on neurotransmitters, antioxidation,
nitric oxide synthesis, neuroinflammation, neurotrophic
factors, hormonal regulation in depression. New
association found between irritable bowel syndrome and
depression, while berberine reversed the physical damage
brought about by stress within the gastric mucosa and
intestinal microvilli of the stomach, ileum, caecum, and
colon. [71] Dysregulation of neurotransmitters can cause
depression. Berberine can regulate brain
neurotransmitters, especially biogenic amines (NE, 5-HT,
DA) [12] [57]
Norepinephrine (NE), serotonin (5‐HT) and dopamine (DA)
are neurotransmitters released from neurons during
synaptic transmission in the nervous system. [12] Studies
demonstrated that berberine (10, 20 mg/kg, p.o.),
dramatically reduced the immobility time during the
forced swim test and the tail suspension test. [18] Either
acute or chronic administration of berberine at low doses
results in increased levels of NE, 5‐HT, and DA in whole‐
brain samples. Kulkarni et al showed that acute
administration of berberine (5 mg/kg, i.p.) in mice caused
increased levels of norepinephrine (31%), serotonin (47%),
and dopamine (31%). Chronic administration of berberine
(5 mg/kg, ip) for 15 days significantly increased the levels
of norepinephrine (29%), serotonin (19%) as well as
dopamine (52%). [59]
High concentrations of berberine can protect rats from
various symptoms of chronic stress and depression,
indicating its potential clinical use. [59]
„Our findings indicate that berberine may have
antidepressant effects, based on its ability to decrease the
immobility time in the forced swimming test in OVX mice
without affecting body weight. [57]
Cognitive impairment Berberine ameliorates cognitive impairment caused by
diabetes. with the activation of the cholinergic anti-
inflammatory and insulin signaling pathways
Ameliorated spatial learning memory impairment Berberine restored hippocampal synaptic plasticity which
is the changes of the synaptic conntection strength be-
tween neurons by it’s activity preferences. [106] [61] [60]
Bipolar disorders Berberine inhibits human prolyl oligopeptidase which is
associated with schizophrenia, bipolar affective disorder,
and related neuropsychiatric disorders. Study suggests the
initiation of clinical trials in patients with schizophrenia,
bipolar affective disorder, or related diseases like
cognitive capabilities. [60]
Antiaging Chinese herb rhizoma coptidis and its main bioactive
components (berberine) has been used in aging-related
diseases widely, i.e. hyperglycemia, hyperlipidemia and
some neurodegenerative diseases. Berberine, has found
to extend life span, overall health, and attenuate
premature cellular senescence in animal models.
Berberine as a natural supplement that can potentially
combat aging. [56]
Scientists learn from berberine’s killer mechanism NorA is a drug efflux pump found in resistant pathogenic
bacteria such as MRSA. Berberine inhibits NorA action.
Berberine causes DNA damage: creates genomic lesions in
bacteria then Tumor suppressor P53 protein induces cell
cycle arrest causes the bacteria’s programmed death.
Berberine inhibits Nuclear factor kappa B (NF-κB)
inflammatory response and COX-2 transcriptional activity
which has a key role in colon tumor cell growth.
Antimutagenic activity of berberine from the inhibition of
DNA Topoisomerase enzyme which participates in the
overwinding and underwinding of the DNA.
Induced cell cycle arrest in gastric cancer cells, leukemia
cells and many others.
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Refined Sugar Berberine
Aging Anti-aging, extends life span, overall health, and attenuates premature cellular senescence [56]
Inflammation Anti-Inflammatory [5] [54]
Non-Alcoholic Fatty Liver Disease NAFLD Improves Liver Function, an effective treatment for NAFLD (Meta study),[82] [84] [104] [108]
Non-Alcoholic Liver Cirrhosis Anti-fibrotic effect of berberin [110][112]
Non-Alcoholic SteatoHepatitis NASH Berberine Improves Steatohepatitis, Prevents progression of hepatic steosis to steatohepatitis Prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma, [97] [99][108]
Prediabetes, Type 2 diabetes Berberine affects glucose metabolism, increases insulin secretion, stimulates glycolysis, suppresses adipogenesis, inhibits mitochondrial function. Offers side effect free Type2 diabetes treatment 14] [39] [41],
Cancer Anticancer activites, strongest effects on breast cancer and lung cancer,colorectal cancer and gastric cancer, cell cycle arrest in a wide variety of cancer cell lines [80] (Systematic Review strong evidence)
Coronary Heart Disease CHD Berberine reduced the incidence of ventricular arrhythmia after coronary artery occlusion; [101] - Ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention; [102], - Inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells, [103]
Cardiovascular risks Anti-arrhythmic, Prevents heart failure [100]
Congestive Heart Failure CHF Improvement of ventricular tachycardia with “torsades de pointes” morphology, Prolonged the duration of ventricular action potential [110] Berberine improved quality of life and decreased ventricular premature complexes , ventricular tachycardia and mortality in patients with CHF (no side effects) [96]
Diabetic Nephropathy Renoprotective, decreased inflammatory response [48]
Diabetic Neuropathy Anti-neuroinflammatory, Improves nerve conduction velocity [46]
Neurodegenerative diseases Alleviated synaptic loss, mitochondrial dysfunction, Prevented dopaminergic neuronal loss (Parkinson’s), [69] [70]
Alzheimer’s disease - dementia Prevented brain damage,prevents brain inflammation, enhances cognition, + improves Alzheimer’s indirectly through alleviating risk factors such as metabolic dysfunction, , cerebral ischaemia, mental depression, schizophrenia and cardiovascular, kidney and liver diseases. [68] [71] [83]
Growth of pathogenic microorganisms Antimicrobial, mostly antibacterial including MRSA
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High Blood Pressure Hypotensive by alpha adrenoceptor blockage [95][109] Improved vasodilation by activation of BKCa channel in smooth muscle cells [95]
High Triglyceride levels Triglyceride lowering effects [113], [114]
High Cholesterol Berberine Lowers Cholesterol [114]
Sugar crawings, dependency withdrawal
Reduced the acquisition and reinstatement from morphine [116] (sugar causes similar addictions)
Depression Antioxidation, Regulation of nitric oxide synthesis, neuroinflammation, neurotrophic factors, hormonal regulation in depression; regulates biogenic amines [12] [57]
Anxiety Significant anxiolytic effect , increased turnover rates of monoamines in the brain stem, decreased serotonergic system activity, berberine binds to benzodiazepine site on the GABAA receptor[59]
Bipolar disorders Berberine inhibits human prolyl oligopeptidase which is associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders[60]
Mood disorders Shown to alleviate mood disorders in a number of ways has the potential to become a mainstream drug for treating mood disorders [59]
Caries tooth decay Inhibited the growth of streptococcus mutans and other streptococcus species [117]
Probably most people suffer from smaller or bigger side effects of the Refined Sugars. It can be
acquired in younger ages and we know that the continuous eating of Refined Sugars and processed
foods just aggrevate the conditions every day.
Is there any other remedy that have broad benefits to human health, such as berberine?
I have examined part of this incredible literature of studies, review articles, research articles,
systematic reviews about berberine. For all of the examined side effects Refined Sugars caused can be
opposed with one or more effect of berberine. Berberine is the single substance which is able to
counteract all of the above conditions. Berberine is the Opposite of Sugar.
Safety: A review [115]presented that berberine is a safe Anti-cancer agent. Human and animal trials -
tests of hematological, cardiovascular, liver, and kidney function following berberine treatment
showed no detrimental side effects to this natural compound. [114]
Regardless how effective berberine was in the research articles there is no guarantee that it will work
for you. A lot depends on the quality of the herbs you can get, the way you take them and your
whole diet and lifestyle is a huge factor. Besides berberine is something worth to try for everyone.
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Get Well
Our complex Berberine formula offers you pure natural
biologically active berberine and an added absorbtion
booster. Includes multiple sources of Berberine.
Additive Free- We do not use synthetic Additives or
binders, fillers, whiteners other unnecessary chemicals
A special aroma protective packaging ensures the
freshness of these herbal ingredients.
https://onlynatureknows.com/product/get-well/
Spleen Balance
Spleen has the function to keep our organs in their right
places. It stores energy from the food also has key role
in gathering the nutrition from the food what we eat.
Because of the dietary imbalances we need to support
our spleen.
Balances the Spleen,
Alleviates Spleen deficiency
Counteracts dampness caused by
Refined Sugars and processed food.
COMING SOON
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