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[Na + ] cytosol. [Ca 2+ ] cytosol. contraction. Action of cardiotonic steroids eg ouabain, digoxin (cardiac glycosides). Na +. Ouabain. Na + /Ca 2+ Exchanger. Cytosol. Ca 2+. 2K +. 3Na +. Na + /K + ATPase. Cardiotonic steroids increase the force of - PowerPoint PPT Presentation
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Action of cardiotonic steroidseg ouabain, digoxin
(cardiac glycosides)
Heart Cell
Cytosol
3Na+
2K+
Ouabain
Na+/K+ ATPase
Na+/Ca2+ Exchanger
Cardiotonic steroids increase the force ofcontraction in the heart by inhibiting the Na+/K+ ATPase.
Na+
Ca2+
[Na+]cytosol [Ca2+]cytosol contraction
Used to treat cardiac insufficiency or fibrillation
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