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Bcl-2 and its Role in Cancer. Mitochondria in the Cell. http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg. Cytochrome C’s Dual Functionality. Protein that carries electrons in electron transport chain between mitochondrial membranes - PowerPoint PPT Presentation
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Bcl-2 and its Role in Cancer
Mitochondria in the Cell
http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg
Cytochrome C’s Dual FunctionalityProtein that carries electrons in electron transport chain between mitochondrial membranes
BUT released into cytosol, triggers apoptosis
http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Cytochrome_C.png/250px-Cytochrome_C.png
Bcl-2 family – apoptosis regulators
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_htmlcourse/page3
Stress signal (DNA damage, heat shock)
Pro-apoptotic members activated
Cytochrome c release via MOMP
Cytochrome c complexes with ATP and Apaf-1 (enzyme)
Caspase-9 activated, then forms apoptosome with previous complex
Caspase cascade to apoptosis
http://www.reading.ac.uk/nitricoxide/intro/apoptosis/mito2.jpgApoptosis Pathway
http://openi.nlm.nih.gov/detailedresult.php?img=2132464_JCB.amling5g&req=4
• Viable, but smaller• Half die by 6 weeks• Smaller kidneys• Skeletal
development• Immune failure
Bcl-2 Knockout Mice
https://encrypted-tbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4UWe9Cusd-A
Non-Hodgkin
Lymphoma
http://www.sciencedirect.com/science/article/pii/S0167488903001885
Bcl-2 Translocations Found in Cancer
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_htmlcourse/page3
Overexpression of Bcl-2 on the Outer Membrane of Mitochondria
Inhibiting Bcl-2
http://www.cancer.gov/images/targetedtherapies/lymphoma/m4s3c_1.jpg
http://www.cancer.gov/PublishedContent/Images/images/targetedtherapies/lymphoma/m4s3c_3.jpg
Potential Therapeutic Undergoing Clinical Trials
Sources
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132464/
• http://www.scq.ubc.ca/apoptosis/• http://www.ncbi.nlm.nih.gov/pmc/articles/
PMC3220196/pdf/iep_79.pdf• http://www.cancer.gov/cancertopics/
understandingcancer/targetedtherapies/lymphoma_htmlcourse
• http://www.sciencedirect.com/science/article/pii/S0167488903001885
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