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British Journal of Clinical Pharmacology
A. M. Breckenridge (Chairman)Annmarie Hedges (Press Editor)
Executive Editorial BoardJ. FeelyM. LaderM. J. S. Langman
Editorial BoardW. H. AelligL. BeeleyP. N. BennettP. BrooksD. M. Chaput de SaintongeD. Grahame-Smith
C. F. George (Editorial Secretary)
G. MawerA. N. NicholsonL. Ramsay
P. LewisJ. C. MucklowM. L'E. OrmeJ. P. PayneA. W. PeckM. Rawlins
G. T. Tucker
J. ReidA. TattersfieldP. Turner0. L. WadeF. Woods
British Journal of Clinical Pharmacology ispublished monthly by Blackwell Scientific Pub-lications Ltd for the British PharmacologicalSociety. Papers on all aspects of drug action inman will be considered for publication. Manu-scripts (four copies) and editorial correspon-dence should be addressed to Professor C. F.George, British Journal of Clinical Pharma-cology, 8 John Street, London WC1N 2ES.Papers are assumed to have been submittedexclusively to the journal as they becomecopyright on acceptance for publication. Fordetailed information, see 'Instructions toAuthors' at the front of each issue.
Subscription rates. The journal is publishedmonthly with six issues forming each volume.The subscription for 1985 is £110.00 (UK),£139.00 (overseas) and $250.00 (USA andCanada). The journal is delivered to NorthAmerica by accelerated surface post and sub-scribers there can expect to receive their copieswithin 2 weeks of British publication. Currentissues for the Indian subcontinent, Australasiaand the Far East are sent by air to regionaldistribution points from where they are for-warded to subscribers by surface mail. Anyback numbers are normally despatched by sur-face to all regions, except North America,
where they are sent by a.s.p., and India, wherethey are sent by air freight.
Copyright and photocopying. 1985 BlackwellScientific Publications Ltd. Authorization tophotocopy items for internal or personal use ofspecific clients is granted by Blackwell ScientificPublications Ltd for libraries and other usersregistered with the Copyright Clearance Center(CCC) Transactional Reporting Service, pro-vided that the base fee of $02.00 per copy ispaid directly to CCC, 27 Congress Street,Salem, Massachusetts 01970, USA. This consentdoes not extend to other kinds of copying, suchas copying for general distribution, for advertis-ing or promotional purposes, for creating newcollective works or for resale. Special requestsshould be addressed^ to Professor George.
0306-5251/85 $02.00.
Business correspondence. Orders and remit-tances relating to subscriptions and offprintsshould be sent to Blackwell Scientific Publica-tions, PO Box 88, Oxford. Advertisementbookings and enquiries should be sent to theAdvertisement Manager, Blackwell ScientificPublications, Osney Mead, Oxford OX2 OEL(telephone 0865 240201).
Whilst every effort is made by the publishers and editorial committee to see that no inaccurate or misleading data, opinion or statementappears in this Journal, they wish to make it dear that the data and opinions appearing in the articles and advertisements herein are theresponsibility of the contributor or advertiser concerned. Accordingly, the publishers and the editorial committee and their respectiveemployees, officers and agents accept no liability whatsoever for the consequences of any such inaccurate or misleading data, opinion orstatement.
Instructions to authors
Papers will be considered for publication on allaspects of drug action in man, including chemo-therapy. A recent issue of the Journal is a goodguide to style. Further information on style canbe found in Instructions to authors (Br. J. clin.Pharmac. 1982, 14, 3-6) and Symbols in Phar-macokinetics (Br. J. clin. Pharmac. 1982, 14,7-13).
Manuscripts (four copies) should be sent toProfessor C. F. George, British Journal ofClinical Pharmacology, 8 John Street, LondonWC1N 2ES.
1. Manuscript should be typed in double spacingon one side of standard paper (A4-206 x 294mm). There should be a separate title pagegiving the names and addresses of the authors.A short title of not more than 50 letters shouldalso be suggested. For indexing purposes asmall number (up to 5) of keywords should besupplied.
2. Statement Papers are accepted only if accom-panied by a statement that they have not beenand will not be published in whole or in part inany other Journal. Ethical considerations ofstudies reported will be particularly noted bythe Editorial Board.
3. Figures These should not be larger than A4and may be in the form of original drawings,recorded tracings or high quality photographicprints made from them. Symbols which are toappear in figures or legends should be chosenfrom the following:
O * * A A V vPhotographs and photomicrographs should beunmounted glossy bromide prints of good con-trast, well matched and preferably with a trans-parent overlay for protection. The overlay shouldbe used to indicate masking instructions, letteringor arrows.
4. Tables These should not have more than 85characters to a line (counting spaces betweencolumns as 4 characters) and certainly not morethan 110 characters to a line, unless absolutelyunavoidable. Figure legends and tables shouldbe typed on separate sheets of paper.
5. References References in the text should bequoted by the author's name(s) and year ofpublication. In the case of 2 authors both namesshould be stated. If there are more than 2authors, only the first author plus et al. should
be quoted in the text. The list of referencesshould be collected in alphabetical order at theend of the paper. The references should includethe names of all the authors, year or publication(in brackets), title of the article, title of publi-cation (abbreviated in accordance with thefourth edition of the World List of ScientificPeriodicals), volume number and first and lastpage numbers. References to books should, inaddition, include the names of the editor, theedition number, where appropriate, and thetown of origin and name of publisher. Theaccuracy of references is the responsibility ofthe author.
Two page proofs will be supplied, one of whichmay be retained by the authors. The othershould be corrected immediately and returnedto the Press Editor. Corrections should be keptto a minimum. Extensive changes may be chargedto the author.
Twenty-five offprints will be supplied to theauthors free of charge. Additional offprints canbe purchased. An offprints order form, whichshould be returned promptly, will be sent outwith the proofs. No offprints of abstracts aresupplied.
Main papers These should be divided into thefollowing sections: title page, numbered sum-mary, introduction, methods, results, dis-cussion, acknowledgements, references, tablesand figures.
Short reports These should be set out in thesame format as main papers except that theSummary should not be numbered. The length,including title, summary and references mustnot exceed 1200 words plus two figures ortables, or one of each.
Letters to the Editors Brief original communi-cations or comments upon previously publishedpapers in the Journal will be accepted underthis heading. The length, including references,must not exceed 800 words plus one figure ortable. The letter should not be divided intosections, and names and addresses of authorsshould appear at the end.
Units These are normally expressed as SI units.If other units are used a conversion factorshould be included in the Methods section. SeeEditorials, Br. J. clin. Pharmac. (1983), 16, 1,3-7.
AUTHOR INDEX
(S = supplement; L = letter to the Editors; P = proceedings)
ABADIE, F. see LECAILLON, J. B.ABERNETHY, D. R., GREENBLATT, D. J., MORSE, D. S.& SHADER, R. I. Interaction of propoxyphenewith diazepam, alprazolam and lorazepam, 51
ABERNETHY, D. R. see SCHWARTZ, J. B.ABRAMS, S. M. L. see MEKKI, Q. A.ADAMS, E. F. see STRUTHERS, A. D.ADDIS, G. J. see BRYSON, S. M.AELLIG, W. H. Pharmacological experiments in
healthy volunteers with bopindolol, a long-acting1-adrenoceptor blocking drug with partial agonistactivity, 775
AGNEW, E. see BRODIE, M. J.AGNEW, E. see MaCPHEE, G. J. A.AHOKASS, J. T. see PELKONEN, 0.AINSWORTH, S. see McBURNEY, A.ArTCHISON, T. C. see HOWIE, C. A.AJAYI, L. A. A. see HOCKINGS, N.ALBA, M. see DOMENECH, J.ALBRICI, A. see PERUCCA, E.ALDHOUS, M., FRANEY, C., WRIGHT, J. & ARENDT, J.Plasma concentrations of melatonin in man follow-ing oral absorption of different preparations, 517
ALI, N., MARSHALL, R. W. & RICHENS, A. CNS de-pressant effect of ethanol alone and in combinationwith dextropropoxyphene or meptazinol, 551P
ALLEN, E. M. see EL-BAHIE, N.ALLEN, M. see GRIFFITHS, A. N.ALLEN, W. L. see STEAD, R. J.ALLEN, W. L. see WINSTANLEY, P. A.ALLSOPP, L. F. see MULLER, F. B.AL-SAFI, S. A. & MADDOCKS, J. L. Strength of thehuman mixed lymphocyte reaction (MLR) and itssuppression by azathioprine or 6-mercaptpurine,105
AL-SAFI, S. A. see MADDOCKS, J. L.AL-SHARMA, Y. see WORTH, D. P.ALVAN, G. see SJOVALL, J.ANKIER, S. I. see MCINNES, G. T.ANTONIN, K.-H., BIECK, P., SCHEURLEN, M., JED-RYCHOWSKI, M. & MALCHOW, H. Oxprenololabsorption in man after single bolus dosing into twosegments of the colon compared with that after oraldosing, 137S
ARENDT, J. see ALDHOUS, M.ARNOLD, J. D. see GOOD, W.ARNOLD, J. M. 0. & McDEvrrr, D. G. Indirect blood
pressure measurement during intravenous isopre-naline infusions, 114L
ARNOLD, J. M. O., O'CONNOR, P. C., RIDDELL, J. G.,HARRON, D. W. G., SHANKS, R. G. & McDEvrrr,D. G. Effects of the 02-adrenoceptor antagonistICI 118,551 on exercise tachycardia and isoprenaline-induced ,B-adrenoceptor responses in man, 619
ARNOLD, J. M. 0. see O'CONNOR, P. C.
ARR, S. see SKEHAN, J. D.ARR, S. M. see VANDENBURG, M. J.ASCALONE, V. see STOECKEL, K.ASHBY, L. see POSNER, J.AVIRAM, M., VINTERSTEIN, G. & BROOK, J. G. Dif-
ferential effect of platelet inhibitors in normal and inhypercholesterolaemic subjects, 715
AWADZI, K. see EDWARDS, G.AYER, A. see THEEUWES, F.
BACK, D. J., GRIMMER, S. F. M., ORME, M. L'E.,ROGERS, S. M. & STODDARD, C. J. Intestinal trans-port and metabolism of ethinyloestradiol in vitro,146P
BACK, D. J. see GRIMMER, S. F.BACK, D. J. see STEAD, R. J.BACK, D. J. see WINSTANLEY, P. A.BAIRD, A. see NUNN, B.BAKER, L. R. I. see MATHEY, F.BAKER, S. see BUSS, D. C.BAKSHI, M. see MacMAHON, B.BALL, S. G. see CLELAND, J. G. F.BARBER, H. see HAMILTON, M. J.BARCLAY, S. P. see WARRINGTON, S. J.BARENDREGT, J. N. M. see STRICKER, B. H. CH.BARNES, J. N. see DREW, P. J. T.BARNES, N. C. see ZAKRZEWSKI, J. T.BARNES, P. J. see WARREN, J. B.BARRY, H. see O'BOYLE, C. A.BATTEN, J. C. see STEAD, R. J.BATY, J. see ISLES, T. E.BAUMELOU, H. see MERDJAN, H.BAx, N. D. S., JONES, R. W., LENNARD, M. S.,TUCKER, G. T. & WOODS, H. F. Penbutolol andpropranolol: a comparison of their effects on anti-pyrine clearance in man, 593
BAx, N. D. S., JONES, R. W., LENNARD, M. S.,TUCKER, G. T. & WOODS, H. F. The effect of pen-butolol and propranolol on antipyrine kinetics, 120P
BAx, N. D. S., TUCKER, G. T., LENNARD, M. S. &WOODS, H. F. Impairment of lignocaine clearanceby propranolol-major contribution of enzyme in-hibition, 589P
BAx, N. D. S., TUCKER, G. T., LENNARD, M. S.& WOODS, H. F. The impairment of lignocaine clear-ance by propranolol-major contribution ofenzyme inhibition, 597P
BEATE, J. M. see RAE, A. P.BEAUNE, P. see BOOBIS, A. R.BELL, G. D. see KAMALI, F.BENITEZ, J. see NORDIN, C.BENNETr, E. D. & DAVIS, A. L. A possible explanation
for the absence of anti-anginal properties of trans-dermal nitroglycerin units: an echocardiographicstudy, 435
863
864 IndexBENNETT, J. see BENNETT, P. N.BENNETT, P. N., BENNETT, J., BRADBROOK, I.,
FRANCIS, J., JOHN, V. A., ROGERS, H., TURNER, P.& WARRINGTON, S. J. Single-dose pharmacokineticand pharmacodynamic comparison of polymer-matrix (Slow Trasicor) and Oros dosage forms ofoxprenolol in healthy volunteers, 171S
BENNETT, P. N., JOHN V. A. & KENDALL, M. J. Orosdrug delivery systems for the ,-adrenoceptor anta-gonists: oxprenolol and metoprolol, 63S
BENNETT, S. see BLAND, J. M.BERGLUND, G. see BERGSTRAND, R.BERGSTRAND, R., HERLITZ, H., JOHANNSSON, S.,BERGLUND, G., VEDIN, A., WILHELMSSON, C.,GOMEZ, H. J., CIRILLO, V. J. & BOLOGNESE, J. A.Effective dose range of enalapril in mild to moder-ate essential hypertension, 605
BERNIER, J. J. see EVARD, D.BERNIER, J. J. see GODBILLON, J.BERNIER, J. J. see JOBIN, G.BERNIER, J. J. see VIDON, N.BERTILSSON, L. see NORDIN, C.BEST, N. R., COWEN, P. J., ELLmOTT, J. M., FRASER, S.,GOSDEN, B. & STUMP, K. Changes in imipramine anda2-adrenoceptor binding sites in the early puerper-ium, 555P
BEVAN, J. S. see COWEN, P. J.BEWICK, M. see HOLT, D. W.BHATTACHARJEE, P. see WALDEN, R. J.BIANCO, L. see GHIRHARDI, P.BIECK, P. see ANTONIN, K.-H.BIRMINGHAM, A. T. see PATRICK, J. M.BIRNIE, G. G. see BRODIE, M. J.BLANCHARD, J., SAWERS, S. J. A., JONKMAN, J. H. G.& DAN-SHYA TANG-LIU, D. Comparison of theurinary metabolic profile of caffeine in young andelderly males, 225
BLAND, J. M., JONES, D. R., BENNETT, S., COOK,D. G., HAINES, A. P. & MacFARLANE, A. J. Is theclinical trial evidence about new drugs statisticallyadequate? 155
BLYDEN, G. T. see GREENBLATT, D. J.BOLLI, P. see MULLER, F. B.BOLOGNESE, J. A. see BERGSTRAND, R.BOOBIS, A. R., HAMPDEN, C. E., MURRAY, S.,BEAUNE, P. & DAVIS, D. S. Attempts to pheno-type human liver samples in vitro for debriso-quine 4-hydroxylase activity, 721
BOOBIS, A. R., TEE, L. B. G., HAMPDEN, C. E.,HUGGETT, A. C. & DAVIES, D. S. Comparativeability of man to activate paracetamol to its hepato-toxic metabolite, 590P
BOOBIS, A. R. see TEE, L. B. G.BORCHARD, U. see BRINKMANN, M.BOSCH, E. see MALAN, J.BOSSuYT, A. M. see DUPONT, A. G.BOUCHIER, A. D. see SHEPHERD, A. N.BOURNE, D. W. A. see Ho, P. C.BOVET, M. see EVARD, D.BOYCE, M., DALTON, N., GOODWIN, B., WALKER, P.,WEG, M. & SANDLER, M. Disposition of equimolardoses of epinine and ibopamine, the di-isobutyrylester of epinine, in healthy subjects, 143P
BRADBROOK, I. D., JOHN, V. A., MORRISON, P. J.,ROGERS, H. J. & SPECTOR, R. G. Pharmacokineticinvestigation of the absorption of oxprenolol from
Oros delivery systems in healthy volunteers: com-parison of in vivo and in vitro drug release, 163S
BRADBROOK, I. see BENNETT, P. N.BRADDOCK, L. E. see COWEN, P. J.BRADSHAW, C. M. see BUCETA, J. M.BRADSHAW, C. M. see LONGMORE, J.BRAITHWAITE, P. A. see DAWSON, M.BRANAGAN, P. see MacMAHON, B.BRECKENRIDGE, A. M. see EDWARDS, G.BRECKENRIDGE, A. M. see MIHALY, G. W.BRECKENRIDGE, A. M. see SCOTT, A. K.BRECKENRIDGE, A. M. see WARD, S. A.BRECKENRIDGE, A. M. see WINSTANLEY, P. A.BREIMER, D. D., JOCHEMSEN, R., KAMPHUISEN,H. A. C., NICHOLSON, A. N., SPENCER, M. B. &STONE, B. M. Central effects during the continuousosmotic infusion of a benzodiazepine (triazolam),554P
BREIMER, D. D., JOCHEMSEN, R., KAMPHUISEN,H. A. C., NICHOLSON, A. N., SPENCER, M. B. &STONE, B. M. Central effects during the continuousosmotic infusion of a benzodiazepine (triazolam),807
BREIMER, D. D. see KLEINBLOESEM, C. H.BRINKMANN, M., BORCHARD, U., BRODDE, O.-E.,DAUL, A., O'HARA, N. & SCHEMUTH, R. Alterationof human lymphocyte 032-adrenoceptor density by02-adrenoceptor blocker administration: the roleof ISA, 588P
BRINKMANN, M., BRODDE, O.-E., DAUL, A., O'HARA,N. & SCHEMUTH, R. Reversal of agonist-inducedhuman lymphocyte 02-adrenoceptor desensitiza-tion by prednisone and ketotifen, 587P
BROCKMEYER, N., DYELWICZ, P., HABICHT, H. &OHNHAUS, E. E. The metabolism of diazepamfollowing different enzyme inducing agents, 544P
BRODDE, O.-E. see BRINKMANN, M.BRODIE, M. J., FITzsIMMONS, C., CZARNECKI, D.,COOK, A., SCOBIE, G. & BIRNIE, G. G. Hepaticmetabolic function in psoriatics receiving long termmethotrexate therapy, 569P
BRODIE, M. J., MUIR, S. E., AGNEW, E., MacPHEE,G. J. A., VOLO, G., TEASDALE, E. & MacPHERSON,P. Protein binding and CSF penetration ofphenytoin following acute oral dosing in man, 161
BRODIE, M. J. see MaCPHEE, G. J. A.BRODIE, M. J. see MCINNES, G. T.BROOK, J. G. see AVIRAM, M.BROOKS, B. A. see McNABB, W. R.BROUGHTON PIPKIN, F. see O'BRIEN, P. M. S.BROWN, A. N. see O'CONNOR, P. C.BROWN, J. see HARVEY, J. N.BROWN, M. J. & STRUTHERS, A. D. Guanfacine lowersplasma noradrenaline by peripheral cL2-adreno-ceptor stimulation in man, 534P
BROWN, M. J. see STRUTHERS, A. D.BRUSONI, B. see GHIRHARDI, P.BRYSON, S. M., MCGOVERN, E. M., KELMAN, A. W.,WHITE, K., ADDIS, G. J. & WHITING, B. The phar-macokinetics of high dose metoclopramide inpatients with neoplastic disease, 757
BUCETA, J. M., BRADSHAW, C. M. & SZABADI, E.Hyper-responsiveness of eccrine sweat glands tocarbachol in anxiety neurosis: comparison of maleand female patients, 817
BUCHANAN, N. see MaCKINTOSH, D.
BUHLER, F. R. see MULLER, F. B.BUNTING, E. A. see MCINNES, G. T.BURGOYNE, W. see COOK, P. J.BURKE, C. see HAMILTON, M. J.BUSH, R. see COOK, P. J.BUSS, D. C., EBDEN, P., BAKER, S. & ROUTLEDGE,
P. A. Protein binding of theophylline, 529LBUss, D. C. see LEOPOLD, D.BUss, D. C. see WATT, A. H.BYE, A. see WHITEMAN, P. D.
CALDWELL, J. & COTGREAVE, I. A. The metabolic fateof ethylenediamine in man in relation to acetylatorstatus, 148P
CANNON, J. see SCOTT, A. K.CARTER, A. J. see COWLEY, A. J.CHAMBERLAIN, P. D. see NUNN, B.CHAMPION, D. see LEE, E. J. D.CHAN, E., O'REILLY, R. & ROWLAND, M. Stereoche-
mical aspects of warfarin in man: a combined phar-macokinetic-pharmacodynamic model, 545P
CHAN, E., PEGG, M., MacKAY, A. D., COLE, R. B. &ROWLAND, M. Stereochemical aspects ofwarfarin inpatients receiving chronic therapy, 571P
CHAN, K., TEOH, R. & SAMARASINGHE, H. T. Plasmaconcentrations of antiepileptic drugs in mentallyhandicapped children with epilepsy, 125P
CHANNER, K. S. & ROBERTS, C. J. C. The kinetics andCNS effects of zopiclone depend upon posture attime of administration, 152P
CHANTHAVANICH, P. see WARD, S. A.CHAPRON, D. J., SWEENEY, K. R., FEIG, P. U. &KRAMER, P. A. Influence of advanced age on thedisposition of acetazolamide, 363
CHAPUT DE SAINTONGE, D. M. see PASIC, J.CHESTNUTT, W. N., CLARKE, R. S. J. & DUNDEE, J. W.
Side effects of nalbuphine, 580PCHIANG, B. N. see HONG, C. Y.CHICK, 0. see MERDJAN, H.CHILTON, A. see THOMAS, M.CHURCH, M. K. see KIM, Y.-Y.CIRILLO, V. J. see BERGSTRAND, R.CLAAS, F. H. J. see STRICKER, B. H. CH.CLARE, A. Introduction, 5SCLARKE, R. S. J. see CHESTNUTT, W. N.CLARKE, R. S. J. see GIBSON, F. M.CLAYTON, J. K., LEES, J. & SENIOR, J. The responses
of human myometrial strips to leukotrienes, 573PCLELAND, J. G. F., DARGIE, H. J., GILLEN, G., HODS-MAN, G. P., BALL, S. G. & ROBERTSON, J. I. S.Effects of enalapril on clinical state and serum elec-trolytes in congestive heart failure, 542P
COELHO, J., SCHNELLE, K., JOUBERT, L., VENTURA,D. & MULLANE, J. Dynamics of 1-adrenoceptorblockade with cetamolol, 411
COHEN, A. F. see POSNER, J.COL, J. see GHIRHARDI, P.COLE, R. B. see CHAN, E.COLLIER, P. S. see FEE, J. P; H.COLLIER, P. S. see HALLIDAY, N. J.COLLINS, P. J. see HOROWrTZ, M.COOK, A. see BRODIE, M. J.COOK, D. G. see BLAND, J. M.COOK, P. J., BURGOYNE, W., LOGAN, L., BUSH, R. &DAWLING, S. Temazepam half-life in fasting and
Index 865nonfasting subjects, the relation to FFA and diaze-pam protein binding, 587P
COOKE, J. see PRICE, D.COOPER, G. L. see MULLER, F. B.COOPER, S. J., KING, D. J. & LEAHEY, W. J. ECT,dopamine and delusions, 551P
COOPER, W. D. see VANDENBURG, M. J.CORTOT, A. see JOBIN, G.COSTELLO, J. F. see ZAKRZEWSKI, J. T.COTGREAVE, I. A. see CALDWELL, J.COUNIHAN, H. E. see CROWE, M. J.COWEN, P. J., BEVAN, J. S., GOSDEN, B. & ELLIOTT,
S. A. Treatment with 1-adrenoceptor blockers re-duced plasma melatonin concentration, 258
COWEN, P. J., BRADDOCK, L. E., GREEN, A. R. &GRAHAME-SMITH, D. G. Noradrenergic transmissionin the pineal gland during desmethylimipraminetreatment, 579P
COWEN, P. J., GREEN, A. R. & GRAHAME-SMITH, D. G.& BRADDOCK, L. E. Plasma melatonin duringdesmethylimipramine treatment: evidence forchanges in noradrenergic transmission, 799
COWEN, P. J. see BEST, N. R.COWEN, P. J. see SCHACHTER, M.COWIE, A. see GRIMMER, S. F.COWLEY, A. J., JONES, E. W., CARTER, A. J., HANLEY,
S. P. & HEPTrINSTALL, S. The effects ofdazoxiben, aninhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and plateletbehaviour in different individuals, 1
CREASY, W. A., PLATT, T. B., FRANTZ, M. &SUGERMAN, A. A. Pharmacokinetics of aztreonamin elderly male volunteers, 233
CREEK, R. A. & LADER, M. H. Preface, 3SCREGEEN, R. see HARVEY, J. N.CROME, P., GAIN, R., SURI, A. C. & DAWLING, S.Temazepam in elderly women: single and multipledose kinetics and effects on psychomotor perform-ance, 583P
CRONIN, C. J. see TOMLINSON, B.CROWE, M. J., COUNIHAN, H. E. & O'MALLEY, K. A
comparative study of a new selective 12-adreno-ceptor agonist, procaterol, and salbutamol inasthma, 787
CUBELA, R. see LARMOUR, I.CULLEN, J. see O'BOYLE, C. A.CURRIE, W. J. C. see VANDENBURG, M. J.CURRY, S. H. & KWON, H.-R. Influence of posture onplasma nitroglycerin, 403L
CUSS, F. see WARREN, J. B.CZARNECKI, D. see BRODIE, M. J.
DALTON, N. see BOYCE, M.DANESHMEND, T. K. see HOMEIDA, M. A.DANQUECHIN-DORVAL, E. see JOBIN, G.DAN-SHYA TANG-LIU, D. see BLANCHARD, J.DARGIE, H. J. see CLELAND, J. G. F.DARGIE, H. J. see FINDLAY, I. N.DAUL, A. see BRINKMANN, M.DAVIES, A. L. see BENNETT, E. D.DAVIS, D., GROSSMAN, KITCHELL, B. B., SHAND, D. G.& ROUTLEDGE, P. A. The effects of age and smokingon the plasma protein binding of lignocaine anddiazepam, 261
DAVIES, D. S. see BOOBIS, A. R.
866 IndexDAVIES, D. S. see SHAFFER, J. L.DAVIES, D. S. see TEE, L. B. G.DAVIES, I. B. see KILFEATHER, S. A.DAVISON, K., FARQUHARSON, R. G., KHAN, M. C. &MAJID, A. A double-blind comparison of alprazo-lam, diazepam and placebo in the treatment ofanxious out-patients, 37S
DAWLING, S. see COOK, P. J.DAWLING, S. see CROME, P.DAWSON, M. & WATSON, T. R. The effect of dose formon the bioavailability of mebendazole in man, 87
DAWSON, M., BRAITHWAITE, P. A., ROBERTS, M. S. &WATSON, T. R. The pharmacokinetics andbioavailability of a tracer dose of [3H]-mebendazolein man, 79
DAY, R. see LEE, E. J. D.DAYA, S. see VENTER, C. P.DEBBAS, N. M. G., JACKSON, S. H. D., & TURNER, P. A
study of the haemodynamic effects of nicardipineinfusion in man, 563P
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DUBACH, U. C. see STOECKEL, K.DUKA, T H. see KLOTZ, U.DUNAGAN, F. M., KELMAN, A. W., MCGILL, P. E. &WHITING, B. Estimation of the NSAID concentra-tion-effect relationship in rheumatoid arthritis,548P
DUNDEE, J. W., WILSON, C. M., ROBINSON, F. P.,THOMPSON, E. M. & ELLIOTT, P. The effect of raniti-dine on the hypnotic action of single doses of mida-zolam, temazepam and zopiclone, 553P
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EHSANULLAH, M., LEE, D. A. H., WILLIAMS, T., POL-LARD, P. & GAZZARD, B. The effect of secoverinehydrochloride on stimulated sigmoid motility: adouble-blind, placebo controlled cross-over study inirritable bowel syndrome, 301
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EVALDSON, G. R., LINDGREN, S., NORD, C.-E. &RANE, A. T. Tinidazole milk excretion and pharma-cokinetics in lactating women, 503
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EVARD, D. see GODBILLON, J.EVARD, D. see VIDON, N.EWEN, S. W. see NYEMITEI-ADDO, I.
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FAIRRIS, N. see FAIRRIS, G. M.FARA, J. W., MYRBACK, R. E. & SWANSON, D. R.
Evaluation of oxprenolol and metoprolol Oros sys-
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FARQUHARSON, R. G. see DAVISON, K.FARROW, P. R. see McBURNEY, A.FEE, J. P. H., MCCLEAN, E., COLLIER, P. S. & DUNDEE,
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FEELY, J. see MacWALTER, R. S.FEELEY, M. see PRICE, D.FEIG, P. U. see CHAPRON, D. J.FERGUSON, I. see GUAY, D. R. P.FERRERO, E. see PERUCCA, E.FEYERABEND, C., INGS, R. M. & RUSSELL, M. A. H.
Nicotine pharmacokinetics and its application tointake from smoking, 239
FIFIELD, R. A. see LEOPOLD, D.FILE, S. E. & LISTER, R. G. A comparison of the effects
of lorazepam with those of propranolol onexperimentally-induced anxiety and performance,445
FINCH, M. B. & JOHNSTON, G. D. The acute peripheralvascular effects of diltiazem in man-dose-responsecharacteristics, 131P
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treatment of angina pectoris in patients with chronicobstructive airways disease, 150P
FINDLAY, I. N., DARGIE, H. J., GILLEN, G. & ELLIOTT,A. T. Effects on cardiac function, heart rate andblood pressure during combination therapy withverapamil and atenolol, 565P
FITZHARRIS, P., MCLEAN, A. E. M., SPARKS, R. G.,WEATHERLEY, B. C., WHITE, R. D. & WOOTTON, R.The effects in volunteers of BW12C, a compounddesigned to left-shift the blood oxygen saturationcurve, 471
FITZSIMMONS, C. see BRODIE, M. J.FLASKOS, J., GEORGE, A. J. & THEOPHILOPOULOS, N.
Platelet 5-HT uptake in obsessional neurosis andneurotic depression, 556P
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Index 867FRY, J. R. see KAMALI, F.FURLANUT, M., MONTANARI, G. & RUSCA, F. Possible
interaction between aminophylline and ascorbicacid, 528L
GABRIEL, R. see HOUGHTON, G. W.GAIN, R. see CROME, P.GALLOWAY, D. B. see O'CONNOR, P. C.GARD, P. R. see RYLANCE, G. W.GAZZARD, B. see EHSANULLAH, M.GEANEY, D. P. see SCHACHTER, M.GEORGE, A. J. see FLASKOS, J.GERARDIN, A. see GODBILLON, J.GERBER, P. P. see EDWARDS, R. H. T.GHIRHARDI, P., BRUSONI, B., MANGIAVACCHI, M.,BIANCO, L., COL, J., METRA, M. & DEI CAS, L.Acute haemodynamic effects of ibopamine inpatients with severe congestive heart failure, 613
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GODBILLON, J., GERARDIN, A., RICHARD, J., LEROY,D. & MOPPERT, J. Osmotically controlled-delivery ofmetoprolol in man: in vivo performance of Orossystems with different durations of drug release,213S
GODBILLON, J. see EVARD, D.GODBILLON, J. see JOBIN, G.GODBILLON, J. see VIDON, N.GOLDHILL, D. R. see WALDMANN, C. S.GOLDIE, C. see MaCPHEE, G. J. A.GOMEZ, H. J. see BERGSTRAND, R.GOOD, W., LEESON, L. J., ZAK, S. L., WAGNER, W. E.,MEEKER, J. B. & ARNOLD, J. D. Oros controlled-release formulations of metoprolol: an approach tothe development of a system for once daily adminis-tration, 231S
GOOD, W. see WARRINGTON, S. J.GOODWIN, B. see BOYCE, M.GORDON, J. see FLEISS, P. M.GORGOLEWSKA, G. see KILFEATHER, S. A.GOSDEN, B. see BEST, N. R.GOSDEN, B. see COWEN, P. J.GOSDEN, B. see NuTr, D. J.GRAHAM, B. R. see TOMLINSON, B.GRAHAM, B. R. see WALDEN, R. J.GRAHAM, D. see JAMIESON, M. J.GRAHAM, G. see LEE, E. J. D.GRAHAME-SMITH, D. G. see COWEN, P. J.GRAHAME-SMITH, D. G. see SCHACHTER, M.GRAINGER, S. L., JOHN, V. A., SHOTTON, P. A. &
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GRIGGS, R. C. see EDWARDS, R. H. T.GRIMMER, S. F., BACK, D. J., ORME, M. L'E., COWIE,
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SMITH, H. & LIGHT, B. Mexiletine clearance duringperitoneal dialysis, 857
GUITTARD, G. see THEEUWES, F.
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HALSEY, A. see WOODS, K. L.HAMILTON, C. A. see SELLERS, E. M.HAMILTON, M. J., BARBER, H., BURKE, C., LETLEY, E.OWEN, R. & PECK, A. W. Antihistamine drowsiness:effects of triprolidine and BW825C on repeatedadministration, 585P
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HARRON, D. W. G. see ARNOLD, J. M. 0.HARRON, D. W. G. see NICHOLLS, D. P.HARRON, D. W. G. see O'CONNOR, P. C.HARRON, D. W. G. see RIDDELL, J. G.HARRY, J. see ROBB, 0. J.HARVEY, J. N., WORTH, D. P., BROWN, J. & LEE, M. RThe effect of oral fenoldopam (SKF 82526-J), aperipheral dopamine receptor agonist, on bloodpressure and renal function in normal man, 21
HARVEY, J. N., WORTH, D. P., CREGREEN, R. & LEE,M. R. Fenoldopam (SKF 82526), a dopaminergicvasodilator: studies in essential hypertension, 143P
HARVEY, J. N. see WORTH, D. P.HASSAN, S. M., WAINSCOTr, G. & TURNER, P. A com-
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HAWKSWORTH, G. M. see NYEMITEI-ADDO, I.HAXHOLDT, 0. see LoFr, S.HAYES, P. C. see SHEPHERD, A. N.HEAPY, C. G. see O'NEILL, P. A.HEAZLEWOOD, V. J. see Ho, P. C.
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HENNES, U. see STOECKEL, K.HEPTINSTALL, S. see COWLEY, A. J.HERLITZ, H. see BERGSTAND, R.HILL, T. W. K. see MacLEOD, D.HIRTZ, J. The gastrointestinal absorption of drugs inman: a review of current concepts and methods ofinvestigation, 77S
HIRTZ, J. see EVARD, D.HIRTZ, J. see GODBILLON, J.HIRTZ, J. see JOBIN, G.HIRTZ, J. see VIDON, N.Ho, P. C., TRIGGS, E. J., BOURNE, D. W. A. &HEAZLEWOOD, V. J. The effects of age and sex onthe disposition of acetylsalicylic acid and its meta-bolites, 675
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HODSMAN, G. P. see CLELAND, J. G. F.HODSON, M. E. see STEAD, R. J.HOLGATE, A. M. & READ, N. W. Metoclopramide
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HOLTKAMP, A. see JONKMAN, J. H. G.HOMEIDA, M. A. & DANESHMEND, T. K. Antipyrinemetabolism in hepatocellular carcinoma, 570P
HONG, C. Y., CHIANG, B. N., Ku, J., WEI, Y. H. &FONG, J. C. Calcium antagonists stimulate spermmotility in ejaculated human serum, 45
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HORNBY, E. J. see THOMAS, M.HOROWITZ, M., COLLINS, P. J., TUCKWELL, V.,VERNON-ROBERTS, J. & SHEARMAN, D. J. C. Fen-fluramine delays gastric emptying of solid food, 849
HOROWITZ, M. see MADDERN, G. J.HOUGHTON, G. W., DENNIS, M. J. & GABRIEL, R.
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JACK, D. B., KENDALL, M. J., LAUGHER, S. J. & SMITH,S. R. Reproducibility of oxprenolol plasma concen-
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JACK, D. B. see WOODS, K. L.JACKSON, B. see LARMOUR, I.
JACKSON, N. C., SILKE, B., LEE, P. HAFIZULLAH, M.,VERMA, S. P., REYNOLDS, G. & TAYLOR, S. H. Dose-response studies with a transdermal formulation ofnitroglycerine in angina pectoris, 561P
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Index 869nolol and digoxin on the acute vascular responses tofrusemide in normal man, 417
JOHNSTON, G. D., FINCH, M. B. & SHANKS, R. G.Peripheral vascular effects of bufuralol in normalsubjects and hypertensive patients: a comparisonwith propranolol and pindolol, 537P
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JONKMAN, J. H. G. see BLANCHARD, J.JOUBERT, J. R. see SHEPHERD, E. G.JOUBERT, L. see COELHO, J.JOUBERT, P. H. see COELHO, J.JOUBERT, P. H. see VENTER, C. P.JUHL, R. P. see KROBOTH, P. D.JURIMA, M., INABA, T., KADAR, D. & KALOW, W.
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KAMALI, F. see FRY, J. R.KAMPHUISEN, H. A. C. see BREIMER, D. D.KAPLAN, H. L. see SELLERS, E. M.KAUFMANN, B. see STAIGER, CSC.KAYE, C. M., MITCHELL, P. & STANLEY, C. A simpleand sensitive reverse-phase h.p.l.c. method for thespecific assay of pipothiazine in plasma, 576P
KELLY, J. G., SALEM, S. A. M., KINNEY, C. D.,SHANKS, R. G. & McDEVITr, D. G. Effects of raniti-dine on the disposition of metoprolol, 219
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870 IndexKERR, F. A. & SZABADI, E. Comparison of the effects
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KHAN, M. C. see DAVISON, K.KHANNA, S. see THEEUWES, F.KILFEATHER, S. A., GORGOLEWSKA, G., DAVIES, I. B.& TURNER, P. Elevated lymphocyte 3-adrenoceptordensity in multiple system atrophy with associatedsympathetic degeneration, 128P
KIM, Y.-Y., HOLGATE, S. T. & CHURCH, M. K. Inhibi-tion of histamine release from dispersed human lungand tonsillar mast cells by nicardipine and nifedi-pine, 631
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LEE, D. A. H. see EHSANULLAH, M.LEE, E. J. D., WILLIAMS, K., DAY, R., GRAHAM, G. &CHAMPION, D. Stereoselective disposition of ibu-profen enantiomers in man, 669
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LEROY, D. see GODBILLON, J.LETLEY, E. see HAMILTON, M. J.LEWIS, R. V., JACKSON, P. R. & RAMSAY, L. E.Measuring side-effects of 13-adrenoceptor blockers:a comparison of two methods, 136P
LEWIS, R. V., JACKSON, P. R. & RAMSAY, L. E.Measuring side-effects of ,B-adrenoceptor receptorantagonists: a comparison of two methods, 826
LEWIS, R. V., JACKSON, P. R. & RAMSAY, L. E. Phar-macokinetics and pharmacodynamics of nifedipineand debrisoquine oxidation phenotype, 562P
LEWIS, R. V., JACKSON, P. R. & RAMSAY, L. E. Side-effects of 3-adrenoceptor blocking drugs assessedby visual analogue scales, 255
LEWIS, R. V., JACKSON, P. R. & RAMSAY, L. E. Why dosome hypertensive patients feel unwell? 562P
LEWIS, R. V., LENNARD, M. S., JACKSON, P. R.,TUCKER, G. T., RAMSAY, L. E. & WOODS, H. F.Timolol and atenolol: relationships betweenoxidation phenotype, pharmacokinetics andpharmacodynamics, 329
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MacLEOD, D., WATHEN, C. G., TUCKER, L., MUIR,A. L. & HILL, T. W. K. Felodipine, a potent calciumantagonist for use in hypertension, 535P
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MELANDER, A. see NITELIUS, E.MERDJAN, H., BAUMELOU, A., DIQUET, B., CHICK, 0.& SINGLAS, E. Pharmacokinetics of ornidazole inpatients with renal insufficiency influence of haemo-dialysis and peritoneal dialysis, 211
MEREDITH, P. A., KELMAN, A. W., ELLIOTT, H. L. &REID, J. L. Trimazosin effect modelling: an alterna-tive approach, 141P
MEREDITH, P. A., ELLIOTT, H. L., KELMAN, A. W. &REID, J. L. Doxazosin concentration-effect rela-tionships, 541P
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MORrrz, J. see DUSING, R.MORRISON, L. see SHEPHERD, A. N.MORRISON, P. J. see BRADBROOK, I. D.MORRISON, R. see O'BRIEN, P. M. S.MORSE, D. S. see ABERNETHY, D. R.MORTON, P. B. see O'NEILL, P. A.MOUTON, W. see SHEPHERD, E. G.MUIR, A. L. see MacLEOD, D.MUIR, S. E. see BRODIE, M. J.MULLANE, J. see COELHO, J.MULLER, F. B., ALLSOPP, L. F., COOPER, G. L., BOLLI,
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NUNN, B., BAIRD, A. & CHAMBERLAIN, P. D. Effect oftemocillin and moxalactum on platelet responsive-ness and bleeding time in normal volunteers, 568P
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NYBERG, G. Anti-anginal and anti-ischaemic effects(immediate and 1 and 3 h post-dose) of sublingual,buccal and transdermal nitroglycerine, 559P
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Methods of assessing potential risk of sedative drugsto drivers, 127P
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Hospital outpatients: who knows what drugs theyare taking, 586P
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Index 873RACINE-POON, A. & MOPPERT, J. Concentration-effect
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RALSTON, D. see MacPHEE, G. J. A.RAMAGE, J. K., DENTON, A. & WILLIAMS, J. G. Inhi-
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Rrrz, R. see MOLLER, F. B.ROBB, 0. J., PETRIE, J. C., WEBSTER, J. & HARRY, J. ICI
118551 does not reduce BP in hypertensive patientsresponsive to atenolol and propranolol, 541P
ROBERTS, C. J. C. see CHANNER, K. S.ROBERTS, C. J. C. see ENE, M. D.ROBERTS, M. S. see DAWSON, M.ROBERTSON, J. I. S. see CLELAND, J. G. F.ROBINSON, F. P. see DUNDEE, J. W.ROBINSON, J. see MCINNES, G. T.ROBINSON, P. see VANDENBURG, M. J.ROBINSON, P. J. see VANDENBURG, M. J.ROGERS, H. see BENNETT, P. N.ROGERS, H. J. see BRADBROOK, I. D.ROGERS, S. M. see BACK, D. J.ROGERSON, M. E. see HOLT, D. W.
874 IndexRONGIER, M. see VIDON, N.RossINI, A. see TERRUZZI, J.ROUTLEDGE, P. A. see Buss, D. C.ROUTLEDGE, P. A. see DAVIS, D.ROUTLEDGE, P. A. see EL-BAHIE, N.ROUTLEDGE, P. A. see LEOPOLD, D.ROUTLEDGE, P. A. see WATT, A. H.ROWLAND, M. see CHAN, E.RUSCA, F. see FURLANUT, M.RUSSELL, N. J. W. see O'NEILL, P. A.RurrER, N. see EVANS, N. J.RYLANCE, G. W., GARD, P. R. & EDWARDS, C.
Steady-state carbamazepine 10, 1 1-epoxide concen-trations in children, 126P
SALEM, S. A. M. see KELLY, J. G.SAMARASINGHE, H. T. see CHAN, K.SANDBERG, T. W. H. see KLEINBLOESEN, C. H.SANDERS WILLIAMS, R. see MCCLEOD, A. A.SANDLER, M. see BOYCE, M.SANDLER, M. see LITTLEWOOD, J. T.SAkWE, J., KAGER, L., SVENSSON, ENG, J.-O., & RANE,A. Oral morphine in cancer patients: in vivokinetics and in vitro hepatic glucoreduction, 495
SAWERS, S. J. A. see BLANCHARD, J.SCAVONE, J. M. see GREENBLATT, D. J.SCHACHTER, M., GEANEY, D. P., GRAHAME-SMITH,D. G., COWEN, P. J. & ELLIOTT, J. M. Increasedplatelet membrane [3H]-LSD binding in patients onchronic neuroleptic treatment, 453
SCHARSCHMIDT, L. A. see RrITER, J. M.SCHEMUTH, R. see BRINKMANN, M.SCHEURLEN, M. see ANTONIN, K.-H.SCHNELLE, K. see COELHO, J.SCHOELLER, J. P. see EVARD, D.SCHOELLER, J. P. see GODBILLON, J.SCHOELLER, J. P. see JOBIN, G.SCHOELLER, J. P. see LECAILLON, J. B.SCHOELLER, J. P. see VIDON, N.SCHOENMAKER, R. see JONKMAN, J. H. G.SCOBIE, G. see BRODIE, M. J.SCOTT, A. K., CANNON, J. & BRECKENRIDGE, A. M.Lack of effect of influenza vaccination on warfarinin healthy volunteers, 144P
SCHWARTZ, J. B., ABERNETHY, D. R., TAYLOR, A. A.& MITCHELL, J. R. An investigation of the cause ofaccumulation of verapamil during regular dosing inpatients, 512
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SENIOR, J. see CLAYTON, J. K.SHADER, R. I. see ABERNETHY, D. R.SHADER, R. I. see GREENBLATT, D. J.SHAFFER, J. L. & HOUSTON, J. B. The effect of rifampi-
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SHAFFER, J. L., PLEUVRY, B. J., DAVIES, D. S. &MURRAY, S. A comparison ofstandard and sustainedrelease clonidine with respect to plasma concen-tration and blood pressure changes, 524L
SHAND, D. G. see DAVIS, D.SHAND, D. G. see McLEOD, A. A.
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Differences in haemodynamic effects of nicardipineand verapamil in coronary heart disease, 539P
SILKE, B. see JACKSON, N. C.SILKE, B. see TAYLOR, S. H.SILKE, B. see VERMA, S. P.SILVER, M. R. see KROBOTH, P. D.SIMS, A. C. P. Neurotic illness: conserving a
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SKEHAN, J. D., ARR, S. & VANDENBURG, M. J.Attenuation of hydralazine tachycardia bymethyldopa, 134P
SNAITH, R. P. & TAYLOR, C. M. Rating scales fordepression and anxiety: a current perspective, 17S
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SORKIN, M. I. see KROBOTH, P. D.SOTANIEMI, E. A. see PELKONEN, 0.SOWEMIMO-COKER, S. O., KOVACS, I. B., KIRBY,
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SPALDING, D. J. see MYEMrrEI-ADDO, I.
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STANIFORTH, D. H. Correction equation for QTinterval, 862L
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STEGMEIER, K. see STAIGER, CSC.
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STRUTHERS, A. D., BROWN, M. J., ADAMS, E. F. &DOLLERY, C. T. The plasma noradrenaline andgrowth hormone response to a-methyldopa andclonidine in hypertensive subjects, 311
STRUTHERS, A. D. see BROWN, M. J.STRYDOM, W. J. see VENTER, C. P.
STUMP, K. see BEST, N. R.STUMP, K. see NuTr, D. J.SUGERMAN, A. A. see CREASY, W. A.SUMNER, D. J. see KELMAN, A. W.SURI, A. C. see CROME, P.
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Index 875TAYLOR, S. H. see JACKSON, N. C.TAYLOR, S. H. see SILKE, B.TAYLOR, S. H. see VERMA, S. P.TEASDALE, E. see BRODIE, M. J.TEE, L. B. G., SEDDON, T., BOOBIS, A. R. & DAVIES,D. S. Drug metabolising activity of freshly isolatedhuman hepatocytes, 279
TEE, L. B. G. see BOOBIS, A. R.TEMPLE, D. M. see HUGHES, J. M.TEOH, R. see CHAN, K.TERRUZZI, V., MINOLI, G., TADEO, G., NESPOLI, M. &
ROsSINI, A. The influence of cimetidine and rani-tidine on the plasma lipid pattern, 846
THEEUWES, F., SWANSON, D. R., GUITTARD, G., AYER,A. & KHANNA, S. Osmotic delivery systems for theP-adrenoceptor antagonists metoprolol and ox-
prenolol: design and evaluation of systems for once-daily administration, 69S
THEOBALD, W. see JOHN, V. A.THEOPHILOPOULOS, N. see FLASKOS, J.THIEN, TH. see SMIrS, P.THOMAS, M., LUMLEY, P., HORNBY, E. J. A study to
investigate the effects of a novel thromboxanereceptor blocking drug AH 23848 on plateletaggregation ex vivo in man, 123P
THOMAS, M., MICHAEL, M., CHILTON, A., FOWLER, P.,MACONOCHIE, J. G. & WOODS, J. Effect of higherdoses of ranitidine on antipyrne metabolism inman, 543P
THOMPSON, E. M. see DUNDEE, J. W.THOMPSON, G. G. see MCINNES, G. T.THOMSON, G. D. see MCINNES, G. T.TILL, A. E. see McNABB, W. R.TJIA, J. see GRIMMER, S. F.TjIA, J. see WINSTANLEY, P. A.TOMLINSON, B., CRONIN, C. J., GRAHAM, B. R., SMITH,
C. C. T. & PRICHARD, B. N. C. Haemodynamics andpharmacokinetics of carvedilol (BM 14,190), 566P
TONER, J. M. & RAMSAY, L. E. Pharmacokinetics ofpotassium chloride in wax-based and syrup forms,145P
TONER, J. M. & RAMSAY, L. E. Pharmacokinetics ofpotassium chloride in wax-based and syrup formu-lations, 489
TRIGGS, E. J. see Ho, P. C.TRUEB, V. see STOECKEL, K.TUCKER, G. T. see BAX, N. D. S.TUCKER, G. T. see MCGOURTY, J. C.TUCKER, L. see MacLEOD, D.TUCKWELL, V. see HOROWITZ, M.TURNER, P. see BENNETT, P. N.TURNER, P. see DEBBAS, N. M. G.TURNER, P. see HASSAN, S. M.TURNER, P. see KILFEATHER, S. A.TURNER, P. see MEKKI, Q. A.TURNER, P. see PASIC, J.TURNER, P. see SOWEMIMO-COKER, S. 0.
VAN BRUMMELEN, P. see KLEINBLOESEM, C. H.VAN DER BOON, W. J. V. see JONKMAN, J. H. G.VANDENBURG, M. J., ROBINSON, P., ARR, S. &COOPER, W. Effects of angiotensin convertingenzyme inhibition on the increase in serum potas-sium associated with exercise, 134P
VANDENBURG, M. J., ROBINSON, P. J., COOPER, W. D.,
876 IndexARR, S. M. & CURRIE, W. J. C. The effect of angio-tensin converting enzyme inhibition on plasma metenkaphalins at rest and on exercise, 567P
VANDENBURG, M. J. see SKEHAN, J. D.VAN FURTH, R. see OVERBOSCH, D.VAN'T LARR, A. see SMITS, P.VEDIN, A. see BERGSTRAND, R.VENTER, C. P., DAYA, S., JOUBERT, P. H. & STRYDOM,W. J. Ethnic differences in human lymphocyticcyclic AMP production after isprenaline stimulationand propranolol blockade, 187
VENTURA, L. see COELHO, J.VERGHESE, C. see WALDMAN, C. S.VERMA, S. P., SILKE, B. & TAYLOR, S. H. Haemo-dynamic dose-response effects of amrinone in leftventricular failure complicating myocardial in-farction, 540P
VERMA, S. P. see JACKSON, N. C.VERMA, S. P. see SILKE, B.VERMA, S. P. see TAYLOR, S. H.VERNON-ROBERTS, J. see HOROWITZ, M.VIDON, N., EVARD, D., GODBILLON, J., RONGIER, M.,DUVAL, M., SCHOELLER, J. P. & HIRTZ, J. Investi-gation of drug absorption from the gastrointestinaltract of man. II. Metoprolol in the jejunum andileum, 107S
VIDON, N. see EVARD, D.VIDON, N. see GODBILLON, J.VINTERSTEIN, G. see AVIRAM, M.VISCONTI, M. see PERUCCA, E.VOLO, G. see BRODIE, M. J.VON WTrr, R. J. see PETERSON, G. M.VOZEH, S. & FOLLATH, F. Influence of chronic dosingon theophylline clearance, 712L
WADDELL, G. see ENE, M. D.WAGNER, W. E. see GOOD, W.WAHLIN-BOLL, E. see NITELIUS, E.WAINSCOTT, G. see HASSAN, S. M.WALDEN, R. J., BHATrACHARJEE, P., GRAHAM, B. R.& PRITCHARD, B. N. C. Lack of antihypertensiveeffect of a new putative dopamine agonist (BK 34-530): a pilot study, 558P
WALDMANN, C. S., VERGHESE, C., SHORT, S. M.,GOLDHILL, D. R. & EVANS, S. J. W. The evaluationof domperidone and metaclopramide as antiemeticsin day care abortion patients, 307
WALKER, P. see BOYCE, M.WALLER, D. G., MIHINDUKULASURIYA, J. & WARREN,D. J. A comparison of the effects of intravenouspropranolol and nadolol on the renal response tohypertonic saline infusion, 37
WALSH, M. J. see MacMAHON, B.WARD, J. W. see McBURNEY, A.WARD, S. A., MIHALY, G. W., EDWARDS, G.,LOOAREESUWAN, S., PHulPS, R. E., CHANhAVANICH,P., WARRELL, D. A., ORME, M. L'E. &BRECKENRIDGE, A. M. Pharmacokinetics of prima-quine in man. II. Comparison of acute vs chronicdosage on Thai subjects, 751
WARD, S. A. see M:ALY, G. W.WARDLE, H. M. see WARRINGTON, S. J.WARRELL, D. A. see WARD, S. A.WARREN, D. J. see WALLER, D. G.WARREN, J. B., Cuss, F. & BARNES, P. J. Posture and
theophylline kinetics, 707
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WARRINGTON, S. J., BARCLAY, S. P., JOHN, V. A.,SHOTrON, P. A. & GOOD, W. Comparison of single-dose pharmacokinetic and pharmacodynamicproperties of two metoprolol Oros systems withdifferent initial zero-order release rates, 225S
WARRINGTON, S. J. see BENNETr, P. N.WARRINGTON, S. J. see WOODS, K. L.WARWICK, S. see POSNER, J.WATHEN, C. G. see MacLEOD, D.WATSON, T. R. see DAWSON, M.WATr, A. H., Buss, D. C., STEPHENS, M. R. &ROUTLEDGE, P. A. Amiodarone reduces plasmawarfarin clearance in man, 591P
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WILLIAMS, J. see EL-BAHIE, N.WILLIAMS, J. G. see RAMAGE, J. K.WILLIAMS, K. see LEE, E. J. D.WILLIAMS, P. 0. Wellcome Trust support for clinicalpharmacology in the UK, 116L
WILLIAMS, T. see ENSANULLAH, M.WILLIAMSON, P. J. see ENE, M. D.WILSON, C. G. see PATRICK, J. M.WILSON, C. M. see DUNDEE, J. W.WING, L. M. H., MINERS, J. 0. & LILLYWHITE, K. J.Verapamil disposition-effects of sulphinpyrazoneand cimetidine, 385
WINSTANLEY, P. A., ALLEN, W. L., TJIA, J., HOBSON,D., BRECKENRIDGE, A. M. & BACK, D. J. Lack ofeffect of highly purified subunit influenza vaccine ontheophylline metabolism, 569P
WOODS, H. F. see BAX, N. D. S.WOODS, H. F. see LEWIS, R. V.WOODS, H. F. see McGOURTY, J. C.WOODS J. see THoMAS, M.WOODS, K. L., JACK, D. B., KENDALL, M. J., HALSEY,
A., O'DONNELL, M. L., WARRINGTON, S. J. & JOHN,V. A. A multiple dose comparative study of the
Index 877pharmacodynamic and pharmacokinetic behaviour YAP, L. S. see NG, V. K. K.of polymer-matrix and Oros dosage forms ofoxprenolol in healthy volunteers, 177S ZAK, S. L. see GOOD, W.
WOOrTON, R. see FTHARRIS, P. ZAKRZEWSKI, J. T., BARNES, N. C., PIPER, P. J. &WORTH, D. P., AL-SHARMA, Y., HARVEY, J. N., COSTELLO, J. F. Quantitation of leukotrienes inHAINSWORTH, R. & LEE, M. R. Renal haemo- asthmatic sputum, 549Pdynamics and cardiac output in essential hyper- ZAKRZEWSKI, J. T., BARNES, N. C., PIPER, P. J. &tension: the effect of oral nadolol, 130P COSTELLO, J. F. Measurement of leukotrienes in
WORTH, D. P. see HARVEY, J. N. arterial and venous blood from normal and asth-WRIGHT, J. see ALDHOUS, M. matic subjects by radioimmunoassay, 574PWu, P. see HONG, C. Y.WYmNE, R. D. see WILKINS, M. R.
SUBJECT INDEX
(S = supplement; L = letter to the Editors; P = proceedings)
A51SU, 149PAcetazolamide, 363Acetylsalicylic acid
age and sex, 675dipyridamole, 379
Activated charcoalmefenamic acid, 836
Adenosine deaminase, 108Adenosineasthma 685
Adimolol, 142Pcardiovascular effects, 405
Adinazolam, 45Sac-adrenoceptor antagonists, 266a2-adrenoceptor, 534P, 555PP-adrenoceptor
density, 128Pmelatonin, 799
12-adrenoceptor, 534Pdesensitization, 587P
P-adrenoceptor agonists, 177, 534P, 619asthma, 787Ro31-118, 319side effects, 136P, 826
1-adrenoceptor blockers, 169, 255, 258, 411, 775,63S-212Sanxiety, 783depression, 557PISA, 588P
Affective disorders, 1S-62Salprazolam, 29S
Age, 140P, 261acetylsalicylic acid, 675oxaprozin, 373
Agonist activitypartial, 775
AH 23848, 123PAldosterone, 139PAldrin, 279Alprazolam, 21S, 37S, 45S, 51S, 57S
affective disorders, 29SAluminium hydroxide, 839Aminophylline, 528Amiodarone
warfarin clearance, 591PAmitriptyline, 295, 578P
binodaline, 592Ptyramine pressor test, 705, 829
Amoxicillin, 99, 191Ampicillin, 191Amrinone, 540PAnaerobic threshold, 13Angina pectoris, 150P
bepridil, 343Angiotensin II, 29, 139P, 335
Angiotensin converting enzyme inhibition, 134P, 353,567P, 605
AntiarrhythmicsClass III, 266
Antidepressants, 45SAntidotal efficacy
charcoal-drug ratio, 767Antiemetics, 307Antiepileptic drugs, 125PAntihistamine, 127P
drowsiness, 585PAntipyrine, 120P
clearance, 593, 698metabolism, 570P
Anti-sickling compound, 471Anxiety, 17S, 37S, 57S
carbachol, 817performance, 445, 783
ArthritisD-penicillamine, 557PNSAID concentration-effect, 548P
Ascorbic acid, 528Aspirin
midazolam, 581Pplatelet aggregation, 715
Asthma, 63102-adrenoceptor agonist, 787antigen-induced, 459
Asthmatics, 549Pleukotriene concentrations, 574P
Atenolol, 13, 138PICI 118551, 541Ptimolol, 429verapamil, 565P
Azathioprine, 105, 108Aztreonam, 233
pharmacokinetics, 509
Bayesian method, 546PBenzodiazepines, 95
central effects, 807depression, 31Spharmacokinetics, 649real life stress, 582Preceptor binding, 554Ptriazolam, 554P
Bepridil, 343Betaxolol, 138PBinodaline, 295, 592PBioavailability, 79, 87
oral contraceptives, 122Pprimaquine, 745
BK 34-530, 558PBlood pressure, 21, 114L
ambulatory, 129P
878
Index 879caffeine, 852
Blood-oxygen saturation curve, 471BM 13.177, 572PBM 14,190 (carvedilol), 566PBopindolol, 775Breast milk
aztreonam, 509disopyramide, 856tinidazole, 503
Breathlessnesschlorpromazine, 793
Bronchial carcinomametoclopramide, 757
Bronchoconstrictionadenosine, 685
Bucindolol, 132PBufuralol, 537PBufuralol 1'-hydroxylase
liver phenotyping, 721BW 12C, 471BW 825C, 585P
CSF concentrations, 161Caffeine, 225
decaffeinated coffee, 852sperm motility, 739
Calciumsperm motility, 739
Calcium antagonist, 45, 535PCalcium chelator, 45Calcium entry blockers, 631Calcium ionophore, 45Calmodulinsperm motility, 739
Cancermorphine, 495
Captopril, 29, 133P, 393Carbachol, 295
anxiety, 817Carbamazepine, 584PCardiac effects, 73Cardiac function, 129PCardiac output, 130PCarvedilol, 566PCatecholamines, 311blood pressure, 852
Cetamolol,-adrenoceptor blockade, 411
Charcoal-drug ratioantidotal efficacy, 767
Chlorpromazinebreathlessness, 793
CholesterolHDL, 846
Chronic dosing with theophylline, 712L, 713LChronic obstructive airways disease, 150PChronopharmacology
paracetamol, 843Ciclazindol
pupillary response, 639Cimetidine, 272plasma lipid pattern, 846verapamil disposition, 385
Circadian rhythmstheophylline, 707
Circadian variation, 147PClass III antiarrhythmic, 266Class experiment, 169Clearance methods, 29Clinical trials, 155Clonidine, 311
blood pressure, 524Coffee
cardiovascular effects, 852Collagenase dispersion, 279Congestive heart failure
ibopamine, 613Contraceptive steroids, 122PConverting enzyme, 29Coronary heart disease, 539PCoumarin 7-hydroxylase, 59Crystalluria, 191Cyclic AMP, 739
lymphocytic, 187Cyclosporin, 548PCystic fibrosis, 122PCytotoxicity assay, 102
Dazoxiben, 1Debrisoquine
depression, 8324-hydroxylase, 721hydroxylation, 832oxidation phenotype, 562Ppolymorphism, 547P
Deesterification, 701Delusions, 551PDepression, 17S, 31S, 557P, 57S
alprazolam, 31Sdebrisoquine, 832
Desipraminepupillary response, 639
Desmethylimipramine, 579Pmelatonin, 799
Dextropropoxyphene, 551PDiabetics, 121Pdomperidone, 441
Dialysismexiletine clearance, 857L
Diazepam, 51, 261, 37Smetabolism, 544Poral surgery, 582Pplasma concentrations, 581Pprotein binding, 587P
Diethylcarbamazine, 545PDigoxin vascular response, 417Diltiazam, 131PDipyridamole, 379
platelet aggregation, 715Disopyramide in breast milk, 856LDiuretics, 258Domperidone, 307
oesophageal emptying, 441Dopamine, 21, 5IPDopamine agonist, 558PDose-response, 605Doxazosin, 541PDrivers, 127PDrowsiness, 127PDrug absorption
880 Indexcolon, 113Sduodenum, 97Sfood, 119Sgastric function, 127Sileum, 107Sjejunum, 97S, 107Smetoprolol, 63S-212Soxprenolol, 63S-212Sstomach, 97S
Drug disposition, 385Drug interaction, 379, 385Drug metabolism, 279Drug release kinetics
Oros, 63S-212SDyspnoea, 575P
ECG time intervals, 860L, 861LECT, 551PEchocardiography, 435Elderly volunteers, 225, 233
acetazolamide, 363oxaprozin, 373
Enalapril, 140Pcongestive heart failure, 542Phypertension, 605liver status, 701met enkephalins, 567Prenal function, 353
Enalaprilat, 140PEnalaprilic acid (KM422), 701Enzyme inducing agents, 544PEnzyme inhibition, 589P
antipyrine clearance, 593lignocaine clearance, 597
Epigastric impedance, 151PEpinine, 143PErythromycin, 120PEthanol, 147P, 275, 551Ppropoxyphene, 398psychomotor effects, 578P
Ethinyloestradiol, 146Pbioavailability, 572P
Ethnic difference, 187mephenytoin, 483primaquine, 751
7-ethoxycoumarin, 279Ethylenediamine, 148PExaminations
anxiety, 783Exercise, 134P
chlorpromazine, 793Experimental infection, 657
Fatty acids, 335Felodipine, 535P(±)-fenfluramine, 849Fenoldopam, 21, 143PFlow rate, 67Fooddrug absorption, 119Soxprenolol, 191S
Formulation, 87Frusemide, 417
Gastric acid secretion, 9Gastric emptying 67
(±)-fenfluramine, 849Gastric function, 127SGastrointestinal absorption, 77SGenetic polymorphism, 483Glibornuride, 249Glipizide, 121PGlucoronidationmorphine, 495
Glucose, 249Growth hormone, 311Guanfacine, 534P
HI-receptor antagonist, 272Haemodialysis, 557P
omidazole, 211Haemodynamic effects, 539P
amrinone, 540Pcarvedilolmetoprolol, 239Snicardipine infusion, 563Ptocainide, 429transdermal nitrate, 560P
Heart rate, 1775-HT platelet uptake, 556PHuman hepatocytes, 279Human liver microsomes, 59Human mixed lymphocyte reaction, 105Hydralazine, 135P5-hydroxytryptamine
receptors, 453uptake, 126P
Hyoscine, 836Hypercholesterolaemia, 715Hypertension, 311, 535P, 562P
nadolol, 129Poxprenolol, 207S
Hypnotics, 649Hypoglycaemia, 121P
ICI 118, 551, 541Ptachycardia, 619
ICI 141, 292, 137PIbopamine, 143P
congestive heart failure, 613Ibuprofen stereoselection, 669Ileostomy
bioavailability, 572PImipramine binding sites, 555PIndirect immunofluorescence, 102Indocyanine green, 393Indomethacin, 459
ocular hypotensive effect, 523Indoramin, 266Influenza vaccination, 144P, 569PInsulin response, 249Interaction, 51, 99, 219Intestinal absorption, 67Intrinsic sympathomimetic activity, 588PIrritable bowel, 301Isoprenaline, 114L, 187LIsosorbide mononitrate, 393
J receptors, 575P
6-keto-prostaglandin Fl,, 459Ketotifen, 587PKineticsnoncompartmental analysis, 855Lverapamil, 512
L-644, 122, 550PLabetalol, 142P
heart rate, 405Leishmaniasis, 73Leucopenia, 102Leukotrienes
blood concentrations, 574Phuman uterus, 573Psputum, 549P
Levonorgestrel bioavailability, 572PLignocaine, 261, 589P
clearance, 597Liver blood flow, 393Liver
deesterification, 701phenotype, 721
Loprazolam 51anxiety performance, 445pharmacokinetics, 649
Lymphocyte, 534Pl32-adrenoceptor density, 587P, 588P
MEN 935, see AdimololMast cells, 631Mebendazole, 79, 87Mediator release, 711Mefenamic acid, 836Melatonin, 258
desmethylimipramine, 799oral administration, 517
Mephenytoin, 483Meptazinol, 551P6-mercaptopurine, 105Met enkephalins
enalapril, 567PMetabolism
age and sex, 675Metabolite, 91, 225Methotrexate, 569PMethoxamine pupillary response, 639Methyldopa, 134P, 311Metoclopramide, 67, 151P, 307
pharmacokinetics, 757Metoprolol, 219
absorption, 63S-212Sgastrointestinal absorption, 77Smetabolism, 547POros systems, 63S-212S
Metronidazole, 203Mexiletine clearance, 857LMianserin, 102Midazolam
ranitidine, 553Pserum binding, 581P
Misoprostol, 9Monitoring service, 693Morphine pharmacokinetics, 495Moxalactam, 568PMuscle protein synthesis, 124P
Index 881Muscular dystrophy, 124PMyelography, 161Myocardial infarction
tocainide, 429Myocardial oxygen consumption, 435
NSAID concentration-effect, 548PNadolol
hypertension, 129Poral, 130P
Nalbuphine, 580PNatriuresis, 423Neuroleptics
platelets, 453Neurotic depression, 556PNeurotic illness, 9SNicardipine, 536P, 539P
angiotensin II, 139Phaemodynamic effects, 563Phistamine release, 631pituitary hormone release, 139P
Nicotine, 239Nifedipine, 537P
debrisoquine oxidation phenotype, 562Phistamine release, 631natriuresis, 423pharmacokinetics, 562P
Nitrendipine, natriuresis, 423Nitroglycerin, 559P
posture, 403Ltransdermal, 435, 561P
Non-diuretic effects, 417Non-steroidal anti-inflammatory drugs, 155Non-compartmental analysis, 855LNoradrenaline, 534PNortriptyline
depression, 832
Obesity, 849Obsessional neurosis, 556POesophageal emptying, 441One-sample method, 698Oral contraceptive steroids, 572POrnidazole, 211Oros drug delivery systems 63S-212SOsmotic delivery systems, 63S-212SOut-patients, 37Sdrug therapy, 586P
Oxaprozin, 373Oxidation phenotype, 329Oxidation polymorphism, 721Oxiracetam, 577POxprenolol, 132POros systems, 63S-212Sconcentration-effect, 143Sdrug absorption, 137Sosmotic delivery systems, 63S-212S
Paracetamol, 113L, 590Ppharmacokinetics, 843probenecid, 590P
Paroxetine, 578Ptyramine pressor response, 705
Penbutolol, 120Pantipyrine clearance, 593
882 IndexD-Penicillamine, 557PPerceived exertion, 177Performance
anxiety, 445triazolam, 807
Peritoneal dialysis, 211PharmacodynamicsACE inhibitors, 140Patenolol, 329loprazolam, 649metoprolol 63S-212Stimolol, 329Ro31-118, 319oxprenolol 63S-212S
Pharmacokinetic interaction, 379Pharmacokinetics, 79, 91, 99
aztreonam, 233, 509diethylcarbamazine, 545Ploprazolam, 649metoclopramide, 757metoprolol 63S-212Smetronidazole, 203morphine, 495nicotine, 239ornidazole, 211oxaprozin, 373oxiracetam, 577Poxprenolol 63S-212Sparacetamol, 843parameter optimisation, 546Ppheneticillin, 657phenoxymethylpenicillin, 657potassium chloride, 145P, 489primaquine, 745, 751propoxyphene and ethanol, 398Ro31-118, 319tenoxicam, 249timolol and atenolol, 329tinidazole, 503tocainide, 429triazolam, 807, 839warfarin, 545P
Pheneticillin pharmacokinetics, 657Phenolsulphotransferase, 275Phenotype
liver, 721Phenoxymethylpenicillin
pharmacokinetics, 657Phenylephrine, 295, 405Phenytoin, 161
monitoring service, 693Physical activity, 177Pilocarpine
pupillary response, 639Pinacidil pyridine-N-oxide, 91Pinacidil, 91, 538PPindolol, 169, 537PPineal gland, 579P
melatonin, 799Pipothiazine, 576PPirenzepine
tyramine pressor test, 829Pituitary hormone release, 139PPlasma concentrations, 125PPlasma protein binding, 261
Platelet aggregation, 123Phypercholesterolaemia, 715
Platelet inhibition, 71%Platelet receptor binding, 554PPlatelets, 459human, 453temocillin and moxalactam, 568P
Post market surveillance, 21SPosture
theophylline, 707Potassium chloride, 145P
pharmacokinetics, 489Potassiumserum levels, 134P
Prednisone, 587PPregnancy toxaemia, 335Primaquine pharmacokinetics, 745, 751Probenecid, 590PProcainamide disposition, 858LProcaterol, 787Proceedings
University of Dundee, 119PUniversity of London, 533P
Promethazine, 793Propoxyphene, 51
ethanol, 398Propranolol, 13, 37, 120P, 138P, 169, 187, 537P, 538P
antipyrine clearance, 593anxiety performance, 445anxiety, 783bepridil, 343cardiovascular effects, 538Peffect comparison, 142Pheart rate, 405ICI 118551, 541Plignocaine clearance, 589P, 597vascular response, 417verapamil, 564P
Prostaglandin, 335El analogue, 9thiazolidine analogue, 550P
Protein binding, 161, 261theophylline, 529, 823
Psoriasis, 569PPsychomotor effects
zopiclone, 584PPsychomotor performance
carbamazepine, 584Ptemazepam, 583P
Psychotropic drugs, 152PPupil diameter, 295Pupillary response, 639Purine nucleoside phosphorylase, 108
OT time interval, 862L
Radioimmunoassayenalapril, 701
Ranitidine, 121P, 219, 553antipyrine metabolism, 543Pmediator release, 711Lplasma lipid pattern, 846procainamide disposition, 858L
Rating scales, 17SReceptor binding, 554P
Red cell deformability, 731Registration procedures, 155Renal disease
theophylline binding, 823triazolam, 839
Renal excretion, 191Renal failure, 203Renal function, 29, 37
enalapril, 353Renal haemodynamics
hypertension, 129, 130PRenal transplantation, 548PRenin, 335Reproducibility, 185SRespiratory gas exchange, 13Rifampicin, 526Ro 15-1788, 95Ro 31-1118, 319
S-9490-3, 132PSalbutamol, 787Salivation, 295Sclerosis, 731Secoverine, 301Sedative drugs
driving, 127PSeizure prophylaxis, 161Serum bindingmidazolam, 581P
Serum aztreonam, 509Sex, 675Short-term growth curve, 657Side effects, 177, 255
3-adrenoceptor agonists, 826nalbuphine, 580P
Sigmoid motility, 301SKF 82526, see FenoldopamSKF 82526-J, see FenoldopamSleep, 807Smoking, 239Sodium stibogluconate, 73Sperm motility, 45, 739Stanozolol, 124PStatistical methods, 155Steady-state accumulation, 512Stereoselective disposition, 669Sucralfate, 113LSulphasalazine, 526Sulphinpyrazone, 385Sweat glands, 295
carbachol, 817Symposia
Affective disorders, 1S-62SOros drug delivery systems, 63S-212S
Systolic time intervals, 536P
Tachycardia, 134PTemazepam
elderly women, 583Phalf-life, 587Poral surgery, 582Pranitidine, 553P
Temocillin, 568PTenoxicam, 249Theophylline, 99, 120P
Index 883administration, 125Pasthma, 685clearance, 712L, 713Linfluenza vaccine, 569Pposture, 707protein binding, 529
Thrombocytopenia, 1023-thromboglobulin, 45902-thromboxane, 459Thromboxane antagonist, 572PThromboxane synthetase inhibition, 1Time intervalECG correction, 860L, 861LQT correction, 862L
Timolol, 329hypotensive effect, 523
Tinidazolepharmacokinetics, 503
Tocainidehaemodynamic effects, 429
Tolerance, 272triazolam, 807
Transdermal nitrate, 560PTransdermal nitroglycerine, 435Transit time, 67
metoprolol, 77STrial size, 155Triazolam, 554P
pharmacokinetics, 839tolerance, 272
Trimazosin, 141PTriprolidine, 585PTyramine pressor response, 705, 829Tyramine pupillary response, 639
Urinary solubility, 191
Valium mixed micelles, 581PVascular effects, 131PVasoconstriction, 1Vecuronium, 552PVerapamil, 539
atenolol, 565Pdisposition, 385kinetics, 512propranolol, 564Psclerosis, 731
Viewdata, 21SVisual analogue scales, 255, 557P, 793
hypertension, 562Pside effects, 826
Warfarin, 144Pamiodarone, 591Pstereochemical aspects, 545P, 571
Wellcome Trust, support, 116L
Young volunteers, 225
Zero-order release rate, 225SZopiclone, 553Ppsychomotor effects, 584P
The British Journal of
Clinical Pharmacology
Volume 191985
Published forThe British Pharmacological Society byBlackwell Scientific Publications
( 1985 Blackwell Scientific PublicationsOsney Mead, Oxford OX2 OEL8 John Street, London WC1N 2ES23 Ainslie Place, Edinburgh EH3 6AJ52 Beacon Street, Boston, Mass. 02108, USA667 Lytton Avenue, Palo Alto, Calif. 94301, USA107 Barry Street, Carlton, Victoria 3053, Australia
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