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Innovation with Integrity

Eric Leonardis

Regional Sales Manager Western&Southern Europe

Bruker BioSpin, France

BeNeLux Users Meeting

Brussels, November 25th, 2016

Magnetic Resonance

At the Heart of our Company

• Committed to serve the MR community

• Continue to invest heavily in innovation with ~10% annual R&D investment

• Provide scientists with

• Cutting-edge innovations: e.g. GHz NMR technology, DNP-NMR

• Highest performance NMR, EPR, DNP, preclinical MRI instruments

• Drug discovery & development p plus QC tools for Biopharma

• High-value analytical solutions for Applied, Industrial & Clinical Markets: e.g. NMR FoodScreener, Avance™ IVDr, Minispec TD-NMR

• First-class global support and service, & after-market services: LabScape™

Innovation with Integrity

Bruker Announces René Lenggenhager as

BioSpin Group President

Innovation with Integrity

• Appointment of Dr. René Lenggenhager as President of the Bruker BioSpin Group, effective November 1st, 2015

• Since 2004, Dr. Lenggenhager has served as General Manager for Laboratory Weighing at METTLER TOLEDO (MTD).

• Very successful track record in sustainable, profitable growth with a focus on customers and innovation

Dr. René Lenggenhager combines academic and scientific qualification with international management skills.

Innovation with Integrity

• Inauguration of a new Prize to be awarded in an annual fashion at the European Magnetic Resonance (EUROMAR) conference

• Awarded to recognize recent beneficial applications of Magnetic Resonance going beyond fundamental research

• 2016 Ernst Prize committee: Profs. Lucia Banci (chair), Marina Bennati, Lucio Frydman, Robert Griffin, Wiktor Kozminski, Vladimir Sklenar, and Thomas Vosegaard

The Richard R. Ernst Prize in Magnetic Resonance

The Evolution of Magnetic Resonance

Productivity and Throughput

Bigger and Better New Applications

Innovation in

Magnetic

Resonance

Innovation with Integrity

Innovation with Integrity

• Active shielding reduces space requirements by > one order of magnitude

• Aeon 1 GHz magnets leverage advanced BEST superconductors

• Active refrigeration eliminates LN2, reduces LHe boil-off essentially to zero

New GHz-class magnet, novel CryoProbes, 111 kHz MAS probes, and

new NMR methods expand frontiers in structural biology, membrane protein and intrinsically disordered protein (IDP) research

World's first shielded Aeon 1 GHz installed

Aeon 1 GHz at Research Center for Bio-Macromolecules at University of Bayreuth

Solid-State DNP Spectrometer Gyrotron and Klystron Options

Work in Progress: 263 GHz Klystron

• Offer a lower-price more compact

microwave source at 263 GHz

• Design compatible with possible upgrade later to gyrotron for full power performance

• Power output ~ 5W

• Available 2017

DNP with Gyrotron

DNP with Klystron

(EIK)

Triple-Resonance 111kHz MAS 1GHz Probe Fully protonated 15N,13C Proteorhodopsin

Innovation with Integrity

Courtesy: Guido Pintacuda,

Daniela Lalli, ENS Lyon

Pharma: Shorter time-to-market

Drug Discovery

• New TS tools facilitate FBS data analysis

• Complete workflow: samplePro Tube, sampleJet, QCI/TCI, CMC_q & TS FBS tools!

Process Understanding and Optimisation

• Growing InsightMR family with InsightXpress & InsightEPR

• InsightXpress greatly streamlines Rxn optimisation, monitors decay t1/2=1s!

QC – Potency by qNMR

• One single experiment determines the amount of active ingredient in a drug

• Rapid, selective, reliable method that frees the expert from routine testing!

QC – Quantification of Components in Solid Mixtures

• Rapid, push-button, bench top: The minispect mq20 + Dynamics Center

• Quantifies components based on their t1 saturation recovery curve

Researcher sees this:

High Field ‘Benchtop’ NMR: Lab2NMR

The details:

Honey Profiling and updated Wine

Modules of the NMR FoodScreener™

• Authentication, fraud detection and labeling compliance enable brand protection, guarantee quality and protect investment and reputation of merchants

• Quickly gaining acceptance by global food analysis labs and honey-packers

• Stand-alone application modules further enhance ROI of our Food Screeners™

– Fam. Michaud Apiculteurs, MELI® first honey-packers to adopt novel NMR solution

– Wine module now includes extended coverage of regions in France, Italy and Spain

• Laboratory at Bruker for food authenticity and quality determination granted ISO/IEC 17025 accreditation

Innovation with Integrity

Preclinical Imaging Innovations New 3T Preclinical MRI System with Superior Cryogen-free Magnet and PET/MRI Option

• Novel, superior liquid cryogen-

free 3 Tesla magnet

• No liquid Helium or Nitrogen

filling required

• Magnet stays at field up to

4 hours during power or cold

water failure

• Upgradable to PET/MRI

Innovation with Integrity

LabScape™

Service and Life Cycle for Support Magnetic

Resonance & Preclinical Imaging

• New, flexible approach to life-cycle management, maintenance and service

• Maintenance, repair and upgrade agreements for NMR, EPR, MRI and other preclinical imaging product lines

• Reliable, optimal instrument performance

• Access to up-to-date expertise from trained engineers and applications scientists

More at bruker.com/LabScape

Innovation with Integrity

AVANCE Console Generations & Support

• AVANCE D*X: end of production 2000

• AVANCE I: end of production 2004

• AVANCE II: end of production 2006

• AVANCE III: end of production 2012

• AVANCE III HD: in production (since 2012)

AVANCE Console Generations & Support AVANCE II

• AVANCE II:

• 2016: 10 years end of production

• End of Service (EOS) January 2018, support on best effort at reasonable endeavour basis

www.TheResonance.com: A new look to a very successful site!

www.TheResonance.com

Innovation with Integrity

Announcement:

Free TopSpin™ Processing

www.bruker.com/FreeTopSpin

Innovation with Integrity

Download your free version today!

Sales and Service organization in Benelux Bruker BioSpin

Leiderdorp

Brussels

Sales

• Sales Manager : Marc Penders

• Sales engineer : Chu Sun Wong

Application/Training

• Henny Janssen

Service

• Michel Gilles (BE)

• Adri Schipper (NL)

• Henri van Etten (NL)

• Bert Van Zijl (NL)

Back-office in Brussels and Leiderdorp

Welcome to our Guest Speaker!

Innovation with Integrity

Dr. Alex De Groot

Janssen Pharmaceutica

Q2C-NMR: a new way of using NMR

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Innovation with Integrity

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