View
3
Download
0
Category
Preview:
Citation preview
O U R S T O R Y …
C. difficile in Long Term Care
Nadine Sitaram RN BScN Program Support NursePeel Long Term Care
April 2016
Introduction
• August 2015 Malton Village declared a unit specific outbreak of C. difficile
• Total of 5 cases
• 1 death
• No staff cases
• Outbreak declared over October 2015
Goal: Information Transfer
• Experience
• Challenges
• Impact
• Outcome
• Recommendations
• Next steps
Timeline of Events
• Index case: 65 year old male who has lived in our long term care facility for 11 years. He has a medical diagnosis of Type 2 DM, Schizophrenia, HTN, CVA, Hemiplegia and Vascular Dementia
• He resides on the 2nd floor of our facility
• Hospitalized April 12th, 2015 for urinary retention and diagnosed with a UTI, treated with a/b and returned to LTC
Timeline of Events
April 19, 2015
• Presented with loose stools, one week after antibiotics for UTI• Results positive for C. difficile toxin
May 1-5, 2015
• Transfer to hospital C. difficile enteritis, treated with Metronidazole & Ceftriaxone, return to LTC
June 1st, 2015 (Relapse)• Re-tested for C. difficile, positive result • Treated with Vancomycin for 10 days
July 3rd, 2015 (Relapse)• Re-tested for C. difficile, positive result • Treatment protocol restarted
July 18, 2015
• Becomes a case in respiratory outbreak
Outbreak Development
• August 1st – 12th, 2015
• 4 cases in the respiratory outbreak presented with frequent loose stools
• 3 of the 4 residents treated with antibiotics for a secondary pneumonia
• Stool collected:
• All results positive for C. difficile toxin
Declaring the OutbreakCase Number Date Symptom
Onset
Date Contact
Precautions Initiated
Date of Specimen
Collection
Date of C. Difficile
Isolation/Result
1 Relapsing;
July 1, 2015
July 1, 2015 July 4, 2015 July 7, 2015
2 July 30, 2015 July 30, 2015 August 4, 2015 August 5, 2015
3 July 30, 2015 July 30, 2015 August 4, 2015 August 5, 2015
4 August 4, 2015 August 4, 2015 August 6, 2015 August 7, 2015
5 August 9, 2015 August 9, 2015 August 10, 2015 August 11, 2015
August 14th, 2015:
C. difficile outbreak declared on 2nd floor unit
Case Control Measures
• Contact precautions and isolation
• Private room accommodation (4 out of 5)
• Affected residents received bed baths
• Dedicated equipment disinfected with sporicidal wipes
• Appropriate treatment of cases
Outbreak Control Measures
• Enteric outbreak measures
• Surveillance for new suspect and confirmed cases
• Appropriate and timely specimen testing
• Staff cohorted to cases
• Activation staff only 1:1 visits
• Appropriate and timely specimen testing
• Antimicrobial stewardship initiated by Medical Director
Communication and Education
• Daily staff education and review of outbreak minutes every shift
• review of PPE application/removal every shift and audits of staff and cleaning procedures daily all shifts
• family education and updates
Cleaning and Disinfection
• Increased frequency of environmental cleaning• Twice daily cleaning and disinfection of
case rooms and bathrooms • Use of sporicidal disinfectant in all rooms and
common areas• Double cleaning with sporicidal when
discontinuing precaution (terminal clean)• Additional environmental services staff
scheduled
Additional Control Measures
• Potential reservoirs of bacterial spores (i.e. live plants, upholstered furniture) were removed from the affected unit.
Challenges
Infection Control Audits
• Gastroenteritis outbreak audit
• Intense cleaning, hand hygiene and PPE audits were conducted
Infection Control Audits
Sporicidal Disinfectant
• Sporicidal cleaning agent not implemented with index case of active C. difficile NOR during onset of C. difficile outbreak
• We were utilizing 0.5% accelerated hydrogen peroxide based cleaner as per respiratory outbreak protocol, but not effective against C. difficile
• A 4.5 % hydrogen peroxide based cleaner and disinfectant purchased to eliminate C. difficile
Infection Control Audits
Cleaning and Disinfection
• Glow germ audits revealed high touch surfaces missed during cleaning routine
• Cleaning missed on various pieces of equipment revealed the need to review roles and responsibilities of nursing and housekeeping staff
• Re-education of all environmental services staff on high touch surfaces, use of friction, cleaning protocols, product use
Infection Control Audits
Personal Protective Equipment
• Staff and visitor compliance with proper PPE use
Hand Hygiene
• Use of resident sinks to wash hands
• Identified with staff the need to wash hands with soap and water in addition to using Alcohol Based Hand Rub (ABHR) at point of care
Infection Control Audits
Laundry Services
• Heavily soiled items were pre-cleaned on the unit increasing risk of contamination
• Review and address the handling and transporting of soiled laundry in the home area and to the laundry department
CLOTHING LINEN GARBAGE
Against all odds…
• Noted treatment failure in all 4 cases - no resolution of symptoms.
• Medical Director reached out to Medical Officer of Health for additional support and recommendations on treatment of cases
INNOVATIVE TREATMENT FOR C. difficile
FECAL MICROBIAL TRANSPLANTS(FMT)
Collaborative Efforts
• Outbreak Management Meeting with Peel Public Health and Malton Village representatives
• Referral made to Infectious Disease Specialist at William Osler Health System
• The attending physician connected with Infectious Disease Specialist, Dr. Lee at St. Joseph’s Health Care in Hamilton
Collaboration with Infectious Diseases Specialist
• Dr. Lee's research interests include optimal laboratory methods to diagnose and treat Clostridium difficile — associated diarrhea
• Dr. Christine Lee’s clinical focus:
• treatment of refractory Clostridium difficile
infection using fecal transplants
Collaboration with infectious disease specialist
• We began discussions to transfer the index case for a fecal transplant in Hamilton by Dr. Lee
• Dr. Christine Lee agreed to perform a fecal transplant on all 4 active cases IN HOUSE!!!
• Consents obtained from families
• Health history for cases sent to Dr. Lee
• Protocols implemented prior and post treatment
Fecal Microbial Transplants (FMT)
• The human gut contains trillions of bacteria
• The gastrointestinal microbiome (GIMb) may be considered an additional organ of the body
• When GIMb is disturbed, it is possible to restore normal function with FMT
• The first use of FMT dates back to Ge Hong 2000 years ago
Fecal Microbial Transplants
• FMT is a procedure which fecal matter is collected and tested from a donor, mixed with saline solution, strained and placed in patient, by colonoscopy, endoscopy, sigmoidoscopy or enema
• Purpose is to replace good bacteria that has been killed or suppressed by antibiotics-causing bad bacteria bad i.e. c. diff to over –populate the colon
Fecal Microbial Transplants
Pre-Treatment Preparation:
• Antibiotics are stopped 24 hours before the procedure
• Collection of stool specimens and confirm CDI
• Blood work analysis (WBC analysis)
Fecal Microbial Transplants
Treatment:
• A pre-filled syringe containing FMT liquid is inserted into the rectum
• Process takes less than 3 minutes
• Patient lies flat for 30-45 minutes
Fecal Microbial Transplants
Post- Treatment:
• Close monitoring of cases symptoms
• Daily Bristol stool scale
• Blood work monitoring every other day
• Do not resume antibiotic treatment
Post Treatment
• Some results in the first week
• 2nd treatment performed one week later
• Analysis of previous stool compared to present stool was done
Overall Impact - Residents
• Residents socially isolated – unable to participate in group activities
• Meals in rooms- deprived of the dining experience
• Loss of dignity
• Skin Breakdown- fecal incontinence
• Poor appetite, weight loss and general malaise
• Physical discomforts
Overall Impact - Families
• Additional stressor
- limited knowledge
- Increased visits - assistance during meals, and blood work
- Extra precaution /ensure their family’s safety
- Exhaustion due to the length of outbreak
- Anxiety re: new treatment proposed
- Impact of treatment
Overall Impact - Staff
• Low staff morale
• Fear of contracting C. difficile
• Staff exhaustion-workload issues for registered staff
• Staff under the microscope – auditing and enhanced cleaning
Financial Implications
• Outbreak declared August 14, 2015
• Outbreak declared over October 20th , 2015
• Total of 2158 hours of extra labor:
1634 hours – PSW
72 hours – Registered Practical Nurse
452 hours - Housekeeping
Other Costs
• Nursing Department:
• Cost of gowns, gloves, masks and disinfectant wipes in addition to weekly regular orders
• Approximately $5500
• Housekeeping Department:
• Disinfectant wipes, liquid and gel
• Approximately $4200
•Cost of supplies: appx $10,000
Lessons Learned
Lessons Learned
C. difficile in long term care
• Prevent Transmission of C. difficile
-Ensure new cases of C. difficile are managed
as per the PIDAC: Testing Surveillance and Management of Clostridium difficile guidelines
• Importance of Antimicrobial Stewardship program
Lessons Learned
C. difficile in long term care
• Develop department specific policies and procedures on C. difficile management based on PIDAC guidelines
• Staff education and training on facility’s policies and procedures
Lessons Learned
Outbreak Management • Report cases sooner to Public Health• Establish clear roles and responsibilities • Develop an outbreak communication plan • Increased focus on environmental cleaning, hand
hygiene and PPE audits• Review audit results and provide feedback to
frontline staff• Assign a delegate Infection Control Practitioner• Facility Service Supervisor complete Infection
Control program/course for environmental cleaning
Future Plans…
• Education blitz for all staff, extended education for environmental service staff
• Create and utilize an outbreak binder
• Designate for ICP in the building
• Review policies and procedures
Questions
Contributions
• Michelle Vadori RN, Infection Control Specialist Peel Public Health
• Dr. Joseph Niedoba Medical Directory, Malton Village Long Term Care
• Tessa George Director of Care, Malton Village Long Term Care
• Sharron-Lee Zizman RN, Malton Village Long Term Care
REFERENCES
PHAC (2013). C. difficile infection: Infection Prevention and Control Guidance for Management in LTC facilities. http://www.phac-aspc.gc.ca/nois-sinp/guide/c-dif-ltc-sld/index-eng.php
PHAC (2014). Fact sheet: C. difficile http://www.phac-aspc.gc.ca/id-mi/cdiff-eng.php
Public Health Ontario, Monthly Infectious Diseases Surveillance Report. Vol. 4, Issue 8. August 2015.https://www.publichealthontario.ca/en/DataAndAnalytics/Documents/PHO_Monthly_Infectious_Diseases_Surveillance_Report_-_August_2015.pdf
Infectious Disease Protocol Appendix A C. difficile http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/cdi_chapter.pdf
PHAC (2013). C. difficile infection: Infection Prevention and Control Guidance for Management in LTC facilities. http://www.phac-aspc.gc.ca/nois-sinp/guide/c-dif-ltc-sld/index-eng.php
PHAC (2014). Fact sheet: C. difficile http://www.phac-aspc.gc.ca/id-mi/cdiff-eng.php
PHAC (2014). Pathogen Safety Data Sheet: C. difficile. Retrieved from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/msds36e-eng.php
REFERENCES
Public Health Ontario. (2014). Reportable Disease Trends 2012: Chapter 10: Clostridium difficile infections (CDI) outbreaks. Retrieved from: https://www.publichealthontario.ca/en/eRepository/Reportable_Disease_Trends_in_Ontario_2012.pdf
Public Health Ontario. (2014). Reportable Disease Trends 2012: Chapter 10: Clostridium difficile infections (CDI) outbreaks. Retrieved from: https://www.publichealthontario.ca/en/eRepository/Reportable_Disease_Trends_in_Ontario_2012.pdf
Public Health Ontario. (2014). Reportable Disease Trends 2012: Chapter 10: Clostridium difficile infections (CDI) outbreaks. Retrieved from: https://www.publichealthontario.ca/en/eRepository/Reportable_Disease_Trends_in_Ontario_2012.pdf
Public Health Ontario. (2015). Reportable Disease Trends 2013: Chapter 11: Clostridium difficile infections (CDI) outbreaks. Retrieved from: https://www.publichealthontario.ca/en/eRepository/Reportable_Disease_Trends_in_Ontario_2013.pdf
References
Public Health Ontario, Monthly Infectious Diseases Surveillance Report. Vol. 4, Issue 8. August 2015. https://www.publichealthontario.ca/en/DataAndAnalytics/Documents/PHO_Monthly_Infectious_Diseases_Surveillance_Report_-_August_2015.pdf
Simor, A. (2010). Diagnosis, management and prevention of Clostridium difficile in Long Term Care Facilities: A Review. Journal of the American Geriatrics Society v. 58 (8) p. 1556-1564.
Infectious Disease Protocol Appendix A C. difficile http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/cdi_chapter.pdf
Public Health Ontario, Antimicrobial Stewardship
https://www.publichealthontario.ca/en/BrowseByTopic/InfectiousDiseases/AntimicrobialStewardshipProgram/Pages/Antimicrobial-Stewardship-Program.aspx
The Fecal Transplant Foundation 2016. http://thefecaltransplantfoundation.org/what-is-fecal-transplant/
Recommended