View
218
Download
3
Category
Tags:
Preview:
Citation preview
A Not So Simple UTI
Case ConferenceNovember 20th, 2012
Jiten Patel & Alisha Lacour
Headache X 1 week
Chief Complaint
49 year old woman with history of COPD and
nephrolithiasis (first diagnosed 2011) 4 Weeks ago:
She presented to an outside hospital with urinary symptoms, nausea, vomiting and flank pain.
HPI
4 Weeks ago:
Urine cultures showed mixed flora Sent home on ciprofloxacin Follow-up with urology.
She presented to the urology clinic 2-3 days later Clinically looked poor so she was admitted from the clinic
for: IV antibiotics Placement of stents for hydronephrosis.
She was sent home with ciprofloxacin and clindamycin Urine cultures drawn prior to discharge were negative. .
HPI
2 Weeks ago:
Followed up with urology Had successful laser ablation of the kidney stone
5 days ago: She presented to the an outside hospital complaining
of a headache Constant and aching Fluctuated in intensity from 8/10 to 10/10 No radiation Diffusely throughout the head No alleviating factors Worsened by light and sounds
HPI Continued
5 days ago (cont.):
CT showed a possible subarachnoid hemorrhage She was transferred to UH for neurosurgical
evaluation. She was admitted by neurosurgery and
observed in the ICU. A repeat head CT showed a stable subarachnoid
hemorrhage She was discharged home with follow-up.
HPI Continued
3 days ago
After being home for a few days she presented to UH with persistent headache.
Also complained of: Mild dysuria No increase in frequency or incontinence No flank pain Low grade fevers
HPI Continued
Kidney Stones
ESWL 2011 COPD
Past Medical History
Cystolithotomy 2005
Past Surgical History
Ciprofloxicin 500mg PO BID Oxycodone-Acetaminophin 5-325mg PO Q4-6
hours Tamsulosin 0.4mg PO QDay
Medications
Penicillin – swelling of extremities
Allergies
Father passed away from cardiac disease –
70’s Mother passed away from lung cancer – 60’s Siblings healthy Several family members with kidney stones
Family History
Smokes 1-2 packs per day for 35 years
Quit 3 weeks ago Denies any current alcohol use Denies any illicts Lives with her fiancé
Social History
Up to date on influenza immunization Up to date on pneumococcal immunization Up to date on Tetanus immunization Up to date on PAP Up to date on Mammogram No colonoscopy
Health Maintenance
Gen: No weight changes HEENT: no visual changes, sore throat,
rhinorrhea CV: Per HPI RESP: Per HPI GI: no N/V/D/C/melena/BRBPR Neuro: No dizziness, numbness, seizure Skin: no new rashes GU: Per HPI
ROS
Vitals
Triage BP 110/60 P 68 RR 18 T 99.2 O2 100%
on RA 5’6” 77kg BMI 27
Exam BP 125/79 P 61 RR 16 T 98.8 O2 98%
on RA
Physical Exam
GENERAL: Awake, alert, and oriented. No acute
distress. HEENT: The patient does have a hyperpigmentation
over her left eyebrow. Normocephalic, atraumatic. Mucous membranes are slightly dry. No papilledema.
CARDIOVASCULAR: Regular rate and rhythm. No murmurs
RESPIRATORY: Mild expiratory wheezing bilaterally. ABDOMEN: Bowel sounds present. Soft. Nontender.
Nondistended. EXTREMITIES: No clubbing, cyanosis, or edema.
Physical Exam
NEUROLOGIC:
Mental: Awake, alert, and oriented x4. Sensation intact to light touch. Reflexes are 2+ in biceps, triceps, patellar, ankle Strength is 5/5 bilaterally in the upper and lower
extremities. Cerebellar function intact to finger to nose and heel to
shin CN II-XII: EOMI intact, PERRLA, sensation intact to light
touch, raises eyebrows, closes eyes tight, symmetric smile, tongue midline, good palate elevation, phonation/cough intact, shoulder shrug appropriate
Physical Exam
Labs OSH (Day prior)
134 98 133.8 29 0.93 (24-32)
131
Ca 8.2 (8.4-10.3) Mg 1.6 P 2.1
TP Alb TB AST ALT ALP7.2 2.7 1.6 20 20 61 (3.5-5.0)(<1.3)
Received dose of Gentamicin
UA:SgpHProtGluKetBiliBloodNitriteUrobiliginLE
1.0107.025NegNegNeg25Pos4.0500
RBC 6-10 WBC >100Sq 20-100Bact ManyCasts 3-5 Hyaline
(4.5-11.0) 18.0 224
13.3
40.0
N 92 L 4 M 3
93
13.3
Labs Admit
134 102 134.0 26 0.9
150
Ca 8.5 Mg 1.6 P 2.1
Blood Cultures drawn
UA:SgpHProtGluKetBiliBloodNitriteUrobilLE
1.0117.025NegNegNeg25Neg8.0500
RBC 0-2 WBC 3-5Sq 1-2BactnegativeCasts 0
(4.5-11.0) 13.9 224
12.6
36.2
N 96 L 3 M 1
93
13.3
CT Head 2/18
CT Head 2/18
CT Head 2/18
CTA Brain (2/19)
CTA Brain (2/19)
CT Brain (2/24)
CT Brain (2/24)
LP
CSF Clear Glucose 12 Total Protein 100.4 WBC 198
SEGS 67% LYMPHOCYTES 33%
RBC 0 Gram Stain:
Many WBC’s Few Gram negative rods
Labs
Gram Stain
Gram Stain
Gram Stain
She was admitted:
Placed in respiratory isolation Treated with:
Dexamethasone Vancomycin Imipenem due to her penicillin allergy.
Her headache improved.
Hospital Course
Day 2:
Urine Cx from OSH: E. Coli >100,000 Resistant to Ciprofloxacin Susceptible to ticarcillin/clavulinate, ampicillin,
gentamicin, nitrofurantoin, piperacillin/tazobactam, ampicillin/sublactam, tetracycline, cefazolin
Intermediate to cephalothin Blood Cxs and CSF Cxs with
Gram negative rods
Hospital Coarse
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRI Brain
MRA Brain
MRA Brain
Day 3 of hospital course
She had a seizure sending her to the ICU Cause due to the carbapenem or meningitis
Neurology was consulted EEG done
Mild to moderate abnormality Diffuse slowing Excessive beta activity
Imipenem stopped and treated with gentamicin
Hospital Course
Repeat LP
Clear Glu 37 Pro 64 WBC 130
N 9% L 89% M 2% RBC 0 Gram Stain:
No Organisms
Hospital Coarse
Hospital Day 4
Initial Blood and CSF cultures : E. Coli CSF sensitive to aztreonam, ampicillin, piperacillin/tazobactam,
imipenem Blood sensitive with above and gentamicin, bactrim, cefazolin Blood resistant to ciprofloxicin, moxifloxicin
Antibiotics changed to aztreonam Somnolent from seizure
Hospital Day 6 Clinically improved Reported feeling the best she had in weeks Stepped down to the floor
Hospital Course
Hospital Day 7
Became more lethargic On call intern notified
Evaluated patient, noted papilledema STAT CT head Ordered
Hospital Course
CT Brain
CT Brain
CT Brain
CT Brain
CT Brain
CT Brain
CT Brain
Transferred back to ICU Neurosurgery Consulted Subdural Hematoma with midline shift Taken to the OR for emergent hemicraniotomy Mental status did not improve Family elected for palliative care Passed away
Hospital Course
Thank You
Recommended