ChemInform Abstract: A Novel and Highly Efficient Synthesis of the Aza Analogues of Tacrine

1999 fused pyridine derivatives

fused pyridine derivativesR 0450

40 - 128A Novel and Highly Efficient Synthesis of the Aza Analogues ofTacrine. — Analogues (II) and (IV) of tacrine, an acetylcholinetransferaseinhibitor with proven efficiency in the treatment of Alzheimer’s disease, aresuccessfully prepared by cyclization of the imines (I) via an anionically activatedtrifluoromethyl group. — (SMITH, LEON; KISELYOV, ALEXANDER S.;Tetrahedron Lett. 40 (1999) 31, 5643-5646; Small Mol. Drug Discovery, AmgenInc., Thousand Oaks, CA 91320, USA; EN)

ChemInform Abstract: A Novel and Highly Efficient Synthesis of the Aza Analogues of Tacrine

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