Comparison of Pulmonary Function Testing with Distribution ...apacity was adm cquired during a ......

Hoom

1RadioState

INTROobstrucstructuwith podiffusihumaneach grMETHtwentypAO2 asubject20% inpulse 8.3×8.3was dovalues=(6.25×Lung Cwere apAO2 aγADC) fcalculatailed Ain ordesmoker

RESUand ADand ADwere inof pAOobservcorrelaμpAO2 snot sho95% CaveragLung VFig.2. ResidubetweesmalleCONCphysioFEV1/F

Comparison

man Hamedani1, Ki

ology, University oes, 3Otolaryngolog

ODUCTION: Conctive and interstiti

ure. The use of hypotentially higher son coefficient (AD

n subjects and asymroup of measurem

HODS: Ten healty asymptomatic smand ADC MRI stts. pAO2 imaging nterslice gap, usin

sequence [Ham3×15.3mm3, TR/Tone using an interl=0,1.6 s/cm2 with 6.25×15.3mm3). ACapacity was admacquired during aand ADC mean (μfor each subject wated for each compANNOVA test waer to compare the rs and nonsmokers

Fig.2- The coULTS & DISCUS

DC maps for a repDC distributions fon the range of 102

O2 among all subjved between ADC ation between μADC

shows a significanow any correlation

CI: −0.73, −0.17), ge alveolar oxygenVolume (r = −0.5The mean values

ual Volume and Den the two groups st overlap and mo

CLUSION: Regiological relevance.FVC). The richer i

of PulmonaryCoe

arash Emami1, Ste

of Pennsylvania, Pgy - Head and Nec

U

nventional pulmonial lung diseases. perpolarized (HP) sensitivity. In this DC) of 3He obtainmptomatic smoker

ments in differentiatthy non-smokers

mokers (13 M, 53±tudies. Before MRwas performed o

ng an interleaved omedani et al.

TE=6.7/3.2ms, FOleaved diffusion-wsimilar imaging p

A normoxic mixtministered at end-ea 12-sec end-inspiμpAO2, μADC), dispewere compared toparison to relate thas performed on bo

sensitivity of MRs.

rrelation plots of PFTSION: Fig.1(a, b

presentative subjecor both groups. Th2.1±11.9 Torr andjects ranged over and pAO2 measur

C and γpAO2 (r = −0nt variability amonn with any of the Psuggesting that th

n tension. Skewnes7, P = 0.001, 95%of 3He ADC (μADC

DLCO. γADC also afor two key PFT

st discrimination ponal distributions . However specifiinformation embed

y Function Teefficient in Asyephen J. Kadlecek1

Philadelphia, PA, Uk Surgery, Johns H

United States, 5Med

nary function testsPFT however is cgas MRI has beenstudy we compareed with oxygen- ars to highlight undting the subject gr(5 F, 56±8 yrs.

±12 yrs., BMI=25RI session, PFT wover twelve 13-moxygen-weighted

MRM 2011] OV=30×40cm2, α=weighted gradient parameters except

ture of 3He:N2:O2

expiration in a siniratory breath-holdersion (σpAO2, σADC

PFT results. Peahe global values ooth PFT and MRI

RI and PFT param

T versus imaged pAOb) shows a represect from each grouphe overall pAO2 andd 0.22±0.04 cm2/s,

33.9±6.1 Torr. Nrement and their d0.37, P = 0.06). Asng all subjects. ThPFT metrics eitherhe heterogeneity oss of the pAO2 distr% CI: 0.27, 0.77).

C) showed a signifassociated with DL

metrics, and pAO2power between twoof oxygen tensio

ic MRI metrics, idded in regional lu

sting with Disymptomatic S1, Yi Xin1, Puttisar

Milton RossmUnited States, 2BioHopkins Universitydicine, University

s (PFT) provide a gconsidered to hav

n under investigatioed common PFT mand diffusion-weigderlying physiologoups and to evalua, BMI=27.3±6.6)

5.3±8.4) participatewas performed om coronal slices gradient echo ima

(spatial resolu=5˚) and ADC ima

echo sequence wit for spatial resolu based on 12% T

ngle breath and imd. Imaged whole-) and skewness (γ

arson’s coefficientf PFT with MRI. results for both gr

meters in differenti

O2 and ADC. entative coronal slip. Fig.1(c–f) summd ADC values for respectively. The

No apparent assocderivatives except s can be seen fromhe global averager. σpAO2 on the otheof pAO2 distributioribution also show

γpAO2 also correlaficant correlation wLCO (r = 0.52, P2 dispersion. Amono groups and its Pn and diffusivity including pAO2 disung measurements

stribution of Amokers Usingrn Mongkolwisetwman5, and Rahim Rological Basis of By, Baltimore, MD,of Pennsylvania, P

global measure ov

ve a poor sensitivion for probing botmeasurement with ghted HP gas MRIical relationships bate the potential of

and ed in n all with

aging ution aging ith b-ution Total

mages -lung γpAO2,

t was One-roups ating

ice of pAO2

marize pAO2 all subjects

e dispersion ciation was for a weak

m Fig.1(c,d), e pAO2 does er hand associates

on can be a more ws an interesting treated with Thoracicwith DL/VA (r = = 0.006, 95% C

ng all measuremen-value was significin lungs show to

spersion showed a therefore advocat

Fig.1- RepAO2 and respective

FiHP

Alveolar Oxygg Hyperpolariwara1, Biao Han1, HR. Rizi1

Behavior Program, United States, 4RaPhiladelphia, PA,

ver the entire lung ity for detecting loth microstructural distributions of al

I respectively. Thibetween the two mf MRI metrics as i

s with Maximum Fsensitive marker end as it significanc Gas Volume, Fo−0.65, P < 0.001,

CI: 0.15, 0.71). Finnts performed, σpAcantly less than ano have significantan even more distes their suitability

epresentative maps o3He ADC measurem

ely.

ig. 3- DiscriminationP MRI metrics.

gen Tension anized 3He MRI Harrison McAdam

, University of Penadiology, UniversUnited States

as a tool for diagnocalized, early or and functional asplveolar partial preis comparison wasmethods. We also imaging biomarker

Forced Expiratory to smoking-relatently correlates withorced Inspiratory F, 95% CI: −0.33, −nally Fig. 3 summAO2 (dispersion of ny other PFT meast correlations withscriminatory powey for further invest

of (a) pAO2 and (b) 3Hments in (c,d) healthy

n of smokers and non

nd Apparent D

ms2, Masaru Ishii3,

nnsylvania, Philadity of Virginia, Ch

nosis and monitorismall changes in

pects of lungs on aessure of oxygen (ps performed in twoattempted to assesrs in monitoring ac

Flow, FEFmax (r =ed changes in the h DL/VA - DiffusFlow and FEV1/F−0.84) and a weak

marized the resultsoxygen tension in

surements as well h key PFT metricer compared to gtigation as respirat

He ADC in a healthyy subjects and (e,f) as

n-smokers with key re

Diffusion

G. Wilson Miller4

delphia, PA, Unitedharlottesville, VA,

ing of a majority on lung function ana regional basis anpAO2) and appareno groups of healthss the sensitivity octive smokers...

= −0.51, P = 0.004lungs compared t

sion per unit area oFVC as is shown iker association wits of ANNOVA tesn the lungs) had thas ADC values. cs supporting the

gold standards (e.gtory biomarkers.

y subject. Summary osymptomatic smoker

epresentative PFT an

4,

d

of nd nd nt hy of

4, to of n

th st

he

ir g.

of s,

nd

3994Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)