Controlled Medicine Database - · XLS file · Web viewVAPI-396 195.(GUJARAT ),INDIA...

Opioid substitution therapy and morphine database

Disclaimer

Producer of controlled medicines (finished formulation)

Quoted price and treatment cost (per patient per year treatment)*

Producer and cost of active pharmaceutical ingredients

Reference Material

Inport and Export

*based on WHO recommended daily dose

This database provides information on two medicines (methadone and buprenorphine ) which are used for the treatment of opioid dependence, and morphine which is used for the relief of pain. These medicines are controlled substances under the international drug control conventions. These medicines are not available in many countries due to a range of issues, including the cost of medicines and difficulties with procurement. This database aims to raise awareness of current prices and sources of methadone, buprenorphine, and morphine in order to increase their availability.

Opioid substitution therapy with methadone and/or buprenorphine is an effective, evidence-based treatment for opioid dependence. It helps to reduce the transmission of HIV among injecting drug users. In 2005, WHO added methadone and buprenorphine to the WHO Model List of Essential Medicines.

The WHO/HIV Department, in collaboration with the WHO Department of Mental Health and Substance Abuse and the Department of Medicines Policy and Standards, is collecting information from the pharmaceutical companies producing and distributing methadone, buprenorphine, or morphine. This data includes, the available forms and formulations, procurement issues, registration procedures and prices. This database will provide countries and organizations purchasing these essential medicines with information to improve access to these medications.

Disclaimer

BuprenorphineMethadoneMorphine

Buprenorphine MethadoneMorphine

Reference Material

Export requirements

Disclaimer

Back to Introduction

WHO has compiled the data in the table below, however, the information represented in the tables has been provided and validated exclusively by the manufacturers. This information will be updated as new data becomes available, including WHO's six-monthly surveys. WHO has made every effort to ensure the accuracy of the information presented in this report, but the readers should bear in mind that this is a highly dynamic area, and that data can therefore never be complete. The data and information contained herein are being provided as received and WHO makes no representations or warranties, either expressed or implied, as to their accuracy, completeness or fitness for a particular purpose. WHO accepts no responsibility or liability with regard to the reliance on, or use of, such data and information. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by WHO in preference to others of a similar nature that are not specifically mentioned.

Reader’s attention is also drawn to the importance of quality assurance for pharmaceutical products. Licensing authorities in the countries of origin are expected to be responsible for the review and approval of the detailed composition and formulation when authorizing a pharmaceutical product to be marketed, including the specifications of its ingredients, as submitted by the manufacturer of the dosage form, and to oversee compliance with Good Manufacturing Practice requirements as recommended by WHO. Errors or omissions excepted, the names of proprietary products are distinguished by initial capital letters. The designations employed and the presentation of the material in this report, including tables, do not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

Companies producing buprenorphine, methadone and morphine as active pharmaceutical ingredients and/or finished formulation that are not represented in this database are encouraged to contact amds@who.int for the inclusion of their information in the database.

Buprenorphine ProducersManufacturer/Distributor Country/Address Generic Name Brand Name Remarks

ARROW Génériques 0.4 mg/tab 7 tablets France

2 mg/tab 7 tablets

8 mg/tab 7 tablets

Bedford laboratories 0.3 mg/ml 10x1ml

CTS Chemical Industries LTD Nopan 0.2 mg/tab 2x10 tablets Israel

5x10/tablets

Essex pharma GmbH TEMGÉSIC 0.2mg/tab 20 tablets 28 countries worldwide

TEMGÉSIC forte 0.4mg/tab 20 tablets 28 countries worldwide

Dosage Form

Strength (Concentration of Drug)

Base Unit of Measure

Companies/Countries purchasing product

France26, avenue Tony Garnier69007 LYONFrance0033 4 72 72 60 720033 4 72 72 60 70arrow@arrow-generiques.comhttp://www.arrow-generiques.com/

buprenorphine hydrochloride

BUPRENORPHINE ARROW cp subling (Subutex generic)

sublingual tablets

United States300 Northfield RoadBedford, OH 44146 U.S.A.Phone:(440) 232-3320Fax: (440) 232-6264 U.S.A. Ordering Number 1-800-562-4797Professional & Tech Support 1-800-521-5169bedfordlabs@cle.boehringer-ingelheim.com ; BedfordLabs_InternationalSales@cle.boehringer-ingelheim.com.http://www.bedfordlabs.com/

Buprenorphine Hydrochloride Injection (Buprenex)

liquid (injection)

IsraelHead office: 4 Haharash St.Hod-Hasharon 45240Tel. +972-9-7626333Fax. +972-9-7626300

sublingual tablets

GermanyThomas-Dehler-Straße 2781737 MünchenTelefon: +49 (0) 89 / 6 27 31 - 0 Telefax: +49 (0) 89 / 6 27 31 - 499 E-Mail: info@essex-pharma.de

Abteilung ArzneimittelsicherheitTelefon: +49 (0) 89 / 6 27 31 - 395bzw. 0800 / 6 27 31 - 395 Telefax: +49 (0) 89 / 6 27 31 - 380bzw. 0800 / 6 27 31 -380 E-Mail: ams@essex.de

Medizinisch-wissenschaftliche Abteilungen Telefon: +49 (0) 89 / 6 27 31 - 900 Telefax: +49 (0) 89 / 6 27 31 - 499 E-Mail: medwiss@essex-pharma.de

sublingual tablets

These products are manufactured by Schering-Plough (France), 2 rue Louis Pasteur, 14200 Hérouville St. Clair, France.

sublingual tablets

Manufacturer/Distributor Country/Address Generic Name Brand Name RemarksDosage Form

Essex pharma GmbH

0.3mg/ml ampoule 28 countries worldwide

0.3mg/ml 1mlx10 U.S.A.

Merck Génériques 0.4 mg/tab 7 tablets France2 mg/tab 7 tablets8 mg/tab 7 tablets

Mundipharma Pty Ltd. buprenorphine Norspan 5 mg/patch 2 patches Australia

no exports10 mg/patch 2 patches

20 mg/patch 2 patches

Narcotics Control Division Temgesic sublingual 0.2 mg/tab (Use within country)

GermanyThomas-Dehler-Straße 2781737 MünchenTelefon: +49 (0) 89 / 6 27 31 - 0 Telefax: +49 (0) 89 / 6 27 31 - 499 E-Mail: info@essex-pharma.de

Abteilung ArzneimittelsicherheitTelefon: +49 (0) 89 / 6 27 31 - 395bzw. 0800 / 6 27 31 - 395 Telefax: +49 (0) 89 / 6 27 31 - 380bzw. 0800 / 6 27 31 -380 E-Mail: ams@essex.de

Medizinisch-wissenschaftliche Abteilungen Telefon: +49 (0) 89 / 6 27 31 - 900 Telefax: +49 (0) 89 / 6 27 31 - 499 E-Mail: medwiss@essex-pharma.de

TEMGÉSIC ampullen

solution for injection

This product is manufactured by Reckitt Benckiser Healthcare (UK) Lt., Dansom Lane Hull, HU8 7DS.

Hospira, Inc 600 N. Field Drive, Lake Forest, Illinois 60045, USA

Buprenorphine Hydrochloride 0409-2012-32 - Carpuject

liquid (injection)

France34, rue Saint Romain69359 Lyon cedex 08 Tel : +33 (0)4 72 78 27 35Fax : +33 (0)4 37 53 20 15

BUPRENORPHINE MERCK

sublingual tablets

AustraliaLevel 26, 6 O'Connell Street,Sydney NSW 2000 AustraliaGPO Box 5214,Sydney 2001 Tel: +61-2-9231 7200Fax: +61-2-9223 0011Email: mpl@mundipharma.com.auhttp://www.mundipharma.com.au

transdermal patch

ThailandDirectorFood and Drug AdministrationMinistry of HealthNanthaburi 11000Tel: +66 2 590 7335 / 7336 / 7317Fax: +66 2 590 7309Narcotics Control Division Tel: 66- 2590-7340, 66- 2590-7341, 66- 2590-7344 Fax: 66-2590-7333e-mail: narcotic@fda.moph.go.thDrug Control Division Tel: 66- 2590-7160, 66- 2590-7171Fax: 66-2591-8390, 66-2591-8489, 66-2590-7170e-mail:drug@fda.moph.go.thhttp://www.fda.moph.go.th/

Reckitt Benckiser Healthcare (UK) Ltd. Hull, United Kingdom

Narcotics Control Division

Temgesic injection 0.3 mg/ml (Use within country)

buprenorphine Bunondol 0.2 mg/tab 60 tablets

0.3 mg/ml 5x1ml

0.4 mg/tab 30 tablets

SUBOXONE

SUBUTEX 0.4mg/tab

2mg/tab

8mg/tab

Reckitt Benckiser Healthcare (UK) Ltd. Hull, United Kingdom

Warszawskie Zakłady Farmaceutyczne Polfa SA (Polfa Warszawa SA)

22/24 Karolkowa St.01-207 Warszawa, PolandTel: +48 22 691 39 00; +48 22 691 39 01Fax: +48 22 691 38 27polfa@polfawar.com.plmarketing@polfawar.com.plexport@polfawar.com.plhttp://www.polfawar.com.pl

sublingual tablets

Lithuania, Poland minimum rrder quantity (units): 5000

liquid (injection)

minimum order quantity (units): 5000

sublingual tablets

minimum order quantity (units): 5000

Reckitt Benckiser Healthcare Ltd

United Kingdom44 Wharf Road West Ryde NSW 2114 Tel: (02) 9857 2000 Fax: (02) 9857 2004 Reckitt & Colman Products,Dansom lane Hull, England HU8 7DSTel: + 44 1482 326151Fax: + 44 1482 582532support@reccolpharm.com http://www.reccolpharm.com

buprenorphine hydrochloride and naloxone hydrochloride at a ratio of 4:1 buprenorphine/ naloxone

sublingual tablets

2mg buprenorphine + 0.5mg naloxone/tab

Austria Belgium Bulgaria Canada Croatia Czech Republic Denmark Estonia Finland France Germany Greece Holland Hong Kong Hungary Indonesia Ireland Israel Italy Latvia Lithuania Malaysia Malta Norway Portugal Romania Singapore Slovakia Slovenia Mexico South Africa Spain Sweden Switzerland UAE United Kingdom

The company supply directly to Reckitt Benckiser companies in USA, Australia and New Zealand (contact via Australia).Distribution Agreement with Schering Plough Pharmaceuticals that currently distribute the product in the countries listed

8mg buprenorphine + 2mg naloxone/tab

sublingual tablets

TEMGÉSIC ampullen

liquid (injection)

300mcg/ml buprenorphine as the hydrochloride in a 5% glucose solution

marketing authorization holder: Essex Pharma GmbH, Thomas-Dehler-Str. 27, 81737 München, Germany.Special export requirement as this is a controlled drug.

TEMGÉSIC 0.2mg/tab

TEMGÉSIC forte 0.4mg/tab

Rusan Pharma Ltd, ADDNOK – N 8/2 tablet India

ADDNOK-N 2/0.5 tablet India

ADDNOK 8mg tablet 8 mg/tab

ADDNOK 2 mg tablet 2 mg/tab

Sandoz 0.2 mg/tab Denmark

Schering Plough buprenorphine SUBUTEX 2mg/tab 1 tablet

7 tablets

28 tablets

United Kingdom44 Wharf Road West Ryde NSW 2114 Tel: (02) 9857 2000 Fax: (02) 9857 2004 Reckitt & Colman Products,Dansom lane Hull, England HU8 7DSTel: + 44 1482 326151Fax: + 44 1482 582532support@reccolpharm.com http://www.reccolpharm.com

Austria Belgium Bulgaria Canada Croatia Czech Republic Denmark Estonia Finland France Germany Greece Holland Hong Kong Hungary Indonesia Ireland Israel Italy Latvia Lithuania Malaysia Malta Norway Portugal Romania Singapore Slovakia Slovenia Mexico South Africa Spain Sweden Switzerland UAE United Kingdom

marketing authorization holder: Essex Pharma GmbH, Thomas-Dehler-Str. 27, 81737 München, Germany.Special export requirement as this is a controlled drug.

sublingual tablets

India58-D, Government Industrial Estate,Charkop, Kandivli (west),Mumbai - 40006 Tel.: +91-22-286 87035, 286 82512 + 91-22-286 82515Fax.: +91-22-286 89056E-mail: rusan@bom2.vsnl.net.inhttp://www.rusanpharma.com"

buprenorphine hydrochloride + naloxone hydrochloride tablet

buprenorphine 8mg + naloxone 2mg/tab

Product discount available on volume or long term supply agreement.

buprenorphine 2mg/naloxone 0.5 mg/tab

buprenorphine hydorochloride tablet

Nepal, Ukraine, United Kingdom, Uzbekistan

India, Nepal, U.A.E., Ukraine, Uzbekistan

Denmark1A Farma A/S Herstedøstervej 27-29, blok G, 1., DK-2620 Albertslund

Buprenorfin 1A Farma

sublingual tablet (solid)

SloveniaDunajska 20, 1000 Ljubljana, Alenka Cuk, M.Sc.alenka.cuk@spcorp.comSchering-Plough Central East AGDunajska 221000 LjubljanaSloveniaTelephone: 386 1 300 1070Address: Dunajska cesta 22, 1000 LjubljanaTel: (01) 300-1070Fax: (01) 300-1080administracija@spcorp.comhttp://www.schering-plough.com

sublingual tablets

Schering Plough buprenorphine SUBUTEX

8mg/tab 1 tablet

7 tablets

28 tablets

Suboxone 2 mg/0.5 mg 7 tablets

28 tablets

8 mg/2 mg 7 tablets

28 tablets

Schering-Plough SUBUTEX 0.4 mg/tab 7 tablets2 mg/tab 7 tablets8 mg/tab 7 tablets

TEMGESIC 0.2 mg/tab 20 tablets

0,3 mg/ml 10x1ml

SUBOXONE 2 mg/tab 7 and/or 28 tablets

8mg/tab8 and/or 28 tablets

Schering-Plough (France) TEMGÉSIC 0.2 mg/tab 20 tablets

TEMGÉSIC forte 0.4 mg/tab 20 tablets

buprenorphine Subutex tablets 0.4 mg/tab

2 mg/tab

SloveniaDunajska 20, 1000 Ljubljana, Alenka Cuk, M.Sc.alenka.cuk@spcorp.comSchering-Plough Central East AGDunajska 221000 LjubljanaSloveniaTelephone: 386 1 300 1070Address: Dunajska cesta 22, 1000 LjubljanaTel: (01) 300-1070Fax: (01) 300-1080administracija@spcorp.comhttp://www.schering-plough.com

sublingual tablets

buprenorphine and naloxone

sublingual tablets

Schering-Plough CorporationMarketing Director Subutex/SuboxoneGlobal Virology Marketing2000 Galloping Hill RoadKenilworth, NJ 07033 USATelephone: 1 908 298 5000http://www.scheringplough.com

sublingual tablets

authorized by Reckitt Benckiser plc to distribute in certain countries.sublingual

tabletsliquid (injection)sublingual tablets

France2, rue Louis Pasteur14200 Hérouville St. Clairhttp://www.schering-plough.com

sublingual tablets

Marketing authorization holder: Essex PharmaGmbH, Thomas-Dehler-Str. 27, 81737 München, Germany. Special export requirement as this is a controlled drug.sublingual

tablets

Schering-Plough Division of Sol Ltd.

26/F., 248 Queen's Road EastWanchai, Hong KongTelephone: (852) 2578 9811Fax: +(852) 2807 24 23

buprenorphine Subutex tablets

8 mg/tab

Temgesic 0.3 mg/ml

0.2 mg/tab

26/F., 248 Queen's Road EastWanchai, Hong KongTelephone: (852) 2578 9811Fax: +(852) 2807 24 23

liquid (Injection)tablets (sublingual)

Methadone ProducersManufacturer/Distributor Country/Address Generic Name Brand Name Dosage Form Remarks

5mg/tablet United Kingdom

ALKALOID AD Skopje METADON tablet 5 mg/tab 20 tablets Macedonia10 mg/1ml 10 ml

oral solution 10mg/1ml 100 mloral solution 10 mg/1ml 1000 ml

10mg/1ml 5 ampoules Macedonia50 ampoules Macedonia

Biomed Ltd. Biodone oral liquid solution 2 mg/ml 200 ml

Biodone Forte oral liquid solution 5 mg/ml 1L

200 ml

Biodone Extra Forte oral liquid solution 10 mg/ml 1L

tablet 5 mg/tab United Kingdom

Dee Pharmaceuticals Ltd Eptadone oral solution oral liquid 1mg/ml 20 ml United Kingdom

40 ml United Kingdom

1 L United Kingdom

5mg/ml 20 ml United Kingdom

1L United Kingdom

Douglas Pharmaceuticals Ltd PALLIDONE tablet 5 mg/tab New Zealand

AH Cox & Company Ltd. United KingdomWhiddon Valley, Barnstable, Devon, EX 32 8NS, United Kingdom & Glaxo Wellcome Operations, Temple Hill, Dartford, Kent, DA1 5AH (Cardinal)

methadone hydrochloride

Methadone tablet BP 5mg: Physeptone tablet 5mg

R. Macedonia12, Aleksandar Makedonski blvd, 1000 Skopje, Telephone: + 389 2 310 40 00Fax: + 389 2 310 40 14; + 389 2 3104 036e-mail: alkaloid@alkaloid.com.mkhttp://www.alkaloid.com.mk

* only registered but not launched due to marketing reasonsoral drops,

solutionBulgaria, Kosovo, Macedonia, Serbia, Slovenia

Kosovo, Macedonia, Serbia, Slovenia

New ZealandMs. Arlene WallendorfManaging directorPO Box 44-06952 Carrington RoadPoint ChevalierAuckland 1025Tel: +64 9 815 5405Fax: +64 9 815 5406E-mail: Biomed@Biomedltd.co.nzarlenew@Biomedltd.co.nz

Australia, Myanmar, New Zealand, (Indonesia)

Sea Freight included. Air Freight at cost of customer. Purchase order, Import permit for the total mg/ kg of methadone within that order, Payment by letter of credit, funds transfer when goods are with freight forwarder at the port of Auckland.

Dales Pharmaceuticals Ltd. United KingdomSnaygill Industrial Estate, Keighley Road, Skipton, Yorkshire, BD23 2RW, UK (Cardinal)

Methadone 5mg tablet BP

United KingdomUnit 3K6Redwither TowerRedwither ParkWrexham Industrial EstateWrexhamLL13 9XTTelephone01978 661953Fax: 01978661993Contact: Phylyp longworthphylyplongworth@deepharmaceuticalsltd.co.uk

This company does not manufacture and only sells to the UK market. This company purchases the product from:

Molteni Farmaceutici Polska Sp. z o.o.ul. Obroncow Modlina 330-733 KrakowPolandPL 521 04 21 696

New ZealandHead OfficeCentral Park Drive, Lincoln, Auckland 0610P0 Box 45 027, Auckland 0651, New ZealandPhone +64 9 835 0660Fax +64 9 835 0665 warrens@douglas.co.nzhttp://www.douglas.co.nz/

Import permit from importing country and export permit from New Zealand

Manufacturer/Distributor Country/Address Generic Name Brand Name Dosage Form RemarksStrength (Concentration of Drug)

10 mg/ml Only Austria

Extractum-Pharma Rt. Metadon-EP tablet 5 mg/tab 200 tablets Denmark, RO20 mg/tab 200 tablets

Methadone Syrup oral liquid 5mg/ml 200 ml N/A

oral liquid 5mg/ml 1L

Physeptone (analgesic) tablet 10mg/tab N/A

liquid (injection) 10mg/ml

tablet 5mg/tab 100 tablets Thailand

oral liquid solution 10mg/ml 1L

Hemopharm Metadon 10 mg/ml 100 mg

KRKA d.d. oral liquid solution 10 mg/ml 100 ml Slovenia

1000 ml Slovenia

liquid (syrup) 5mg/ 3,75ml 3,75ml France

Ebewe Pharma GmbH Nfg. KG

AustriaMondseestraße 11A–4866 UnterachTel: +43 7665 81230Fax: +43 7665 812311E-mail: office@ebewe.comEBEWE PharmaGes.m.b.H Nfg.KGDivision Specialty PharmaceuticalsMondseestrasse 114866 Unterach, Austria Tel.: +43 7665 8123 0Fax: +43 7665 8123 490 international@ebewe.comhttp://www.ebewe.at/

Heptadon 10 mg ampoules

liquid in ampoules and powder

10mg/ml x 10 ampoules

ex factory price no exportation

HungaryDirector: Mr Jozsef NemesH-1044 Budapest, Megyeri út 64., Tel: +36 1 233 0661, Fax: +36 1 233 1426

GlaxoSmithKline Australia Pty Ltd.

AustraliaPrincess HighwayPort FairyVictoria 3284...1061 Mountain HighwayBoronia, Victoria 3155 Telephone: (03) 9721 6000Fax: (03) 9729 5319Mailing Address:PO Box 168Boronia, Victoria 3155Australia

packs of 20 tablet

packs of 5 ampoules

Governmental Pharmaceutical Organization

Thailand75/1 Rama VI RoadRatchathewiBangkok 10400ThailandEmail : intgpo@intergpomed.com intgpo@yahoo.comTel : +662 3548857 +662 2038850-4Fax : +662 3548858

Methadone HCl 5 mg tablet

Methadone HCl oral solution 10mg/ml (1000ml/bottle)

Serbia Beogradski put bb26300 VrsacTel.: +381 13 803 100Fax: +381 13 803 100E-mail: www.hemofarm.co.yu

Hemofarm Group PR Centre

+381 13 803-686+381 13 803-696+381 13-803-100e-mail: info@hemofarm.co.yu

oral liquid solution 10 ml

Registered in Serbia and FYR Macedonia

SloveniaŠmarješka cesta 6 SI-8501 Novo mestophone: +386 7 331 21 11telefax: +386 7 332 15 37Tina Dular Merljak, M.Sc.E-mail: Tina.dular@krka.bizDirector of Pharmaceutical ProductionVesna Voćanec

Metadon Krka oral solution 10 mg/ml

produced in Al chimars, Italy, Krka d.d. is only importer and marketing authorization holder.produced in Al chimars, Italy, Krka d.d. is only importer and marketing authorization holder.

Synerlab, Laboratoires SOPHATEX (Laboratoires Bouchara-Recordati )

Laboratoires Sophatex21 rue du Pressoir28500 VernouilletFranceTel: 00 33 (0) 2 37 62 76 76Fax: 00 33 (0) 2 37 62 76 75

Laboratoires Bouchara-Recordati68, rue MarjolinB.P. 6792302 Levallois Perret CedexTel. ++33 1 45191000Fax ++33 1 47560246 Parc Mécatronic03410 Saint VictorTel. ++33 4 70037900Fax ++33 4 70037890http://www.Recordati.ItContact: Mr. Thierry Kint.kin@bouchara-recordati.fr

Chlorydrate de méthadone AP/HP sirop

Companies/Countries purchasing productliquid (syrup)

10mg/ 7,5ml 7,5ml

France

20mg/ 15 ml 15ml

40mg/15 ml 15ml

60mg/ 15 ml 15ml

capsules 1 mg/tab 7 capsules France5 mg/tab 7 capsules

10 mg/tab 7 capsules

Dr. Lazar & Cía Metagesic tablet 5 mg/tab

10 mg/tab

40 mg/tab

oral liquid solution 1 mg/ml 20 ml

Laboratoires Sophatex21 rue du Pressoir28500 VernouilletFranceTel: 00 33 (0) 2 37 62 76 76Fax: 00 33 (0) 2 37 62 76 75

Laboratoires Bouchara-Recordati68, rue MarjolinB.P. 6792302 Levallois Perret CedexTel. ++33 1 45191000Fax ++33 1 47560246 Parc Mécatronic03410 Saint VictorTel. ++33 4 70037900Fax ++33 4 70037890http://www.Recordati.ItContact: Mr. Thierry Kint.kin@bouchara-recordati.fr

Méthadone AP/HP gélules (in may 2008)

Finished Product Manufacturer name and address:Dr. Lazar & Cía S.A.Av. Vélez Sársfield 5855CarapachayBuenos Aires, Argentina.Tel: (54.11) 5550-2900 Fax (54.11) 5550-2900 Executive: Dr. Eduardo Fernández efernandez@lazar.com.ar secproduccion@lazar.com.ar

Stupefacient Import Authorization issued by the Health’s Authorities of the import country and legalized by the Argentinean consulate or apostilled.

L. Molteni & C. dei Fratelli Alitti Società di Esercizio S.p.A.

ItalyHead Office: Strada Statale 67 (Tosco romagnola)Località Granatieri - 50018 Scandicci (Florence) Tel: +39 55 73 611Fax: +39 55 720 057E-mail: Molteni@Moltenifarma.it info@moltenifarma.ithttp://www.moltenifarma.it/

Eptadone™ or Methadone Molteni

Italy, Poland, United Kingdom (Other countries where product is registered but not yet marketed are: Germany and Netherlands).

Italy, Poland, United Kingdom

oral liquid solution 5 mg/ml 20 ml Italy, United Kingdom

1mg/ml United Kingdom

10mg/ml United Kingdom

Narcotics Control Division oral solution 10 mg/ml Thai FDA

tablet 5 mg/tab 100 tab/bot Thai FDA

Nycomed Danmark ApS methadone Metadon "DAK" oral solution 1 mg/ml 5 ml

ItalyHead Office: Strada Statale 67 (Tosco romagnola)Località Granatieri - 50018 Scandicci (Florence) Tel: +39 55 73 611Fax: +39 55 720 057E-mail: Molteni@Moltenifarma.it info@moltenifarma.ithttp://www.moltenifarma.it/

Eptadone™ or Methadone Molteni

Georgia, Italy, Poland, United Kingdom

(Countries where product is ongoing registration procedure are: Ukraine, Spain, Greece, Croatia and Taiwan (this one for the Sugar Free formulation).

Georgia, Italy, Taiwan, United Kingdom

(Eptadone is an European brand name registered. In Italy and Poland and in other non European countries the product is sold with the generic name: Methadone Molteni).

Macarthy's Laboratories Ltd. t/a Martindale Pharmaceuticals

United Kingdom

Hubert RoadBrentwoodEssex CM14 4LZTelephone: 01277 266 600Fax: 01277 848 976

Bampton RoadHarold HillRomfordEssex RM3 8UGTelephone: 01277 266 600Fax: 01708 384 032Email: info@martindalepharma.co.ukexport@martindalepharma.co.uk http://www.martindalepharma.co.uk/

Methadone Mixture DTF 1mg/ml : Physeptone Mixture

Methadone Mixture DTF (sugar free) 1mg/ml : Physeptone Mixture SF

Methadone injection BP 1%: Physeptone injection

Methadone HCl oral solution 10 mg/ml

10,000 mg (estimation)

Methadone tablet 5 mg/tab

Nycomed Danmark Langebjerg 1 4000 Roskilde Denmark Phone: +45 46 77 11 11Fax: +45 46 75 66 40Marketing/sale contact person: Mads Krebs

Denmark, Estonia, Finland , Lithuania

Nycomed Danmark ApS methadone Metadon "DAK" oral solution 1 mg/ml

100 ml

300 ml

1000 ml

5000 ml

solution for i.v. 10 mg/ml 10 ml

tablet 5mg/tab 10 tablets

20 tablets

100 tablets

20mg/tab 25 tablets

100 tablets

Paladin Labs Inc. tablet 1mg/tab 100 tablets Canada

5mg/tab 100 tablets

10mg/tab 100 tablets

oral suspension 10mg/ml 100 ml

1mg/ml 250 ml

oral liquid 80 mg/20ml 8 litters

Pharmascience Inc Metadol oral concentrate 10mg/ml 100 ml Ukraine

oral solution 1mg/ml 250 ml Canada

tablet 1mg/tab 100 tablets

5mg/tab 100 tablets

Nycomed Danmark Langebjerg 1 4000 Roskilde Denmark Phone: +45 46 77 11 11Fax: +45 46 75 66 40Marketing/sale contact person: Mads Krebs

Denmark, Estonia, Finland , Lithuania

Canada6111 Royalmount Ave. Suite 102Montreal, QuebecH4P 2T4Tel: (514) 340-1112Fax: (514) 340-4675info@paladin-labs.comhttp://www.paladin-labs.com/

Metadol (Squire Pharmaceuticals Inc.)

Pharmaceutical Manufactory Dept. of Health

China14/F GOVERNMENT LOGISTICS CTR, 11 CHONG FU ROAD, CHAI WAN21/F, Wu Chung House 213 Queen's Road East Hong Kong Fax: (852) 2836 0071Phone:(852) 2961 8989 or (852) 2961 8991enquiries@dh.gov.hk http://www.dh.gov.hk/

METHADONE LINCTUS 80MG/20ml (PM) For use by Hong Kong SAR Government only

CANADA6111 Av RoyalmountSuite 100Montreal QCH4P 2T4Tel.: +1-514-340-98001-800-363-8805 CAN & USFax: +1-514-342-7764www.pharmascience.comContact: Mr. Khaled Faridkfarid@pharmascience.com

Pharmascience Inc Metadol

tablet

25mg/tab 100 tablets5mg tabs 5mg/tab 50 tablets United Kingdom

Pliva Croatia Limited tablet 5mg/tab

METHATABS tablet 5 mg/tab 10 tablets New Zealand

oral solution 1mg/ml 50ml

oral solution 1mg/ml 500ml EIRE, United Kingdom

oral solution 1mg/ml 500ml United Kingdom

Pharmchem International Ltd.

United KingdomPharmchem House Unit B1, Neptune Industrial Estate,Neptune Road, HA1 4YF, Harrow, UK+44 20 8427 4261+44 20 8427 4262info@pharmchem.co.uk

Methadone Hydrochloride 5mg

CROATIA, 10000 Zagreb, Prilaz baruna Fillipovica 25

Methadone HCl tablet B.P. 5mg

Universal Pharmaceutical Laboratories Ltd (HK). Doctors, Community Pharmacist and hospitals in Hong Kong

PSM Healthcare Ltd. t/a Healthcare Manufactoring Group

14-16 Norman Spencer DrivePO Box 76 401Manukau CityAucklandNew ZealandPhone +64-9-279 7979Fax +64-9-279 7999Email sales@api.net.nzpharmacy@api.net.nzNZ Freephone 0508 776 746http://www.psm.co.nz/

Rosemont Pharmaceuticals Ltd.

United KingdomHead Office AddressRosemont HouseYorkdale Industrial ParkBraithwaite StreetLeeds LS11 9XET: +44 (0)113 244 1400F: +44 (0)113 245 3567E: infodesk@rosemontpharma.com

Methadone Sugar Free (Green) 1mg/ml (50ml)

Methadone Sugar Free Rosemont (Green) 1mg/ml (500ml)

Metharose Methadone Sugar Free (Brown) 1mg/ml

Methadone DTF 1mg/ml (50ml) Rosemont

oral solution 20mg/ml 150ml UK, The Netherlands

Rusan Pharma Ltd, liquid oral solution 5 mg/ml 1L Mauritius, Myanmar, Nepal 10mg /ml 150ml. bottle

0.10% 5 ml Cyprus, Greece10 ml20 ml40 ml60 ml100 ml500 ml1000 ml

0.50% 5 ml10 ml20 ml1000 ml

Methadone Linctus BP 1mg/ml 500ml (1mg/ml)

1mg/ml 500ml

Rosemont Pharmaceuticals Ltd.

United KingdomHead Office AddressRosemont HouseYorkdale Industrial ParkBraithwaite StreetLeeds LS11 9XET: +44 (0)113 244 1400F: +44 (0)113 245 3567E: infodesk@rosemontpharma.com

Methadose Methadone Concentrate 20mg/ml

Methadose Methadone Concentrate 10mg/ml

India58-D, Government Industrial Estate,Charkop, Kandivli (west),Mumbai - 40006

METHADONE HYDROCHLORIDE oral CONCENTRATE B.P

Mauritius, Myanmar, Nepal, Uzbekistan

Samaritan Pharmaceuticals Inc. ( products manufactured by Molteni Farmaceutici SpA)

United StatesBusiness Headquarters101 Convention Center DriveSuite 310Las Vegas, Nevada 89109 Tel: 702-735-7001fax: 702.737.7016info@samaritanpharma.com http://www.samaritanpharma.com/Samaritan Pharmaceuticals Europe S.A. 11, Filopappou Street, 11741, Athens, GREECE Tel: +302109237890, FAX: +302109237892 E-mail cdakas@samaritanpharma.com

METHADONE HCL® (Molteni Farmaceutici)

liquid oral solution (Syrup)

Thornon & Ross Ltd,

UK Linthwaite, Huddersfield, HD7 5QH, UK

Methadone Hydrochloride BP

Methadone Mixture (1mg/ml)

Methadone Oral solution BP (Sugar Free)

Morphine ProducersManufacturer/Distributor Country/Address Generic Name Brand Name Dosage Form Base Unit of Measure Remarks

Adcock Ingram Limited morphine sulfate 10 mg/tab 60 tablets South Africa

30 mg/tab 60 tablets

Antigen Pharmaceuticals morphine sulfate liquid (injection) 1mg/5ml 10 ampoules x 1ml Ireland

liquid (injection) 10 mg/ml 10 ampoules x 1ml Ireland

ALKALOID AD Skopje 20 mg/ml 10 ampoules

4 mg/ml 10 ampoules air freight

NOVAMORF® sublingual tablets 10 mg/tab 20 tablets Macedonia60 tablets Macedonia

20 mg/tab 20 tablets Kosovo, Macedonia air freight

Adcock Ingram Park17 Harrison AvenuePrivate Bag X 69Bryanstone 2021South Africa Telephone: +27 11 840 3000http://www.adcock.co.za/

MST CONTINUS Prolonged Release (Mundipharma)

tablets, slow release

United KingdomGoldshield Hospital EuropeNLA Tower12-16 Addiscombe RoadCroydon SurreyCR0 0XT UKTel: +44 (0)20 8410 2134Fax: +44 (0)20 8686 0807www.antigenpharma.cominfo@goldshieldplc.comwww.goldshieldplc.com

Morphine Sulphate injection 1 mg / 5 ml liquid injection

Antigen was acquired by Goldshield PLC in 2001. These products are manufactured by: B Braun Melsungen AGMistelweg 2,D-12357 ,Berlin,Germany

Morphine Sulphate injection 10mg /1ml liquid injection

Morphine Sulphate injection 30 mg / 1 ml liquid injection

Morphine Sulphate injection 60mg/1mlliquid injection

morphine hydrochloride

MORPHINI HYDROCLORIDUM

Bosnia and Herzegovina, Croatia, Kosovo, Macedonia, Republic of Srpska, Serbia, Slovenia

Bosnia and Herzegovina, Croatia, Kosovo, Macedonia

morphine sulphate pentahydrate

Manufacturer/Distributor Country/Address Generic Name Brand Name Dosage Form Base Unit of Measure RemarksStrength (Concentration of Drug)

ALKALOID AD Skopje

NOVAMORF® sublingual tablets

20 mg/tab60 tablets Macedonia

30 mg/tab 20 tablets Macedonia60 tablets Macedonia

Asmeco (Thailand) Ltd. morphine sulfate 10 mg/tab Thailand

30 mg/tab

60 mg/tab

100 mg/tab

Archimedes Pharma Ltd. morphine sulfate 10 mg/cap 60 capsules United Kingdom

30 mg/cap 60 capsules

200mg/cap 60 capsules

Baxter Intenational Inc. morphine sulfate Duramorph liquid (injection) 5mg/10ml (0.5mg/ml) 10 ampoules U.S.A.

10mg/ml (1mg/ml) 10 ampoules

liquid (injection) 200mg/20ml (10mg/ml) 20 ampoules

500mg/20ml (25mg/ml) 20 ampoules

Boehringer Ingelheim Ltd. morphine sulfate 20mg/ml 30ml Ireland, United Kingdom

morphine sulphate pentahydrate

60/2 Krungtep-Non7Rd, BangkhenNon taburiBangkok 11000Thailand

United KingdomHead Office250 South Oak WayGreen ParkReadingRG2 6UGTelephone: +44 (0)118 931 5050Facsimile: +44 (0)118 931 5051Michael ClarkGroup Marketing and Business Development Directormichaelclark@archimedespharma.comhttp://archimedespharma.com/

ZOMORPH Sustained-release capsules (Ethypharm, France)

capsules, slow release

United StatesOne Baxter ParkwayDeerfield, IL 60015-4625 Switchboard 847-948-2000Products and Services 800-422-9837; 800-4Baxter; 847-948-4770Products and Services Fax 847-948-3642Baxter Healthcare Corporation25212 W. Illinois Route 120Round Lake, IL 60073Toll-free: 1-800-4-BAXTER1-847-948-4770E-mail: onebaxter@baxter.com

Infumorph (preservative-free morphine sulfate sterile solution)

United KingdomEllesfield AvenueBracknell Berkshire RG12 8YS United Kingdom Tel: +44 (0) 1344 424600 Fax: +44 (0) 1344 741444 UK company enquiries:communications@bra.boehringer-ingelheim.comUK Medical information enquiries:medinfo@bra.boehringer-ingelheim.com http://www.boehringer-ingelheim.co.uk/

Oramorph® Concentrated oral solution 20 mg/ml

oral liquid solution

Boehringer Ingelheim Ltd. morphine sulfate

10mg/5ml 100 ml

Ireland, United Kingdom

300 ml

500 ml.

10 mg/5 ml 20x5ml

30 mg/5 ml 20x5ml

100 mg/5 ml 20x5ml

CDM LAVOISIER liquid (injection) 10 mg / ml 10x1ml

10x5ml

100x1ml

100x5ml

20 mg/ml 10x1ml

10x5ml

100x1ml

100x5ml

United KingdomEllesfield AvenueBracknell Berkshire RG12 8YS United Kingdom Tel: +44 (0) 1344 424600 Fax: +44 (0) 1344 741444 UK company enquiries:communications@bra.boehringer-ingelheim.comUK Medical information enquiries:medinfo@bra.boehringer-ingelheim.com http://www.boehringer-ingelheim.co.uk/

Oramorph® oral solution 10 mg/5 ml

Oramorph® Unit Dose Vials

FranceLaboratoires CHAIX et DU MARAIS7, rue Labie - 75017 PARISTel : 01 55 37 83 83Fax : 01 55 37 83 84E-mail : contact@lavoisier.com export@lavoisier.comhttp://www.lavoisier.com/

MORPHINE CHLORHYDRATE LAVOISIER

PCH (Algeria)morphine Chlorhydrate 10 mg/1 mlmorphine Chlorhydrate 20 mg/ 1 ml

CDM LAVOISIER

morphine sulfate liquid (injection) 50 mg/ml 1x10ml

10x10ml

liquid (injection) 1 mg / ml 10x1ml

morphine sulfate 30 mg/tab China, Taiwan

60 mg/tab

Codipharma morphine sulfate 10 mg/tab Lebanon

30 mg/tab

60 mg/tab

100 mg/tab

liquid (injection) 10mg/ml 10x1ml

10x2ml

100x1ml

100x2ml

morphine sulfate Morfenil liquid (injection) 10mg/mL 1mlx50 None

morphine sulfate LA-MORPH 10 mg/tab 10 tablets New Zealand

FranceLaboratoires CHAIX et DU MARAIS7, rue Labie - 75017 PARISTel : 01 55 37 83 83Fax : 01 55 37 83 84E-mail : contact@lavoisier.com export@lavoisier.comhttp://www.lavoisier.com/

PCH (Algeria)morphine Chlorhydrate 10 mg/1 mlmorphine Chlorhydrate 20 mg/ 1 ml

MORPHINE (SULFATE) LAVOISIER 50 mg / ml, solution injectable

ChardDeh Drugs Enterprise, Company Limited

485, Fu-Chin StreetTaipeiTaiwan

Samir Karkou & Lie4, rue St. MarounImm. Madame NahasBP. 3063Bevrouth-Liban

COOPER - Coopération Pharmaceutique Française

Place Lucien Auvert77020 Melun CédexTél: 01 64 87 20 00Fax: 01 64 87 86 71Mail: info@cooper.frhttp://www.cooper.fr/ExportTél: 01 64 87 86 17 Fax: 01 64 87 20 75export@cooper.fr

MORPHINE (CHLORHYDRATE) COOPER

Cambodia, Central African Republic, Cote d'Ivoire, Morocco, Senegal, Chad

Instituto BioChímico Indústria Farmacêutica Ltda.

BrazilRodovia Presidente Dutra, Km 310Rio de Janeiro CEP 27.580-000BrazilTel: +55 (24) 3355-9392Fax: +55 (24) 3355-8854Contact: Flávia Beatriz Adão Gerente de Vendas e Marketing Email: flavia@biochimico.ind.brTel: 24 3355-9392 / 24 9263-5989Web page: www.biochimico.ind.br

Douglas Pharmaceuticals Ltd

morphine sulfate LA-MORPH

New Zealand

SEVREDOL® tablets 10 mg/tab 10 tablets New Zealand

EMS S/A morphine Sulphate - injection 10mg/ml Box with 50 ampoules x 1ml

morphine Sulphate - injection 0.2mg/ml Box with 50 ampoules x 1ml

morphine Sulphate - injection 1mg/ml Box with 50 ampoules x 2ml

Flynn Pharma Ltd morphine sulfate liquid (injection) 10 mg/ml

morphine sulfate Kapanol 10mg/cap 20 capsules N/A

Hizon Laboratories, Inc. morphine sulfate Morphine sulfate liquid injection Philippines

Ampules 1 ml 1/6 grain

tablets 10 mg/tab

20 mg/tab

40 mg/tab

Douglas Pharmaceuticals Ltd

BrazilRodovia SP-101, Km 8Hortolândia - SPCEP 13186-901Tel: +55 19 3887-9800Fax: +55 19 3887-9515Toll free: 0800 194966 orUnited KingdomThe MaltingsBridge StreetHitchinHerts SG5 2DET: +44 (0) 1462 458974F: +44 (0) 1462 450755David Walters Director +44 1462 458974 dwalters@flynnpharma.com

DepoDur® (morphine sulfate extended-release liposome injection)(Parcira Pharmaceuticals)

10 mg/1 ml vial packaged in cartons of 5

Europe, the Middle East and Africa. (In December 2007, it is only registered in the United Kingdom)

The export requirements will be for cold-chain delivery. We plan to register the product through the Mutual Recognition process in Europe.

15 mg/1.5 ml vial packaged in cartons of 520 mg/2 ml vial packaged in cartons of 5

AustraliaPrincess HighwayPort FairyVictoria 3284...1061 Mountain HighwayBoronia, Victoria 3155 Telephone: (03) 9721 6000Fax: (03) 9729 5319Mailing Address:PO Box 168Boronia, Victoria 3155Australia

Bo. Dela PazAssumption RoadSumulong hiwayAntipolo City1870 PhilippinesFax No.: (632) 697.5937

MS. LUCITA Y. SORIANOExecutive Vice President for Plant OperationsTel. No.: (632) 696-4220E-mail: lysoriano@hizonlab.com

Ampules 1 ml 1/4 grain

liquid (injection) 0.5mg/ml 10mlx5 U.S.A.

Hospira UK Limited QueenswayRoyal Leamington SpaWarwickshire CV31 3RW+44 (0)1926 821010medinfouk@hospira.com

morphine sulfatePharma-Ject Morphine prefilled syringe

liquid (injection)1 mg/ml

2 mg/ml

Discontinued

Hospira Australia Pty Ltd Level 21, 390 St Kilda RoadMelbourneVictoria 3004Tel +613 9868 0700Fax +613 9868 0299 (03) 9868 0111

morphine sulfate Code – 08190B-AU DBL® Morphine

Sulfate injection

liquid (injection)5 mg/ml (1 ml x5) Asia Pacific Country of manf:

Germany

morphine sulfate Code – 08191B-AU

DBL® Morphine Sulfate injection

liquid (injection)

10 mg/ml (1 ml x5) Asia Pacific Country of manf:Germany

liquid (injection)

morphine tartrate Code – 08200B-AU

DBL® Morphine Tartrate injection

liquid (injection)

120 mg/1.5 ml (1.5 ml x5) Asia Pacific Country of manf:Germany

liquid (injection)

400 mg/5 ml 5 ml x5) Asia Pacific Country of manf:Germany

morphine Sulfate 0409-3814-12 - Fliptop Vialmorphine Sulfate 0409-4057-12 - Ampule

liquid (injection) 1mg/ml 10mlx5 U.S.A.

1mg/ml 10mlx5 U.S.A.

morphine Sulfate 0409-3815-12 - Fliptop Vialmorphine Sulfate 0409-4058-12 - Ampule

liquid (injection)

morphine Sulfate 0409-1762-30 - Carpuject

liquid (injection

liquid (injection)

morphine Sulfate 0409-1135-02 - Fliptop Vial

liquid (injection)

morphine Sulfate 0409-6177-14 - ADD-Vantage Vial

liquid (injection)

morphine Sulfate 0409-2029-02 - PCA vial

liquid (injection)

morphine sulfate Morfenil liquid (injection) 10mg/ml 1mlx50 None

morphine 10mg/tab 60 tablets

30mg/tab 60 tablets

60mg/tab 60 tablets

Lords Healthcare Limited morphine sulfate 10mg/tab 60 tablets Kenya

30mg/tab 60 tablets

Mahakam Beta Farma morphine sulfate 5 mg/tab Indonesia

10mg/tab

30mg/tab

60mg/tab

100 mg/tab

200 mg/tab

morphine 10mg/tab India

Instituto BioChímico Indústria Farmacêutica Ltda.

BrazilRodovia Presidente Dutra, Km 310Rio de Janeiro CEP 27.580-000BrazilTel: +55 (24) 3355-9392Fax: +55 (24) 3355-8854Contact: Flávia Beatriz Adão Gerente de Vendas e Marketing Email: flavia@biochimico.ind.brTel: 24 3355-9392 / 24 9263-5989Web page: www.biochimico.ind.br

Jacobson Medical (Hong Kong) Ltd.

Jacobson Medical (Hong Kong) Ltd.15/F China Trade Centre,No. 122-124 Wai Yip Street,Kwun Tong,Kowloon,Hong KongTel: (852) 2827 1616Fax: (852) 2507 2829E-mail: info@jacobsonmedical.com.hk

MST Continus (prolonged release) (Mundipharma)

Distributed by Jacobson only in Hong Kong.

Dr. Evelyn Tiren Company Pharmacist Capital Hill Towers Cathedral Road P.O Box 49397 Nairobi Kenya Telephone: 2717111-5 Email:lords@swiftkenya.com, lords@lordshealthcare.com

PT. Mahakam Beta FarmaJl Pulo Kambing II No. 21, Kawasan Industri Pulogadung Jakarta 13930Phones: (021) 4603543, Fax: (021) 4603706email : marketing@betadine-ina.com

MST Continus Prolonged Release tablets (Mundipharma)

Modi.Mundipharma Private Ltd.

1400, Hemkunt Tower, 98Nehru PlaceNew Delhi 110019India

MORCONTIN CONTINUS Prolonged Release tablets (Mundipharma)

morphine

30mg/tab

60mg/tab

100 mg/tab

Mundipharma Beijing morphine sulfate 10mg/tab China

30mg/tab

60mg/tab

100 mg/tab

morphine sulfate 10mg/tab Philippines

30mg/tab

60mg/tab

100 mg/tab

morphine sulfate 10mg/tab Malaysia

30mg/tab

60mg/tab

100 mg/tab

morphine sulfate 10mg/tab Singapore

30mg/tab

60mg/tab

100 mg (POM)

Mundipharma Pty Ltd. Ordine 2 2mg/ml 200mL Only Australia

Ordine 5 5mg/ml 200mL

Ordine 10 10mg/ml 200mL

morphine sulfate MS Mono 30 mg/cap 10 capsules

1400, Hemkunt Tower, 98Nehru PlaceNew Delhi 110019India

Rm 1808Tower DCentral International Trade Center6A Jiangguomenwai AvenueChao Yang DistrictBeijingChina 100022

MS Contin Prolonged Release (Mundipharma)

Mundipharma Distribution GmbH Branch Philippines

Unit 1706-1709Robinson Equitable Tower4 ADB Avenue CornerPoveda StreetOritas CenterPasig CityPhilippines 1605

Mundipharma Pharmaceuticals Sdh.Bhd.

74 Jalan University46200 Petalin JayaSengalor DEMalaysia

Mundipharma Pte. Ltd. Singapore

10 Hoe Chiang Road20-04/05 Kepple TowersSingapore 089315

oral liquid solutionoral liquid solutionoral liquid solutioncapsule, slow release

Mundipharma Pty Ltd.

morphine sulfate MS Mono

Only Australia

MS Contin Suspension 20 sachets

30 mg/sachet 20 sachets

100 mg/sacet 20 sachets

MS Contin 5 mg/tab 20 tablets

Sevredol tablets 10 mg/tab 20 tablets

Mundipharma SAS France morphine sulfate 10 mg/tab 14 tablets

200 mg/tab 14 tablets Tunisia

morphine sulfate 30mg/tab Korea

60mg/tab

Munir Sukhtian Group Ltd. morphine sulfate tablets 10 mg/tab Jordan

30 mg/tab

60 mg/tab

100 mg/tab

capsule, slow release

sachet containing controlled release granules for oral suspension, slow release

20 mg/sachet

France2, rue du Dr Lombard 92130 Issy-les-MoulineauxTél : 01 55 38 92 30Fax: 01 55 38 92 45http://www.mundipharma.fr/

Moscontin Prolonged Release

tablets L.P., slow release

Algeria, Gabon, Ivory Coast, Morocco, Senegal, Tunisia

Mundipharma Yuhan Hosea

6th Fl.Gusang Building1009-5, daechi-dongKangnam-KuSeoul 135-283Korea

MST CONTINCONTINUS Prolonged Release (Mundipharma)

King Hussein StreetAl-AbdaliAmmanJordanP.O.Box 1027 Amman - Jordan Tel: 962 6 5688888 Fax: 962 6 5601568 Telex: 21316 / 22347 E-mail: info@sukhtian.com.jo

MST CONTINUS (Mundipharma)

morphine sulfate 10 mg/tab Oman

30 mg/tab

60 mg/tab

100 mg/tab

morphine sulfate 5 mg/tab 60 tablets10 mg/tab 60 tablets15 mg/tab 60 tablets30 mg/tab 60 tablets60 mg/tab 60 tablets100 mg/tab 60 tablets200 mg/tab 60 tablets20 mg/sachet 30 sachets30 mg/sachet 30 sachets60 mg/sachet 30 sachets100 mg/sachet 30 sachets200 mg/sachet 30 sachets30 mg/cap 28 capsules60 mg/cap 28 capsules90 mg/cap 28 capsules120 mg/cap 28 capsules150 mg/cap 28 capsules200 mg/cap 28 capsules

Sevredol® 10 mg/tab 24 tablets56 tablets112 tablets

20 mg/tab 24 tablets56 tablets112 tablets

50 mg/tab 24 tablets56 tablets112 tablets

Narcotics Control Division morphine Sulfate injection 10 mg/ml 1 ml/Ampoule Thai FDA

morphine Sulfate MST Continous tablet

Muscat Pharmacy & Stores LC

Street No. 44Building No 51Block No. 144Off. El Bustan RoadAl Wadi Al KabirMuscat 113Oman

Napp Pharmaceuticals Limited (Bard Pharmaceuticals Limited)

United KingdomCambridge Science ParkMilton RoadCambridgeCB4 0GW Tel: 01223 424444Fax: 01223 424441 E-mail: enquiries@napp.co.ukproduction@napp.co.ukcarol.butcher@napp.co.ukhttp://www.napp.co.uk/

MST Continus tablets (Prolonged release Morphine Sulphate PhEur)

Australia, Austria, Costa Rica (30mg only), Hong Kong, Ireland, Jordan, Kenya, Lebanon, Malta, Philippines (10 &30mg only), Singapore (10 & 30 only), Spain, Taiwan (60mg only), Thailand ( 10,30 & 60 only). SUSPENSION Australia, Austria, Germany, Switzerland capsuleS Australia, Austria, Sweden, SEVREDOL Austria, Costa Rica (20mg only), Cyprus, Ireland

MST Continus suspensions (Prolonged release morphine)

sachets, slow release

MXL® prolonged release capsules

film-coated tablets

Morphine Sulfate injection 10 mg/ml

10 mg/tab 30mg/tab 60 mg/tab

30 tablets 30 tablets 30 tablets

Bard Pharmaceutical United Kingdom

morphine Sulfate Kapanol capsule

Noramco Inc. morphine NA NA NA NA NA

Pfizer New Zealand Ltd 1mg/ml 200ml New Zealand

2mg/ml 200ml

5mg/ml 200ml

10mg/ml 200ml

Pyramid Scientific Office morphine sulfate 30 mg/tab Egypt

morphine sulfate 10 mg/tab 10 tablets14 tablets20 tablets30 tablets28 tablets50 tablets56 tablets60 tablets100 tablets

30 mg/tab 10 tablets14 tablets20 tablets30 tablets28 tablets50 tablets56 tablets60 tablets100 tablets

20 mg/cap 50mg/cap 100 mg/cap

20 capsules 20 capsules 20 capsules

GlaxoSmithKline Australia

500 Swedes Landing RoadWilmington, Delaware 19801USATel.: +1 302-761-2909Fax: +1 302-761-2914E-mail: mdarby@norus.jnj.comhttp://www.noramco.com/

Level 3, Pfizer House14 Normanby RoadMt Eden AucklandPhone: 09 638 0000Fax: 09 638 0021Toll-free tel: 0800 699 276Email: ContactUs.NewZealand@pfizer.com http://www.pfizer.co.nz/Contact: Gary Cooper Business Support ManagerCustomer Services, Supply Chain, Business TechnologyPfizer New Zealand Phone: 64 9 638 0056Fax: 64 9 638 0021 Mobile: 027 574 1815Email: gary.cooper@pfizer.com Website: <www.pfizer.co.nz>

morphine Hydrochloride

RA MORPH® (Morphine Hydrochloride solution BP)

liquid oral solution

In New Zealand product pricing is controlled and in many cases funded by the Government so our pricing will be very different due to our welfare/medical policies.

41 Farid StreetHeliopolisCairo 11361Egypt

MS Continus Prolonged Release (Mundipharma)

Teva-Pharmachemie B.V. {Manufacturing location: Teva Pharmaceutical Works Inc. Pallagi Street 13H-4024 Debrecen}

The NetherlandsPharmaceutical developmentmanufacture and marketingSwensweg 5, P.0.B. 5522003 RN HaarlemThe Netherlands+31-23-5147147+31-23-5312879 faxbdu@pharmachemie.comhttp://www.pharmachemie.com/

Morphine sulphate prolonged release

Austria, Bangladesh, Belgium, Bulgaria, Denmark, Germany, Hong Kong, Ireland, Netherlands, Norway, Philippines, Sri Lanka, Thailand, United Kingdom

PENDING REGISTRATION : Argentina, Australia, South Africa, Switzerland

Austria, Bangladesh, Belgium, Bulgaria, Denmark, Germany, Hong Kong, Ireland, Netherlands, Norway, Philippines, Sri Lanka, Suriname, Thailand, United Kingdom, Venezuela

PENDING REGISTRATION : Argentina (AR); Australia (AU); Malaysia (MY); South Africa (ZA); Switzerland (CH)

morphine sulfate

Pharmascience Inc morphine Sulphate Statex drops 20mg/ml 25 ml Canada, Jordan

100 mldrops 50mg/ml 50 ml Canada, Jordan

syrup 1mg/ml (unflavoured) 250 ml

1mg/ml (unflavoured) 500 ml Canada

1mg/ml ( Orange flavour500 ml Singapore

Jordan

5mg/ml (unflavoured) 250 ml Malaysia

5mg/ml (unflavoured) 500 ml

10mg/ml (unflavoured) 250 mlsuppositories 5 mg 10s Malaysia

10 mg 10s Jordan

20 mg 10s Canada

30 mg 10stablets 5 mg/tab 100 tablets Malaysia

5 mg Control Pack 4 tablets x 25 (Blisters) Jamaica

Canada

The NetherlandsPharmaceutical developmentmanufacture and marketingSwensweg 5, P.0.B. 5522003 RN HaarlemThe Netherlands+31-23-5147147+31-23-5312879 faxbdu@pharmachemie.comhttp://www.pharmachemie.com/

Austria, Bangladesh, Belgium, Bulgaria, Denmark, Germany, Hong Kong, Ireland, Netherlands, Norway, Philippines, Thailand, United Kingdom, Venezuela

PENDING REGISTRATION : Argentina, Australia, Malaysia, South Africa, Sri Lanka, Switzerland

Austria, Belgium, Bulgaria, Denmark, Germany, Ireland, Netherlands, Norway, Thailand, United Kingdom

PENDING REGISTRATION : Argentina, Australia, Bangladesh, South Africa, Switzerland, Venezuela

Denmark, Germany, Ireland, Norway, United Kingdom

PENDING REGISTRATION : Austria, Netherlands, Switzerland

Pharmascience Inc morphine Sulphate Statex

tablets

10 mg/tablets 100 tablets Malaysia

10 mg Control Pack 4 tablets x 25 (Blisters) Canada

25 mg 100 tablets Canada

25 mg Control Pack 4 tablets x 25 (Blisters)

50 mg 100 tablets Canada

50 mg Control Pack 4 tablets x 25 (Blisters)morphine sulfate MORPHINI SULFAS liquid (injection) 10 mg/ml 10x1ml Poland

20 mg/ml 10x1ml

Rusan Pharma Ltd, morphine SULPHATE tablet 10mg/tab India

tablet 30mg/tab India

tablet 60mg/tab India

liquid injection 10mg/ml none

22/24 Karolkowa St.01-207 Warszawa, PolandTel: +48 22 691 39 00; +48 22 691 39 01Fax: +48 22 691 38 27polfa@polfawar.com.plmarketing@polfawar.com.plexport@polfawar.com.plhttp://www.polfawar.com.pl

Minimum Order Quantity (units): 5000Minimum Order Quantity (units): 5000

MORPHINI SULFAS 0,1% Spinal

Minimum Order Quantity (units): 7400

India58-D, Government Industrial Estate,Charkop, Kandivli (west),Mumbai - 40006 Tel.: +91-22-286 87035, 286 82512 + 91-22-286 82515Fax.: +91-22-286 89056E-mail: rusan@bom2.vsnl.net.inhttp://www.rusanpharma.com"

MORPHINE SULPHATE tablet 10mg

Production Capacity of API in kg/ year: 2000 Kg (through International Tie-up)

MORPHINE SULPHATE INJ. 2ml. Ampoule 20mg

MORPHINE SULPHATE INJ 1ml AMPOULE 10mg

morphine sulfate 10 mg/5 ml Cyprus, Greece

30 mg/5 ml

100 mg/5 ml

2 mg/ml 100 ml

250 ml

500 ml

20 mg/ml 20 ml

100 ml

liquid (injection) 10 mg/ml

morphine Morphine syrup oral liquid 5 mg/5 ml 450 ml

morphine sulfate liquid (injection) 1 mg/ml 10 x 30ml

10 x 50ml

morphine sulfate liquid (injection) 2 mg/ml 10 x 30ml

10 x 60ml

10x1ml

United StatesBusiness Headquarters101 Convention Center DriveSuite 310Las Vegas, Nevada 89109 Tel: 702-735-7001fax: 702.737.7016info@samaritanpharma.com http://www.samaritanpharma.com/Samaritan Pharmaceuticals Europe S.A. 11, Filopappou Street, 11741, Athens, GREECE Tel: +302109237890, FAX: +302109237892 E-mail cdakas@samaritanpharma.com

Oramorph® (Molteni Farmaceutici)

liquid oral solution

20 single-dose containers pack20 single-dose containers pack

20 single-dose containers pack

Morphine Sulphate® (Molteni Farmaceutici)

Universal Pharmaceutical Laboratories Ltd.

ChinaUnits 1-5, 1/F.,Eastern Centre1065 King's RoadHong KongPhone: (852) 2563 1173Fax: (852) 2565 7913

Doctors and hospitals in Hong KongDoctors and hospitals in Hong KongDoctors and hospitals in Hong Kong

Torbay Pharmacy Manufacturing Unit

United KingdomKemmings Close,Paignton,Devon,TQ4 7TWTel: 01803 664707FAx: 01803664354kath.punshon@nhs.nethttp://www.torbaypmu.nhs.uk/

Morphine Sulphate 1mg/ml injection.

United Kingdom NHS (Licenced for PPA Patient Controlled Analgesia)

morphine Sulphate 1mg/ml injection.

10 x 50ml

Recipharm ( UCB Pharma Ltd.)

RecipharmVale of Bardsley,Ashton-under-Lyne, Lancashire, OL7 9RR

UCB Pharma S.A.United KingdomUK - Slough, BerkshireTel: +44 1 753 534 655Fax: +44 1 753 536 632E-mail: info-uk@UCB-Group.com http://www.ucb-group.com/UK - Great Abington, CambridgeTel: +44 1 223 896 300 UCB Pharma LtdUK - Dunstable, BedfordshireFax: +44 582 813 100

Ann Jonsson-MackayCommercial Operations ManagerUCB Pharma LtdTel: 01753-447544Fax: 01753-447604E-mail: ann.jonsson-mackay@ucb-group.com

Morphine Sulphate injection

United Kingdom and any country accepting a UK licenced pack

morphine sulfate liquid (injection)

15 mg/ml 5x1ml

10x1ml

30 mg/ml 5x1ml

10x1ml

60 mg/ml 5x1ml

Shionogi & Co. Ltd morphine sulfate tablets 10 mg/tab Japan only

30 mg/tab

60 mg/tab

morphine Sulphate 10 mg/5ml 5ml

50 mg/5ml 5ml

5 mg/5ml 5ml

Wael Pharmacy morphine sulfate 10 mg Bahrain

30 mg Bahrain

60 mg Bahrain

100 mg (POM) Bahrain

Recipharm ( UCB Pharma Ltd.)

RecipharmVale of Bardsley,Ashton-under-Lyne, Lancashire, OL7 9RR

UCB Pharma S.A.United KingdomUK - Slough, BerkshireTel: +44 1 753 534 655Fax: +44 1 753 536 632E-mail: info-uk@UCB-Group.com http://www.ucb-group.com/UK - Great Abington, CambridgeTel: +44 1 223 896 300 UCB Pharma LtdUK - Dunstable, BedfordshireFax: +44 582 813 100

Ann Jonsson-MackayCommercial Operations ManagerUCB Pharma LtdTel: 01753-447544Fax: 01753-447604E-mail: ann.jonsson-mackay@ucb-group.com

Morphine Sulphate injection

United Kingdom and any country accepting a UK licenced pack

12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan Tel 06-6458-5861

ChinaUnits 1-5, 1/F Eastern Centre, 1065 King's Road, Hong Kong. Tel: +852 2562 8131 Fax: +852 2561 7058; (852) 25657913Email:upll@upll.com.hkhttp://www.upll.com.hk/

Morphine syrup (alcohol free)

liquid oral solution (syrup)

Doctors, Community Pharmacist and hospitals in Hong Kong

Building No. 310Street 1805Manama 318BahrainPh : +973- 17537707Fax : +973 – 17533556, 17531689Email Address : sales@waelpharmacy.com

Buprenorphine Price and CostGeneric Name Brand Name Dosage Form Base Unit of Measure

ARROW Génériques buprenorphine hydrochloride sublingual tablets 0.4 mg/tab 7 tablets $3.7940 $1.35502 mg/tab 7 tablets $8.8900 $0.63508 mg/tab 7 tablets $25.4660 $0.4548

Bedford laboratories buprenorphine hydrochloride liquid (injection) 0.3 mg/ml 10x1ml

buprenorphine hydrochloride Nopan sublingual tablets 0.2 mg/tab 2x10 tablets

5x10 tablets $8.02 $0.8020Essex pharma GmbH buprenorphine hydrochloride TEMGÉSIC sublingual tablets 0.2mg/tab 20 tablets 24.65 €/20 tab. € 6.16

TEMGÉSIC forte sublingual tablets 0.4mg/tab 20 tablets0.3mg/ml amp.

buprenorphine hydrochloride 0.3mg/ml 1mlx10 £8.30

Merck Génériques buprenorphine hydrochloride sublingual tablets 0.4 mg/tab 7 tablets $3.00 $1.07142 mg/tab 7 tablets $6.00 $0.42868 mg/tab 7 tablets $17.00 $0.3036

buprenorphine Norspan transdermal patch 5 mg/patch 2 patches $25.97 $2.5970

10 mg/patch 2 patches $30.70 $1.5350

20 mg/patch 2 patches $30.70 $0.7675

buprenorphine hydrochloride Temgesic sublingual 0.2 mg/tab ~0.60 baht 3.0 baht

buprenorphine hydrochloride Temgesic injection 0.3 mg/ml ~3.33 baht 11.10 baht

Manufacturer/Distributor

Price Per Base Unit of Measure

price per smallest unit (mg)

BUPRENORPHINE ARROW cp subling (Subutex generic)

Buprenorphine Hydrochloride injection (Buprenex)

CTS Chemical Industries LTD

TEMGÉSIC ampullen

Hospira, Inc Buprenorphine Hydrochloride 0409-2012-32 - Carpuject

liquid (injection)

£2.49/ml£24.90

BUPRENORPHINE MERCK

Mundipharma Pty Ltd.

Generic Name Brand Name Dosage Form Base Unit of MeasureManufacturer/Distributor

buprenorphine Bunondol sublingual tablets 0.2 mg/tab 60 tablets 7.50 $0.6250

liquid (injection) 0.3 mg/ml 5x1ml 2.36 $1.5667

sublingual tablets 0.4 mg/tab 30 tablets 7.50 $0.6250

SUBOXONE sublingual tablets $0.40 - $2.00

buprenorphine hydrochloride SUBUTEX sublingual tablets 0.4mg/tab

2mg/tab

8mg/tab

buprenorphine hydrochloride liquid (injection) $1.00 - $2.50

TEMGÉSIC sublingual tablets 0.2mg/tab $1.00 - $3.00

TEMGÉSIC forte sublingual tablets 0.4mg/tab

Rusan Pharma Ltd, ADDNOK – N 8/2 tablet $3.1725 or €2.35 $0.3966

ADDNOK-N 2/0.5 tablet $1.0125* or €0.75 $0.5063

ADDNOK 8mg tablet 8 mg/tab $2.95* or €2.18 $0.3688

ADDNOK 2 mg tablet 2 mg/tab $0.95* or €0.7buprenorphine hydrochloride 0.2 mg/tab $0,50 $2.5000

Schering Plough buprenorphine subutex sublingual tablets 2 mg/tab 1 tablet € 0.72 € 0.36007 tablets28 tablets

buprenorphine hydrochloride and naloxone hydrochloride at a ratio of 4:1 buprenorphine/ naloxone

2mg buprenorphine + 0.5mg naloxone/tab

8mg buprenorphine + 2mg naloxone/tab

TEMGÉSIC ampullen

300mcg/ml buprenorphine as the hydrochloride in a 5% glucose solution

buprenorphine hydrochloride + naloxone hydrochloride tablet

buprenorphine 8mg + naloxone 2mg/tab

buprenorphine 2mg/ naloxone 0.5 mg/tab

buprenorphine hydrochloride tablet

Sandoz Buprenorfin 1A Farma

sublingual tablet (solid)

Generic Name Brand Name Dosage Form Base Unit of MeasureManufacturer/Distributor

Schering Plough buprenorphine subutex sublingual tablets

8mg/tab 1 tablet € 2.52 € 0.31507 tablets28 tablets

buprenorphine and naloxone Suboxone sublingual tablets 2 mg/0.5 mg 7 tablets € 5.53 € 0.395028 tablets € 22.12 € 0.3950

8 mg/2 mg 7 tablets € 21.98 € 0.392528 tablets € 87.92 € 0.3925

Schering-Plough buprenorphine hydrochloride SUBUTEX sublingual tablets 0.4 mg/tab 7 tablets2 mg/tab 7 tablets8 mg/tab 7 tablets

TEMGESIC sublingual tablets 0.2 mg/tab 20 tabletsliquid (injection) 0,3 mg/ml 10x1ml

SUBOXONE sublingual tablets 2 mg/tab

8 mg/tab

buprenorphine hydrochloride TEMGÉSIC sublingual tablets 0.2 mg/tab 20 tabletsTEMGÉSIC forte sublingual tablets 0.4 mg/tab 20 tablets

buprenorphine Subutex tablets 0.4 mg/tab

2 mg/tab8 mg/tab

Temgesic liquid (injection) 0.3 mg/mltablets (sublingual) 0.2 mg/tab

7 and/or 28 tablets (depending on the country)8 and/or 28 tablets (depending on the country)

Schering-Plough (France)

$7,913.20$3,708.40$2,655.74

$4,683.68€ 35,989.00

£48,472.00

$6,257.14$2,502.86$1,772.86

$15,166.48

$8,964.40

$4,482.20

17,520 baht

64,824 baht

Price Per Patient Per Year (PPPY) for a daily dose of 16 mg ( price/mg x 16 x 365)

$3,650.00

$9,149.33

$3,650.00

$2,315.92

$2,956.50

$2,153.50

$14,600.00

€ 2,102.40

Price Per Patient Per Year (PPPY) for a daily dose of 16 mg ( price/mg x 16 x 365)

€ 1,839.60

€ 2,306.80€ 2,306.80

€ 2,292.20€ 2,292.20

Methadone Price and CostManufacturer/Distributor Generic Name Brand Name Dosage Form

methadone hydrochloride 5mg/tablet

ALKALOID AD Skopje methadone hydrochloride METADON tablets 5 mg/tab 20 tablets N/Aoral drops, solution 10 mg/1ml 10 ml € 0.80 €0.0800 €233.60oral solution 10mg/1ml 100 ml € 8.00 €0.0800 €233.60oral solution 10 mg/1ml 1000 ml € 80.00 €0.0800 €233.60solution for injection 10mg/1ml 5 ampoules N/A

50 ampoules N/ABiomed Ltd. methadone hydrochloride Biodone oral liquid solution 2 mg/ml 200 ml $4.70 $0.0118 $343.10

Biodone Forte oral liquid solution 5 mg/ml 1L $25 $0.0050 $146.00

200 ml $5.00 $0.0050Biodone Extra Forte oral liquid solution 10 mg/ml 1L $30.20 $0.0030 $88.20

methadone hydrochloride tablet 5 mg/tab

Dee Pharmaceuticals Ltd methadone hydrochloride Eptadone oral solution oral liquid 1mg/ml 20 ml £0.29 £0.0145 £423.40

40 ml £0.5800 £0.0145 £423.4060 ml £0.87 £0.0145 £423.40100 ml £1.35 £0.0135 £394.201 L £13.48 £0.0135 £393.62

5mg/ml 20 ml £1.47 £0.0147 £429.241L £73.33 £0.0147 £428.25

Douglas Pharmaceuticals Ltd methadone hydrochloride PALLIDONE tablet 5 mg/tab 10's $2.1300 $245.28

methadone hydrochloride 10 mg/ml $3.7100

Extractum-Pharma Rt. methadone hydrochloride Metadon-EP tablet 5 mg 200X $13 $0.0130 $379.6020 mg 200X $54 $0.0135

~$0,013

methadone hydrochloride Methadone Syrup oral liquid 5mg/ml 200 ml $16.91 $0.0169 $493.77

oral liquid 5mg/ml 1L $36.00 $0.0072 $210.24Physeptone (analgesic) tablet 10mg $15.47 $0.0774 $2,258.62

liquid (Injection) 10mg/ml $29.91 $0.5982 $17,467.44

Price Per Patient Per Year (PPPY) for a daily dose of 80 mg (price/mg x 80 x 365)

AH Cox & Company Ltd. Methadone Tablets BP 5mg: Physeptone Tablets 5mg

Dales Pharmaceuticals Ltd. Methadone 5mg Tablets BP

Ebewe Pharma GmbH Nfg. KG

Heptadon 10 mg ampoules

liquid in ampoules and Powder

10mg/ml x 10 ampoules

1 mg (estimation)

packs of 20 tabletspacks of 5 ampoules

Manufacturer/Distributor Generic Name Brand Name Dosage Form Strength (Concentration of Drug)

methadone hydrochloride tablet 5 mg/tab 100 tablets $2.20 $0.0044 $128.48

oral liquid solution 10mg/ml 1L $9.70 $0.0010 $28.32

Hemopharm methadone hydrochloride Metadon oral liquid solution 10 ml 10 mg/ml 100 mg/bottle € 0.0157 € 458.08

KRKA d.d. methadone hydrochloride oral liquid solution 10 mg/ml 100 ml € 20.26 € 0.0203 € 591.591000 ml

methadone hydrochloride liquid (syrup) 5mg/ 3.75ml 3.75ml € 0.43 € 0.0860 € 2,511.0010mg/ 7.5ml 7.5ml20mg/ 15 ml 15ml40mg/15 ml 15ml60mg/ 15 ml 15ml € 0.77 € 0.0128 € 374.70

capsules 1 mg/cap 7 capsules € 1.89 € 0.2700 € 7,884.005 mg/cap 7 capsules10 mg/cap 7 capsules20 mg/cap 7 capsules40 mg/cap 7 capsules € 4.90 € 0.0175 € 511.00

Dr. Lazar & Cía methadone hydrochloride Metagesic tablets 5 mg/tab $0.1880 $5,489.60

10 mg/tab $ 1,175/tablet $0.1175 $3,431.00

40 mg/tab $ 2,29 /tablet $0.0573 $1,671.70

methadone hydrochloride oral liquid solution 1 mg/ml 20 ml $0.6000 $0.0300 $876.00oral liquid solution 1 mg/ml 100 ml $2.50 $0.0250 $730.00oral liquid solution 1 mg/ml 1000 ml $ 25 $0.0250 $730.00oral liquid solution 5 mg/ml 20 ml $2.50 $0.0250 $730.00oral liquid solution 5 mg/ml 1000 ml $ 125 $0.0250 $730.00

methadone hydrochloride 1mg/ml

1mg/ml

10mg/ml

Narcotics Control Division methadone hydrochloride oral solution 10 mg/ml $13 $0.0013 $37.96

methadone hydrochloride tablet 5 mg/tab 100 tabs/bottle $2.85 $0.0057 $166.44

Governmental Pharmaceutical Organization

Methadone HCL 5 mg Tablet

Methadone HCL Oral Solution 10mg/ml (1000ml/bottle)

1,57 €

Metadon Krka oral solution 10 mg/ml

Méthadone AP/HP gélules (in may 2008)

$ 0,94/tablet

Eptadone™ or methadone Molteni

Macarthy's Laboratories Ltd. t/a Martindale Pharmaceuticals

Methadone Mixture DTF 1mg/ml : Physeptone Mixture

Methadone Mixture DTF (sugar free) 1mg/ml : Physeptone Mixture SF

Methadone Injection BP 1%: Physeptone InjectionMethadone HCl Oral Solution 10 mg/ml

10,000 mg (estimation)

Methadone Tablet 5 mg/Tab

Nycomed Danmark ApS methadone Metadon "DAK" oral solution 1 mg/ml 5 ml 33.70DKK/5ml € 0.9047 € 26,417.18

10 ml € 0.4201 € 12,267.92

25 ml 37.10DKK/25ml € 0.1987 € 5,800.81

40 ml 41.15DKK/40ml € 0.1383 € 4,037.05

50 ml 44.45DKK/50ml € 0.1195 € 3,488.32

80 ml 49.85DKK/80ml € 0.0832 € 2,430.07

100 ml 60.15DKK/100ml € 0.0805 € 2,351.68

300 ml 66.30DKK/300ml € 0.0295 € 862.28

1000 ml 113.95DKK/1000ml € 0.0148 € 431.14

5000 ml 397.05DKK/5000ml € 0.0107 € 313.56

solution for i.v. 10 mg/ml 10 ml 56.35DKK/1x10ml € 0.0757 € 2,210.58

tablet 5mg/tab 10 tablets € 0.1052 € 3,072.86

20 tablets € 0.0577 € 1,685.37

100 tablets € 0.0199 € 580.08

20mg/tab 25 tablets 69.45DKK/25x20mg € 0.0187 € 544.81

100 tablets 200.00DKK/100x20mg € 0.0134 € 391.95

Paladin Labs Inc. methadone hydrochloride tablets 1mg/tab 100 tablets $14.90 $0.1490 $4,350.805mg/tab 100 tablets $74.50 $0.149010mg/tab 100 tablets $149.00 $0.149025mg/tab 100 tablets $372.50 $0.1490

oral suspension 10mg/ml 100 ml $80.00 $0.0800 $2,336.001mg/ml 250 ml $20.00 $0.0800

methadone hydrochloride oral liquid 80 mg/20ml 8 Litres Not for sale Not for sale

Pharmascience Inc methadone hydrochloride Metadol oral concentrate 10mg/ml 100 ml 30.35 $0.0304 $886.22

oral solution 1mg/ml 250 ml 21.00 $0.0840 $2,452.80

tablets 1mg/tab 100 tablets 15.00 $0.1500 $4,380.00

5mg/tab 100 tablets 50.00 $0.1000 $2,920.00

10mg/tab 100 tablets 80.00 $0.0800 $2,336.00

25mg/tab 100 tablets 150.00 $0.0600 $1,752.00

31.30DKK/10ml

39.15DKK/10x5mg

42.95DKK/20x5mg

73.60DKK/100x5mg

Metadol (Squire Pharmaceuticals Inc.)

Pharmaceutical Manufactory Dept. of Health

Methadone LINCTUS 80MG/20ml (PM)

methadone hydrochloride tablets 5mg/tab 50 tablets $8.5000 $0.0340 $992.80

Pliva Croatia Limited methadone hydrochloride tablets 5mg/tab $0.38 $0.0756 $2,208.55

methadone hydrochloride METHATABS tablets 5mg/tab 10 tablets NZ $ 2.10 $0.0420 $1,226.40

methadone hydrochloride oral solution 1mg/ml 50ml £1.04 £0.0208 £607.36

oral solution 1mg/ml 500ml $15 $0.0300 $876.00

£7.25 £0.0145 $423.40oral solution 1mg/ml 30ml £0.62 £0.0207 $603.47

oral solution 1mg/ml 100ml £2.08 £0.0208 $607.36

oral solution 20mg/ml 150ml $24.02 $0.0080 $233.79

oral solution 10mg/ml 150ml $12.01 $0.0080 $233.79

Rusan Pharma Ltd, methadone hydrochloride liquid oral solution 5 mg per ml 1L $0.0089 $260.17

10mg /ml 150ml. bottle $0.0099 $289.08

methadone hydrochloride 0.10% 5 ml Tender Basis10 ml Tender Basis20 ml Tender Basis40 ml Tender Basis

Pharmchem International Ltd.

Methadone Hydrochloride 5mgMethadone HCl Tablets B.P. 5mg

PSM Healthcare Ltd. t/a Healthcare Manufactoring GroupRosemont Pharmaceuticals Ltd.

Methadone Sugar Free (Green) 1mg/ml (50ml)

Metharose methadone Sugar Free (Brown) 1mg/ml

Methadose methadone Concentrate 20mg/ml

Methadose methadone Concentrate 10mg/ml

Methadone HYDROCHLORIDE ORAL CONCENTRATE B.P

$ 44.55 or € 33 Per 1000 ml.

$ 14.85 or € 11.0 per 150ml bottle

Methadone HCL® (Molteni Farmaceutici)

methadone hydrochloride 0.10%

60 ml Tender Basis100 ml Tender Basis500 ml Tender Basis1000 ml Tender Basis

0.50% 5 ml Tender Basis10 ml Tender Basis20 ml Tender Basis1000 ml Tender Basis

methadone hydrochloride 1g £7.1 ($13.82) £0.0071 £207.32

5g £23.69 ($46.12) £0.0047 £138.35

25g £94.76 ($184.44) £0.0038 £110.68

Methadone Linctus BP 1mg/ml 500ml (1mg/ml) £5.43 ($10.6) £0.0109 £317.111mg/ml 500ml £6.18 ($12.02) £0.0124 £360.91

1mg/ml 500ml £6.18 ($12.02) £0.0124 £360.91

Methadone HCL® (Molteni Farmaceutici)

Thornon & Ross Ltd,

Methadone Hydrochloride BP Methadone Hydrochloride BP Methadone Hydrochloride BP

Methadone Mixture (1mg/ml) Methadone Oral Solution BP (Sugar Free)

Morphine Price and CostManufacturer/Distributor Generic Name Brand Name Dosage Form Base Unit of Measure Price Per Unit

Adcock Ingram Limited morphine sulfate tablets, slow release 10 mg/tab 60 tablets

Antigen Pharmaceuticals morphine sulfate liquid (injection) 1mg/5ml 10x1ml $38.91

liquid (injection) 10 mg/ml 10x1ml $6.49

ALKALOID AD Skopje morphine hydrochloride solution for injection 20 mg/ml 10 ampoules € 11.87

solution for injection 4 mg/ml 10 ampoules € 5.53NOVAMORF® sublingual tablets 10 mg/tab 20 tablets N/A

60 tablets N/A20 mg/tab 20 tablets € 15.90

60 tablets N/A30 mg/tab 20 tablets N/A

60 tablets N/AAsmeco (Thailand) Ltd. morphine sulfate tablets, slow release 10 mg/tab

30 mg/tab60 mg/tab100 mg/tab

Archimedes Pharma Ltd. morphine sulfate capsules, slow release 10 mg/cap 60 capsules £4.0830 mg/cap 60 capsules £9.7760 mg/cap 60 capsules £19.06

R 264.95 / 60 tbl. (SINGLE EXIT PRICE Incl. VAT)

R 483.24 / 60 tbl. (SINGLE EXIT PRICE Incl. VAT)

R 706.11/ 60 tbl. (SINGLE EXIT PRICE Incl. VAT)

R 1 078.07 / 60 tbl. (SINGLE EXIT PRICE Incl.

VAT)Morphine Sulphate injection 1 mg / 5 ml liquid injectionMorphine Sulphate injection 10mg /1ml liquid injectionMorphine Sulphate injection 30 mg / 1 ml liquid injectionMorphine Sulphate injection 60mg/1mlliquid injection

MORPHINI HYDROCLORIDUM

morphine sulfate pentahydrate

Archimedes Pharma Ltd. morphine sulfate capsules, slow release

100 mg/cap 60 capsules £30.18200mg/cap 60 capsules £60.35

Baxter International Inc. morphine sulfate Duramorph liquid (injection) 5mg/10ml (0.5mg/ml) 10 ampoules $1.93

10mg/ml (1mg/ml) 10 ampoules $3.80

liquid (injection) 200mg/20ml (10mg/ml) 20 ampoules $65.00

500mg/20ml (25mg/ml) 20 ampoules $110.00

Boehringer Ingelheim Ltd. morphine sulfate oral liquid solution 20mg/ml 30ml £5.24120ml £19.57

oral liquid solution 10mg/5ml 100 ml £1.87

300 ml £5.21500 ml. £7.86

oral liquid solution 10 mg/5 ml 20x5ml £2.6530 mg/5 ml 20x5ml £7.44100 mg/5 ml 20x5ml £24.80

CDM LAVOISIER morphine hydrochloride liquid (injection) 10 mg / ml 10x1ml $7.0710x5ml $12.06100x1ml $44.45100x5ml $69.18

20 mg/ml 10x1ml $7.2910x5ml $13.10100x1ml $47.47100x5ml $93.54

morphine sulfate liquid (injection) 50 mg/ml 1x10ml $4.9710x10ml $42.72

liquid (injection) 1 mg / ml 10x1ml $6.18

morphine sulfate tablets, slow release 30 mg/tab

60 mg/tabCodipharma morphine sulfate tablets, slow release 10 mg/tab

30 mg/tab60 mg/tab100 mg/tab

morphine hydrochloride liquid (injection) 10mg/ml 10x1ml € 7.02

Infumorph (preservative-free morphine sulfate sterile solution)

Oramorph® Concentrated oral solution 20 mg/mlOramorph® oral solution 10 mg/5 ml

Oramorph® Unit Dose Vials

MORPHINE CHLORHYDRATE LAVOISIER

ChardDeh Drugs Enterprise, Company Limited

morphine hydrochloride liquid (injection) 10mg/ml10x2ml € 7.26100x1ml € 28.06100x2ml € 38.43

morphine sulfate Morfenil liquid (injection) 10mg/ml 1mlx50 R$143.21

morphine sulfate LA-MORPH tablets, slow release 10 mg/tab 10 tablets $1.3830 mg/tab 10 tablets $2.7660 mg/tab 10 tablets $5.52100 mg/tab 10 tablets $6.52

SEVREDOL® tablets 10 mg/tab 10 tablets $2.0220 mg/tab 10 tablets $3.9150 mg/tab 10 tablets N/A

EMS S/A morphine sulfate - injection 10mg/ml $29.05

morphine sulfate - injection 0.2mg/ml $27.06

morphine sulfate - injection 1mg/ml $29.82

Flynn Pharma Ltd morphine sulfate liquid (injection) 10 mg/ml €100 per vial

€100 per vial

morphine sulfate Kapanol capsules, slow release 10mg/cap 20 capsules $17.1720mg/cap 20 capsules $22.0750mg/cap 20 capsules $34.94100mg/cap 20 capsules $60.28

Hizon Laboratories, Inc. morphine sulfate Morphine sulfate liquid injection

Ampoules 1 ml 1/6 grain

tablets 10 mg/tab20 mg/tab40 mg/tab

Discontinued

AUD$5.41

AUD$4.65

AUD $4.96

AUD $6.34

Instituto BioChímico Indústria Farmacêutica Ltda.Douglas Pharmaceuticals Ltd

Box with 50 ampoules x 1mlBox with 50 ampoules x 1mlBox with 50 ampoules x 2ml

DepoDur® (morphine sulfate extended-release liposome injection) (Parcira Pharmaceuticals)

10 mg/1 ml vial packaged in cartons of 515 mg/1.5 ml vial packaged in cartons of 520 mg/2 ml vial packaged in cartons of 5

Ampoules 1 ml 1/4 grain

Hospira UK Limited morphine sulfate Pharma-Ject Morphine prefilled syringe

liquid (injection) 1 mg/ml2 mg/ml

50 ml50 ml

Hospira Australia Pty Ltd morphine sulfate Code – 08190B-AU

liquid (injection) 5 mg/ml (1 ml x5)

liquid (injection)

10 mg/ml (1 ml x5)

liquid (injection)

15 mg/ml (1 ml x5)

liquid (injection)

30 mg/ml (1 ml x5)

AUD$15.65

AUD $80.88

liquid (injection) 0.5mg/ml 10mlx5

liquid (injection) 1mg/ml 10mlx5

1mg/ml 10mlx5

2mg/ml 1mlx10

4mg/ml 1mlx10

8mg/ml 1mlx10

10mg/ml 1mlx10

15mg/ml 1mlx10

25mg/ml 10mlx1

25mg/ml 4mlx10

25mg/ml 10mlx10

50mg/ml 20mlx1

50mg/ml 50mlx1

1mg/ml 30mlx10

5mg/ml 30mlx10

morphine sulfate Morfenil liquid (injection) 10mg/ml 1mlx50 R$143.21

morphine tablets, slow release 10mg/tab 60 tablets30mg/tab 60 tablets60mg/tab 60 tablets

Lords Healthcare Limited morphine sulfate tablets, slow release 10mg/tab 60 tablets30mg/tab 60 tablets

Mahakam Beta Farma morphine sulfate tablets, slow release 5 mg/tab10mg/tab30mg/tab60mg/tab100 mg/tab

Hospira Australia Pty Ltd

liquid (injection)

120 mg/1.5 ml (1.5 ml x5)

liquid (injection)

400 mg/5 ml (5 ml x5)

Hospira, Inc morphine Sulfate 0409-3814-12 - Fliptop Vial

£5.22/10ml£26.10

morphine Sulfate 0409-4057-12 - Ampoule

£2.34/10ml£11.70

£ 4.90/10ml£24.50

morphine Sulfate 0409-4058-12 - Ampoule

liquid (injection) £2.53/10ml£12.65

liquid (injection) £0.94/ml£9.40

Instituto BioChímico Indústria Farmacêutica Ltda.Jacobson Medical (Hong Kong) Ltd.

MST Continus (prolonged release) (Mundipharma)

Mahakam Beta Farma morphine sulfate tablets, slow release

200 mg/tabmorphine tablets, slow release 10mg/tab

30mg/tab60mg/tab100 mg/tab

Mundipharma Beijing morphine sulfate tablets, slow release 10mg/tab30mg/tab60mg/tab100 mg/tab

morphine sulfate tablets, slow release 10mg/tab30mg/tab60mg/tab100 mg/tab

morphine sulfate tablets, slow release 10mg/tab30mg/tab60mg/tab100 mg (POM)

Mundipharma Pty Ltd. morphine hydrochloride Ordine 2 oral liquid solution 2mg/ml 200ml $18.75Ordine 5 oral liquid solution 5mg/ml 200ml $21.54Ordine 10 oral liquid solution 10mg/ml 200ml $25.94

morphine sulfate MS Mono capsule, slow release 30 mg/cap 10 capsules $20.7960 mg/cap 10 capsules $29.5790mg/cap 10 capsules $30.70120 mg/cap 10 capsules $30.70

MS Contin Suspension 20 sachets $22.0730 mg/sachet 20 sachets $29.5760 mg/sachet 20 sachets $30.70100 mg/sacet 20 sachets $30.70200 mg/sachet 20 sachets $30.70

MS Contin tablets, slow release 5 mg/tab 20 tablets $16.0410 mg/tab 20 tablets $17.1715 mg/tab 20 tablets $20.7930 mg/tab 20 tablets $29.5760 mg/tab 20 tablets $30.70100 mg/tab 20 tablets $30.70200 mg/tab 20 tablets $30.70

Sevredol tablets 10 mg/tab 20 tablets $15.0520 mg/tab 20 tablets $16.13

Mundipharma SAS France morphine sulfate tablets, slow release 10 mg/tab 14 tablets

Mundipharma Distribution GmbH Branch Philippines

Mundipharma Pharmaceuticals Sdh.Bhd.

Mundipharma Pte. Ltd. Singapore

sachet containing controlled release granules for oral suspension, slow release

20 mg/sachet

MS Contin Prolonged Release

Mundipharma SAS France morphine sulfate tablets, slow release30 mg/tab 14 tablets60 mg/tab 14 tablets100 mg/tab 14 tablets200 mg/tab 14 tablets

morphine sulfate tablets, slow release 30mg/tab

60mg/tab

Munir Sukhtian Group Ltd. morphine sulfate tablets 10 mg/tab30 mg/tab60 mg/tab100 mg/tab

morphine sulfate tablets, slow release 10 mg/tab30 mg/tab60 mg/tab100 mg/tab

morphine sulfate tablets, slow release 5 mg/tab 60 tablets £3.2910 mg/tab 60 tablets £5.4815 mg/tab 60 tablets £9.6130 mg/tab 60 tablets £13.1760 mg/tab 60 tablets £25.69100 mg/tab 60 tablets £40.66200 mg/tab 60 tablets £81.34

Sachets, slow release 20 mg/sachet 30 sachets £24.5830 mg/sachet 30 sachets £25.5460 mg/sachet 30 sachets £51.09100 mg/sachet 30 sachets £85.15200 mg/sachet 30 sachets £170.30

capsules, slow release 30 mg/cap 28 capsules £10.9160 mg/cap 28 capsules £14.9590 mg/cap 28 capsules £22.04120 mg/cap 28 capsules £29.15150 mg/cap 28 capsules £36.43200 mg/cap 28 capsules £46.15

Sevredol film-coated tablets 10 mg/tab 24 tablets56 tablets £5.61112 tablets

20 mg/tab 24 tablets56 tablets £11.21112 tablets

50 mg/tab 24 tablets56 tablets £28.02112 tablets

Narcotics Control Division morphine Sulfate injection 10 mg/ml 1 ml/Ampoule $0.14

morphine Sulfate MST Continous tablet tablets, slow release

Morphine Sulfate Kapanol capsule Control Release capsule

MS Contin Prolonged Release

Mundipharma Yuhan Hosea

MST CONTINUS Prolonged Release (Mundipharma)MST CONTINCONTINUS (Mundipharma)

Muscat Pharmacy & Stores LC

Napp Pharmaceuticals Limited (Bard Pharmaceuticals Limited)

MST Continus tablets (Prolonged release Morphine Sulphate PhEur)

MST Continus suspensions (Prolonged release morphine)

MXL® prolonged release capsules

Morphine Sulfate injection 10 mg/ml

10 mg/tab 30mg/tab 60 mg/tab

30 tablets 30 tablets 30 tablets

$12.85 $25.71 $37.71

20 mg/cap 50mg/cap 100 mg/cap

20 capsules 20 capsules 20 capsules

$13.71$27.14$45.14

Noramco Inc. morphine N/A starting material N/A N/A ConfidentialPfizer New Zealand Ltd morphine Hydrochloride liquid oral solution 1mg/ml 200ml $8.06/200ml

2mg/ml 200ml $8.56/200ml

5mg/ml 200ml $9.61/200ml

10mg/ml 200ml $12.56/200ml

Pyramid Scientific Office morphine sulfate tablets, slow release 30 mg/tab

morphine sulfate tablets, slow release 10 mg/tab 10 tablets14 tablets20 tablets30 tablets $4.38 (0.146/tablet)28 tablets50 tablets56 tablets60 tablets100 tablets

30 mg/tab 10 tablets14 tablets20 tablets30 tablets $9.29 (0.3097/tablet)28 tablets50 tablets56 tablets60 tablets100 tablets

200 mg/tab 10 tablets14 tablets20 tablets30 tablets28 tablets50 tablets56 tablets

RA MORPH® (Morphine Hydrochloride solution BP)

MS Continus Prolonged Release (Mundipharma)

morphine sulfate tablets, slow release

200 mg/tab

60 tablets100 tablets

Pharmascience Inc morphine sulfate Statex drops 20mg/ml 25 ml $12.45100 ml $38.57

drops 50mg/ml 50 ml $47.32syrup 1mg/ml (unflavoured) 250 ml $5.00

1mg/ml (unflavoured) 500 ml $10.001mg/ml ( Orange flavoured) 500 ml5mg/ml (unflavoured) 250 ml $20.085mg/ml (unflavoured) 500 ml $40.1510mg/ml (unflavoured) 250 ml $45.95

suppositories 5 mg 10s $16.6910 mg 10s $18.6420 mg 10s $22.1930 mg 10s $24.34

tablets 5 mg/tab 100 tablets $11.005 mg/tab Control Pack 4 tablets x 25 (Blisters) $14.2010 mg/tab 100 tablets $17.0010 mg Control Pack 4 tablets x 25 (Blisters) $18.6025 mg/tab 100 tablets $22.5025 mg/tab Control Pack 4 tablets x 25 (Blisters) $26.0050 mg/tab 100 tablets $34.5050 mg/tab Control Pack 4 tablets x 25 (Blisters) $36.69

morphine sulfate MORPHINI SULFAS liquid (injection) 10 mg/ml 10x1ml20 mg/ml 10x1ml

Rusan Pharma Ltd, morphine sulfate tablet 10mg/tab

tablet 30mg/tab $ 0.2565 or € 0.19

tablet 60mg/tab $ 0.405 or € 0.30

liquid injection 10mg/ml $ 1.62 or € 1.20

liquid injection 10mg/ml $ 1.1745 or € 0.87

morphine sulfate liquid oral solution 10 mg/5 ml Tender Basis

30 mg/5 ml Tender Basis

100 mg/5 ml Tender Basis

2 mg/ml 100 ml Tender Basis250 ml Tender Basis

MORPHINI SULFAS 0,1% SpinalMORPHINE SULPHATE tablet 10mg

$ 0.1485 or € 0.11

MORPHINE SULPHATE tablet 30mgMORPHINE SULPHATE tablet 60mgMORPHINE SULPHATE INJ. 2ml. Ampoule 20mg

MORPHINE SULPHATE INJ 1ml AMPOULE 10mg

20 single-dose containers pack20 single-dose containers pack20 single-dose containers pack

morphine sulfate liquid oral solution

2 mg/ml

500 ml Tender Basis20 mg/ml 20 ml Tender Basis

100 ml Tender Basisliquid (injection) 10 mg/ml Tender Basis

morphine Morphine Syrup oral liquid 5 mg/5 ml 450 ml HK$90 morphine Morphine Syrup oral liquid 10 mg/5 ml 450 ml HK$116 morphine Morphine Syrup oral liquid 50 mg/5 ml 450 ml HK$284 morphine sulfate liquid (injection) 1 mg/ml 10 x 30ml £27.15

10 x 50ml £18.70morphine sulfate liquid (injection) 2 mg/ml 10 x 30ml £33.55

£24.4810 x 60ml £40.23

10x1ml $14.6015 mg/ml 5x1ml $8.47

10x1ml $16.9430 mg/ml 5x1ml $10.99

10x1ml $21.9960 mg/ml 5x1ml 16.02

Shionogi & Co. Ltd morphine sulfate tablets, slow release 10mg/tab30mg/tab60mg/tab

morphine sulfate 10 mg/5ml 5ml $0.0950 mg/5ml 5ml $0.415 mg/5ml 5ml $0.04

Wael Pharmacy morphine sulfate tablets, slow release 10mg/tab30mg/tab60mg/tab100 mg (POM)

Morphine Sulphate® (Molteni Farmaceutici)

Torbay Pharmacy Manufacturing Unit

Morphine Sulphate 1mg/ml injection.

morphine Sulphate 1mg/ml injection. 10 x 50ml

Recipharm ( UCB Pharma

Ltd.)Morphine Sulphate injection

1 pack of 5amps of 10mg: $ 7.40

morphine Syrup (alcohol free)

liquid oral solution (Syrup)

Buprenorphine Active Pharmaceutical IngredientsManufacturer/Distributor Country/Address Generic Name Price Per Unit

Dolder AG buprenorphine base 250 Kg gr $42.90

gr $40.00

IVAX Pharmaceuticals s.r.o. N/A N/A N/A

buprenorphine base

production capacity of API in kg /year

Immengasse 9CH-4004 Basel, SuisseTel: +41 (0)61 326 66 00Fax: +41 (0)61 326 62 04pharma@dolder.comBusiness Team Leader "Pharma Sales": marco.pickel@dolder.com, Tel. +41 (0)61-326 65 12Business Team Leader "Pharma Business Development": christian.schulz@dolder.com , Tel. +41 (0)61-326 62 31

Switzerland and all countries of European Union

USA, Switzerland and all countries of European Union

Czech RepublicOstravská 29747 70 Opava - KomárovTel.: +420-553 644 620/633Fax.: +420-553 644 625E-mail: Eva_Kavkova@ivax-cz.come-mail: api@ivax-cz.com

Johnson Matthey Macfarlan Smith

United Kingdom10 Wheatfield Rd., Edinburgh, United KingdomTel.: +44 0131 337 2434Fax.: +44 0131 337 981310 Wheatfield RoadEdinburghEH11 2QAScotland, UKTel +44(0) 131 337 2434Fax +44(0) 131 337 9813Email: msl@macsmith.comhttp://www.macsmith.com/

Manufacturer/Distributor Country/Address Generic Name Price Per Unitproduction capacity of API in kg /year

Micro Orgo Chem buprenorphine HCl 30 kg /year kg $37.00

buprenorphine (API) 300 kg/year gr € 30.00 N.A.

Siegfried Ltd 1,000 kg Worldwide

C -1B-57,LIC SECTOR , G.I.D.C.,VAPI-396 195.(GUJARAT ),INDIAPh : 91 22 24448834Ph : 91 22 24448834Email : microorg@vsnl.com , microorg@gmail.comContact Person : Rajiv Jain

Pioneer Agro Industries (Pharmaceutical Division), Prop. Sanvin Laboratories Pvt. Ltd.

IndiaFactory Address: Plot nos. 6,7,8,20 & 24, MIDC, Badlapur, Post Kulgaon, Dist. Thane-421503.

Office address: 206, Eric House, 16th Road, Chembour, Mumbai-400071Tel.: +91-22-2521 70 72 - 75Fax.: +91-22-2521 70 70E-mail: sanvin@vsnl.comSwitzerlandUntere Brühlstrasse 44800 ZofingenTel.: +41 62 746 1212E-mail: info@siegfried.chSales: juerg.ammann@siegfried.chR&D: regina.thiergardt@siegfried.chhttp://www.siegfried.ch

buprenorphine basebuprenorphine hydrochloridePhEurUSP

This information is confidential and

will be only disclosed with a

confidentiality agreement in

place.

Manufacturer/Distributor Country/Address Generic Name Price Per Unitproduction capacity of API in kg /year

buprenorphine baseTasmanian Alkaloids Pty Ltd.

AustraliaBirralee RoadTasmania P.O. Box 130Westbury TAS 7303Telephone: (03) 6393 5202; +61 3 6393 5202Facsimile: (03) 6393 1575; +61 3 6393 1575http://www.tasalk.com.au

Remarks

Export permit issued by SWISSMEDIC.

According to the CZECH legislation No.167/1998 Coll.

Remarks

authorization for the export as per local government & INCB guidelines.

Remarks

Methadone Active Pharmaceutical IngredientsManufacturer/Distributor Country/Address Generic Name Remarks

kg $3,000.00 U.S.A.

Dolder AG 2000 Kg kg $390.00

production capacity of API in kg /year

Price Per Unit ($)

Boehringer Ingelheim Pharmaceuticals, Inc.

United States2820 North Normandy DrivePetersburg, VA-23805Tel.: +804-504 8809E-mail: jwilson@bichemicals.comPostal Address: P.O. Box 16582820 North Normandy DrivePetersburg, VA 23805-0658Phone:001-804-504-8631Fax:+1/804/504 8637Contact:Mr Chris Vancee-mail:cvance@bichemicals.comhttp://us.boehringer-ingelheim.com/

methadone hydrochloride 100%

SuisseImmengasse 9CH-4004 BaselTel: +41 (0)61 326 66 00Fax: +41 (0)61 326 62 04pharma@dolder.comBusiness Team Leader "Pharma Sales": marco.pickel@dolder.com, Tel. +41 (0)61-326 65 12Business Team Leader "Pharma Business Development": christian.schulz@dolder.com , Tel. +41 (0)61-326 62 31

Switzerland and all countries of European Union

Export permit issued by SWISSMEDIC.

methadone hydrochloride Macf Smith (25g) powder

Manufacturer/Distributor Country/Address Generic Name Remarksproduction capacity of API in kg /year

Price Per Unit ($)

Triquim S.A. Méthadone active N/A kg $900.00 Argentina and Uruguay.

Harman Finochem Limited 2000 kgs kg $350.00 N.A.

Pharmascience Inc pms-methadone N/A 1 G $13.75 Canada

N/A 25 G $76.58

N/A 100 G $280.20

methadone hydrochloride Macf Smith (100g) powder

Drug Manufacturer name and address:Triquim S.A.Commercial Offices: Av. Vélez Sársfield 5855Laboratories: Av. Vélez Sársfield 5928 CarapachayBuenos Aires, Argentina. Tel.: +54-11-4762 6405Fax.: +54-11-4762 6405 triquim@lazar.com.ar

more than 100 kg Stupefacient Import Authorization issued by the Health’s Authorities of the import country and legalized by the Argentinean consulate or apostilled.

India107 A, Vinay Bhavya Complex159a CST RoadKalina, Santa Cruz (East)Mumbai-400098Te.: +91-22-265 28080Fax.: +91-22-265 28285E-mail: harmanfinochem@vsnl.comhttp://www.harmanfinochem.com/

Price Per Unit ($)

methadone (API) 3000 kg kg € 260.00 N.A.

Siegfried (USA), Inc 5000 kg kg U.S.A.

Siegfried Ltd 16000 kg kg

around 600 kgs N/A N/A N/A

around 1000 kgs N/A N/A N/A

Zentiva, a.s. 1kg -

Pioneer Agro Industries (Pharmaceutical Division), Prop. Sanvin Laboratories Pvt. Ltd.

IndiaFactory Address: Plot nos. 6,7,8,20 & 24, MIDC, Badlapur, Post Kulgaon, Dist. Thane-421503.United States33 Industrial Park RoadPennsville, NJ 08070Tel.: +1 877 763 8630E-mail: info@siegfried-usa.comSales: milton.boyer@siegfried-usa.comR&D: richard.haldimann@siegfried.chhttp://www.siegfried.ch

methadone hydrochloride USP

This information is confidential and will be only disclosed with a confidentiality agreement in place.

DEA export permit

SwitzerlandUntere Brühlstrasse 44800 ZofingenTel.: +41 62 746 1212E-mail: info@siegfried.chSales: juerg.ammann@siegfried.chR&D: regina.thiergardt@siegfried.chhttp://www.siegfried.ch

methadone hydrochloride PhEurUSP

This information is confidential and will be only disclosed with a confidentiality agreement in place.

Worldwide except USA.Universal Pharmaceutical Laboratories Ltd.(China)

Swissmedic export permit

Laboratoires Sophatex21 rue du Pressoir28500 VernouilletFranceTél: 00 33 (0) 2 37 62 76 76Fax: 00 33 (0) 2 37 62 76 75

Laboratoires Bouchara-Recordati68, rue MarjolinB.P. 6792302 Levallois Perret CedexTel. ++33 1 45191000Fax ++33 1 47560246 Parc Mécatronic

chlorydrate de méthadone AP/HP sirop

méthadone AP/HP gélules (in may 2008)

Slovak Republic Nitrianska 100 920 27 Hlohovec Tel: (+421) 33 736 1111 Fax: (+421) 33 736 0890 E-mail: info@zentiva.skhttp://www.zentiva.sk/

unmentioned, unpublished

Czech Republic, P.T. Kimia (Indonezia), Biomed (New Zealand), Slovak Republic, UniHelp (Ukraine), M&A (United Kingdom),

Price Per Unit ($)

Zentiva, a.s. N/A 1kg $800-1000Czech Republic U Kabelovny 130 102 37 Praha 10 Tel: (+420) 267 241 111 Fax: (+420) 272 702 402 E-mail: zentiva@zentiva.czhttp://www.zentiva.cz/Commercial unit in CZZentiva CZ, s.r.o.Na Strži 63140 62 Praha 4Czech RepublicTel: (+420) 267 242 111Fax: (+420) 261 141 254

Morphine Active Pharmaceutical IngredientsManufacturer/Distributor Country/Adress Generic Name

Alcaliber, S.A. morphine (AMA) 54.000kg

morphine HCl 155 Kg

Fine Chemicals Corporation morphine +1000 kg 1kg R6780.00

morphine sulfate 500 kg kg $1,350.00

500 kg kg $1,350.00

Alcaliber, S.A. 1 g2 g

Production Capacity of API in kg / year

Quoted unit price per smallest unit (mg / ml)

Fernando El Santo 2328010 Madrid - EspañaTelephone: +34 91 575 46 67Fax: +34 91 576 08 45E-mail:alcaliber@alcaliber.comhttp://www.alcaliber.es/

Argentina, Czech Republic, France, Germany, Guatemala, Iran, Italy, Pakistan, Portugal, South Africa, Switzerland, United Kigdom among others.

South AfricaEpping I7475 EppindustCape TownSouth-AfricaTelephone: +27.21.531.6421Telefax: +27.21.531.4555; +927-21531 1458E-Mail: maske@iafrica.com

VARIOUS IN SOUTH AFRICA

Government Opium and Alkaloid Works

IndiaNeemuch (M P)-458441Tel.: +91-7423-220 199Fax.: +91-7423-220 674Ghazipur (U P)-233001Tel.: +91-548-222 0237Fax.: +91-548-222 060127, Saraswati House, 5th Floor,Nehru Place, New Delhi – 110 019Fax: +91-11-26485186Tel.: +91-11-26417475E-mail : goaf@vsnl.comWebsite: http://goaf.gov.in

No exports at present as capacity being utilized to cater to domestic requirement

morphine sulfate powder

Manufacturer/Distributor Country/Adress Generic Name Production Capacity of API in kg / year

Companies/Countries purchasing productAlcaliber, S.A.

5 g25 g100 g500 g1 g2 g5 g25 g100 g250 g500 g

morphine TartrateS.A.L.A.R.S. S.p.A. N.A. 1Kg $3,500.00 N. A.

Siegfried (USA), Inc 15000 kg USA

morphine sulfate powder

morphine hydrochloride powder

ItalyVia San Francesco, 5 22100 Como Tel.: +39.031.52 40 95 / 520 610 Fax: +39.031.52 07 51E-mail: contact@salars.ithttp://www.salars.it/

United States33 Industrial Park RoadPennsville, NJ 08070Tel.: +1 877 763 8630E-mail: info@siegfried-usa.comSales: milton.boyer@siegfried-usa.comR&D: richard.haldimann@siegfried.chhttp://www.siegfried.ch

morphine sulfate USP

This information is confidential and will

be only disclosed with a confidentiality agreement in place.

Manufacturer/Distributor Country/Adress Generic Name Production Capacity of API in kg / year

Siegfried Ltd 10000 kg Worldwide except USA

TMO - Opium Alkaloids Plant 1000 mg $635.00 Switzerland

morphine sulfate 1000 mg $765.00 Thailand

1000 mg $1,145.00 Germany, Switzerland

Zentiva, a.s. morphine sulphate 1 kg

SwitzerlandUntere Brühlstrasse 44800 ZofingenTel.: +41 62 746 1212E-mail: info@siegfried.chSales: juerg.ammann@siegfried.chR&D: regina.thiergardt@siegfried.chhttp://www.siegfried.ch

morphine sulfate PhEurUSP

This information is confidential and will

be only disclosed with a confidentiality agreement in place.

03310 Bolvadin / AfyonkarahisarTurkeyTel.: +90-312-425 92 24Fax.: +90-312-416 34 00E-mail: hashas.db@tmo.gov.tr

Ethylmorphine Hydrochloride

Slovak Republic Nitrianska 100 920 27 Hlohovec Tel: (+421) 33 736 1111 Fax: (+421) 33 736 0890 E-mail: info@zentiva.skhttp://www.zentiva.sk/

unmentioned, unpublished

In 2007 any export, only sales in Slovak Republic

Remarks

DEA export permit

Remarks

Swissmedic export permit

Manufacturer Country/Address Generic Name

N.A. N.A. 5 mg $60.00 N.A. Confidential information

N.A. N.A. 100 μg/ml $10.80 N.A.

N.A. N.A. 100 μg/ml $26.10 N.A.

N.A. N.A. 1.0 mg/ml $18.00 N.A.

(±)-methadone N.A. N.A. 1.0 mg/ml $18.00 N.A.

(±)-methadone-D3 N.A. N.A. 100 μg/ml $26.10 N.A.

(±)-methadone, N.A. N.A. 100 μg/ml $18.00 N.A.

(±)-methadone-D3 N.A. N.A. 1.0 mg/ml $103.50 N.A.

Brand Name

Dosage Form

Price Per Unit ($)

Price Per Patient Per Year (PPPY) for a daily dose of 16 mg

Cerilliant Corporation

United States811 Paloma DriveSuite A | Round RockTexas 78665 Phone: 1.800.848.7837 (USA or Canada) -or- 512.238.9974 (International) Fax: 1.800.654.1458 (USA or Canada) -or- 512.238.9129 (International) custserv@cerilliant.comtechserv@cerilliant.comhttp://www.cerilliant.com/

EDDP-D3 perchlorate (methadone metabolite) as salt

(reference material)

EDDP perchlorate (methadone metabolite) as pyrolinium

EDDP-D3 perchlorate (methadone metabolite) as pyrolinium

(EDDP perchlorate (methadone metabolite) as pyrolinium

Manufacturer Country/Address Generic Name Brand Name

Dosage Form

Price Per Unit ($)

(±)-methadone-D9 N.A. N.A. 100 μg/ml $26.10 N.A.

Confidential information

(±)-methadone-D9 N.A. N.A. 1.0 mg/ml $103.50 N.A.

N.A. N.A. 100 μg/ml $195.00 N.A.

buprenorphine-D4 N.A. N.A. 100 μg/ml $30.00 N.A.

buprenorphine N.A. N.A. 100 μg/ml $18.00 N.A.

naloxone N.A. N.A. 1.0 mg/ml $25.00 N.A.

N.A. N.A. 100 μg/ml $189.00 N.A.

norbuprenorphine N.A. N.A. 100 μg/ml $25.00 N.A.

norbuprenorphine-D3 N.A. N.A. 100 μg/ml $30.00 N.A.

buprenorphine glucuronide

norbuprenorphine Glucuronide

Dosage Form

Price Per Unit ($)

6-acetylmorphine N.A. N.A. 100 μg/ml $10.80 N.A.

6-acetylmorphine-D3 N.A. N.A. 100 μg/ml $26.10 N.A.

6-acetylmorphine N.A. N.A. 1.0 mg/ml $18.00 N.A.

6-acetylmorphine-D3 N.A. N.A. 1.0 mg/ml $103.50 N.A.

6-acetylmorphine-D6 N.A. N.A. 100 μg/ml $28.00 N.A.

dihydromorphine N.A. N.A. 1.0 mg/ml $85.00 N.A.

ethylmorphine N.A. N.A. 1.0 mg/ml $79.00 N.A.

morphine N-oxide N.A. N.A. 100 μg/ml $98.00 N.A.

10-hydroxymorphine N.A. N.A. 100 μg/ml $300.00 N.A.

Dosage Form

Price Per Unit ($)

morphine-D3 N.A. N.A. 100 μg/ml $26.10 N.A.

morphine N.A. N.A. 1.0 mg/ml $18.00 N.A.

N.A. N.A. 100 μg/ml $26.10 N.A.

N.A. N.A. 100 μg/ml $18.00 N.A.

morphine, N.A. N.A. 100 μg/ml $10.80 N.A.

N.A. N.A. 1.0 mg/ml $18.00 N.A.

morphine-D6 N.A. N.A. 1.0 mg/ml $110.00 N.A.

N.A. N.A. 100 μg/ml $120.00 N.A.

morphine-3-β-D-glucuronide-D3

morphine-3-β-D-glucuronide

Dosage Form

Price Per Unit ($)

N.A. N.A. 100 μg/ml $199.00 N.A.

normorphine N.A. N.A. 1.0 mg/ml $18.00 N.A.

N.A. N.A. 50 mg $162.00 N.A.

N.A. N.A. 1 mg $162.00 N.A.

liquid 10 ng/mcl 1ml 80.00$ N/A N/A

liquid 10 ng/mcl 1ml 136.00$ N/A N/A

10ml 440$ N/A N/A

N.A. N.A. in progress in progress N.A.

morphine-6-β-D-glucuronide-D3

morphine base monohydrate

d3-morphine base monohydrate

Dr. Ehrenstorfer GmbH

GermanyBürgermeister-Schlosser-Str. 6A86199 AugsburgTel: +49-821-906 080Fax: +49-821-906 0888Contact: Sarah Giselle Marques Kauer.

morphine-3-glucuronide (reference material)

morphine-3-glucuronide

morphine-6-glucuronide (reference material)

morphine-6-glucuronide

National Measurement Institute

AustraliaBradfield RoadLindfield, NSW 2070Tel: (61 2) 8467 3600Fax: (61 2) 8467 3610PO Box 264Lindfield, NSW 20701 Suakin StreetPymble, NSW 2073Tel: (61 2) 9449 0111Fax: (61 2) 9449 1653PO Box 385Pymble, NSW 2073General queries: info@measurement.gov.auChemical reference materials: chemref@measurement.gov.auhttp://www.measurement.gov.au/

Contact: Dr Laurence M Besley General Manager, Chemical & Biological Metrology National Measurement Institute 1 Suakin St, Pymble NSW 2073 Australia phone +61 2 9449 0159 Fax: +61 2 9983 1398 mobile +61 (0)412 633 550 email: laurie.besley@measurement.gov.au

This distribute these materials in Europe through LGC Standards (www.lgcstandards.com), and in North America through Cerilliant Corporation (www.cerilliant.com), but clients in other parts of the world can purchase materials directly from this company as well.

Dosage Form

Price Per Unit ($)

N.A. N.A. 50mg N.A.

N.A. N.A. 20mg N.A.

N-oxide morphine N.A. N.A. 10mg N.A.

N.A. N.A. 1mg N.A.

normorphine N.A. N.A. 5mg N.A.

triacetynormorphine N.A. N.A. 5mg N.A.

d9-triacetylnormorphine N.A. N.A. 5mg N.A.

National Measurement Institute

AustraliaBradfield RoadLindfield, NSW 2070Tel: (61 2) 8467 3600Fax: (61 2) 8467 3610PO Box 264Lindfield, NSW 20701 Suakin StreetPymble, NSW 2073Tel: (61 2) 9449 0111Fax: (61 2) 9449 1653PO Box 385Pymble, NSW 2073General queries: info@measurement.gov.auChemical reference materials: chemref@measurement.gov.auhttp://www.measurement.gov.au/

Contact: Dr Laurence M Besley General Manager, Chemical & Biological Metrology National Measurement Institute 1 Suakin St, Pymble NSW 2073 Australia phone +61 2 9449 0159 Fax: +61 2 9983 1398 mobile +61 (0)412 633 550 email: laurie.besley@measurement.gov.au

This distribute these materials in Europe through LGC Standards (www.lgcstandards.com), and in North America through Cerilliant Corporation (www.cerilliant.com), but clients in other parts of the world can purchase materials directly from this company as well.

morphine base monohydrate

110 AUD (Domestic

price), 155 AUD (Intl.

price)3-monpacetylmorphine sulfamate

135 AUD (Domestic

price)6-monoacetylmorphine base

135 AUD (Domestic

price)(reference material)

110 AUD (Domestic

price)d3- morphine base monohydrate

110 AUD (Domestic

165 AUD (Domestic

price)

Remarks

Buyers have to provide a signed statement that products containing controlled substances will not be re-exported. The appropriate controlled drug import document(s) required by the buyer's government must be provided. Shipping and handling charges are prepaid and added to the buyer's invoice. Cerilliant reserves the right to require prepayment for export shipments.

Remarks

These materials are intended to be used to calibrate measuring equipment used for the detection and quantification of these drugs. NMIA is accredited as a reference materials producer against ISO Guide 34.

Remarks

These materials are intended to be used to calibrate measuring equipment used for the detection and quantification of these drugs. NMIA is accredited as a reference materials producer against ISO Guide 34.

1) The importer applies for an import licence from the national authority of the importing country

2) The importer send the issued import licence to the exporter.

3) The exporter applies for an export licence from the national authority of the exporting country.

4) The exporter ship the products to the importer with both export and import licences.

please see below for more details

Exportaion of the controlled substances should follow the steps below to which is common for all formulations under the drug conventions. Each national authority for the drug conventions may have different requirements for the documents to be submitted for the issue of licence.

http://www.unodc.un.or.th/drugsandhiv/publications/2007/Step-by-Step.pdf

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