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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017 IPStudies SARL
CRISPRPATENTLANDSCAPEAugust2017
Intangibleassets deserve closer scrutiny
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Copyright
• Unless otherwise specified, all content included on this document, such astext, graphics, logos, button icons, images, audio and video clips, digitaldownloads, data compilations, and software, including but not limited toIPStudies surveys, is the property of IPStudies SARL and protected byinternational copyright laws.
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Ourteam
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CorinneLEBUHAN,PhDICTExpertIPStrategy&Management
• FundedIPStudiesin2010tohelpSwiss&EUhigh-techSMEsdevelopandexecutetheirIPvaluationplansusingthelatestpatentanalyticstoolsandtrends
• 15yearsexperienceinIPstrategyandmanagement– formerVPKnowledgeManagementofNagravision-Kudelski Group,inchargewithpatents(200families),standards,R&Dcollaborations,licensingandtechnicalpublicationsportfolios
• TeachesinternationallicensingpracticesandIPstrategyatIEEPI–EUHorizon2020expertonInnovationinSMEs2013-2015
• ICTTechnologyExpertforvariouslicensingfacilitatorsandaggregatorsinFrance,GermanyandtheUS
• Universitypostgraduateinmanagementofinnovationandintellectualproperty(UniversityofStrasbourg,2008),PhDinCommunicationsScience(EPFL,1998),MsC inElectricalEngineering(INSARennes,1994)
• ExperiencedwithPatbase,EPO/RegisterPlus,USPTO/PAIR
• InternationalnetworkofIPpractitionersandlicensingmanagers-MemberLES,IEEE,AROPI,AAIEEPI
FabienPALAZZOLI,PhDLifeSciencesExpertPatentAnalysis&Landscapes
• JoinedIPStudies in2013todeveloptheIPanalyticsofferinginlifesciences&biotechnology
• 9+yearsexperienceintechnologytransfers,patentmapping/landscapingandFTO-drivenresearchintelligencefortheFrenchpublicsectorandbiotechSMEs- formerIPanalyticssalesmanagerforFISTSA,theCNRStechnologytransferoffice
• Author/co-authorof18scientificandtechnicalpublications/communications,aswellasonebookchapter
• Lifesciencespatentanalystforvariousbiotech/medtech SMEsinSwitzerlandandinEurope
• PhDinLifeSciences(Exploitationofpatentinformationinapublicresearchlaboratory:identificationoftechnologicalnichesinbioproduction andgenetherapy,UniversityofTours,2011),MsC inBiotechnologyandLaw(UniversityofTours,2007)
• ExperiencedwithOrbit,Patbase,Intellixir,patentofficesdatabases
• Internationalnetworkofpatentinformationanalysts
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Tableofcontents
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• Methodology
• OveralltrendsoftheCRISPRpatentdatabase• Temporaldistributionofpatentfilings(2002-2017)• Temporaldistributionofpatentfilingsbytypeofplayers(2002-2017)• Worldmapofpriorityfilings• Temporaldistributionofpriorityfilings(2002-2017)• Worldmapofpatentextensions• Mainpatentapplicants/assigneesandtemporaldistributionoftheirfilings• Co-filingsbetweenapplicants/assignees
• BreakdownoftheCRISPRpatentdatabase• BreakdownbyClaimcoverageofpatentfamilies
• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningofapplicants/assignees
• BreakdownbyComponents• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningoftheapplicants/assignees
• BreakdownbyChimericproteins• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningofapplicants/assignees
• Mainforwardcitedpatentfamilies• Appendice1– Licensingannouncements• Appendice2– Affiliationmappingofplayerspresentinthepatentlandscape
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20175
Temporaldistributionofpatentfilingsbytypeofplayers(2002-2017)
Ø 1043 filings by institutional applicants/assignees (60.5%),Ø 553 filings by industrial applicants/assignees (32.1%),Ø 74 filings by individual inventors (4.3%),Ø 57 co-filings between industrial applicants/assignees and institutional applicants/assignees (3.3%).Ø The years 2016 and 2017 are not complete due to the delay of publication of 18 months.
1724patentfamilies
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20176
Mainpatentapplicants/assignees (≥12patentfamilies)
Institutional applicant/assignee
Industrial applicant/assignee
Ø Affiliates & subsidiaries have been gathered under their parent company (Danisco with DuPont…). Co-filings arecounted for each co-owner: a patent application co-filed between the MIT, the Harvard University and theBroad Institute is counted once for each of this applicant.
Ø The patent portfolio of DuPont comprises historical patent families on CRISPR sequences dealing with the typingof bacterial strains, cultures with improved phage resistance and applications for preparing food.
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Temporaldistributionoffilingsofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Co-filingsbetweenapplicants/assignees(≥2co-filings)
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Number ofpatentfamiliesintheportfolio
Co-filing(s)betweenthetwo applicants
Ø The co-filing map shows the co-filings between applicants/assignees. The same type of link can be found whenan assignment occurred between two players, giving the historical applicants as well as the new owners.
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20179
BreakdownoftheCRISPRpatentdatabase(1)
Ø A patent family can be classified in several categories (e.g. ‘Genome Editing’ and ‘Therapeutic application’and ‘Human cell-subject’ and ‘CRISPR-Cas system’…).
• Genomeediting
• Transcriptional-epigeneticregulation
• Otherapplication
• Therapeutics-Diagnostics
• Bioproduction
• Drugscreening
• Modifiedcell
• Modifiedanimal
• Modifiedplant
Applications
• Humancell-subjet
• Mammaliancell-organism
• Otheranimalcell-organism
• Plantcell-organism
• Fungi-algae-yeast
• Eukaryoticcell-organism
• Prokaryoticcell
• Otherorganism
• Undefinedcell-organism
Cells/Organisms
• Nuclease
• ZFNuclease-ZFP
• Meganuclease
• TALENuclease-TALEP
• gRNA-guidesequence
• Cas-CRISPRenzyme
• CRISPRsystem
• Otherchimericprotein
• Vector-Delivery
• CRISPRsequence
‘Moleculartools’
‘CLAIMCOVERAGE’
The1724patentfamilies havebeenmanually classified
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-201710
BreakdownoftheCRISPRpatentdatabase(2)
Ø A patent family can be classified in several categories (e.g. ‘Genome Editing’ and ‘Therapeutic application’and ‘Human cell-subject’ and ‘CRISPR-Cas system’…).
COMPONENTS CHIMERICPROTEINS
Chimericnucleases
• Undefinednucleases
• ZFNucleases
• Meganucleases
• TALENucleases
• RNA-GuidedNucleases
• Otherchimericnucleases
Otherchimericproteins
The1724patentfamilies havebeenmanually classified
• Cas-CRISPRenzyme
• MutatedCas - nickase
• dCas
• Cas9
• mutatedCas9- nickase
• dCas9
• OtherCas
• OthermutatedCas
• Cpf1-mutatedCpf1
• gRNA
• sgRNA-chiRNA
• crRNA
• tracrRNA
• Nuclease-Nickase
• Meganuclease
• Integrase
• Recombinase
• Repressor-Activator
• Acetyltransferase
• Deacetylase
• Methyltransferase
• Demethylase
• Kinase
• Othercatalyticdomain
• Undefinedcatalyticdomain
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyClaimcoverageofpatentfamiliesBreakdownofthepatentportfolio
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Applications Cell /Organism ‘Covered molecular tools’
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyClaimcoverageofpatentfamiliesPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyComponentsBreakdownofthepatentportfolio
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyComponentsPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyChimericproteinsBreakdownofthepatentportfolio
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Nucleases including chimeric nucleases Other chimeric proteins
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyChimericproteinsPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-201717
Licenseannouncements(samplepage4)
Licensor Scope Licensee Date
Toolgen
Worldwidelicense&sublicensesrightsforresearchapplicationsincludingthedevelopmentandsaleofreagents,celllines,andanimalmodels,aswellasrightsforhighthroughputscreening,diagnostics,andbioproduction.ToolGen retainsitsrightsinbroadareasincludinghighthroughputscreening,diagnostics,bioproduction,plantbiotechnologyandgene/celltherapy.
ThermoFisher Scientific 2015/03
VilniusUniversityExclusiverights tothe Cas9-mediatedgenomeeditingintellectualpropertyownedbyVilniusUniversityforallcommercialuses,includinginagriculture.
DuPont 2015/06
UniversityofMinnesota
Exclusiveworldwiderights toanAAVgenetherapyandintellectualpropertyfromtheUniversityofMinnesotatotreatpatientswithFanconianemia(FA)disorderandotherrareblooddiseasesusingtheCRISPR/cas9technology platform.
AbeonaTherapeuticsInc 2015/06
CaribouBiosciencesDupont(incl.VilniusUniversity)
Multi-faceted agreementincludes thecross-licensing ofkeyIP,aresearch collaboration,andfinancial investments byDuPont inCariboutodevelopandutilizeCRISPR-Castechnologyforproductdevelopmentinmultiplefieldsincludinghumanandanimaltherapeutics,diagnostics,industrialbiotechnology,researchtools,andcertainagriculturesegments.TheDuPontlicensetoCaribouincludesrightstotheCas9-mediatedgenomeediting IPownedbyVilniusUniversityandexclusivelylicensedtoDuPont inmultiplefields and exclusiveaccess intheresearch tools field.
CaribouBiosciencesDuPont(incl.VilniusUniversity)
2015/10
CrisprTherapeutics
$105millionupfront—$75millionincash,$30millionequityinvestment- futuredevelopment,regulatoryandsalesmilestonesofupto$420millionforeachofuptosixCRISPR-Cas9-basedtreatmentsforwhichVertexhasagreedtolicenseexclusivedevelopmentrights (incl.cystic fibrosis).Royaltiesonfuturesales.
Vertex 2015/10
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Furtheranalyticsforyourspecificneedswiththeonlinedatabase
• Zoomonpatentportfoliosofspecificapplicants
• Zoomonpatentsfiledinacountry/region(US,EP,CN…),withinatimeperiod
• Zoomonpatentscoveringanapplication,adedicatedtechnology,aspecificationorafunctionalsubset
• Linktoonlinepatentofficeregisterstoreviewlatestlegalstatus
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Accesstotheinteractive“navigate,zoom,clickandshowpatent”database
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Order
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This is only a sample report with partial data. Our fulloffer includes:• ananalysisofthepatentlandscape,covering1724patentfamilies,worldwide• asynthesisofIPstrategyfindings,tovisualizekeytrendsintermsofpatentapplicants,collaborationnetworks,competitortechnologypositioning,keyinventorsandR&Dwhitespacesoutofthelandscape• anon-lineaccesstothe1724patentfamiliesset,soyoucanvisualize,navigate,focusandextractthemostrelevantpatentdataaccordingtoyourspecificneeds.
Contactustodayforanofferatsales@ipstudies.ch+41797875746
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