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Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Gee ndash isnrsquot that what I just told you
Gee ndash isnrsquot that what I just told you
Canrsquot you give me any added value
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
You have depression
Gee ndash isnrsquot that what I just told you
Gee ndash isnrsquot that what I just told you
Canrsquot you give me any added value
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Gee ndash isnrsquot that what I just told you
Gee ndash isnrsquot that what I just told you
Canrsquot you give me any added value
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Gee ndash isnrsquot that what I just told you
Canrsquot you give me any added value
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Doctor my stomach hurts What do I have doctor Please tell me
You have gastritis
Doctor I am depressed and sad What do I have doctorPlease tell me
You have depression
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to it
It is infected
How to treat itAntibiotics
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Doctor my stomach hurts What do I have doctorPlease tell me
You have gastritis
Doctor I am depressed and sad What do I have doctor Please tell me
You have depression
Place in the body
What happened to itIt is infected
How to treat itAntibiotics
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Gastroenteritis
Gastroenterologist
Mitral Valve Prolapse
Cardiologist
Urologist
Depression
Psychiatrist
Glomerulonephritis
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Medicine = Etiological DiagnosisPsychiatry = Descriptive Diagnosis
SPACE
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
PsychosisMoodAnxiety
Psychosisdue to injuries etc
Negative symptomsDeficiency
Positive symptoms
delirium
Schizophrenia
Depression Mania
Reactive Secondary
Endogenous Major
Mixed anxiety and depression
Psychosis Depression
ManiaPsychosis
Schizoaffective disorder
Generalized
Phobia
Personality disorders
Learning disability
OCD
PTSD
Eating disorders
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
ldquo hellip
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
helliprdquo
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Why we failed
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Proposed RDoC
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Clinical Brain ProfilingCBP
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Clinical Brain ProfilingCBP
Explanatory power
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Clinical Brain ProfilingCBP
Translation matrix
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
General
Neuroscientific
consideration
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Bernard Baars 1980s
Stanislav Dehene 2006
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
1010)107(
Marcel Mesulam
From sensation to cognition Mesulam 1998
Stanislav Dehene 2006
Giulio Tononi
UnitaryUndividable 2-3s
Taps into large repertoireStatistical combinations
One of billion others thus dramatically reduces uncertainty
Information = reduction of uncertainty (entropy) thus Can be quantified with Information measurements
Ф = (info in whole) measures
complexes
Bernard Baars 1980s
Emergent Properties
One neuron has no awareness or feelings but many organized neurons do
The whole is more than the sum of its parts
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
To make as perfect or effective as possible
Optimization
To find the best compromise among several often conflicting requirements
Small World Network
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Clustering Coefficient = Measure of density of connections between nearest neighbors
Path length = inversely related to global efficacy of parallel information transfer
Small-worldness = high clustering small path lengthcomparable to random graph
Hierarchy = Hubs with many long distance connections and few local connections
Rent exponent = topo-physical embedment in physical space of the network scaling relationships
Mean connection distance = Euclidean distance between centers in stereotactic space
Assortativity = measures the preference of a node to connect to other nodes of similar degree
Node = cortical region or neuron
Edge = statistical measure of association
Degree = the number of edges connecting a node
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
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control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Specific
Neuroscientific
consideration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
EGO
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO Experience dependent plasticity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Theodore Meynert(1833-1892)
Donald Hebb 1948
Carl Rogers
Otto Kernberg1928 1990
Hinz Kohut1913-1981
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
Object relations
psychology
Personality amp Personality Disorders
Karl Friston
FreeEnergy
Giulio Tononi
Matching complexity
De-optimization Optimization
Depression
Elevated moodMania
Multiple constraint frustration
Anxiety
Herbert Simon
1962
Marcel Mesulam
Negative
symptoms
Loosening
associations
Perseverations
Delusions
Psychosis Negative (restriction)
Negative (volition)
Delusional
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Translation of signs and
symptoms to presumed
brain disturbances
Testable predictions
Validation
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Delusions
Hallucinations
History of delusions
depressed
Complains of depressed mood
History of depression
Complains of Confused thoughts
Signs
Symptoms
History
Is it as good as scales
Is it good as consensual
current descriptive
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Theodore Meynert(1833-1892)
Donald Hebb 1948
EGO=Default mode network
EGO Experience dependent plasticity
Internal Representations
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
[DDMN]
Disturbance to the default mode network
[DMDd]
Disturbance to Matching dynamics Deoptimization type
[DMDo]
Disturbance to Matching dynamics Optimization type
[DMCO]
Disturbance to Multiple constrain organization
[ibDMCO]
Input bound Disturbance to Multiple constrain organization
[DD]
Disconnection Dynamics
[OD]
Over-connection Dynamics
[TDS]
Top down shift
[BUI]
Bottom-upInsufficiency
Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs Signs
Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms Symptoms History History History History History History History History History History
Nissen C Holz J Blechert J Feige B Riemann D Voderholzer U Normann C Learning as a model for neural plasticity in major depression Biol Psychiatry 2010 Sep 1568(6)544-52
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
J Neurosci 2010 Nov 2430(47)15915-26Aberrant frontal and temporal complex network structure in
schizophrenia a graph theoretical analysisvan den Heuvel MP Mandl RC Stam CJ Kahn RS Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs resulting in a limited structural capacity to integrate information across brain regions
Yu Q Sui J Rachakonda S He H Pearlson G Calhoun VD Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task Front Syst Neurosci 2011 Feb 857
Pettersson-Yeo W Allen P Benetti S McGuire P
Mechelli A Dysconnectivity in schizophrenia
Where are we now Neurosci Biobehav Rev
2011 Apr35(5)1110-24 Epub 2010 Nov
27Review
Jones MW Errant ensembles dysfunctional neuronal network dynamics in schizophrenia Biochem Soc Trans 2010 Apr38(2)516-21 Review
Bassett DS Bullmore E Verchinski BA Mattay VS Weinberger DR Meyer-Lindenberg A Hierarchical organization of human cortical networks in health and schizophrenia J Neurosci 2008 Sep 1028(37)9239-48
Bodnar M Harvey PO Malla AK Joober R
Lepage M The parahippocampal gyrus as a
neural marker of early remission in first-
episode psychosis a voxel-based
morphometry study Clin Schizophr Relat
Psychoses 2011 Jan4(4)217-28
Guye M Bettus G Bartolomei F
Cozzone PJ Theoretical analysis of
structural and functional connectivity
MRI in normal and pathological brain
networks MAGMA 2010 Dec23(5-
6)409-21 Epub 2010 Mar 27Graph
Wolf RC Sambataro F Vasic N
Schmid M Thomann PA
Bienentreu SD Wolf ND Aberrant connectivity of resting-
state networks in borderline
personality disorder J Psychiatry
Neurosci 2011 Mar
136(2)100150
Congdon E Mumford JA Cohen JR Galvan A
Aron AR Xue G Miller E Poldrack RA
Engagement of large-scale networks is
related to individual differences in inhibitory
control Neuroimage 2010 Nov 153(2)653-
63 Epub 2010 Jun 30
Monk CS Nelson EE Woldehawariat G
Montgomery LA Zarahn E McClure EB
Guyer AE Leibenluft E Charney DS Ernst M
Pine DS Experience-dependent plasticity for
attention to threat Behavioral and neurophysiological evidence in humans Biol
Psychiatry 2004 Oct 1556(8)607-10
Volkow ND Tomasi D Wang GJ
Fowler JS Telang F Goldstein RZ
Alia-Klein N Woicik P Wong C Logan
J Millard J Alexoff D
Positive emotionality is associated
with baseline metabolism in
orbitofrontal cortex and in regions of
the default network
Mol Psychiatry 2011 Apr 12
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Central Executive Network
DefaultModeNetwork
SalienceNetwork
[DD]Disconnection Dynamics
[OD]Over-connection Dynamics
[BUI]Bottom-up
Insufficiency
[TDS]Top down shift
[DMDd]Disturbance to Matching dynamics
Deoptimization type
[DMDo]Disturbance to Matching dynamics
Optimization type
[DDMN]Disturbance to the default mode
network
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect diagnose amp monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity Free energy estimations Entropy measurements integrated information theory
Mood amp AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity Free energy estimations Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition Estimating hierarchy k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations Synchrony Granger causality Mutual information Dimension estimation Bayesian statistics Dynamic Causal Modeling Independent components analysis Neural complexity (Correlation matrix) overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
N e u r o A n a l y s I sneuroanalysisorgil
N e u r o A n a l y s I sneuroanalysisorgil
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