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Excitation Excitation-contraction coupling Contraction Regulation of contraction Metabolism of contraction Smooth muscle. Excitation. Excitation-contraction coupling. dihydropyridine. ryanodine. Andrew HUXLEY 1953. TITIN. actinin. ACTIN. - PowerPoint PPT Presentation
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1. Excitation2. Excitation-contraction coupling3. Contraction4. Regulation of contraction5. Metabolism of contraction
Smooth muscle
1. Excitation
Excitation-contraction coupling
ryanodine
dihydropyridine
TITIN
actinin
Andrew HUXLEY 1953
ACTIN
Actin together with Mg a ATP se binds to myosin, When tropomyosin is added binding releases
In presence of Ca the efekt of troponin on tropomyosin complex on A - M interaction disapears
Ca binds to troponin C – binding sites of actin arc uncovered
MYOSIN
CONTRACTION
Regulation of contraction
2 um
Force gradation:a. Recruitment (spacial sumation)b. temporal sumation
tetany
A cartoon diagram of myosin and its
A cartoon diagram of myosin and its
Metabolism of contraction
MYOGLOBIN
10 sec min
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