View
15
Download
0
Category
Preview:
Citation preview
February, 2002Genetics 453
Evolutionary Genetics
Chromosome Rearrangements
Joe Felsenstein
Department of Genome SciencesUniversity of Washington, Seattle
email: joe@genetics.washington.edu
Chromosome Rearrangements
Inversion Translocation Transposition Tetraploidy
Additional question: when these occur they are
rare in a population: how do they spread?
plate
hot spot
Formation of the Hawaiian Islands
A B C�
E F G H I JD
A Paracentric Inversion
A Pericentric Inversion
A�
B C E F G H I J�
D
A�
B C�
E F G�
H I J�
D
A�
B G H I J�
CEF D
A�
B G H I J�
CEF D
A B C�
E F G H I JD
A B C�
I JEFG�
H D
A�
B C I J�
EFGH D
A�
B
C
D
E
F
G H I
A�
B
C
D E
F
G H I
J�
J�
Pairing in a paracentric
inversion heterozygote
A�
B
C
D
E
F
G H I
A�
B
C
D E
F
G H I
J�
J�
Crossing−over in a paracentric
inversion heterozygote
A�
B
C
D
E
F
G H I
A�
B
C
D E
F
G H I
J�
J�
Crossing−over in a paracentric
inversion heterozygote
A�
B C
D
E
F
G
H
I
A�
B C
D
E F G
H
I
J�
J�
Pairing in a pericentric
inversion heterozygote
A�
B C
D
E
F
G
H
I
A�
B C
D
E F G
H
I
J�
J�
Crossing−over in a pericentric
inversion heterozygote
A�
B C
D
E
F
G
H
I
A�
B C
D
E F G
H
I
J�
J�
Crossing−over in a pericentric
inversion heterozygote
A�
B C�
D E F G�
H I�
J�
K L M�
N O�
P Q�
A�
B C�
D E F G�
H I�
J�
N O�
P Q�
K L M�
E F G�
H I�
J�
N O�
PQ�
K L M�
A�
BC�
DE F G�
H I�
J�
N O�
PQ�
K L M�
A�
BC�
D
A translocation
Before
After
Breaks
Rearrangement
at first division of meiosis metaphase
EFGHIJ
Q
AB
CD
NOP KLM
Q
NOP KLM
EFGHIJ
AB
CD
A translocation heterozygote
pairs with a pair of untranslocated chromosomes
A pair of translocated chromosomes�
Barriers between mating of polyploids and euploids
gametes
triploid offspring
a tetraploid an ordinary diploid
gametes
the resulting aneuploid offspring
This freeware-friendly presentation prepared with
• Linux (operating system)
• PDFLaTeX (mathematical typesetting and PDF preparation)
• Idraw (drawing program to modify plots and draw figures)
• Adobe Acrobat Reader (to display the PDF in full-screen mode)
(except that we had to use Microsoft Windows to project this as the Xserver I have in Linux is not too great)
Recommended