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Name: Joshua Alex Cornforth
Reg No. : 130150408
Title: What role does the actin cytoskeleton play in cancer metastasis?
Supervisor: Jason King
Epithelial Cells
(Regimented, tightly bound collective
of cells that are anchored in place) Mesenchymal Cells
(non-polarised, motile cells that have
dedifferentiated and lost interactions
with surrounding cells )
EMT
Local Break Down
of blood vessel wall
Primary Site of Tumour
(initial invasion of blood stream)
Secondary Site
(Metastasis)
Formation of “Podia”
(lamellipodia, pseudopodia, invadopodia etc)
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