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High Profile Publishing in Molecular Biology
Hélène Hodak, h.hodak@elsevier.com Marina Ostankovitch, m.ostankovitch@elsevier.com
© 2014 Elsevier
The field of Molecular Biology, inception to current trends
Behind the scenes or the role of the editor
Preparing a high profile article in Molecular Biology
© 2014 Elsevier
1880 1959 1974 1914 1982 2003
Reference journals in Molecular Biology
1869
1993-94
1997
© 2014 Elsevier
Establishment of the field of Molecular Biology
• ~1930: First mention of molecular biology
• Biological problems approached using various disciplines (chemistry, physics) • Problem of specificity of structure and action
• ~1960: Creation of the field molecular biology
• Creation by scientists at leading institutions in USA (Caltech Institute, CA) and Europe (Medical Research Council laboratory, UK; Pasteur Institute, France; Max-Plank, Germany; Israel; Italy; Switzerland; …)
• Founding disciplines
• Structural biology (X-ray crystallographers) • Perutz, Kendrew, Crick, Watson
• Microbiology and Genetics as microbial (molecular) genetics • Monod, Jacob, Brenner
• Biochemistry, as enzymology or protein chemistry (Sanger, Monod) • Biophysics • Embryology
© 2014 Elsevier
Journal of Molecular Biology: 1959 – founded by Sir John Kendrew, Medical Research Council laboratory (Cambridge, UK), Nobel Prize winning biochemist and crystallographer
First multidisciplinary Life Science journal focused on Molecular Biology
© 2014 Elsevier
The field of Molecular Biology is managerial, problem oriented, and multidisciplinary
• New fundamental research enterprise, closely related to physics, relying on expensive instrumentation
• Funds administered by centralized agencies rather than universities (National public and private Science, Technologies and Research agencies and institutions)
• Caltech • Rockefeller Foundation • National Science Foundation • National Institutes of Health • Pasteur Institute • Medical Research Council Laboratory • European Molecular Biology Organization • …
© 2014 Elsevier
The field of Molecular Biology is managerial, problem oriented, and multidisciplinary
• Relevance to medicine and capable of eventually bringing medical benefits
‘a given number of problems which are among the most important in pathology seem to come directly under the jurisdiction of molecular biology . . . above all, the problem of cancer is obviously a molecular biology problem’ (Strasser BJ, 2002)
• Integration of multiple disciplines to approach fundamental problems of life
• Function and cellular significance of molecular interactions • Structure–function relationship
© 2014 Elsevier
Disciplines in Molecular Biology
• Molecular Cell biology • Genetics and Epigenetics
• Developmental biology (Regenerative
medicine, Stem Cell biology, Aging…) • Engineering • Computational Biology • Synthetic Biology
Since inception • Microbiology
• Molecular genetics
• Structural Biology • Biochemistry, enzymology, protein chemistry • Biophysics • Embryology
Later included
© 2014 Elsevier
Multi-disciplinary to inter-disciplinary research
• Multidisciplinary research uses multiple disciplines to address a problem from each of their perspectives. The research is collaborative but a separation between the disciplines remains.
• Interdisciplinary research integrates multiple disciplines to create new instruments, models, approaches. New understanding is achieved by creating a new way of raising new questions.
© 2014 Elsevier
Current approaches in Molecular Biology
• Diversification of biological samples (from test tube to cells, organs, whole organisms, cohorts) allows basic to translational science studies
• Smaller samples (miniaturization)
• Improvement of biological models and higher relevance to biology and medicine (in-vitro, in-silico, in-situ, ex-vivo, in-vivo, human health and disease samples..)
• Higher relevance of cellular environment of in vitro models (3D culture, microfluidics techniques, engineering of matrices and cellular media)
• More powerful and quantitative technologies (better resolution, more efficient) • single cell, single molecule, time-resolved crystallography, microcrystals,
deep-sequencing (detecting fewer number of copies), super-resolution imaging …
© 2014 Elsevier
Current approaches in Molecular Biology
• Structural biology: Nuclear Magnetic Resonance, Time-Resolved Crystallography, crystallography in microplates, cryo-electron microscopy
• Computational biology, bioinformatics, statistics: predictive, modelling, reconstruction studies of molecular interactions in biological systems using larger scale datasets.
• Automation, high-throughput and systematic studies allow large scale analyzes of systems and networks (proteomics, genomics, transcriptomics, metabolomics,…)
• Imaging, kinetics and computational studies address spatiotemporal and dynamic aspects of biological questions
• Single molecule analysis: optical/magnetic tweezers, atomic force microscopy, fluorescence spectroscopy, Förster resonance energy transfer
• High order genomic structure, Chromosome Conformation Capture and variants
© 2014 Elsevier
Current trends in Molecular Biology
Allosteric Interactions and Biological Regulation
Non-coding RNAs in Systems
Molecular Effects of Naturally Occurring Genetic Differences
Regulation of DNA Replication and Genomic Instability
Antiviral Innate Immunity
The Molecular and Cellular Mechanisms of Amyloidosis
© 2014 Elsevier
Current trends in Molecular Biology
Emerging concepts in epigenetic signaling
Molecular mechanisms of microbiota
Functional and mechanistic aspects of ion channels
Functional relevance and dynamics of nuclear organization
© 2014 Elsevier
The field of Molecular Biology, inception to current trends
Behind the scenes or the role of the editor
Preparing a high profile article in Molecular Biology
© 2014 Elsevier
Before you start writing • Conception of your research project
• Novelty • Biologically significance • Reproducibility • Combine and integrate approaches to make new discoveries
• Choosing the right journal and the format of your paper
• Who is the journal’s audience? • How fast does the journal make a decision and publish your paper? • What is the appropriate format of your paper? : Research article,
Communication, Brevia, Method Notes, Database….
Preparing a high profile article in Molecular Biology
© 2014 Elsevier
• Title: appealing, stating the main finding • Figures and legends: self-explanatory, in logical order • Highlights: 4-5 key sentences (background, results, conclusion) • Abstract: includes background, highlights main findings and relevance
Pre-submission
• Clarity, objectivity and accuracy (direct and short sentences, avoid multiple
statements) • Avoid over-interpretation • Cite fairly all reference articles
• Cover letter explains additional research rational and specific circumstances • Recommend Reviewers
Writing your manuscript
Preparing a high profile article in Molecular Biology
© 2014 Elsevier
The field of Molecular Biology, inception to current trends
Behind the scenes or the role of the editor
Preparing a high profile article in Molecular Biology?
© 2014 Elsevier
JMB office
Referees
Authors
Editorial Process
Associate Editors
Editorial Board & Guest Editors
Editor in chief
Scientific editors
• Triage • Oversee and smoothen review process • Invitation of referees • Provide guidance during decision making
• Expert evaluation • Invitation of referees • Make decision
Scientific Editors
Academic Editors
© 2014 Elsevier
Peer-review process at JMB
Initial screening by the Editors
Editorial rejection Peer review °1
Accept Revise Reject
Major revision Minor revision
Accept Reject
Peer review °2
>75%
50% 2%
© 2014 Elsevier
• Editorial Rejection: 3 days • From submission to 1st decision: 4 weeks • Revision: • Minor: 1 month • Major: 2 months • From re-submission to final decision: 2 weeks
Turnaround time from submission to acceptance: 75 days
Manuscripts turnaround
© 2014 Elsevier
Summary Role of the scientific editors
• Shape the content of the journal
• Work with the Editor-in-chief and academic editors
• Selection of articles suitable to the journal
• Commission of special content
• Work with Editorial Board Members during entire review process
• Oversee and smoothen entire review process
• Provide guidance to and ensure communication with authors, academic
editors, and other stakeholders during the publishing process
• Promote content
• Featured articles & commentaries
• Editorials
© 2014 Elsevier
Thank you
• Elizabeth Gaskell, Scientific Editor at Molecular Cell
• Amy Keating, Associate Professor of Biology, MIT, Editorial Board Member
• Daniel Day, co-chair of committee Academics, Research, & Careers,
Graduate Student Council at MIT
• Ryan Bailey, Research Focus, Elsevier
• Peter Wright, Professor, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Editor-in-Chief of JMB
• Editorial Board Members at JMB
• Bart Wacek, Publishing Director, Elsevier • Lucia Franco, Executive Publisher, Elsevier
© 2014 Elsevier
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