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Impact of the « One Health »
approach in public health Example of the EJP on
Foodborne Zoonoses
Biorisk Meeting, Anses, Maisons-Alfort
22 May 2018
This meeting is part of the European Joint Programme One Health EJP. This project has received funding from the European Union’s Horizon 2020
research and innovation programme under Grant Agreement No 773830.
By
CORDEVANT Christophe
ANSES Strategy and Programme Department
Research and Reference Division
No single definition of One Heath; scope can be very large Broad sense:
• Eco-Health, • Global Health, • Planetary Health
In the narrow sense (FAO) ‘A collaborative, international, cross-sectoral, multidisciplinary mechanism to address threats and reduce risks of detrimental infectious diseases at the animal-human-ecosystem interface.’
Interface between human and animal
“Med – Vet approach”
The concept of “One health”
2
Source: OIE - http://www.oie.int/en/for-the-media/onehealth/
HORIZON 2020 - Work Programme
2016 - 2017
Area : “Food security, sustainable
agriculture and forestry, marine and maritime and inland water
research and the bioeconomy healthy and safe foods and diets for all”
Call SFS-36-2017: "One Health" (zoonoses – emerging threats)
Publication date: 14 October 2015 Deadline: 14 February 2017
Type of action: European Joint Programme - EJP
Duration : 5 years
Cofund: 90€M 3
One Health EJP – EU cofund initiative
Partnership: 41 partners /19 Members States
Selected in
October 2017
OH EJP Kick off meeting – Jan 2018
"One Health EJP“ started on January 2018
Launch meeting - 30 & 31 January at ANSES
40 partners from 19 Member States
140 participants: project partners, Ministries of Health, Agriculture, Research,
EFSA, ECDC, DG Agri & Health and REA
4
- Following a One Health approach
“Med-Vet” Partnership
- The EJP aims to create a sustainable European One Health framework
- By alignment and integration of medical, veterinary and food institutes strategies and expertise
- Through joint programming of national research agendas and by funding research projects
- Matching the needs of European and national policy makers and stakeholders 5
One Health EJP Concept
“One Health”
Zoonoses Emerging threats
(ET)
Food Borne Zoonose
(FBZ)
Bacteria
Viruses
Prions
Parasites
Antimicrobial
Resistance
(AMR)
Transmission
by food
or not
Zoonotic potential
suspected
NFBZ
FBZ
(2/3) (1/3)
15%
85%
7
One Health EJP scope
A European network of public research institutes on food safety
8
FP6 Network of Excellence 7 Med + 7 Vet/Food = 14p Foodborne zoonoses
Association (Loi 1901) A self-sustained Network 20 Research institutes Foodborne zoonoses
EJP
2003 2008
2009 2017
A Pre-existing network looking for a long term sustainability plan
2018 2022
Cofund EJP H2020 Network 40 Research institutes Foodborne zoonoses
One Health EJP consortium
Austria Belgium Bulgaria Czech Republic Denmark Estonia France Germany Hungary Ireland Italy Netherlands Norway Poland Portugal Romania Spain Sweden United Kingdom
One Health EJP consortium
9
10
CountryProgramme manager
Med
Programme manager
Vet
AT
BE WIV-ISP CODA-CERVA
NCIPD NDVRI
Stefan Angeloff Ins (LTP)
CZ SZU/NIPH VRI
RKI BfR
FLI
DK SSI DTU
EE University of Tartu VFL
ISCIII INIA
UCM (VISAVET)
EU MVNA
ANSP (LTP) ANSES
Institut Pasteur de Paris INRA
PHE APHA
Surrey Univ
HU NCE IVMR
IE NUIG TEAGASC
ISS IZS AM Teramo
IZS LER Brescia
RIVM WR
NCOH (LTP)
NO FHI/NIPH NVI
PL NIZP-PZH/NIPH-NIH PIWET/NVRI
PT INSA INIAV
RO CNIR IISPV
PHAS NFA
SVA
19 countries +
1 association
ES
BG
AGES
43 Full Members + 3 LTP + MedVetNet Association
NL
IT
GB
FR
SE
DEThe criteria to select a partner MS have been established by the consortium and in agreement with the EC 1. Mandates of reference 2. Scientific production in
zoonoses 3. Networking activities in that
field
41 Partners
One Health EJP
consortium
0
1
2
3
4
5Portugal MED
Portugal VETCZECH…
CZECH…
GREECE MED1
GREECE MED2
GREECE VET
BULGARIA…
BULGARIA…
BULGARIA VETCROATIA MED
CROATIA VETSERBIA VET
ISRAEL VETAUSTRIA…
SWEDEN MED
ESTONIA MED
ESTONIA VET1
ESTONIA VET2
IRELAND VET
IRELAND VET2
IRELAND MEDROMANIA MED
ROMANIA VET
REFERENCE
SCIENCE
NETWORK
One Health EJP governance
11
EC REA
Scientific Steering Board (SSB)
Scientific Directors / Head of Dpts
Project Management Team
(PMT) Coordinator + WP leaders
Programme Managers Committee (PMC)
Directors/CEO
Support Team (ST)
External Scientific
Advisory Board
(ESAB)
Programme Owners Committee
( POC ) (Ministry of authority)
Stakeholders Committee
National Mirror Groups (NMG)
Ethics Advisors
EJP Kick off meeting participants
12
EC REA
Scientific Steering Board (SSB)
Scientific Directors / Head of Dpts
Project Management Team
(PMT) Coordinator + WP leaders
Programme Managers Committee (PMC)
Directors/CEO
Support Team (ST)
External Scientific
Advisory Board
(ESAB)
Committee
( POC ) (Ministry of authority)
Stakeholders Committee
National Mirror Groups (NMG)
Ethics
Advisors
14/41
38/41
15/44
13/13
13
One Health EJP structure
Andre Jestin
Roberto La Ragione Hein Imberechts Ann Lindberg
Arjen van de Giessen
Annemarie Kaesbohrer
Luca Busani
WP2 – Integrative SRA Strategic Research Agenda (SRA) and the priority topics in the three domains identified: foodborne zoonoses, antimicrobial resistance and emerging threats
analytical Isabel Cuesta ISCIII Jean-Yves Madec ^ ANSES Dan Horton Surrey 6 MED
methods Stefano Morabito > ISS Dik Mevius CVI Steven van Borm CODA-CERVA 6 VET
Nadine Botteldoorn WIV-ISP Ana Alastruey ISCIII Ralitsa Popova-Ilinkina NDRVMI
Jeffrey Hoorfar DTU Henrik Hasman SSI Barry Rockx RIVM
host-microbe Karen Krogfelt ^ SSI Bruno González-Zorn > VISAVET-UCM Zoltán Zádori VMRI 4 MED
interaction Karsten Nöckler BfR Didier Mazel IPP Miguel Angel Jiménez INIA 8 VET
Artur Rzezutka PIWet Ákos Tóth NCE Philippe Velge INRA
Cecilia Jernberg PHA Lynda Gun UCD Heinrich Neubauer FLI
epidemiology Henriette de Valk InVS Dariusz Wasyl > Piwet Joke van der Giessen ^ RIVM 8 MED
Paolo Calistri IZSAM Akke Vellinga NUI Simon Cauchemez IPP 4 VET
Klaus Stark RKI Annalisa Pantosti ISS Jenny Frössling SVA
Solveig Jore FHI Alex Cook Surrey Line Vold FHI
risk assessment Renata Karpíšková VRI Aleksander Masny NIZP-PZH Sarah Welby CODA-CERVA 6 MED
Maarten Nauta > DTU Neil Woodford PHE Barbora Macková NIPH 6 VET
Stayanka Stoitsova SAIM-BAS Bernd-Alois Tenhagen BfR Dilys Morgan PHE
Jakob Ottoson NFA Dearbhaile Morris NUI Pascal Hendrikx ANSES
intervention Merete Hofshagen NVI Klemens Fuchs AGES Enikő Bán NCE 5 MED
Rob Davies APHA Mardjan Arvand RKI Marianne Elvander > SVA 7 VET
Christian Kornschober AGES Chris Teale APHA Giorgio Varisco IZSLER
Iva Christova NCIPD Giovanni Alborali IZSLER Katarzyna Pancer NIZP-PZH
11 MED - 9 VET 10 MED - 10 VET 8 MED - 12 VET
Foodborne zoonoses Antimicrobial resistance Emerging threats
15
60 scientific experts gathered over 2 days to produce the research topics Priority setting of research topics using Multi-Criteria Decision Analysis (MCDA)
EJP preparation - SRA & 1st Internal Call
Experts meeting Anses, May 3&4 2016
Domain-theme-area secretaries
16
MRESI grant funding Experts consultation
EJP preparation - SRA & 1st Internal Call
DOMAINES
THEMES Food Borne Zoonoses (FBZ)
AntiMicrobial resistance
(AMR)
Emerging threats
(ET)
Analytical methods
Host-microbe interaction
Epidemiology
Risk assessment
Intervention
17
Selected priority topics first call
NGS based
methods Phenotypic
methods Non-NGS
based methods
Imp.surveillance Epi - AMR
RA - AMR
Biosecurity
Source Attribution
Joint integrative priority topics: Interpretation of surveillance data Common reporting and signalling procedures
Call 1: Selection of projects
18
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 1 2 3 4 5 6 7 8
Task 1. Define guidelines for identification of candidate coordinators and selection of activities to be funded
Define procedures (Task HI)
Task 2. Collect Letters of Intent, perform eligibility check and send them to EJP Coordinator
Launch invitation to propose research activities (Task AJ): 9 June 9
Preparation of Letters of Intent
Deadline submission Letters of Intent: 8 July 8
Collect Letters of Intent (Task AJ)
Invitation to submit full proposal (Task AJ): 15 July 15
Task 3. Collect Full Proposals, perform eligibility check and organize evaluation by external experts
Identify and contact External Experts (Tasks HI + Task leader)
Propose uniform evaluation form with criteria (Task HI)
Preparation of Full Proposals
Deadline submission Full Proposals: 18 September 18
Collect Full Proposals (Tasks HI, AL, RL)
Send full proposals to External Experts (Task HI, AL, RL)
Evaluation of Full Proposals
Deadline evaluation: 6 November 6
Rank proposals and send them to Mgt Team (Task HI, AL, RL)
Task 4. Propose research activities to be funded; final validation by SSB
Send proposals to SSB and PMC for validation (Task AJ/HI): 10 November 10
Validation by SSB in meeting: 24 November 24
Invitation to prepare institutional letter (agreement for funding) (Task AJ): 6 November 6
Preparation of Letter of Commitment
Deadline Institutional letter 18 December 18
Inform research activity coordinators about the outcome: before Xmas (Task AJ or Adm Board)
Include the outcome in the 1Y and 5Y work plan (Task AJ): start 1 December
Submission of DoW Med-Vet EJP: 14 February 2017 (Task AJ) 14
Task 5. Follow up of JRP, JIP & PhD during the 5 year duration of the Med-Vet EJP
Define KPI for follow up of research activities (Task HI + Task leader)
Letter of Intent
April May June July August September
2016 2017
March JanuaryNovember December February
Document of Work
October
Full Proposal
Evaluation
Let. of Commitment
DOMAINES
THEMES Food Borne Zoonoses (FBZ)
AntiMicrobial resistance
(AMR)
Emerging threats
(ET)
Analytical methods
Host-microbe interaction
Epidemiology
Risk assessment
Intervention
19
OH EJP project proposals
METASTAVA
IMPART
MAD-VIR
NOVA ARDIG
RaDAR
AIR-SAMPLE
LISTADAPT
Joint integrative projects: • COHESIVE • ORION
TOX-Detect
MoMIR-PPC
MedVetKlebs
20
Topic
ref
coord
MS
coord
Org
Projects
Acronyme
Projects
Title
IA-1 DE BfR ORION One health surRveillance Initiative on harmOnization of data collection and interpretation
IA-2 NL RIVM COHESIVE One Health Structure In Europe
AMR-1 NL CVI IMPART IMproving Phenotypic Antimicrobial Resistance Testing
AMR-2 GB APHA ARDIG Antibiotic Resistance Dynamics: the influence of geographic origin and management systems on
resistance gene flows within humans, animals and the environment
AMR-3 NL RIVM RADAR Risk and Disease burden of Antimicrobial Resistance
ET-1 FR Anses TOXdetect Development and harmonization of innovative methods for comprehensive analysis of food-borne
toxigenic bacteria, ie. Staphylococci, Bacillus cereus and Clostridium perfringens
ET-1 DK SSI MAD-VIR Metagenomic Array Detection of emerging Virus in EU
FBZ-1 SE SVA NOVA Novel approaches for design and evaluation of cost-effective surveillance across the food chain
FBZ-2 FR Anses LISTADAPT Adaptive traits of Listeria monocytogenes to its diverse ecological niches
FBZ-2 BE CODA-
CERVA METASTAVA
Standardisation and validation of metagenomics methods for the detection of foodborne zoonoses,
antimicrobial resistance and emerging threats.
FBZ-3 DK DTU AIR-SAMPLE A Low-Cost Screening Tool in Biosecured Broiler Production
FBZ-3 FR INRA MoMIR-PPC Monitoring the gut microbiota and immune response to predict, prevent and control zoonoses in
humans and livestock in order to minimize the use of antimicrobials
FBZ-4 FR IP MedVetKlebs Klebsiella pneumoniae: from ecology to source attribution and transmission control
Joint Research & Integrative Projects
13 projects selected and associated with WP3 & WP4
Two rounds of calls
2016 2017
Submission & selection
2018 – 2019 2020 - 2021 - 2022
Start of first round of Research &
Integrative Projects
Start of second round of
Research & Integrative Projects
WP2: Strategic Research
Agenda (1) Identification of
teams
11 Research Projects
2 Integrative Projects
WP2: Strategy
Research Agenda (2) Identification of
teams
10 Research Projects
3 Integrative Projects
21
Budget
• Total budget = 90€M
• EC (50%) = 45€M
• Institutional = 45€M
22
• Allocation of the resources = 90€M
• Overarching = 09€M
• Joint Research Projects = 50€M
• Joint Integrative Projects = 27€M
• Training Education = 04€M
A pilot experience
A cofund exercice
Ministry of authority providing Mandates
A consortium with majority of full partners
One Health , restriction to « Med-Vet »
Narrow scope « FOOD »
Internal calls, in kind
Policy-driven 23
Conclusion
Thank for your attention
André JESTIN - EJP Coordinator ANSES
Strategy and Programme Department
Research and Reference Division
Email : andre.jestin@anses.fr
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