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Introduction to the Antimicrobial Resistance
Global Action Plan
Gyanendra GongalScientist
Health Security and Emergency ResponseWHO Regional Office for South East Asia
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of Zoonoses Sapporo, 28-30 October 2015
Outline
• AMR as a global public health crisis • Global Action Plan on AMR• Sample of actions requested by the Global
Action Plan• Surveillance of AMR• AMR containment strategies and approaches
in the Asia-Pacific Region • Take home message
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
AnimalFeeds
Meat
Direct Contact
EXTENDED
CARE
FACILITIES
HUMAN
Commercial Abattoirs / Processing
Plants
Rendering
FOOD ANIMALS
SHEEP CATTLE
SWINE
POULTRYVEAL
CALVES
OffalVegetation,
Seed Crops, Fruit
Sewage
Drinking water
Drinking Water
Sea / Lakes
SwimmingAQUACULTURE
Rivers and Streams
COMPLEXITY OF ANTIMICROBIAL RESISTANCE
Industrial &Household
AntibacterialChemicals
OTHER FARMED
LIVESTOCK
COMMUNITY- URBAN-RURAL
WILDLIFE
SOIL
Handling Preparation Consumption
After Linton AH (1977), modified by Irwin RJ - 2012 version
Farm Effluents and Manure Spreading
IMPORTS
TRAVELLERS
HOSPITALIZED
COMPANIONANIMALS
Dead stock
Re-mix
Land Fill
Fuel Ethanol
Producers
Fuel & Potable Ethanol
Distillers Grain By-Products
Antibiotics: precious but diminishing resource
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Bringing a new antibiotic in market: Cost USD 1 billion, Time:12-14 years: Life: ??
Alexander Fleming's Nobel Prize Lecture
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
“It is not difficult to make microbes resistant to penicillin ….
“The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily under-dose himself and by exposing his microbes to nonlethal quantities of the drug make them resistant.”
Estimates of Burden of Antibacterial Resistance
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Global information is insufficient to show complete disease burden impacts and costs
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Published on April 29, 2015
Overall Key Findings
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
The survey was completed by
133 countries in 2013-2014.
Few countries (34 out of 133) have a comprehensive national plan tofight resistance to antibiotics and other antimicrobial medicines.
Monitoring is key for controlling antibiotic resistance, but it is infrequent. In many countries, poor laboratory capacity, infrastructure and data management are preventing effective surveillance, which can reveal patterns of resistance and identify trends and outbreaks.
Overall Key Findings
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
$Sales of antibiotics and other antimicrobial medicines without prescription remain widespread, with many countries lacking standard treatment guidelines, increasing the potential for overuse of antimicrobial medicines by the public and medical professionals.
Lack of programmes to prevent and control hospital-acquired infections remains a major problem.
Public awareness of the issue is low in all regions, with many people still believing that antibiotics are effective against viral infections.
Key Findings by Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
WHO African Region
WHO Region of the Americas
WHO Eastern Mediterranean Region
WHO European Region
WHO South East Asian Region
WHO Western Pacific Region
WHO Africa Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
8 out of 47Member States in the region participated in the survey.
All 8 countries in the regionstate that resistance to treatments for malaria and TB are their greatest challenges.
Poor-quality medicines are a general problem, further contributing to the challenge.
The data in this regionare incomplete due to lack of information, however the results suggest that antimicrobial resistance is a growing problem.
Countries who participated in the survey:Burkina Faso, Central African Republic,
Gambia, Ghana, South Sudan, United Republic of Tanzania, Uganda
and Zambia
WHO Region of the Americas
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
26 out of 35Member States in the region participated in the survey.
Only 3 countries in the regionreport having a national plan to address antimicrobial resistance.
Poor quality medicines are a problem, particularly in Latin America.
Antibiotics and other antimicrobial medicines are available over the counter without a prescription in 18 countries.
Only 10 countries have
standard treatment guidelines.
Few countries produced a report on surveillance ofantimicrobial resistance in humans.
Countries who participated in the survey: Antigua and Barbuda, Argentina, Barbados, Belize, Bolivia (Plurinational State of), Brazil,Canada, Chile, Colombia, Costa Rica, Cuba, Dominica, Dominican Republic, Ecuador,
El Salvador, Guatemala, Guyana, Honduras, Jamaica, Mexico, Nicaragua, Paraguay, Peru, Saint
Kitts and Nevis, Suriname, Uruguay
WHO Eastern Mediterranean Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
13 out of 21Member States in the region participated in the survey.
3 countries have conducteda public information campaign in the previous 2 years.
Poor awareness and understanding in all public sectors.
None of the countries report having a national action plan for antimicrobial resistance.
Antibiotics and other antimicrobial medicines are available without a prescription in 9 countries.
Many gaps were found in addressing the issue. This is not surprising, given the other emergencies in the region, including natural disasters and conflicts.
Countries who participated in the survey: Afghanistan, Bahrain, Egypt, Iran (Islamic Republic of), Jordan, Lebanon, Morocco,
Oman, Pakistan, Saudi Arabia, Sudan, Syrian Arab Republic, United Arab Emirates
WHO Europe Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
49 out of 53Member States in the region participated in the survey.
40% of countries
report having comprehensive plans and strategies to address antimicrobial resistance.
About50% of countries have a national Infection Prevention and Control (IPC) programme.
Public information campaigns are common, however about half the population believe that antibiotics are effective against viruses.
All EU countries undertake surveillance of resistantbacteria through the European Antimicrobial Resistance Surveillance Network (EARS-Net), which is facilitated by the European Centre for Disease Prevention and Control.
Countries who participated in the survey: Albania, Armenia, Austria, Azerbaijan, Belarus,
Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, France, Georgia, Germany, Greece,
Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Kyrgyzstan, Latvia, Lithuania,
Luxembourg, Malta, Montenegro, Netherlands, Norway, Poland, Portugal, Republic of
Moldova, Romania, Russian Federation, Serbia, Slovakia, Slovenia, Spain, Sweden,
Switzerland, Tajikistan, The former Yugoslav Republic of Macedonia, Turkey, Turkmenistan,
Ukraine, United Kingdom, Uzbekistan
WHO South-East Asia Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
All11Member States in the region participated in the survey.
5 of 11countrieshave national plans to address antimicrobial resistance.
9 of 11countries havea national IPC programme and a national regulatory agency responsible for ensuring quality of medicines. Countries report that health workers comply poorly with prescribing guidelines.
Public awareness in the region is growing – 5 countries report conducting awareness-raising activities in the previous 2 years.
Monitoring use of antibiotics and other antimicrobial medicines is limited, and medicines are available without a prescription in more than half the countries.
Health ministers expressed their commitment to prevent and control antimicrobial resistance through the Jaipur Declaration in 2011.
Countries who participated in the survey: Bangladesh, Bhutan, Democratic People’s
Republic of Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand,
Timor-Leste
WHO Western Pacific Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
26 out of 27Member States in the region participated.
2/3of the countries report
having an IPC programme.
There is weak enforcement of regulations on the sale of antibiotics and other antimicrobial medicines without prescription and of quality standards.
Only4 of the reporting countries
have a national action plan.
Nearly70%of countriesreport surveillance for antimicrobial resistance in bacteria; this proportion may increase following introduction of the Western Pacific Antimicrobial Resistance Surveillance system in the near future.
Countries who participated in the survey: Australia, Brunei Darussalam, Cambodia, China,
Cook Islands, Fiji, Japan, Kiribati, Lao People's Democratic Republic, Malaysia, Marshall
Islands, Micronesia (Federated States of), Mongolia, New Zealand, Niue, Palau, Papua New
Guinea, Philippines, Republic of Korea, Samoa, Singapore, Solomon Islands, Tonga, Tuvalu,
Vanuatu, Viet Nam
Perspective on the GAP for AMR
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• The impact on health, & implications for health care are the core fundamental concerns
• However, solutions require engagement beyond health sector alone
– Broad range of global / intersectoral stakeholders beyond health – Overlapping but also differing concerns & perspectives
• Stakeholder involvement is currently insufficient
– Consensus & synergy building requires process
Timeline: Consultations on Draft GAP for AMR
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• Strengthened tripartite collaboration (FAO, OIE, WHO)– Worked together on development of global action plan– Shared actions for the collaboration
• Web based call for contributions: July-August 2014
• Consultation with Member States 16 October 2014
• WHO Strategic Technical Advisory Group (STAG) on AMR convened
• Member State consultations– Human, animal, agriculture (The Hague, June 2014)– Optimizing use of medicines (Oslo, November 2014)– Global surveillance (Stockholm, December 2014)– Research needs (Brasilia, March 2015)
WHO ‘Executive Board’ Meeting January 2015
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• Strong support to take plan to World Health Assembly
• 39 country statements, plus 5 NGOs
• Some requests for modification• WHO FAO OIE tripartite meeting 10 Feb 2015• Meeting with Geneva Permanent Missions 20 Feb
2015• WHO Advisory Group meeting 24-25 Feb 2015• Re-submitted to World Health Assembly March
2015EB web site at http://apps.who.int/gb/e/e_eb136.html It is listed as document EB136/20. Available in 6 languages. Supplementary material is available on our AMR webpages at http://www.who.int/drugresistance/global_action_plan/en/
SCOPE
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Global action plan on antimicrobial resistance
Scope
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Differences, but also many commonalities Common biological paths Common drivers Common actors
Scope
• The global action plan covers antibioticresistance in more detail than other ‘antimicrobials’.
• Establishes links to existing action plans where appropriate, for viral, parasitic and bacterial diseases, including HIV/AIDS, malaria and tuberculosis.
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
PRINCIPLES
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Global action plan on antimicrobial resistance
Principles
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• Whole-of-society engagement, including a one-health approach: the issue affects all, so can only be tackled with participation of the entire society
• Prevention first > good sanitation, hygiene and IPC
• Access > preserve ability to prevent and treat infections
• Sustainability > all countries to have a national plan with defined budget within 2 years of the endorsement
• Incremental targets for implementation > different stages for different countries
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
WHA 67. 25 2014 Antimicrobial resistance
World Health Day April 7, 2011
STRATEGIC OBJECTIVES & FRAMEWORK FOR ACTION
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Global action plan on antimicrobial resistance
Global Action Plan Strategic Objectives
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
1. Improve awareness and understanding of AMR through effective communication, education and training.
2. Strengthen the knowledge and evidence base through research and surveillance.
3. Reduce the incidence of infection through effective hygiene and infection prevention measures.
4. Optimize the use of antimicrobial medicines in human and animal health.
5. Develop the economic case for sustainable investment that takes account of the needs of all countries, as well as the case for investment in new medicines, diagnostic tools, vaccines and other interventions.
6. Commitment to report progress
Framework for action
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• Actions defined for each strategic objective for:
Member States
WHO Secretariat
International and national partners
• Central aspect: DEVELOPMENT OF NATIONAL PLANS
Alignment with global action plan
Alignment with standards defined by intergovernmental bodies (e.g., Codex Alimentarius, OIE, FAO)
Sample framework for action from global action plan
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Member State WHO
• Promote awareness raising • Develop global communications strategy
• AMR to be a core component of professional education
• Develop OIE – FAO – WHO core communications
• Establish & support coalitions • Maintain AMR as priority among MS
Member State WHO
• Develop national surveillance system • Develop global surveillance system
• Promote surveillance in animal health • Work with OIE – FAO on integrated surveillance
• Participate in global & regional surveillance
• Report on AMR and antimicrobial use regularly
Strategic objective 1: Improve awareness and understanding
Strategic objective 2: Strengthen the knowledge and evidence base
Sample framework for action from global action plan…
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Strategic objective 3: Reduce the incidence of infectionMember State WHO
• Strengthen animal health and agricultural practices through OIE codes and FAO/WHO Codex Alimentarius
• Work with FAO and OIE, within the tripartite collaboration, to develop recommendations for the use of vaccines in food-producing animals
Strategic objective 4: Optimize the use of antimicrobialsMember State WHO
• Develop policies on use of antimicrobial agents in terrestrial and aquatic animals and agriculture
• Strengthen and align, within the tripartite collaboration with FAO and OIE, the concepts of critically important antibiotics for human and animal health
• Regulate licensing, distribution, use and quality assurance of antimicrobial medicines in human and animal health
• Develop standards and guidance for the presence of antimicrobial agents and their residues in the environment, especially in water, wastewater and food
Sample framework for action from global action plan…
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Strategic objective 5: Develop the economic case for sustainable investmentMember State WHO
• Work with the World Bank and with FAO and OIE, within the tripartite collaboration, to assess the economic impact of antimicrobial resistance and of implementation of the action plan in animal health and agriculture.
NATIONAL PLANS
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Example of activities under the Global action plan on antimicrobial resistance
AMR National plans
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
National action plans: 34 out of 133 countries that responded to the survey.
Development of National Action Plans
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Governance
• Identify/Designate National Focal Point
• Establish National Steering Committee
Assessment & Analysis
• Collect/Compile Available Data on Burden due to AMR
• Generate Data on Practices, Behaviour
• Detailed Info on Policies, Rules, Regulations and Structures
Planning
• Set Targets• Identify Activities• Assign Responsible
Persons/Institutions• Identify Costs and Resources
Required• Identify Technical Assistance
Needs
National
Action Plan
Development of National Action Plans
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• National plans will provide the basis for the assessment of resources needs.
• WHO Secretariat will facilitate through:• supporting countries to develop, implement and
monitor national plans;• leading and coordinating support to countries for
assessment and implementation of investment needs• monitoring development and implementation of action
plans by Member States and other partners• publishing biennial progress reports
DEVELOPMENT OF A GLOBAL SURVEILLANCE SYSTEM
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Example of activities under the Global action plan on antimicrobial resistance
Development of a global surveillance system for common bacteria
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
• Targets
To assess impact and trends of antimicrobial resistance
Episode of infection, instead of (only) laboratory isolates
• What has been done?
Surveillance standards defined
Surveillance manual being developed (WHO)
Country enrolment in global surveillance to start in 2015
What has WHO been doing in the Asia-Pacific Region?
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
South-East Asia Region: Commitment
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Goal: To minimise the morbidity and mortality due to antimicrobial resistant infection and to preserve the effectiveness of antimicrobial agents in the treatment and prevention of microbial infections.
(simplified version of global strategy)
AMR- ‘Flagship Priority Area’
• To work closely with Member States indevelopment of their respective NationalAction Plans in alignment with, and asarticulated in the Global Action Plan
• Following a systematic approach, based ondeliverables and result-based management, toaccelerate the progress being already made byour Member States
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Action Agenda for Antimicrobial Resistance in the Western Pacific Region
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Three Priority Actions: 1) Develop/ implement comprehensive national plans to contain antimicrobial resistance and raise awareness.2) Improve surveillance of antimicrobial resistance and monitoring of antimicrobial use.
3) Strengthen health system's capacity to contain antimicrobial resistance.
Regional Action Agenda - Ongoing Work Development of National Action Plans on AMR with multisectoral collaboration• Australia : First National Antimicrobial Resistance Strategy
for 2015–2019 launched in June 2015• Cambodia National AMR Plan launched 2015 national
multisectoral committee set up• Viet Nam 2013 + multisectoral Aide Memoire - June 2015• Philippines Presidential order on national AMR Plan and
establishment of inter-agency committee 2014• Lao Peoples’ Democratic Republic (development of a road
map for national map ongoing )• Republic of Korea Draft Action Plan on AMR by KCDC
waiting for approvalSixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of Zoonoses
Sapporo, 28-30 October 2015
Key health system strategies to contain and prevent AMR
• Educational strategies– Public awareness campaigns has been shown to reduce
antibiotic consumption• Regulatory strategies
– Regulatory restrictions on use of antibiotics in human and animals have been demonstrated to achieve reduction of resistance
• Managerial strategies– Antimicrobial stewardship program shown to be effective
changing decision-making and prescribing practices• Economic strategies
– Financial incentives to institutions, providers and patients in combination with actions on pricing structure, the price setting and the reimbursement mechanism reduced unnecessary consumption
Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of ZoonosesSapporo, 28-30 October 2015
Take home message..• Antimicrobial resistance is a complex problem at the
human-animal interface that requires a multi-sectoral , "One Health" approach
• Global Action Plan on AMR galvanizes partners around common goals
• WHO, FAO, OIE and other high level fora (G7, GHSA) have prioritized addressing antimicrobial resistance
• For the first time, the governing bodies of FAO, WHO and OIE have adopted resolutions on AMR in the same year, and all three resolutions have stressed the importance of the "One Health "collaboration to combat AMR
• The momentum is high….so are expectations! Sixth Asia-Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of Zoonoses
Sapporo, 28-30 October 2015
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