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Introdcapillardisease(PAH) phase-cparameaccelerwith prshape oinflow pulmonand patMaterifemale(male:5(Siemetriggerivelocitimages(MPA)interestimageshemodpeak flin flowStudennormalResultin PAHrespect3.69 1MPA w(189.51of 1 listemax.not onldifferenDiscushighly hemodWhen tthe resof patiegroup. parame

more putilizedtwo grtreatmepresentpatientexhibitother pinformRefere1. Simoal. (19150:10

lysis of the He

duction: Patients ries. Symptoms sue with a markedlywhich is one of th

contrast MR imageters [2]. Hemodyration time and arrimary pulmonaryof the arterial pres( ) and outflow

nary vascular resistients with PAH. ials and Methods:7; age:42 17 y/o5; female:7; age:3ens Sonata, Erlaning. A 2D FLASHty-encoding gradies and phase image, right pulmonaryt (ROI) of cross-ss and were appliedynamic parameterlow rate (acceleratw rate during ejent’s t-test was usel subjects and PAHts: Fig. 1 showed tH patients and ntively (p<0.001). 1.19 L/s2 (p<0.05)was 361.33 104.11 65.70; p<0.001

of MPA and ed all hemodynam⁄ and the defly MPA but also ance between two g

ssion and Conclucorrelated with th

dynamic parameterthe pressure in puistance and the ents is significantlIn addition, the ra

eter of force. PAH

power against highd to estimate the croups is indistinguent phases of PAHt. For further studyts into different tt satisfied performphysiological para

mation. ences: onneau G et al. (299) Radiology; 21

075-1080. 4. Wang

emodynamic P

1Nat

with pulmonary huch as short and ray decreased toleranhe five categories

ging (PC-MRI) is aynamic parameterterial distensibility

y hypertension (PPsure waveform, ha

w ( ) during a stance (PVR) [2].

s: The study popuo) and 12 normal 39 9 y/o). PC-Mngen, Germany) uH sequence (TR/Tent was acquired, ses were obtained

y artery (RPA) andsection of above ved to phase imagrs were calculatedtion time ( )),ection (max. ⁄ed to comprehendH patients. the calculated hemnormal subjects The values of ma), respectively. Th4, significantly gr). However, in ou

between two mic parameters fined ratio were st RPA and LPA. Agroups. usions: Hemodynat measured with irs were evaluated ulmonary artery is

might be shly larger, suggestinatio, defined by (mpatients showed h

her pressure in theompliance of aortuishable in our prH patients includey, it is necessary totreatment phases. mance to differentameters, such as

2004). J. Am. Coll.12 : 896-902. 3. T

g JJ et al. (2003) Am

Parameters of

tional Tsing Hua U

hypertension (PH)apid breaths, dizzince of exercise anof PH. Before thea convenient methrs of patients wiy, measured by noPH) and volunteeras been used to descardiac cycle [4].In this study, we a

ulation consisted osubjects without hRI was performedusing the torso c

TE=22/4.8ms, flip sampling 90% of tby using PC-MR

d left pulmonary avessels were selecges for calculationd: , the time fr acceleration volu

), and the ratiod the significance

modynamic results were 94.7 27.0

ax. ⁄ of two he mean value of treater than that ob

ur preliminary resugroups were not sof two groups.

statistically signifiAs for and

namic indices estiinvasive catheterizto non-invasivelymuch higher, the

hortened (Fig. 1(a)ng that the ascendmax. ⁄ )/ higher ratio, sugge

eir pulmonary sysic artery [4]. Horeliminary results ed in this study, tho recruit a larger p In conclusion,

tiation PAH patienPVR, can be inc

. Cardiol. 43 (12 STardivon AA et am J Physiol Heart

Patients with

Hung-Hsuan W

University, Hsinch

) usually present iness, faintness, annd heart failure [1 treatment of PAH

hod for diagnosis. Ith PH have beenon-invasive PC-Mrs (p<0.05) [3]. Wscribe the reservoi Moreover, it hasaim to acquire

of 13 PAH patienhistory of pulmonad on a 1.5T clinicoil with prospecangle=15°) with 1

the cardiac cycle.RI at main pulmonartery (LPA). The cted manually on n of flow velocitrom the onset of fume ( ), maximo of max. ⁄e of the differenc

of MPA. The ms and 132.1groups were 6.40the defined ratio i

btained from normults, the differencestatistically signifiThe parameters

icant between two, there was no

imated by non-invzation methods [2]y differentiate PAHcardiac output mi

)). As shown in Fiding slope of flow

with a unit of secesting that PAH pa

tem. In previousowever, the differe

(Fig. 1(e)). Becahe index of

population of PAHseveral hemodyn

nts from normal gcluded to provide

Suppl S): 5S–12S.al. (1994) Am J Rt Circ Physiol 284:

Pulmonary A

Wang1, and Hsu-Hs

u, Taiwan, 2Nation

an increase in blnd so on, are exac]. The subjects in

H-related diseases, In previous study,n proved with hi

MRI and invasive cWindkessel volume

ir in aortic artery ins been demonstrat

and other hemo

nts (male:6; ary disease ical imager ctive ECG 150 cm/sec Magnitude nary artery regions of magnitude

ty. Several flow to the mal change

to . ce between

of MPA 14.0 ms,

0 3.17 and in patients’

mal subjects es of values cant. Table of ,

o groups at significant

vasive PC-MRI w]. In this study, sevH from normal groight be reduced duig. 1(b), max. rate is higher in P

c-2, implied a physatients’ hearts supp

s study, has bnce of betw

ause of the varietymay not be robus

H patients and to grnamic parametersgroups. In the fute more hemodyna

2. Elie MousseauRespir Crit Care M: H1358–H1368

Arterial Hyper

sia Peng2

nal Tsing Hua Un

lood pressure in cerbated while doincluded in this stu clinicians may ha, non-invasive PC-igh correlation cocatheterization mee ( ), a quantifin animal experimeted that some indiodynamic paramete

were veral roup. ue to ⁄ PAH sical plied

been ween y of st at roup can

ture, amic

ux et Med.

Table1. He

Ratio = NS：no st

rtension by M

iversity, Taiwan

pulmonary arterieing exercise. Pulmudy are patients wave to evaluate pat-MRI has been usoefficients. The hethods, were signied parameter of went [4]. It is calculices derived by Pers to investigate d

emodynamic param

. ⁄ ⁄tatistical significan

MR Phase-Con

es, pulmonary vemonary hypertensiowith pulmonary arttients’ severity at ed to provide relia

hemodynamic parnificantly differenwindkessel effect, lated by integratingC-MRI were highdifferences betwee

meters of subjects

; p-value：Stunce

Fig.1. hemodyparametnormalPAH paparametmax.ratio)significa(d,e) fail to groups.

trast Imaging

ins, or pulmonaryon can be a severeterial hypertensionfirst. Non-invasiveable hemodynamicrameters includingnt between patient

accounted for theg the measuremen

hly correlated withen normal subjects

s

dent’s t-test

Comparing ynamic ters between

subjects and atients. (a-c) Theters ( , ⁄ , defined of MPA are

antly different. and

differentiate two

g

y e n e c g s e

nt h s

1198Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)