MARK BARTLETT, PHD Vice President, Global Research and Development Pharmanex

MARK BARTLETT, PHD

Vice President, Global Research and DevelopmentPharmanex

DIE YOUNG

..as late in life as possible

Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business

opportunity through PRODUCT INNOVATION

• Science in product development– Discovery process– Development process

• Scientific assets– Multiple unique tools to discover and

develop anti-aging products with meaningful benefits

Our anti-aging product strategyis to leverage LEADING EDGE SCIENCE to further understand the aging process.

FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a pre-clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column 1.1

1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.

GENE EXPRESSION IN YOUNG TISSUE

GENE EXPRESSION IN OLD TISSUE

OLD GENE EXPRESSION

AFTER AGELOC

Low Expression

HighExpression

Gene Expression Scale

AGELOC GENE TECHNOLOGY

• Our Science, Your guarantee– Quality– Innovation– Safety– Substantiated claims

6S Quality ProcessSelection; Sourcing; Standardization;Safety; Structure; Substantiation

TOOLKIT

ageLOC science 6S process

ANTI-AGING PRODUCT DEVELOPMENT PROCESS

R&D ENGINE - PROVO INNOVATION CENTER

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R&D ENGINE CHINA INNOVATION PARK

NEW ANTI-AGING AGELOC TOOLS

LifeGen • Patented technologies to

study anti-aging interventions through gene expression science

• Acquired November 2011

NOX Technologies • Patented anti-aging

technology• Incorporated in ageLOC

Transformation and Galvanic Gels

• Acquired November 2012

Nutrition Science

Antioxidant Science

Healthy Aging

GeneScience

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AGELOC GAMMA: WEIGHT MANAGEMENT SYSTEM

• AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene expression science

• ageLOC Gamma helps you look slimmer and healthier in 90 days when used in conjunction with a healthy diet and exercise

Simple Eating & Lifestyle Plan

Advanced ageLOC Products

AGELOC GAMMA: INFLUENCING WEIGHT

• Key Tissues – There are key tissues that address critical areas of weight

loss through gene expression. ageLOC Gamma will focus on these key tissues

AGELOC GAMMA

AGELOC GAMMA: STUDIES• LifeGen (gene expression science)

– Gene array analysis to elucidate YGCs• Clinical Studies

– Open label study (ongoing)– Larger trial (starting in 2013)

GAMMA SYSTEM

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Incorporating ageLOC science and clinically demonstrated ingredients

AGELOC GAMMA REPRESENTS A MAJOR INNOVATION WITH GENE

EXPRESSION SCIENCE

S3: SCANNER UPGRADECOMING SUMMER 2013

• 25% smaller• Wireless• Battery operated

FUTURE PIPELINE

INNOVATIVE ageLOC SKIN CARE and NUTRITION

AGELOC INNOVATION PATTERN

2010 20202013