Mateusz Skowron Paweł Ślusarczyk Supervisor: Joanna Deperas-Standyło Higher-order structure of...

Mateusz SkowronPaweł Ślusarczyk

Supervisor: Joanna Deperas-Standyło

Higher-order structure of chromosomes

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0/G1 have formof long and screwed strings

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0 / G1 have formof long and screwed strings

Firstly believed to form a chaotic spaghetti-like structure

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0 / G1 have formof long and screwed strings

Firstly believed to form a chaotic spaghetti-like structure

1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0 / G1 have formof long and screwed strings

Firstly believed to form a chaotic spaghetti-like structure

1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0 / G1 have formof long and screwed strings

Firstly believed to form a chaotic spaghetti-like structure

1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA

Chromosomes in phase G0 / G1 have formof long and screwed strings

Firstly believed to form a chaotic spaghetti-like structure

1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

Nucleus – sphere

Chromosomal domain – sphere

Domains can overlap each other

Nucleus model

Chromosomal domains in the

nucleus

Model chromosome – a chain of connectedspheres

CHROMOSOME MODEL

Chromosomal territories in the nucleus

Spheres in each chromosome cannot overlap each other

A real chromosome

Cпасибо for your attention!