Microarrays, Genomics, and Systems Biology

Microarrays, Genomics, Microarrays, Genomics, and Systems Biologyand Systems Biology

Keys to Science Institute – Molecular Keys to Science Institute – Molecular Biology and Biotechnology 2004Biology and Biotechnology 2004

Scientific DisciplinesScientific Disciplines

BiologyBiology Molecular BiologyMolecular Biology BiotechnologyBiotechnology BioinformaticsBioinformatics GenomicsGenomics Systems BiologySystems Biology

The Challenge over TimeThe Challenge over Time

Identify a single gene (related to Identify a single gene (related to disease)disease)

Identify as many, if not all, genes of Identify as many, if not all, genes of an organisman organism

Identify all sequence, including non-Identify all sequence, including non-coding regions, contained within a coding regions, contained within a genomegenome

Consider how the kinds of scientific Consider how the kinds of scientific questions to be asked change.questions to be asked change.

GCATGCAT

Genome Consortium for Active TeachGenome Consortium for Active Teachinging

Introduction to MicroarraysIntroduction to Microarrays AnimationAnimation

TIGR and CeleraTIGR and Celera

The Institute for Genomics Research The Institute for Genomics Research (TIGR) – non-profit, private(TIGR) – non-profit, private

July 1995, first whole genome July 1995, first whole genome sequenced – sequenced – Haemophilus influenzae Haemophilus influenzae 1.8Mb1.8Mb

Celera – for profit ventureCelera – for profit venture– celere celere is Latin for “swift”is Latin for “swift”– shotgun sequencingshotgun sequencing

All information gleaned from:All information gleaned from:

Campbell, A. Malcolm and Laurie J. Campbell, A. Malcolm and Laurie J. Heyer, “Discovering Genomics, Heyer, “Discovering Genomics, Proteomics, and Bioinformatics”, Proteomics, and Bioinformatics”, ISBN 0-8053-4722-4ISBN 0-8053-4722-4

Genome Consortium for Active Genome Consortium for Active Teaching (GCAT) websiteTeaching (GCAT) website

TIGR powerpoint presentationsTIGR powerpoint presentations TIGR websiteTIGR website