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Nucleotide Structure: Pentose sugar. Nucleotide Structure: Nitrogenous Bases. DNA Linkage. Phosphate group/phosphodiester bond Nucleotides contain one, two, or three phosphate groups. *nucleoside *nucleotide. Nucleic Acid Polarity. *Top of molecule has free 5’-phosphate group - PowerPoint PPT Presentation
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Nucleotide Structure: Pentose sugar
Nucleotide Structure: Nitrogenous Bases
DNA Linkage• Phosphate group/phosphodiester bond• Nucleotides contain one, two, or three
phosphate groups*nucleoside *nucleotide
Nucleic Acid Polarity*Top of molecule hasfree 5’-phosphate
group
This is the 5’ end
*Bottom has a free 3’hydroxyl group
This is the 3’ end
*Early 1950’s Rosalind Franklin
*1953 Watson and Crick
Structural analysis of DNA
Complementarity
DNA Structure:
Alternative Forms of DNA
G + C Content
DNA Melting*Temperature at which DNA strands are ½ denatured is
the melting temperature or Tm
*GC content of DNA has a significant effect on Tm
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