Polymeric micelles from poly(ethylene glycol)–poly(amino acid) block copolymer for drug and gene...

Polymeric micelles from poly(ethylene glycol)–poly(amino acid) block copolymer for drug and gene delivery

by Kensuke Osada, R. James Christie, and Kazunori Kataoka

InterfaceVolume 6(Suppl 3):S325-S339

June 6, 2009

©2009 by The Royal Society

Schematic of the biological distribution for carriers administered intravenously.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Design of a multifunctional delivery system based on polymeric micelles formed with block copolymers capable of encapsulating drugs and pDNA.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Dox-loaded polymeric micelles prepared by hydrophobic interaction.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Platinum drug-loaded polymeric micelles formed by metal complexation.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Block copolymers with ligand installed for targeted gene delivery.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Cross-linked micelles responsive to the intracellular environment.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

Design of a triblock copolymer for promotion of endosome escape.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society

(a) Quantitative aminolysis reaction of PBLA via a succinimidyl ring intermediate, by which appropriate compounds can be installed into the polymer backbone by displacement of benzyl

groups in PBLA side chains.

Kensuke Osada et al. J. R. Soc. Interface 2009;6:S325-S339

©2009 by The Royal Society